ATE206707T1 - Herstellung von omeprazol und lansoprazol und dabei verwendete zwischenprodukte - Google Patents

Herstellung von omeprazol und lansoprazol und dabei verwendete zwischenprodukte

Info

Publication number: ATE206707T1
Authority: AT; Austria
Prior art keywords: lansoprazole; omeprazole; production; intermediate products; products used
Prior art date: 1993-11-04

Application number

AT94924662T

Other languages

English (en)

Inventor

Clarke Slemon

Bob Macel

Original Assignee

Torcan Chemical Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-04

Filing date

1994-08-17

Publication date

2001-10-15

1994-08-17 Application filed by Torcan Chemical Ltd filed Critical Torcan Chemical Ltd

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE206707T1 publication Critical patent/ATE206707T1/de

Links

SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 title abstract 2
229960003174 lansoprazole Drugs 0.000 title abstract 2
MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 title abstract 2
229960000381 omeprazole Drugs 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
-1 amide sulfinyl compound Chemical class 0.000 abstract 2
ZCKIMSGWDFRXIU-UHFFFAOYSA-N acetyl(sulfido)azanium Chemical class CC(=O)[NH2+][S-] ZCKIMSGWDFRXIU-UHFFFAOYSA-N 0.000 abstract 1
238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
238000006114 decarboxylation reaction Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT94924662T 1993-11-04 1994-08-17 Herstellung von omeprazol und lansoprazol und dabei verwendete zwischenprodukte ATE206707T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/145,572 US5374730A (en)	1993-11-04	1993-11-04	Preparation of omeprazole and lansoprazole
PCT/CA1994/000452 WO1995012590A1 (en)	1993-11-04	1994-08-17	Preparation of omeprazole and lansoprazole and intermediates useful therein

Publications (1)

Publication Number	Publication Date
ATE206707T1 true ATE206707T1 (de)	2001-10-15

Family

ID=22513693

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94924662T ATE206707T1 (de)	1993-11-04	1994-08-17	Herstellung von omeprazol und lansoprazol und dabei verwendete zwischenprodukte

Country Status (8)

Country	Link
US (2)	US5374730A (de)
EP (1)	EP0724582B1 (de)
JP (1)	JP2966097B2 (de)
AT (1)	ATE206707T1 (de)
AU (1)	AU7487594A (de)
CA (1)	CA2170250C (de)
DE (1)	DE69428595D1 (de)
WO (1)	WO1995012590A1 (de)

Families Citing this family (47)

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ATE286394T1 (de) *	1995-09-21	2005-01-15	Pharma Pass Ii Llc	Ein säurelabile omeprazol enthaltende arzneizusammensetzung und verfahren zu deren herstellung
US5840737A (en)	1996-01-04	1998-11-24	The Curators Of The University Of Missouri	Omeprazole solution and method for using same
US6699885B2 (en)	1996-01-04	2004-03-02	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en)	1996-01-04	2002-12-03	The Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en)	1996-01-04	2003-11-11	Curators Of The University Of Missouri	Substituted benzimidazole dosage forms and method of using same
SE9600070D0 (sv) *	1996-01-08	1996-01-08	Astra Ab	New oral pharmaceutical dosage forms
WO1997029103A2 (en) *	1996-02-06	1997-08-14	Pdi-Research Laboratories, Inc.	Synthesis of omeprazole-type pyridine derivatives and intermediates thereof
SE508669C2 (sv) *	1996-04-26	1998-10-26	Astra Ab	Nytt förfarande
DE19643593A1 (de) *	1996-10-22	1998-04-23	Privatinstitut Fuer Informatik	Vorrichtung und Verfahren zum frühzeitigen Erkennen und Verhindern unzulässiger Konzentrationsschwächen und des Einschlafens beim Autofahren und bei anderen Tätigkeiten, die hohe Konzentration erfordern
TW385306B (en) *	1996-11-14	2000-03-21	Takeda Chemical Industries Ltd	Method for producing crystals of benzimidazole derivatives
CA2204580A1 (en) *	1997-05-06	1998-11-06	Michel Zoghbi	Synthesis of pharmaceutically useful pyridine derivatives
US6437139B1 (en)	1997-05-06	2002-08-20	Pdi-Research Laboratories, Inc.	Synthesis of pharmaceutically useful pyridine derivatives
US6313303B1 (en)	1997-07-11	2001-11-06	Eisai Co., Ltd.	Process for the preparation of pyridine derivatives
US6096340A (en)	1997-11-14	2000-08-01	Andrx Pharmaceuticals, Inc.	Omeprazole formulation
US6174548B1 (en)	1998-08-28	2001-01-16	Andrx Pharmaceuticals, Inc.	Omeprazole formulation
US6733778B1 (en)	1999-08-27	2004-05-11	Andrx Pharmaceuticals, Inc.	Omeprazole formulation
US6231795B1 (en)	1998-12-04	2001-05-15	The Dow Chemical Company	Soft and flexible foams made from blends of alkenyl aromatic polymers and alpha-olefin/vinyl or vinylidene aromatic and/or sterically hindered aliphatic or cycloaliphatic vinyl or vinylidene interpolymers
US6852739B1 (en)	1999-02-26	2005-02-08	Nitromed Inc.	Methods using proton pump inhibitors and nitric oxide donors
US6362202B1 (en)	1999-03-02	2002-03-26	Sepracor Inc.	Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6353005B1 (en)	1999-03-02	2002-03-05	Sepracor, Inc.	Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6245913B1 (en)	1999-06-30	2001-06-12	Wockhardt Europe Limited	Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
US6780880B1 (en)	1999-08-26	2004-08-24	Robert R. Whittle	FT-Raman spectroscopic measurement
US6369087B1 (en)	1999-08-26	2002-04-09	Robert R. Whittle	Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6268385B1 (en)	1999-08-26	2001-07-31	Robert R. Whittle	Dry blend pharmaceutical formulations
US6262085B1 (en)	1999-08-26	2001-07-17	Robert R. Whittle	Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6262086B1 (en)	1999-08-26	2001-07-17	Robert R. Whittle	Pharmaceutical unit dosage form
US6326384B1 (en)	1999-08-26	2001-12-04	Robert R. Whittle	Dry blend pharmaceutical unit dosage form
US6312723B1 (en)	1999-08-26	2001-11-06	Robert R. Whittle	Pharmaceutical unit dosage form
US6312712B1 (en)	1999-08-26	2001-11-06	Robert R. Whittle	Method of improving bioavailability
US6316020B1 (en)	1999-08-26	2001-11-13	Robert R. Whittle	Pharmaceutical formulations
KR100362947B1 (ko) *	1999-09-21	2002-11-30	주식회사 대웅	설폭시드 화합물의 제조방법
KR100359256B1 (ko) *	1999-10-06	2002-11-04	한미약품공업 주식회사	란소프라졸의 개선된 제조방법
WO2003063840A2 (en) *	2002-01-25	2003-08-07	Santarus, Inc.	Transmucosal delivery of proton pump inhibitors
KR100464174B1 (ko) *	2002-03-06	2005-01-03	코오롱유화주식회사	설피닐 벤즈이미다졸 유도체의 제조방법
EP1534278A4 (de) *	2002-08-01	2006-09-06	Nitromed Inc	Nitrosierte protonenpumpen-hemmer, zusammensetzungen und anwendungsverfahren
CA2519208A1 (en) *	2003-03-17	2004-09-30	Takeda Pharmaceutical Company Limited	Controlled release composition
CA2520157A1 (fr) *	2003-03-28	2004-10-14	Sidem Pharma	Procede de preparation enantioselective de derives de sulfoxydes
US8993599B2 (en)	2003-07-18	2015-03-31	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
ES2201936B1 (es) *	2003-11-10	2005-05-01	Union Quimico-Farmaceutica S.A.	Procedimiento para la sintesis de pantoprazol e intermedios.
EP1716136A1 (de)	2004-02-11	2006-11-02	Ulkar Kimya Sanayii Ve Ticaret A.S.	Pyridin benzimidazol sulfoxide hoher reinheit
US8906940B2 (en)	2004-05-25	2014-12-09	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en)	2004-05-25	2014-08-26	Santarus, Inc.	Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
TW200619198A (en) *	2004-12-10	2006-06-16	Ind Tech Res Inst	Method for preparing 2-(2-pyridylmethylsulphinyl)benzimidazoles
WO2009122435A2 (en) *	2008-03-31	2009-10-08	Council Of Scientific & Industrial Research	A simultaneous method for the preparation of a mixture of 3- acetoxy-17-acetamido-16-formyl-androst-5,17-diene and 3- acetoxy-2'-chloro-5-androsteno[17,16-b]pyridine
WO2010134099A1 (en)	2009-05-21	2010-11-25	Cadila Healthcare Limited	One pot process for preparing omeprazole and related compounds
CN104203938A (zh)	2012-01-21	2014-12-10	朱比兰特生命科学有限公司	用于制备2-吡啶基甲基亚硫酰基苯并咪唑、它们的类似物和光学活性对映体的方法
JP2022548785A (ja)	2019-09-24	2022-11-21	プロラクタバイオサイエンス，インコーポレイテッド	炎症性疾患及び免疫疾患の治療のための組成物及び方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE7804231L (sv) *	1978-04-14	1979-10-15	Haessle Ab	Magsyrasekretionsmedel
JPS6150978A (ja) *	1984-08-16	1986-03-13	Takeda Chem Ind Ltd	ピリジン誘導体およびその製造法
DK171989B1 (da) *	1987-08-04	1997-09-08	Takeda Chemical Industries Ltd	Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler

1993
- 1993-11-04 US US08/145,572 patent/US5374730A/en not_active Expired - Fee Related
1994
- 1994-07-18 US US08/276,378 patent/US5470983A/en not_active Expired - Fee Related
- 1994-08-17 AU AU74875/94A patent/AU7487594A/en not_active Abandoned
- 1994-08-17 AT AT94924662T patent/ATE206707T1/de not_active IP Right Cessation
- 1994-08-17 DE DE69428595T patent/DE69428595D1/de not_active Expired - Lifetime
- 1994-08-17 JP JP7512922A patent/JP2966097B2/ja not_active Expired - Fee Related
- 1994-08-17 CA CA002170250A patent/CA2170250C/en not_active Expired - Fee Related
- 1994-08-17 EP EP94924662A patent/EP0724582B1/de not_active Expired - Lifetime
- 1994-08-17 WO PCT/CA1994/000452 patent/WO1995012590A1/en not_active Ceased

Also Published As

Publication number	Publication date
WO1995012590A1 (en)	1995-05-11
CA2170250C (en)	1997-09-16
JP2966097B2 (ja)	1999-10-25
EP0724582A1 (de)	1996-08-07
EP0724582B1 (de)	2001-10-10
JPH09504530A (ja)	1997-05-06
AU7487594A (en)	1995-05-23
US5374730A (en)	1994-12-20
US5470983A (en)	1995-11-28
DE69428595D1 (de)	2001-11-15
CA2170250A1 (en)	1995-05-11

Legal Events

Date	Code	Title	Description
2002-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE206707T1 (de)	2001-10-15	Herstellung von omeprazol und lansoprazol und dabei verwendete zwischenprodukte
SE9301830D0 (sv)	1993-05-28	New compounds
ATE186535T1 (de)	1999-11-15	Verfahren zur herstellung von omeprazol
DE69200983D1 (de)	1995-02-09	Verfahren zur Herstellung von Wasserstoffsuperoxyd.
DE69204484D1 (de)	1995-10-12	Verfahren zur Herstellung von Wasserstoffperoxyd.
DE69109519D1 (de)	1995-06-14	Verfahren zur Herstellung von Titandixoid.
YU48698A (sh)	2001-09-28	Karboksamidni derivati pirolidina, piperidina i heksahidroazepina za lečenje oboljenja na bazi tromboze
DE69735433D1 (de)	2006-05-04	Verfahren zur herstellung von substituierten pyridinen
YU12000A (sh)	2002-11-15	Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3-benzazocin -10-oli, postupak za njihovo pripremanje i njihova primena kao lekova
DE69202680D1 (de)	1995-06-29	Verfahren zur Herstellung von Wasserstoffperoxyd.
NO982867D0 (no)	1998-06-19	Nye substituerte 4-(1H-benzimidazol-2-yl)£1,4\|diazepaner som er anvendbare for behandling av allergiske sykdommer
DE3880953D1 (de)	1993-06-17	Chinolinderivate, verfahren zur herstellung davon und diese enthaltendes antibakterielles mittel.
ATE275561T1 (de)	2004-09-15	Verfahren zur herstellung von pantoprazol und zwischenprodukte dieses verfahrens
NO20011290D0 (no)	2001-03-14	FremgangsmÕte for fremstilling av et naftyridinkarboksylsyrederivat (metansulfonat-sesquihydrat)
DE69228648D1 (de)	1999-04-22	Verfahren zur Herstellung von komplementären, bipolaren Transistoren
ATE173735T1 (de)	1998-12-15	Thiomarinol-derivate und verfahren zu ihrer herstellung
MXPA02002355A (es)	2004-07-16	Procedimiento para la produccion de derivados de acido naftiridin-3-carboxilico.
ATE385232T1 (de)	2008-02-15	Verfahren zur herstellung von 3, 3', 6, 6'- tetraalkylen-2, 2'-biphenolen und 3, 3', 6, 6'- tetraalkylen-5, 5'-dihalo-2, 2' biphenolen
DE69011367D1 (de)	1994-09-15	Verfahren zur Herstellung von substituierten 2,3-Pyridindicarbonsäuren durch aufeinanderfolgende Oxidation von substituierten Chinolinen.
DE69109121D1 (de)	1995-05-24	Verfahren zur herstellung von substituierten pyridinen via 1-aza-1,3-butadiene und ihre zwischenprodukte.
DE59201325D1 (de)	1995-03-16	Verbessertes Verfahren zur Herstellung von Polyenen.
DE69100200D1 (de)	1993-09-02	Verfahren zur industriellen herstellung von 3-sulfamoyl-4-chlor-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)-benzamide ausgehend von 2,3-dihydro-2-methyl-1h-indol und hydroxylamine-o-sulfonsaeure.
DE69604327D1 (de)	1999-10-28	Herstellung von polyalkylierten Cyclopentadienen aus Isobornylcarboxylaten
ATE264291T1 (de)	2004-04-15	Zwischenprodukte für die herstellung von guanidinomethylcyclohexancarbonsäure-estern
ATE232533T1 (de)	2003-02-15	Carbapenemderivate und herstellungsverfahren dafür