ATE205728T1 - Markiertes interleukin-8 und seine medizinische anwendung - Google Patents

Markiertes interleukin-8 und seine medizinische anwendung

Info

Publication number: ATE205728T1
Authority: AT; Austria
Prior art keywords: medical application; target site; labeled interleukin; interleukin; labeled
Prior art date: 1992-10-05

Application number

AT93923789T

Other languages

English (en)

Inventor

Leon R Lyle

Steven L Kunkel

Original Assignee

Mallinckrodt Medical Inc

Univ Michigan Technology Man W

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-05

Filing date

1993-10-04

Publication date

2001-10-15

1993-10-04 Application filed by Mallinckrodt Medical Inc, Univ Michigan Technology Man W filed Critical Mallinckrodt Medical Inc

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE205728T1 publication Critical patent/ATE205728T1/de

Links

102000004890 Interleukin-8 Human genes 0.000 title 1
108090001007 Interleukin-8 Proteins 0.000 title 1
XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 title 1
229940096397 interleukin-8 Drugs 0.000 title 1
108050006947 CXC Chemokine Proteins 0.000 abstract 2
102000019388 CXC chemokine Human genes 0.000 abstract 2
238000003384 imaging method Methods 0.000 abstract 1
102000010681 interleukin-8 receptors Human genes 0.000 abstract 1
108010038415 interleukin-8 receptors Proteins 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Optics & Photonics (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Physics & Mathematics (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)
Radiation-Therapy Devices (AREA)
Nuclear Medicine (AREA)
Measurement Of Radiation (AREA)

AT93923789T 1992-10-05 1993-10-04 Markiertes interleukin-8 und seine medizinische anwendung ATE205728T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/956,863 US5346686A (en)	1992-10-05	1992-10-05	Labelled interleukin-8 and medical uses thereof
PCT/US1993/009554 WO1994007535A2 (en)	1992-10-05	1993-10-04	Labelled interleukin-8 and medical uses thereof

Publications (1)

Publication Number	Publication Date
ATE205728T1 true ATE205728T1 (de)	2001-10-15

Family

ID=25498784

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93923789T ATE205728T1 (de)	1992-10-05	1993-10-04	Markiertes interleukin-8 und seine medizinische anwendung

Country Status (11)

Country	Link
US (1)	US5346686A (de)
EP (1)	EP0670736B1 (de)
JP (1)	JPH08511765A (de)
AT (1)	ATE205728T1 (de)
AU (1)	AU686119B2 (de)
CA (1)	CA2146239C (de)
DE (1)	DE69330794T2 (de)
DK (1)	DK0670736T3 (de)
ES (1)	ES2168098T3 (de)
PT (1)	PT670736E (de)
WO (1)	WO1994007535A2 (de)

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US6451562B1 (en)	1993-12-22	2002-09-17	Human Genome Sciences, Inc.	Polypeptides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) polynucleotides
US6001606A (en) *	1994-03-08	1999-12-14	Human Genome Sciences, Inc.	Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
US6811773B1 (en) *	1993-12-22	2004-11-02	Human Genome Sciences, Inc.	Human monocyte colony inhibitory factor (M-CIF) polypeptides
US6495129B1 (en)	1994-03-08	2002-12-17	Human Genome Sciences, Inc.	Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3)
US6391589B1 (en)	1994-08-23	2002-05-21	Human Genome Sciences, Inc.	Human chemokine beta-10 mutant polypeptides
US6174995B1 (en)	1994-08-23	2001-01-16	Haodong Li	Human chemokines, CKβ4 and CKβ10/MCP-4
US6458349B1 (en)	1995-06-02	2002-10-01	Human Genome Sciences, Inc.	Chemokine β-4 polypeptides
US5981230A (en) *	1994-08-23	1999-11-09	Human Genome Sciences, Inc.	Polynucleotide encoding chemokine β-4
US5789539A (en) *	1994-10-26	1998-08-04	Repligen Corporation	Chemokine-like proteins and methods of use
US6139832A (en) *	1995-02-08	2000-10-31	Human Genome Sciences, Inc.	Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides
EP0811059A4 (de) *	1995-02-08	1998-04-01	Human Genome Sciences Inc	Menschliche chemokine beta-11 und alpha-1
US5994292A (en) *	1995-05-31	1999-11-30	The United States Of America As Represented By The Department Of Health And Human Services	Interferon-inducible protein 10 is a potent inhibitor of angiogenesis
US6410268B1 (en)	1996-03-18	2002-06-25	Human Genome Sciences, Inc.	Polynucleotides encoding chemokine alpha-3
NZ332318A (en) *	1996-03-19	2000-10-27	Human Genome Sciences Inc	Chemokine alpha 2 and it's therapeutic and diagnostic use in treating illnesses
US6290948B1 (en) *	1996-05-14	2001-09-18	Smithkline Beecham Corporation	Method of treating sepsis and ARDS using chamohine beta-10
ES2191827T3 (es) *	1996-10-17	2003-09-16	Immunomedics Inc	Conjugado de toxina no antigenica y proteina de fusion de un sistema receptor de penetracion intracelular.
US6204024B1 (en)	1997-09-12	2001-03-20	Akzo Nobel N.V.	CCR5 RNA transcription based amplification assay
US6703488B1 (en)	1998-01-15	2004-03-09	Center For Molecular Medicine And Immunology	Antibody/receptor targeting moiety for enhanced delivery of armed ligand
ES2322975T3 (es) *	1998-01-15	2009-07-02	Center For Molecular Medicine And Immunology	Componente direccionador biespecifico que comprende un anticuerpo contra el antigeno carcinoembrionario (cea) y la region de union a ligando de la subunidad alfa del receptor de il-13.
US20030215421A1 (en) *	1999-07-21	2003-11-20	Mcdonald John R.	Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US7157418B1 (en)	1998-07-22	2007-01-02	Osprey Pharmaceuticals, Ltd.	Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
WO2000004926A2 (en) *	1998-07-22	2000-02-03	Osprey Pharmaceuticals Limited	Conjugates for treating inflammatory disorders and associated tissue damage
AU2007201753B2 (en) *	1998-07-22	2008-11-27	Osprey Pharmaceuticals Usa, Inc.	Nucleic acid molecules encoding cytotoxic conjugates that contain a chemokine receptor targeting agent
ATE518884T1 (de) *	2002-05-01	2011-08-15	Human Genome Sciences Inc	Spezifisch an chemokin beta-4 bindende antikörper
EP1437145A1 (de) *	2003-01-07	2004-07-14	Schering AG	Verbesserte szintigraphische bildgebende Mittel zur Darstellung von Infektionen und Entzündungen
GB0905438D0 (en) *	2009-03-30	2009-05-13	Ge Healthcare Ltd	Radiolabelling reagents and methods
MX361929B (es)	2010-11-19	2018-12-19	Eisai R&D Man Co Ltd Star	Anticuerpos anti-ligando de quimiocina cc 20 (ccl20) neutralizantes.

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US4837003A (en) *	1984-09-13	1989-06-06	Mallinckrodt, Inc.	Radiolabeled antibody fragments
US4659839A (en) *	1984-10-10	1987-04-21	Mallinckrodt, Inc.	Coupling agents for radiolabeled antibody fragments
US5037630A (en) *	1985-01-14	1991-08-06	Neorx Corporation	Metal radionuclide labeled proteins for diagnosis and therapy
GB8525974D0 (en) *	1985-10-22	1985-11-27	Nyegaard & Co As	Chemical substance
US4926869A (en) *	1986-01-16	1990-05-22	The General Hospital Corporation	Method for the diagnosis and treatment of inflammation
US4732974A (en) *	1986-03-05	1988-03-22	Mallinckrodt, Inc.	Metal ion labeling of carrier molecules
EP0284071B1 (de) *	1987-03-26	1994-06-08	Neorx Corporation	Metall-Radionuklid-markierte Proteine und Glykoproteine zur Diagnose und Therapie
US4965392A (en) *	1987-03-26	1990-10-23	Neorx Corporation	Chelating compounds for metal-radionuclide labeled proteins
US5120525A (en) *	1988-03-29	1992-06-09	Immunomedics, Inc.	Radiolabeled antibody cytotoxic therapy of cancer
US4986979A (en) *	1989-03-14	1991-01-22	Neorx Corporation	Imaging tissue sites of inflammation
CA2016235C (en) *	1989-05-09	2002-03-12	Alan J. Fischman	Labeled chemotactic peptides to image focal sites of infection or inflammation
ATE120374T1 (de) *	1989-07-20	1995-04-15	Sandoz Ag	Markierte polypeptidderivate.
WO1991008483A1 (en) *	1989-11-29	1991-06-13	Brigham And Women's Hospital	Endothelial-derived il-8
AU6952391A (en) *	1989-11-29	1991-06-26	Brigham And Women's Hospital	(ala il-8)77 as a leukocyte adhesion inhibitor
IE913192A1 (en) *	1990-09-12	1992-02-25	Scripps Research Inst	Active site of interleukin-8: polypeptide analogs and¹antibodies
US5225180A (en) *	1991-09-10	1993-07-06	Diatech, Inc.	Technetium-99m labeled somatostatin-derived peptides for imaging

1992
- 1992-10-05 US US07/956,863 patent/US5346686A/en not_active Expired - Fee Related
1993
- 1993-10-04 JP JP6509411A patent/JPH08511765A/ja not_active Ceased
- 1993-10-04 PT PT93923789T patent/PT670736E/pt unknown
- 1993-10-04 CA CA002146239A patent/CA2146239C/en not_active Expired - Fee Related
- 1993-10-04 EP EP93923789A patent/EP0670736B1/de not_active Expired - Lifetime
- 1993-10-04 ES ES93923789T patent/ES2168098T3/es not_active Expired - Lifetime
- 1993-10-04 WO PCT/US1993/009554 patent/WO1994007535A2/en not_active Ceased
- 1993-10-04 AT AT93923789T patent/ATE205728T1/de not_active IP Right Cessation
- 1993-10-04 DE DE69330794T patent/DE69330794T2/de not_active Expired - Fee Related
- 1993-10-04 AU AU53531/94A patent/AU686119B2/en not_active Ceased
- 1993-10-04 DK DK93923789T patent/DK0670736T3/da active

Also Published As

Publication number	Publication date
PT670736E (pt)	2002-03-28
AU5353194A (en)	1994-04-26
WO1994007535A3 (en)	1994-05-11
WO1994007535A2 (en)	1994-04-14
US5346686A (en)	1994-09-13
EP0670736B1 (de)	2001-09-19
DK0670736T3 (da)	2001-11-05
EP0670736A1 (de)	1995-09-13
DE69330794D1 (de)	2001-10-25
ES2168098T3 (es)	2002-06-01
DE69330794T2 (de)	2002-05-23
JPH08511765A (ja)	1996-12-10
AU686119B2 (en)	1998-02-05
CA2146239C (en)	2003-04-01
CA2146239A1 (en)	1994-04-14

Legal Events

Date

Code

Title

Description

2003-03-15

EEIH

Change in the person of patent owner

2003-04-15

UEP

Publication of translation of european patent specification

Ref document number: 0670736

Country of ref document: EP

2006-07-15

REN

Ceased due to non-payment of the annual fee

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