ATE205846T1 - 2,7-substituierte octahydropyrrolo(1,2- a)pyrazinderivate - Google Patents

2,7-substituierte octahydropyrrolo(1,2- a)pyrazinderivate

Info

Publication number
ATE205846T1
ATE205846T1 AT96935226T AT96935226T ATE205846T1 AT E205846 T1 ATE205846 T1 AT E205846T1 AT 96935226 T AT96935226 T AT 96935226T AT 96935226 T AT96935226 T AT 96935226T AT E205846 T1 ATE205846 T1 AT E205846T1
Authority
AT
Austria
Prior art keywords
pyrazine derivatives
substituted octahydropyrrolo
octahydropyrrolo
substituted
pyrazine
Prior art date
Application number
AT96935226T
Other languages
English (en)
Inventor
Mark A Sanner
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE205846T1 publication Critical patent/ATE205846T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Toxicology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT96935226T 1995-12-21 1996-11-06 2,7-substituierte octahydropyrrolo(1,2- a)pyrazinderivate ATE205846T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US898895P 1995-12-21 1995-12-21
PCT/IB1996/001192 WO1997023482A1 (en) 1995-12-21 1996-11-06 2,7-substituted octahydro-pyrrolo[1,2-a]pyrazine derivatives

Publications (1)

Publication Number Publication Date
ATE205846T1 true ATE205846T1 (de) 2001-10-15

Family

ID=21734893

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96935226T ATE205846T1 (de) 1995-12-21 1996-11-06 2,7-substituierte octahydropyrrolo(1,2- a)pyrazinderivate

Country Status (33)

Country Link
US (1) US5714487A (de)
EP (1) EP0874849B1 (de)
JP (1) JP3204456B2 (de)
KR (1) KR100286786B1 (de)
CN (1) CN1061350C (de)
AR (1) AR005102A1 (de)
AT (1) ATE205846T1 (de)
AU (1) AU704578B2 (de)
BR (1) BR9612246A (de)
CA (1) CA2240594C (de)
CO (1) CO4480107A1 (de)
CZ (1) CZ192998A3 (de)
DE (1) DE69615404T2 (de)
DK (1) DK0874849T3 (de)
ES (1) ES2161377T3 (de)
GR (1) GR3037060T3 (de)
GT (1) GT199600101A (de)
HU (1) HUP9900611A3 (de)
IL (1) IL124453A0 (de)
MA (1) MA26413A1 (de)
MX (1) MX9805088A (de)
NO (1) NO309936B1 (de)
NZ (1) NZ320537A (de)
PE (1) PE25998A1 (de)
PL (1) PL327539A1 (de)
PT (1) PT874849E (de)
RU (1) RU2162470C2 (de)
SI (1) SI0874849T1 (de)
TN (1) TNSN96164A1 (de)
TR (1) TR199801161T2 (de)
TW (1) TW479058B (de)
WO (1) WO1997023482A1 (de)
ZA (1) ZA9610781B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (de) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituierte Octahydropyrrolo(1,2-a)pyrazinderivate als 5ht 1a Liganden
US6355802B1 (en) * 1999-02-05 2002-03-12 Pharmacia & Upjohn Company Process to prepare (5R)-(methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]-quinolin-2(1h)-one
EP1083369B1 (de) 1999-09-10 2004-06-30 Mitsubishi Jidosha Kogyo Kabushiki Kaisha Stufenloses Getriebe
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
PL354514A1 (en) * 1999-09-14 2004-01-26 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
PL208787B1 (pl) * 2001-09-19 2011-06-30 Merck Patent Gmbh (2R, 4R/S)-2-({[5-(4-fluorofenylo)-pirydyn-3ylmetylo)]-amino}-metylo)-chroman-4-ol i (2R, 4R)-2-({[5-(4-fluorofenylo)-pirydyn-3ylmetylo)]-amino}-metylo)-chroman-4-ol, sposoby ich otrzymywania i zastosowanie do wytwarzania preparatów medycznych oraz zawierająca je kompozycja farmaceutyczna
TW200801005A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Acetylenic piperazines as metabotropic glutamate receptor antagonists
US7728031B2 (en) * 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
WO2013049164A1 (en) * 2011-09-29 2013-04-04 Abbvie Inc. SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS
CA3108076A1 (en) * 2018-09-04 2020-03-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine m1 receptor antagonists
IL326597A (en) 2019-10-07 2026-04-01 Contineum Therapeutics Inc Muscarinic M1 acetylcholine receptor antagonists
US11752149B2 (en) 2019-12-02 2023-09-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine M1 receptor antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
US5122515A (en) * 1990-06-19 1992-06-16 Smith Ross C Nutrient composition containing dipeptides and method for administering the same
JP3058945B2 (ja) * 1990-10-26 2000-07-04 三共株式会社 Ｎ−（３，３−ジ置換アクリロイル）ピペラジン誘導体
DE69325662T2 (de) * 1992-10-23 2000-02-10 Merck Sharp & Dohme Ltd., Hoddesdon Dopamin rezeptor subtyp liganden
EP0665840A1 (de) * 1992-10-23 1995-08-09 MERCK SHARP & DOHME LTD. Dopamin-rezeptor subtypliganden
NZ284851A (en) * 1994-08-05 1998-07-28 Pfizer 1-[3-(piperazin-1-yl)-prop-1-yl] benzimidazole derivatives and their use in the treatment of cns disorders
DK0783503T3 (da) * 1994-09-30 2002-02-11 Pfizer 2,7-substituerede octahydro-1H-pyrido(1,2-a)pyrazinderivater
US5576314A (en) * 1994-12-12 1996-11-19 Allelix Biopharmaceuticals Inc. Bicyclic nonane and decane compounds having dopamine receptor affinity

Also Published As

Publication number Publication date
NO982843L (no) 1998-06-19
KR100286786B1 (ko) 2001-04-16
ZA9610781B (en) 1998-06-22
HUP9900611A2 (hu) 1999-08-30
DK0874849T3 (da) 2001-11-19
CO4480107A1 (es) 1997-07-09
NZ320537A (en) 1999-03-29
SI0874849T1 (de) 2001-12-31
CN1205704A (zh) 1999-01-20
IL124453A0 (en) 1998-12-06
JP3204456B2 (ja) 2001-09-04
JPH11508920A (ja) 1999-08-03
MX9805088A (es) 1998-10-31
AU7328096A (en) 1997-07-17
NO982843D0 (no) 1998-06-19
PL327539A1 (en) 1998-12-21
DE69615404T2 (de) 2002-06-06
TNSN96164A1 (fr) 2005-03-15
MA26413A1 (fr) 2004-12-20
PT874849E (pt) 2002-01-30
EP0874849B1 (de) 2001-09-19
CZ192998A3 (cs) 1999-05-12
EP0874849A1 (de) 1998-11-04
HUP9900611A3 (en) 2000-09-28
KR19990076616A (ko) 1999-10-15
GT199600101A (es) 1998-06-12
TR199801161T2 (xx) 1998-10-21
TW479058B (en) 2002-03-11
US5714487A (en) 1998-02-03
ES2161377T3 (es) 2001-12-01
CA2240594A1 (en) 1997-07-03
NO309936B1 (no) 2001-04-23
AR005102A1 (es) 1999-04-14
GR3037060T3 (en) 2002-01-31
CN1061350C (zh) 2001-01-31
DE69615404D1 (de) 2001-10-25
PE25998A1 (es) 1998-05-19
RU2162470C2 (ru) 2001-01-27
BR9612246A (pt) 1999-07-13
AU704578B2 (en) 1999-04-29
WO1997023482A1 (en) 1997-07-03
CA2240594C (en) 2001-07-24

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee