ES2161377T3 - Derivados de octahidro-pirrolo(1,2-a)-pirazina 2,7-sustituidos. - Google Patents

Derivados de octahidro-pirrolo(1,2-a)-pirazina 2,7-sustituidos.

Info

Publication number
ES2161377T3
ES2161377T3 ES96935226T ES96935226T ES2161377T3 ES 2161377 T3 ES2161377 T3 ES 2161377T3 ES 96935226 T ES96935226 T ES 96935226T ES 96935226 T ES96935226 T ES 96935226T ES 2161377 T3 ES2161377 T3 ES 2161377T3
Authority
ES
Spain
Prior art keywords
pirazina
octahidro
pirrolo
derivatives
replaced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96935226T
Other languages
English (en)
Inventor
Mark A Sanner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2161377T3 publication Critical patent/ES2161377T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

ESTA INVENCION TRATA DE COMPUESTOS DE FORMULA (I), EN DONDE R 1 ES FENILO , NAFTILO, BENZOXAZOLONILO, INDOLILO, IN DOLONILO, BENCIMIDAZOLILO, QUINOLILO, FURILO, BENZOFURILO, TIENILO, BENZOTIENILO, OXAZOLILO, BENZOXAZOLILO; R 2 ES H O ALQUILO DE C 1 - C 6 ; R 3 ES FENILO, PIRIDINILO, PIRIMIDINILO, PIRAZINILO, O PIRIDAZINILO; X ES O, S, SO, SO SUB,2 , NR 4 , C=O, CH(OH), CHR 4 , (A), (B), (C) O (D); M ES 0, 1 O 2; N ES 0, 1, O 2. LOS COMPUESTOS DE ESTA INVENCION SON LIGANDOS PARA SUBTIPOS DEL RECEPTOR DE LA DOPAMINA, ESPECIALMENTE EL RECEPTOR D 4 , Y SON POR TANTO UTILES EN EL TRATAMIENTO DE ALTERACIONES EN EL SISTEMA DE LA DOPAMINA.
ES96935226T 1995-12-21 1996-11-06 Derivados de octahidro-pirrolo(1,2-a)-pirazina 2,7-sustituidos. Expired - Lifetime ES2161377T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US898895P 1995-12-21 1995-12-21

Publications (1)

Publication Number Publication Date
ES2161377T3 true ES2161377T3 (es) 2001-12-01

Family

ID=21734893

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96935226T Expired - Lifetime ES2161377T3 (es) 1995-12-21 1996-11-06 Derivados de octahidro-pirrolo(1,2-a)-pirazina 2,7-sustituidos.

Country Status (33)

Country Link
US (1) US5714487A (es)
EP (1) EP0874849B1 (es)
JP (1) JP3204456B2 (es)
KR (1) KR100286786B1 (es)
CN (1) CN1061350C (es)
AR (1) AR005102A1 (es)
AT (1) ATE205846T1 (es)
AU (1) AU704578B2 (es)
BR (1) BR9612246A (es)
CA (1) CA2240594C (es)
CO (1) CO4480107A1 (es)
CZ (1) CZ192998A3 (es)
DE (1) DE69615404T2 (es)
DK (1) DK0874849T3 (es)
ES (1) ES2161377T3 (es)
GR (1) GR3037060T3 (es)
GT (1) GT199600101A (es)
HU (1) HUP9900611A3 (es)
IL (1) IL124453A0 (es)
MA (1) MA26413A1 (es)
MX (1) MX9805088A (es)
NO (1) NO309936B1 (es)
NZ (1) NZ320537A (es)
PE (1) PE25998A1 (es)
PL (1) PL327539A1 (es)
PT (1) PT874849E (es)
RU (1) RU2162470C2 (es)
SI (1) SI0874849T1 (es)
TN (1) TNSN96164A1 (es)
TR (1) TR199801161T2 (es)
TW (1) TW479058B (es)
WO (1) WO1997023482A1 (es)
ZA (1) ZA9610781B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (en) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
AU767089B2 (en) * 1999-02-05 2003-10-30 Pharmacia & Upjohn Company Process to prepare (5R)-(methylamino)-5,6-dihydro-4H- imidazo(4,5,1-ij)-quinolin-2(1H)-one
EP1083369B1 (en) 1999-09-10 2004-06-30 Mitsubishi Jidosha Kogyo Kabushiki Kaisha Continuously variable transmission
US7253165B2 (en) 1999-09-14 2007-08-07 Aventis Pharmaceuticals Inc. Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists
HUP0202706A3 (en) * 1999-09-14 2004-12-28 Aventis Pharmaceuticals Inc Br Benzisoxazolyl-, pyridoisoxazolyl- and benzthienyl-phenoxy derivatives useful as d4 antagonists, their intermediates, process for their preparation and pharmaceutical compositions containing them
US7091199B1 (en) 1999-09-14 2006-08-15 Aventis Pharmaceuticals Inc. Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists
US7125903B1 (en) 1999-09-14 2006-10-24 Aventis Pharmaceuticals Inc. Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists
AU2002331229B2 (en) * 2001-09-19 2008-05-15 Merck Patent Gmbh Novel use of substituted aminomethyl chromans
TW200801005A (en) * 2005-08-15 2008-01-01 Astrazeneca Ab Acetylenic piperazines as metabotropic glutamate receptor antagonists
US7728031B2 (en) * 2006-02-24 2010-06-01 Abbott Laboratories Octahydro-pyrrolo[3,4-b]pyrrole derivatives
WO2013049164A1 (en) * 2011-09-29 2013-04-04 Abbvie Inc. SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS
US12054487B2 (en) 2018-09-04 2024-08-06 Contineum Therapeutics, Inc. Muscarinic acetylcholine M1 receptor antagonists
IL326597A (en) 2019-10-07 2026-04-01 Contineum Therapeutics Inc Muscarinic M1 acetylcholine receptor antagonists
US11752149B2 (en) 2019-12-02 2023-09-12 Pipeline Therapeutics, Inc. Muscarinic acetylcholine M1 receptor antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
MX19222A (es) * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
US5122515A (en) * 1990-06-19 1992-06-16 Smith Ross C Nutrient composition containing dipeptides and method for administering the same
JP3058945B2 (ja) * 1990-10-26 2000-07-04 三共株式会社 Ｎ−（３，３−ジ置換アクリロイル）ピペラジン誘導体
JPH08502508A (ja) * 1992-10-23 1996-03-19 メルク シヤープ エンド ドーム リミテツド ドーパミンレセプターサブタイプリガンド
JPH08502958A (ja) * 1992-10-23 1996-04-02 メルク シヤープ エンド ドーム リミテツド ドーパミンレセプターサブタイプリガンド
DK0775118T3 (da) * 1994-08-05 2003-09-29 Pfizer Benzimidazolderivater, der har dopaminerg aktivitet
PL180899B1 (pl) * 1994-09-30 2001-04-30 Pfizer Nowe pochodne 2,7-podstawionej oktahydro-1H-pirydo[1,2-a]pirazyny i środek farmaceutyczny je zawierający
US5576314A (en) * 1994-12-12 1996-11-19 Allelix Biopharmaceuticals Inc. Bicyclic nonane and decane compounds having dopamine receptor affinity

Also Published As

Publication number Publication date
AR005102A1 (es) 1999-04-14
DE69615404D1 (de) 2001-10-25
NO982843L (no) 1998-06-19
KR100286786B1 (ko) 2001-04-16
AU704578B2 (en) 1999-04-29
HUP9900611A3 (en) 2000-09-28
ATE205846T1 (de) 2001-10-15
CN1061350C (zh) 2001-01-31
IL124453A0 (en) 1998-12-06
KR19990076616A (ko) 1999-10-15
GT199600101A (es) 1998-06-12
CZ192998A3 (cs) 1999-05-12
EP0874849B1 (en) 2001-09-19
EP0874849A1 (en) 1998-11-04
NZ320537A (en) 1999-03-29
AU7328096A (en) 1997-07-17
NO309936B1 (no) 2001-04-23
TNSN96164A1 (fr) 2005-03-15
MA26413A1 (fr) 2004-12-20
HUP9900611A2 (hu) 1999-08-30
ZA9610781B (en) 1998-06-22
BR9612246A (pt) 1999-07-13
TW479058B (en) 2002-03-11
PT874849E (pt) 2002-01-30
DE69615404T2 (de) 2002-06-06
DK0874849T3 (da) 2001-11-19
WO1997023482A1 (en) 1997-07-03
MX9805088A (es) 1998-10-31
RU2162470C2 (ru) 2001-01-27
CA2240594C (en) 2001-07-24
CA2240594A1 (en) 1997-07-03
JPH11508920A (ja) 1999-08-03
CN1205704A (zh) 1999-01-20
NO982843D0 (no) 1998-06-19
TR199801161T2 (xx) 1998-10-21
US5714487A (en) 1998-02-03
CO4480107A1 (es) 1997-07-09
JP3204456B2 (ja) 2001-09-04
SI0874849T1 (es) 2001-12-31
PL327539A1 (en) 1998-12-21
PE25998A1 (es) 1998-05-19
GR3037060T3 (en) 2002-01-31

Similar Documents

Publication Publication Date Title
MX9805253A (es) Antagonistas del receptor de vitronectina.
CY1113047T1 (el) Νεα κρυσταλλικη και αμορφη μορφη μιας ενωσης τριαζολο (4,5-d) πυριμιδινης
BR1100538A (pt) Antagonistas de vasopressina benzazepina tricìclicos
MX9101637A (es) Herbicidas de aril-halogenoalquilpirazoles substituidos
CY1113054T1 (el) Παραγωγα διαμινης
DE60144322D1 (de) Kondensierte heteroarylderivate
ATE186736T1 (de) Aza-zyklohexapeptide
GB9514473D0 (en) Chemical compounds
ATE267164T1 (de) 9-(substituiertes glycyl)amido-6-(substituiert)-5-hydroxy-6-deoxy etracycline
NO932872D0 (no) Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner
PL326024A1 (en) Novel derivatives of cyclodepsipeptidic substance pf1022
ES2195397T3 (es) Quinazolin-2,4-dionas sustituidas en posicion 7 utiles como agentes antibacterianos.
GB9815618D0 (en) Treatment of dyskinesia
HU910294D0 (en) Treating process for concrete floor elements by microbiocide substance
ES2156889T3 (es) Compuestos biciclicos antagonistas de receptores de aminoacidos excitativos.
AR008860A1 (es) Empleo de 1-hidroxi-2-piridonas para el tratamiento de la dermatitis seborreica
MX9204286A (es) Agentes para el tratamiento de semillas.
ES2183843T3 (es) Compuestos triciclicos que tienen afinidad por el receptor 5-ht1a.
ECSP951544A (es) DERIVADOS 2,7- SUSTITUIDOS DE OCTAHIDRO-1H-PIRIDO (1,2,a) PIRAZINA

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 874849

Country of ref document: ES