ATE207118T1 - Hefe zellen so konstruiert, dass sie proteinsurrogate des pheromensystems produzieren und anwendungen dafuer - Google Patents

Hefe zellen so konstruiert, dass sie proteinsurrogate des pheromensystems produzieren und anwendungen dafuer

Info

Publication number: ATE207118T1
Authority: AT; Austria
Prior art keywords: yeast cells; pheroma; applications; surrogate; produce protein
Prior art date: 1993-03-31

Application number

AT94912292T

Other languages

English (en)

Inventor

Dana Merriman Fowlkes

Jim Broach

John Manfredi

Christine Klein

Andrew J Murphy

Jeremy Paul

Joshua Trueheart

Original Assignee

Cadus Pharmaceutical Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-31

Filing date

1994-03-23

Publication date

2001-11-15

1994-03-23 Application filed by Cadus Pharmaceutical Corp filed Critical Cadus Pharmaceutical Corp

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE207118T1 publication Critical patent/ATE207118T1/de

Links

210000005253 yeast cell Anatomy 0.000 title abstract 3
108090000623 proteins and genes Proteins 0.000 title abstract 2
102000004169 proteins and genes Human genes 0.000 title abstract 2
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
108010038049 Mating Factor Proteins 0.000 abstract 1
101800001357 Potential peptide Proteins 0.000 abstract 1
102400000745 Potential peptide Human genes 0.000 abstract 1
102100038344 Vomeronasal type-1 receptor 2 Human genes 0.000 abstract 1
IXKSXJFAGXLQOQ-XISFHERQSA-N WHWLQLKPGQPMY Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)C1=CNC=N1 IXKSXJFAGXLQOQ-XISFHERQSA-N 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
239000003016 pheromone Substances 0.000 abstract 1
239000002427 pheromone receptor Substances 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Mycology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Biophysics (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Inspection Of Paper Currency And Valuable Securities (AREA)
Cash Registers Or Receiving Machines (AREA)

AT94912292T 1993-03-31 1994-03-23 Hefe zellen so konstruiert, dass sie proteinsurrogate des pheromensystems produzieren und anwendungen dafuer ATE207118T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US4143193A	1993-03-31	1993-03-31
US19032894A	1994-01-31	1994-01-31
PCT/US1994/003143 WO1994023025A1 (en)	1993-03-31	1994-03-23	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor

Publications (1)

Publication Number	Publication Date
ATE207118T1 true ATE207118T1 (de)	2001-11-15

Family

ID=26718132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94912292T ATE207118T1 (de)	1993-03-31	1994-03-23	Hefe zellen so konstruiert, dass sie proteinsurrogate des pheromensystems produzieren und anwendungen dafuer

Country Status (10)

Country	Link
EP (2)	EP0915154A1 (de)
JP (3)	JPH08510115A (de)
AT (1)	ATE207118T1 (de)
AU (2)	AU685103B2 (de)
CA (1)	CA2158274C (de)
DE (1)	DE69428689T2 (de)
DK (1)	DK0692025T3 (de)
ES (1)	ES2166371T3 (de)
PT (1)	PT692025E (de)
WO (1)	WO1994023025A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6255059B1 (en)	1993-03-31	2001-07-03	Cadus Pharmaceutical Corporation	Methods for identifying G protein coupled receptor effectors
US5789184A (en) *	1993-03-31	1998-08-04	Cadus Pharmaceutical Corporation	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US7416881B1 (en)	1993-03-31	2008-08-26	Cadus Technologies, Inc.	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US6864060B1 (en)	1993-03-31	2005-03-08	Cadus Technologies, Inc.	Yeast cells expressing modified G proteins and methods of use therefor
US6100042A (en) *	1993-03-31	2000-08-08	Cadus Pharmaceutical Corporation	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US5876951A (en) *	1993-03-31	1999-03-02	Cadus Pharmaceutical Corporation	Yeast cells engineered to produce pheromone system protein surrogates and uses therefor
US7235648B1 (en)	1993-03-31	2007-06-26	Cadus Technologies, Inc.	Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US20030054402A1 (en)	1993-03-31	2003-03-20	Cadus Pharmaceutical Corporation	Methods and compositions for identifying receptor effectors
US5691188A (en) *	1994-02-14	1997-11-25	American Cyanamid Company	Transformed yeast cells expressing heterologous G-protein coupled receptor
WO1995030012A1 (en) *	1994-04-26	1995-11-09	Cadus Pharmaceutical Corporation	Functional expression of mammalian adenylyl cyclase in yeast
WO1996034112A1 (en) *	1995-04-24	1996-10-31	Chromaxome Corp.	Methods for generating and screening novel metabolic pathways
WO1996040939A2 (en) *	1995-06-07	1996-12-19	Cadus Pharmaceutical Corporation	Expression of functional vertebrate phospholipases in yeast
AU7115896A (en) *	1995-09-20	1997-04-09	Molecular Geriatrics Corporation	Yeast receptor and g-protein fusion protein
AU3055697A (en) *	1996-04-23	1997-11-12	Cadus Pharmaceutical Corporation	Functional expression of heterologous adenylyl cyclase
US5783431A (en) *	1996-04-24	1998-07-21	Chromaxome Corporation	Methods for generating and screening novel metabolic pathways
US6242211B1 (en)	1996-04-24	2001-06-05	Terragen Discovery, Inc.	Methods for generating and screening novel metabolic pathways
WO1997041255A1 (en) *	1996-04-26	1997-11-06	Massachusetts Institute Of Technology	Three-hybrid screening assay
DE69731960T2 (de) *	1996-09-24	2005-12-15	Cadus Pharmaceutical Corp.	Verfahren und zusammensetzungen für die identifizierung von receptor effectoren
AU8142598A (en)	1997-06-11	1998-12-30	New York University	Prenylcysteine carboxyl methyltransferase, dna encoding same, and a method of screening for inhibitors thereof
EP1021538A1 (de) *	1997-10-07	2000-07-26	Cadus Pharmaceutical Corporation	Modifizierte g proteine-exprimierende hefezellen und ihre verwendungen
US6355473B1 (en)	1998-05-06	2002-03-12	Cadus Pharmaceutical Corp.	Yeast cells having mutations in stp22 and uses therefor
WO1999058670A1 (en) *	1998-05-08	1999-11-18	Cadus Pharmaceutical Corporation	Ags proteins and nucleic acid molecules and uses therefor
US6746852B1 (en)	1998-05-08	2004-06-08	Osi Pharmaceuticals, Inc.	AGS proteins and nucleic acid molecules and uses thereof
US6733991B1 (en)	1998-05-08	2004-05-11	Osi Pharmaceuticals, Inc.	AGS proteins and nucleic acid molecules and uses therefor
US20020015967A1 (en) *	1998-06-02	2002-02-07	Lauren Silverman	Functional expression of adenosine receptors in yeast
US7081360B2 (en)	1998-07-28	2006-07-25	Cadus Technologies, Inc.	Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
US7273747B2 (en)	1998-08-27	2007-09-25	Cadus Technologies, Inc.	Cell having amplified signal transduction pathway responses and uses therefor
US6251605B1 (en)	1998-10-27	2001-06-26	Cadus Pharmaceutical Corporation	Yeast cells having mutations in Cav1 and uses therefor
AU2030000A (en)	1998-11-25	2000-06-13	Cadus Pharmaceutical Corporation	Methods and compositions for identifying receptor effectors
US6504008B1 (en)	1999-02-01	2003-01-07	Cadus Technologies, Inc.	Cell based signal generation
US6555325B1 (en)	1999-06-14	2003-04-29	Cadus Technologies, Inc.	System for detection of a functional interaction between a compound and a cellular signal transduction component
US7223533B2 (en)	1999-09-10	2007-05-29	Cadus Technologies, Inc.	Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways
GB0030038D0 (en) *	2000-12-08	2001-01-24	Univ Warwick	Yeast-based assay
US20030165873A1 (en)	2001-03-02	2003-09-04	Come Jon H.	Three hybrid assay system
NZ513755A (en)	2001-08-24	2001-09-28	Ann Rachel Holmes	Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
AU2013212008A1 (en) *	2012-01-25	2014-07-10	Alfa Wassermann S.P.A.	Rifaximin derivative and uses thereof
WO2020047138A1 (en) *	2018-08-29	2020-03-05	Amyris, Inc.	Cells and methods for selection based assay
CN109593773B (zh) *	2018-11-22	2021-07-30	北京利德曼生化股份有限公司	一种应用酵母表达系统表达可溶性生长刺激表达基因2蛋白的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1988010308A1 (en) *	1987-06-24	1988-12-29	Whitehead Institute For Biomedical Research	Pheromone-inducible yeast promoter
US5284746A (en) *	1990-02-08	1994-02-08	Zymogenetics, Inc.	Methods of producing hybrid G protein-coupled receptors
JP3348406B2 (ja) *	1990-09-13	2002-11-20	デュークユニバーシティー	酵母におけるｇタンパク質結合受容体の発現

1994
- 1994-03-23 AT AT94912292T patent/ATE207118T1/de not_active IP Right Cessation
- 1994-03-23 ES ES94912292T patent/ES2166371T3/es not_active Expired - Lifetime
- 1994-03-23 PT PT94912292T patent/PT692025E/pt unknown
- 1994-03-23 EP EP98202997A patent/EP0915154A1/de not_active Withdrawn
- 1994-03-23 JP JP6522167A patent/JPH08510115A/ja active Pending
- 1994-03-23 DE DE69428689T patent/DE69428689T2/de not_active Expired - Fee Related
- 1994-03-23 EP EP94912292A patent/EP0692025B1/de not_active Expired - Lifetime
- 1994-03-23 CA CA002158274A patent/CA2158274C/en not_active Expired - Fee Related
- 1994-03-23 WO PCT/US1994/003143 patent/WO1994023025A1/en not_active Ceased
- 1994-03-23 AU AU64909/94A patent/AU685103B2/en not_active Expired
- 1994-03-23 DK DK94912292T patent/DK0692025T3/da active
1998
- 1998-04-23 AU AU63541/98A patent/AU6354198A/en not_active Abandoned
2004
- 2004-07-13 JP JP2004206397A patent/JP2004357713A/ja active Pending
- 2004-07-14 JP JP2004207300A patent/JP2004337174A/ja active Pending

Also Published As

Publication number	Publication date
WO1994023025A1 (en)	1994-10-13
AU6490994A (en)	1994-10-24
JP2004357713A (ja)	2004-12-24
AU6354198A (en)	1998-07-09
CA2158274A1 (en)	1994-10-13
JP2004337174A (ja)	2004-12-02
AU685103B2 (en)	1998-01-15
DE69428689T2 (de)	2002-08-08
DK0692025T3 (da)	2002-02-11
ES2166371T3 (es)	2002-04-16
CA2158274C (en)	2000-05-30
PT692025E (pt)	2002-04-29
EP0692025B1 (de)	2001-10-17
EP0692025A1 (de)	1996-01-17
EP0915154A1 (de)	1999-05-12
DE69428689D1 (de)	2001-11-22
JPH08510115A (ja)	1996-10-29

Legal Events

Date	Code	Title	Description
2002-06-15	UEP	Publication of translation of european patent specification
2010-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69428689D1 (de)	2001-11-22	Hefe zellen so konstruiert, dass sie proteinsurrogate des pheromensystems produzieren und anwendungen dafuer
Masson et al.	1996	Comparative study of 6 types of criteria in adult Still's disease
AU5442200A (en)	2000-12-12	Encoding and decoding of array sensors utilizing nanocrystals
NO20041325L (no)	2004-03-30	Substanser
DE69434299T2 (de)	2006-06-14	Thiol-derivatisierte Nukleoside und Oligonukleoside
DK1047781T3 (da)	2004-12-06	IL-18-receptorer
ATE364704T1 (de)	2007-07-15	Mutanten von op-1
DK0724588T3 (da)	2000-05-15	Lægemiddelbindende protein
AU7266896A (en)	1997-05-15	A novel haemopoietin receptor and genetic sequences encoding same
ATE476495T1 (de)	2010-08-15	Bazillus thuringiensis und dessen insektizide proteine
CA2345024A1 (en)	2000-04-13	Modified tgf-.beta. superfamily proteins
Huang et al.	1980	Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence.
DE69802389D1 (de)	2001-12-13	Verbindungen verwendbar als effektoren von neuroexcitatorischen aminosäure-empfindlichen rezeptoren des zentralnervensystems, ihre herstellung and ihre biologischen verwendungen
DE60017019D1 (de)	2005-02-03	Antikörper gegen Spaltprodukte von Vimentin
WO2004042567A3 (en)	2004-07-29	Information processing systems configured and manipulated under an application framework
ATE204172T1 (de)	2001-09-15	Endothelin-rezeptorantagonisten zur bekämpfung von hyperlipidämie
ATE161543T1 (de)	1998-01-15	Aminoterminale prokollagen 1(i) peptide
DE60210970D1 (de)	2006-06-01	Mutante formen von etxb und ctxb und ihre verwendung als träger
AU1305897A (en)	1997-07-28	Elisa test system
DE69841260D1 (de)	2009-12-10	Bakterielle pheromone und deren verwendungen
ATE207935T1 (de)	2001-11-15	Antikörper gegen ein, einen histidin-anteil aufweisendes fusionspolypeptid
WO2002102847A1 (fr)	2002-12-27	Nouveau ligand et son adn
WO1996023883A3 (en)	1996-11-28	Modified ligands for receptor tyrosine kinases
EP1108212A4 (de)	2001-09-19	Verfahren und materialien zur diagnose instabiler angina
NL1010527A1 (nl)	1999-05-18	Pelletizeren van erts.