ES2138090T3 - Procedimiento e intermedios para doramectina. - Google Patents

Procedimiento e intermedios para doramectina.

Info

Publication number
ES2138090T3
ES2138090T3 ES94925598T ES94925598T ES2138090T3 ES 2138090 T3 ES2138090 T3 ES 2138090T3 ES 94925598 T ES94925598 T ES 94925598T ES 94925598 T ES94925598 T ES 94925598T ES 2138090 T3 ES2138090 T3 ES 2138090T3
Authority
ES
Spain
Prior art keywords
doramectin
procedure
compound
formula
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94925598T
Other languages
English (en)
Inventor
Thomas Charles Crawford
Neil Demers
Stephen P Gibson
Charles William Murtiashaw
Constantine Sklavounos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2138090T3 publication Critical patent/ES2138090T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
    • A01N47/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing —O—CO—O— groups; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)

Abstract

SE PRESENTAN COMPUESTOS INTERMEDIOS Y UN PROCESO PARA PREPARAR DORAMECTINA, EL COMPUESTO DE LA FORMULA (I), SEMISINTETICAMENTE A PARTIR DE UN SUBPRODUCTO EN EL PROCEDIMIENTO DE FERMENTACION QUE TAMBIEN DA COMO RESULTADO UN COMPUESTO DE LA FORMULA (I). LOS COMPUESTOS INTERMEDIOS PREPARADOS POR EL PROCESO DE LA INVENCION TAMBIEN TIENEN ACTIVIDAD COMO AGENTES ANTIPARASITICOS. EL PROCESO DE LA INVENCION UTILIZA EL ROCIADO DE UN GAS INERTE DE REACCION CONTINUA DURANTE EL PASO DE PIROLISIS, DANDO COMO RESULTADO UNA MEJORA SIGNIFICATIVA DEL RENDIMIENTO TOTAL DE ESTA CONVERSION.
ES94925598T 1993-10-05 1994-09-19 Procedimiento e intermedios para doramectina. Expired - Lifetime ES2138090T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13181293A 1993-10-05 1993-10-05

Publications (1)

Publication Number Publication Date
ES2138090T3 true ES2138090T3 (es) 2000-01-01

Family

ID=22451135

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94925598T Expired - Lifetime ES2138090T3 (es) 1993-10-05 1994-09-19 Procedimiento e intermedios para doramectina.

Country Status (42)

Country Link
US (1) US5665708A (es)
EP (1) EP0722453B1 (es)
JP (1) JP2761296B2 (es)
KR (1) KR100186946B1 (es)
CN (2) CN1040113C (es)
AP (1) AP499A (es)
AT (1) ATE185571T1 (es)
AU (1) AU680039B2 (es)
BG (1) BG61842B1 (es)
BR (1) BR9407747A (es)
CA (1) CA2173494C (es)
CO (1) CO4290361A1 (es)
CZ (1) CZ287404B6 (es)
DE (1) DE69421190T2 (es)
DK (1) DK0722453T3 (es)
DZ (1) DZ1816A1 (es)
EG (1) EG20802A (es)
ES (1) ES2138090T3 (es)
FI (1) FI944623A7 (es)
GR (1) GR3032042T3 (es)
GT (1) GT199400065A (es)
HR (1) HRP940642B1 (es)
HU (1) HU219020B (es)
IL (1) IL111075A (es)
LV (1) LV11474B (es)
MA (1) MA23342A1 (es)
MY (1) MY111320A (es)
NO (1) NO305320B1 (es)
NZ (1) NZ271734A (es)
OA (1) OA10577A (es)
PE (1) PE20595A1 (es)
PL (1) PL177039B1 (es)
RO (1) RO115884B1 (es)
RU (1) RU2120943C1 (es)
SI (1) SI9420059A (es)
SK (1) SK45396A3 (es)
TW (1) TW282472B (es)
UA (1) UA45957C2 (es)
UY (1) UY23839A1 (es)
WO (1) WO1995009863A1 (es)
YU (1) YU49171B (es)
ZA (1) ZA947740B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
NO312056B1 (no) * 1998-06-09 2002-03-11 Alpharma As Aquatic Animal Hea Anvendelse av preparater til forebygging og behandling av parasitter hos fisk
RS50813B (sr) * 2002-02-12 2010-08-31 Pfizer Products Inc. Streptomyces avermitilis gen koji određuje odnos b2:b1 avermektina
CN104418927B (zh) * 2013-08-29 2018-03-27 重庆乾泰生物医药有限公司 一种多拉菌素的分离纯化方法
CN104693254B (zh) * 2013-12-10 2018-03-27 重庆乾泰生物医药有限公司 一种多拉菌素的制备方法
CN107723325B (zh) * 2017-11-28 2021-03-30 山东齐发药业有限公司 基于pH控制的多拉菌素发酵生产方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
US4328335A (en) * 1979-08-13 1982-05-04 Merck & Co., Inc. Process for the interconversion of C-076 compounds
US4457920A (en) * 1981-09-03 1984-07-03 Merck & Co., Inc. 4a-Substituted avermectin compounds
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
JPH085893B2 (ja) * 1985-09-13 1996-01-24 アメリカン・サイアナミツド・カンパニー マクロライド抗生物質およびその製法
US4886828A (en) * 1986-09-12 1989-12-12 American Cyanamid Company Δ22 -derivatives of LL-F28249 compounds
IN167980B (es) * 1987-01-23 1991-01-19 Pfizer
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
GB8807280D0 (en) * 1988-03-26 1988-04-27 Pfizer Ltd Antiparasitic agents
GB8815967D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Antiparasitic agents
NZ231773A (en) * 1988-12-23 1992-09-25 Merck & Co Inc Avermectin derivatives, preparation and parasiticidal pharmaceutical compositions thereof
US5023241A (en) * 1989-07-31 1991-06-11 Merck & Co., Inc. Avermectin derivatives
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
GB9201505D0 (en) * 1992-01-24 1992-03-11 Pfizer Ltd Antiparasitic agents
GB9205007D0 (en) * 1992-03-07 1992-04-22 Pfizer Ltd Antiparasitic agents
US5162363A (en) * 1992-03-18 1992-11-10 Merck & Co., Inc. 23-nor-23-thia avermectin analogs are active anthelmintic agents
US5229415A (en) * 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
US5229416A (en) * 1992-04-29 1993-07-20 Merck & Co., Inc. Avermectin difluoro derivatives
US5578581A (en) * 1994-04-26 1996-11-26 Merck & Co., Inc. Active avermectin analogue

Also Published As

Publication number Publication date
YU49171B (sh) 2004-05-12
FI944623A0 (fi) 1994-10-04
UA45957C2 (uk) 2002-05-15
GR3032042T3 (en) 2000-03-31
FI944623L (fi) 1995-04-06
HRP940642B1 (en) 2000-06-30
CA2173494C (en) 1999-04-13
CN1060483C (zh) 2001-01-10
AP9400678A0 (en) 1994-10-31
OA10577A (en) 2002-06-19
PE20595A1 (es) 1995-08-01
ZA947740B (en) 1996-04-04
BR9407747A (pt) 1997-02-12
MY111320A (en) 1999-10-30
AP499A (en) 1996-06-05
JPH08510758A (ja) 1996-11-12
HRP940642A2 (en) 1997-06-30
HUT75344A (en) 1997-05-28
EP0722453B1 (en) 1999-10-13
LV11474B (en) 1996-12-20
WO1995009863A1 (en) 1995-04-13
SK45396A3 (en) 1997-03-05
AU7545494A (en) 1995-05-01
JP2761296B2 (ja) 1998-06-04
IL111075A (en) 2001-01-11
CA2173494A1 (en) 1995-04-13
PL177039B1 (pl) 1999-09-30
NO961380D0 (no) 1996-04-03
CN1040113C (zh) 1998-10-07
RO115884B1 (ro) 2000-07-28
ATE185571T1 (de) 1999-10-15
DE69421190T2 (de) 2000-02-03
NO961380L (no) 1996-04-03
LV11474A (lv) 1996-08-20
US5665708A (en) 1997-09-09
GT199400065A (es) 1996-03-21
TW282472B (es) 1996-08-01
KR960704906A (ko) 1996-10-09
KR100186946B1 (ko) 1999-04-01
HU9600875D0 (en) 1996-06-28
BG100470A (bg) 1996-12-31
CN1202493A (zh) 1998-12-23
EP0722453A1 (en) 1996-07-24
CZ287404B6 (en) 2000-11-15
NZ271734A (en) 1997-12-19
PL313781A1 (en) 1996-07-22
BG61842B1 (bg) 1998-07-31
DK0722453T3 (da) 1999-12-27
DZ1816A1 (fr) 2002-02-17
FI944623A7 (fi) 1995-04-06
AU680039B2 (en) 1997-07-17
CZ96396A3 (en) 1996-10-16
DE69421190D1 (de) 1999-11-18
RU2120943C1 (ru) 1998-10-27
YU57294A (sh) 1997-03-07
SI9420059A (en) 1997-02-28
HU219020B (hu) 2001-01-29
EG20802A (en) 2000-03-29
UY23839A1 (es) 1995-03-28
CO4290361A1 (es) 1996-04-17
CN1132513A (zh) 1996-10-02
NO305320B1 (no) 1999-05-10
IL111075A0 (en) 1994-11-28
MA23342A1 (fr) 1995-07-01

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