NO179908C - Analogifremgangsmåte for fremstilling av terapeutisk aktive, carbocykliske adenosinanaloger - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive, carbocykliske adenosinanaloger

Info

Publication number: NO179908C
Authority: NO; Norway
Prior art keywords: therapeutically active; analogous process; adenosine analogs; carbocyclic adenosine; preparing therapeutically
Prior art date: 1990-09-14

Application number

NO913625A

Other languages

English (en)

Norwegian (no)

Other versions

NO179908B (no

NO913625D0 (no

NO913625L (no

Inventor

David Roger Borcherding

Iii Carl Keith Edwards

Ronald Eugene Esser

Douglas Leon Cole

Original Assignee

Marion Merrell Dow Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-14

Filing date

1991-09-13

Publication date

1997-01-08

1991-09-13 Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc

1991-09-13 Publication of NO913625D0 publication Critical patent/NO913625D0/no

1992-03-16 Publication of NO913625L publication Critical patent/NO913625L/no

1996-09-30 Publication of NO179908B publication Critical patent/NO179908B/no

1997-01-08 Publication of NO179908C publication Critical patent/NO179908C/no

Links

150000003838 adenosines Chemical class 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
XUGWUUDOWNZAGW-UHFFFAOYSA-N neplanocin A Natural products C1=NC=2C(N)=NC=NC=2N1C1C=C(CO)C(O)C1O XUGWUUDOWNZAGW-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)

NO913625A 1990-09-14 1991-09-13 Analogifremgangsmåte for fremstilling av terapeutisk aktive, carbocykliske adenosinanaloger NO179908C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US58228090A	1990-09-14	1990-09-14
US74817291A	1991-08-23	1991-08-23

Publications (4)

Publication Number	Publication Date
NO913625D0 NO913625D0 (no)	1991-09-13
NO913625L NO913625L (no)	1992-03-16
NO179908B NO179908B (no)	1996-09-30
NO179908C true NO179908C (no)	1997-01-08

Family

ID=27078528

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO913625A NO179908C (no)	1990-09-14	1991-09-13	Analogifremgangsmåte for fremstilling av terapeutisk aktive, carbocykliske adenosinanaloger

Country Status (19)

Country	Link
EP (1)	EP0475411B1 (de)
JP (1)	JP3099280B2 (de)
KR (1)	KR100249111B1 (de)
CN (1)	CN1031132C (de)
AR (1)	AR247566A1 (de)
AT (1)	ATE202106T1 (de)
AU (1)	AU647822B2 (de)
CA (1)	CA2051012C (de)
DE (1)	DE69132632T2 (de)
DK (1)	DK0475411T3 (de)
ES (1)	ES2158840T3 (de)
FI (1)	FI102755B (de)
GR (1)	GR3036577T3 (de)
HU (1)	HU209304B (de)
IE (1)	IE913247A1 (de)
IL (1)	IL99466A (de)
NO (1)	NO179908C (de)
NZ (1)	NZ239750A (de)
PT (1)	PT98943B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU642526B2 (en) *	1990-09-14	1993-10-21	Marion Merrell Dow Inc.	Method of immunosuppression using cyclopentenyl substituted nucleoside analogs and compositions thereof
US5470857A (en) *	1990-09-14	1995-11-28	Marion Merrell Dow Inc.	Carbocyclic nucleoside analogs useful as immunosuppressants
US5723466A (en) *	1991-12-06	1998-03-03	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
AU658698B2 (en) *	1991-12-06	1995-04-27	Aventis Pharmaceuticals Inc.	Novel trans cyclopentanyl purine analogs useful as immunosuppressants
US5817672A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817661A (en)	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5292513A (en) *	1992-05-18	1994-03-08	Anthony G. Gristina	Method for nonspecific cellular immune stimulation
KR19990067704A (ko)	1992-12-17	1999-08-25	디. 제이. 우드, 스피겔 알렌 제이	부신피질자극호르몬 유리인자 길항제로서의 피롤로피리미딘을함유하는 약학 조성물
DK0705263T3 (da)	1993-06-21	1997-05-05	Merrell Pharma Inc	Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner
EP0728134A1 (de) *	1993-11-12	1996-08-28	Merrell Pharmaceuticals Inc.	6-oxo-nukleoside als immunosuppressoren
TW282470B (de) *	1993-11-18	1996-08-01	Ajinomoto Kk
DE59500788D1 (de) *	1994-05-03	1997-11-20	Ciba Geigy Ag	Pyrrolopyrimidinderivate mit antiproliferativer Wirkung
TW530047B (en) *	1994-06-08	2003-05-01	Pfizer	Corticotropin releasing factor antagonists
US6956047B1 (en)	1995-06-06	2005-10-18	Pfizer Inc.	Corticotropin releasing factor antagonists
US7067664B1 (en)	1995-06-06	2006-06-27	Pfizer Inc.	Corticotropin releasing factor antagonists
US6403599B1 (en)	1995-11-08	2002-06-11	Pfizer Inc	Corticotropin releasing factor antagonists
HUP0204272A3 (en)	2000-01-18	2005-03-29	Pfizer Prod Inc	Corticotropin releasing factor antagonists, pharmaceutical compositions containing them and their use
RU2358975C2 (ru) *	2003-08-26	2009-06-20	Тейдзин Фарма Лимитед	Пирролопиримидиноновые производные
US8945505B2 (en)	2007-02-02	2015-02-03	Panaphix, Inc.	Use of arsenic compounds for treatment of pain and inflammation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3551428A (en) *	1956-02-10	1970-12-29	Ciba Geigy Corp	New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
US3917837A (en) *	1974-10-21	1975-11-04	American Cyanamid Co	Method of using trans-2-(6-amino-9H-purin-9-yl)-cyclopentanol
US4076711A (en) *	1976-04-05	1978-02-28	Schering Corporation	Triazolo [4,5-d]-pyrimidines
US4221794A (en) *	1979-06-21	1980-09-09	Newport Pharmaceuticals International, Inc.	Method of imparting immunomodulating and antiviral activity
US4386093A (en) *	1981-09-16	1983-05-31	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	(±)3-Deazaaristeromycin and uses
IN164556B (de) *	1986-03-06	1989-04-08	Takeda Chemical Industries Ltd
US4859677A (en) *	1987-04-17	1989-08-22	University Of Kansas	Nucleoside analogues having antiviral activity
US4782062A (en) *	1987-05-11	1988-11-01	Merck & Co., Inc.	9-(2-hydroxymethyl)cycloalkylmethyl) guanines
IL86381A0 (en) *	1987-05-19	1988-11-15	Nippon Kayaku Kk	Oxetanocins and pharmaceutical compositions containing the same
GB8826205D0 (en) *	1988-11-09	1988-12-14	Wellcome Found	Heterocyclic compounds

1991
- 1991-09-09 CA CA002051012A patent/CA2051012C/en not_active Expired - Lifetime
- 1991-09-09 AU AU83729/91A patent/AU647822B2/en not_active Ceased
- 1991-09-10 AR AR91320625A patent/AR247566A1/es active
- 1991-09-11 PT PT98943A patent/PT98943B/pt not_active IP Right Cessation
- 1991-09-11 NZ NZ239750A patent/NZ239750A/en unknown
- 1991-09-12 IL IL9946691A patent/IL99466A/en not_active IP Right Cessation
- 1991-09-12 DK DK91115485T patent/DK0475411T3/da active
- 1991-09-12 ES ES91115485T patent/ES2158840T3/es not_active Expired - Lifetime
- 1991-09-12 AT AT91115485T patent/ATE202106T1/de not_active IP Right Cessation
- 1991-09-12 EP EP91115485A patent/EP0475411B1/de not_active Expired - Lifetime
- 1991-09-12 DE DE69132632T patent/DE69132632T2/de not_active Expired - Lifetime
- 1991-09-13 IE IE324791A patent/IE913247A1/en not_active Application Discontinuation
- 1991-09-13 JP JP03261249A patent/JP3099280B2/ja not_active Expired - Lifetime
- 1991-09-13 FI FI914319A patent/FI102755B/fi active
- 1991-09-13 NO NO913625A patent/NO179908C/no not_active IP Right Cessation
- 1991-09-13 KR KR1019910015974A patent/KR100249111B1/ko not_active Expired - Fee Related
- 1991-09-13 HU HU912961A patent/HU209304B/hu not_active IP Right Cessation
- 1991-09-14 CN CN91108934A patent/CN1031132C/zh not_active Expired - Fee Related
2001
- 2001-09-11 GR GR20010401434T patent/GR3036577T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI102755B1 (fi)	1999-02-15
FI914319A0 (fi)	1991-09-13
CA2051012C (en)	2002-04-02
EP0475411B1 (de)	2001-06-13
FI914319L (fi)	1992-03-15
PT98943A (pt)	1992-07-31
ATE202106T1 (de)	2001-06-15
KR920006357A (ko)	1992-04-27
EP0475411A1 (de)	1992-03-18
HU209304B (en)	1994-04-28
CN1059909A (zh)	1992-04-01
AR247566A1 (es)	1995-01-31
NO179908B (no)	1996-09-30
GR3036577T3 (en)	2001-12-31
JP3099280B2 (ja)	2000-10-16
CN1031132C (zh)	1996-02-28
HU912961D0 (en)	1992-01-28
NO913625D0 (no)	1991-09-13
AU647822B2 (en)	1994-03-31
JPH04270282A (ja)	1992-09-25
FI102755B (fi)	1999-02-15
IL99466A (en)	1996-07-23
KR100249111B1 (ko)	2000-08-01
PT98943B (pt)	1999-02-26
NO913625L (no)	1992-03-16
IL99466A0 (en)	1992-08-18
DE69132632D1 (de)	2001-07-19
DK0475411T3 (da)	2001-10-01
DE69132632T2 (de)	2002-04-18
HUT59138A (en)	1992-04-28
ES2158840T3 (es)	2001-09-16
IE913247A1 (en)	1992-02-25
NZ239750A (en)	1994-02-25
CA2051012A1 (en)	1992-03-15
AU8372991A (en)	1992-03-19

Legal Events

Date	Code	Title	Description
2001-04-30	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN MARCH 2001

Publication	Publication Date	Title
NO179908C (no)	1997-01-08	Analogifremgangsmåte for fremstilling av terapeutisk aktive, carbocykliske adenosinanaloger
NO176759C (no)	1995-05-24	Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-substituerte-2-oksindol-derivater
FI890652A7 (fi)	1989-08-11	Menetelmä terapeuttisesti aktiivisten substituoitujen indolyylipyrrolijohdannaisten valmistamiseksi
FI870903L (fi)	1987-09-08	Menetelmä terapeuttisesti aktiivisten alfa-heterosykleillä substituoitujen tolunitriilien valmistamiseksi
NO180586C (no)	1997-05-14	Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte imidazoler
FI883050L (fi)	1988-12-25	Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi
NO176758C (no)	1995-05-24	Analogifremgangsmåte for fremstilling av terapeutiske anvendbare tetrazolyl-bifenylylmetyl-pyrimidiner
FI891338A0 (fi)	1989-03-21	Parannus menetelmään 2',3'-dideoksi-2',3'-didehydronukleosidien valmistamiseksi
NO180749C (no)	1997-06-11	Analogifremgangsmåte for fremstilling av terapeutisk aktive benzimidazolsubstituerte derivater
FI883632L (fi)	1989-02-05	Menetelmä uusien, terapeuttisesti käyttökelpoisten eetterien valmistamiseksi
FI890286A0 (fi)	1989-01-19	Menetelmä terapeuttisesti käyttökelpoisten dideoksikarbosyklisten nukleosidianalogien valmistamiseksi
FI885153L (fi)	1989-05-13	Menetelmä terapeuttisesti aktiivisten 2',3'-dideoksi-2'-fluorinukleosidien valmistamiseksi
FI873069A7 (fi)	1988-01-12	Menetelmä uusien terapeuttisesti käyttökelpoisten difenyylipropyyliamiinijohdannaisten valmistamiseksi
NO174959C (no)	1994-08-10	Analogifremgangsmåte for fremstilling av terapeutisk aktive N-aminobutyl-N-fenyl-arylamidderivater
FI891339A7 (fi)	1989-09-26	Menetelmä uusien terapeuttisesti käyttökelpoisten aristeromysiini/adenosiinijohdannaisten valmistamiseksi
NO178967C (no)	1996-07-10	Analogifremgangsmåte for fremstilling av terapeutisk aktive pyridazin-derivater
NO177096C (no)	1995-07-26	Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte isokinoliner
FI880467A7 (fi)	1988-08-05	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 3,4-dihydro-2H-bentsopyraanien valmistamiseksi
NO173784C (no)	1994-02-02	Anaslogifremgangsmaate for fremstilling av terapeutisk aktive tieno-tri-azolo-diazepinderivater
FI890123L (fi)	1989-07-15	Menetelmä valmistaa terapeuttisesti vaikuttavia indolyylipiperidiiniyhdisteitä
FI924642L (fi)	1992-10-14	Menetelmä terapeuttisesti aktiivisten 3-indolyylitioasetaattijohdannaisten valmistamiseksi
NO174892C (no)	1994-07-27	Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte dihydropyrrolizinforbindelser
FI884660L (fi)	1989-04-13	Menetelmä terapeuttisesti aktiivisten 2,2-dimetyylikromeenijohdannaisten valmistamiseksi
NO175781C (no)	1994-12-07	Analogifremgangsmåte for fremstilling av terapeutisk aktive tetracykliske forbindelser
FI916058A7 (fi)	1992-06-28	Menetelmä terapeuttisesti aktiivisten dihydrobentsofuraanikarboksamidien valmistamiseksi