ATE207933T1 - Verfahren zur herstellung vom aktieven protein dimerischen - Google Patents

Verfahren zur herstellung vom aktieven protein dimerischen

Info

Publication number: ATE207933T1
Authority: AT; Austria
Prior art keywords: active protein; producing active; dimeric; protein dimeric; beta
Prior art date: 1994-07-25

Application number

AT95926857T

Other languages

English (en)

Inventor

Nico Cerletti

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-25

Filing date

1995-07-12

Publication date

2001-11-15

1995-07-12 Application filed by Novartis Ag filed Critical Novartis Ag

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE207933T1 publication Critical patent/ATE207933T1/de

Links

102000004169 proteins and genes Human genes 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
239000003102 growth factor Substances 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

AT95926857T 1994-07-25 1995-07-12 Verfahren zur herstellung vom aktieven protein dimerischen ATE207933T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94810438		1994-07-25
PCT/EP1995/002718 WO1996003432A1 (en)	1994-07-25	1995-07-12	Novel process for the production of biologically active dimeric protein

Publications (1)

Publication Number	Publication Date
ATE207933T1 true ATE207933T1 (de)	2001-11-15

Family

ID=8218292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95926857T ATE207933T1 (de)	1994-07-25	1995-07-12	Verfahren zur herstellung vom aktieven protein dimerischen

Country Status (19)

Country	Link
US (1)	US6057430A (de)
EP (1)	EP0775159B1 (de)
JP (2)	JP3923516B2 (de)
KR (1)	KR100432839B1 (de)
AT (1)	ATE207933T1 (de)
AU (1)	AU690311B2 (de)
CA (1)	CA2194582C (de)
DE (1)	DE69523605T2 (de)
DK (1)	DK0775159T3 (de)
ES (1)	ES2166401T3 (de)
FI (1)	FI118083B (de)
HU (1)	HU222830B1 (de)
IL (1)	IL114701A (de)
NO (1)	NO316926B1 (de)
NZ (1)	NZ290373A (de)
PT (1)	PT775159E (de)
TW (1)	TW440566B (de)
WO (1)	WO1996003432A1 (de)
ZA (1)	ZA956138B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW517059B (en) *	1994-07-25	2003-01-11	Ciba Geigy Ag	New process for the production of biologically active protein
EP0943690B1 (de) *	1995-12-21	2006-11-29	Ajinomoto Co., Inc.	Verfahren zur rückfaltung von menschlichem activin a
DE19906096A1 (de)	1999-02-13	2000-08-17	Walter Sebald	Protein mit einem Heparin-bindenden Epitop
CA2404567A1 (en) *	2000-03-30	2001-10-11	Takeda Chemical Industries, Ltd.	Process for producing recombinant protein
WO2001072331A1 (en) *	2000-03-31	2001-10-04	Vaccine Chip Technology Aps	Immunostimulating properties of a fragment of tgf-beta
US7572474B2 (en)	2005-06-01	2009-08-11	Mead Johnson Nutrition Company	Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en) *	2008-10-24	2011-12-13	Mead Johnson Nutrition Company	Nutritional composition with improved digestibility
GB0514262D0 (en) *	2005-07-12	2005-08-17	Renovo Ltd	Promotion of epithelial regeneration
GB0604966D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Medicaments and proteins
GB0604964D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Protein folding
GB0604938D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Proteins, nucleic acids and medicaments
GB0617816D0 (en) *	2006-09-11	2006-10-18	Renovo Ltd	Nucleic acids and methods of protein expression
US8986769B2 (en)	2008-10-24	2015-03-24	Mead Johnson Nutrition Company	Methods for preserving endogenous TGF-β
AU2017385096B2 (en)	2016-12-30	2021-07-29	Biogend Therapeutics Co., Ltd.	Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof
CA3113691A1 (en)	2018-09-17	2020-03-26	Board Of Regents, The University Of Texas System	Compositions and methods for treating bone injury

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4731440A (en) *	1985-02-22	1988-03-15	Monsanto Company	Method of somatotropin solubilization using dimethylsulfone and naturation
JPH0759598B2 (ja) *	1986-02-14	1995-06-28	藤沢薬品工業株式会社	ヒトインスリン様成長因子▲ｉ▼の製造法
EP0293785A3 (de) *	1987-05-29	1990-05-02	Oncogen Limited Partnership	Klonierung und Expression von transformierendem Affenwachstumsfaktor-SS 1
US5061786A (en) *	1989-05-25	1991-10-29	Genentech, Inc.	Biologically active polypeptides based on transforming growth factor-β
GB8927546D0 (en) *	1989-12-06	1990-02-07	Ciba Geigy	Process for the production of biologically active tgf-beta
US5144006A (en) *	1991-06-13	1992-09-01	The Rockefeller University	Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides
AU2738392A (en) *	1991-11-11	1993-05-13	Ciba-Geigy Ag	Novel hybrid transforming growth factors

1995
- 1995-07-11 TW TW084107188A patent/TW440566B/zh not_active IP Right Cessation
- 1995-07-12 KR KR1019970700476A patent/KR100432839B1/ko not_active Expired - Fee Related
- 1995-07-12 JP JP50540096A patent/JP3923516B2/ja not_active Expired - Fee Related
- 1995-07-12 ES ES95926857T patent/ES2166401T3/es not_active Expired - Lifetime
- 1995-07-12 HU HU9700210A patent/HU222830B1/hu not_active IP Right Cessation
- 1995-07-12 CA CA002194582A patent/CA2194582C/en not_active Expired - Fee Related
- 1995-07-12 DE DE69523605T patent/DE69523605T2/de not_active Expired - Lifetime
- 1995-07-12 NZ NZ290373A patent/NZ290373A/en not_active IP Right Cessation
- 1995-07-12 WO PCT/EP1995/002718 patent/WO1996003432A1/en not_active Ceased
- 1995-07-12 PT PT95926857T patent/PT775159E/pt unknown
- 1995-07-12 DK DK95926857T patent/DK0775159T3/da active
- 1995-07-12 EP EP95926857A patent/EP0775159B1/de not_active Expired - Lifetime
- 1995-07-12 AU AU31095/95A patent/AU690311B2/en not_active Ceased
- 1995-07-12 AT AT95926857T patent/ATE207933T1/de not_active IP Right Cessation
- 1995-07-24 IL IL11470195A patent/IL114701A/xx not_active IP Right Cessation
- 1995-07-24 ZA ZA956138A patent/ZA956138B/xx unknown
1997
- 1997-01-20 FI FI970229A patent/FI118083B/fi active IP Right Grant
- 1997-01-24 NO NO19970325A patent/NO316926B1/no not_active IP Right Cessation
1998
- 1998-07-28 US US09/123,233 patent/US6057430A/en not_active Expired - Fee Related
2006
- 2006-11-09 JP JP2006304295A patent/JP2007031453A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
WO1996003432A1 (en)	1996-02-08
NO970325L (no)	1997-03-06
DE69523605D1 (de)	2001-12-06
EP0775159A1 (de)	1997-05-28
TW440566B (en)	2001-06-16
AU3109595A (en)	1996-02-22
FI970229A0 (fi)	1997-01-20
FI970229L (fi)	1997-01-20
ES2166401T3 (es)	2002-04-16
JP3923516B2 (ja)	2007-06-06
JPH11505506A (ja)	1999-05-21
DE69523605T2 (de)	2002-07-11
KR100432839B1 (ko)	2004-08-30
NO970325D0 (no)	1997-01-24
CA2194582A1 (en)	1996-02-08
NZ290373A (en)	1998-04-27
CA2194582C (en)	2008-09-02
IL114701A0 (en)	1995-11-27
JP2007031453A (ja)	2007-02-08
HU222830B1 (hu)	2003-11-28
PT775159E (pt)	2002-04-29
US6057430A (en)	2000-05-02
IL114701A (en)	2005-11-20
ZA956138B (en)	1996-03-07
FI118083B (fi)	2007-06-29
AU690311B2 (en)	1998-04-23
DK0775159T3 (da)	2002-02-11
HUT76668A (en)	1997-10-28
EP0775159B1 (de)	2001-10-31
NO316926B1 (no)	2004-06-28

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Legal Events

Date	Code	Title	Description
2002-03-15	UEP	Publication of translation of european patent specification
2012-04-15	REN	Ceased due to non-payment of the annual fee