IL114701A - Process for the production of biologically active dimeric transforming growth factor - Google Patents

Process for the production of biologically active dimeric transforming growth factor

Info

Publication number: IL114701A
Authority: IL; Israel
Prior art keywords: growth factor; biologically active; production; transforming growth; active dimeric
Prior art date: 1994-07-25

Application number

IL11470195A

Other languages

English (en)

Other versions

IL114701A0 (en

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-25

Filing date

1995-07-24

Publication date

2005-11-20

1995-07-24 Application filed by Novartis Ag filed Critical Novartis Ag

1995-11-27 Publication of IL114701A0 publication Critical patent/IL114701A0/xx

2005-11-20 Publication of IL114701A publication Critical patent/IL114701A/xx

Links

102000009618 Transforming Growth Factors Human genes 0.000 title 1
108010009583 Transforming Growth Factors Proteins 0.000 title 1
239000003102 growth factor Substances 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

IL11470195A 1994-07-25 1995-07-24 Process for the production of biologically active dimeric transforming growth factor IL114701A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP94810438		1994-07-25

Publications (2)

Publication Number	Publication Date
IL114701A0 IL114701A0 (en)	1995-11-27
IL114701A true IL114701A (en)	2005-11-20

Family

ID=8218292

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL11470195A IL114701A (en)	1994-07-25	1995-07-24	Process for the production of biologically active dimeric transforming growth factor

Country Status (19)

Country	Link
US (1)	US6057430A (de)
EP (1)	EP0775159B1 (de)
JP (2)	JP3923516B2 (de)
KR (1)	KR100432839B1 (de)
AT (1)	ATE207933T1 (de)
AU (1)	AU690311B2 (de)
CA (1)	CA2194582C (de)
DE (1)	DE69523605T2 (de)
DK (1)	DK0775159T3 (de)
ES (1)	ES2166401T3 (de)
FI (1)	FI118083B (de)
HU (1)	HU222830B1 (de)
IL (1)	IL114701A (de)
NO (1)	NO316926B1 (de)
NZ (1)	NZ290373A (de)
PT (1)	PT775159E (de)
TW (1)	TW440566B (de)
WO (1)	WO1996003432A1 (de)
ZA (1)	ZA956138B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW517059B (en) *	1994-07-25	2003-01-11	Ciba Geigy Ag	New process for the production of biologically active protein
JP4019432B2 (ja) *	1995-12-21	2007-12-12	味の素株式会社	ヒトアクチビンａのリフォールディング方法
DE19906096A1 (de)	1999-02-13	2000-08-17	Walter Sebald	Protein mit einem Heparin-bindenden Epitop
US20030120042A1 (en) *	2000-03-30	2003-06-26	Takao Yamada	Process for producing recombinant protein
EP1292330A1 (de) *	2000-03-31	2003-03-19	Vaccine Chip Technology APS	Immunostimulierende eigenschaften eines tgf-beta-fragmentes
US7572474B2 (en) *	2005-06-01	2009-08-11	Mead Johnson Nutrition Company	Method for simulating the functional attributes of human milk oligosaccharides in formula-fed infants
US8075934B2 (en) *	2008-10-24	2011-12-13	Mead Johnson Nutrition Company	Nutritional composition with improved digestibility
GB0514262D0 (en) *	2005-07-12	2005-08-17	Renovo Ltd	Promotion of epithelial regeneration
GB0604964D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Protein folding
GB0604966D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Medicaments and proteins
GB0604938D0 (en)	2006-03-11	2006-04-19	Renovo Ltd	Proteins, nucleic acids and medicaments
GB0617816D0 (en) *	2006-09-11	2006-10-18	Renovo Ltd	Nucleic acids and methods of protein expression
US8986769B2 (en) *	2008-10-24	2015-03-24	Mead Johnson Nutrition Company	Methods for preserving endogenous TGF-β
WO2018122794A1 (en)	2016-12-30	2018-07-05	Biogend Therapeutics Co., Ltd.	Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof
KR20210080370A (ko) *	2018-09-17	2021-06-30	보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템	뼈 손상 치료용 조성물 및 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4731440A (en) *	1985-02-22	1988-03-15	Monsanto Company	Method of somatotropin solubilization using dimethylsulfone and naturation
JPH0759598B2 (ja) *	1986-02-14	1995-06-28	藤沢薬品工業株式会社	ヒトインスリン様成長因子▲ｉ▼の製造法
AU626524B2 (en) *	1987-05-29	1992-08-06	Bristol-Myers Squibb Company	Cloning and expression of simian transforming growth factor- beta 1
US5061786A (en) *	1989-05-25	1991-10-29	Genentech, Inc.	Biologically active polypeptides based on transforming growth factor-β
GB8927546D0 (en) *	1989-12-06	1990-02-07	Ciba Geigy	Process for the production of biologically active tgf-beta
US5144006A (en) *	1991-06-13	1992-09-01	The Rockefeller University	Oxidative folding of peptide and protein substrates using hydrocarbon sulfoxides
AU2738392A (en) *	1991-11-11	1993-05-13	Ciba-Geigy Ag	Novel hybrid transforming growth factors

1995
- 1995-07-11 TW TW084107188A patent/TW440566B/zh not_active IP Right Cessation
- 1995-07-12 KR KR1019970700476A patent/KR100432839B1/ko not_active Expired - Fee Related
- 1995-07-12 DK DK95926857T patent/DK0775159T3/da active
- 1995-07-12 JP JP50540096A patent/JP3923516B2/ja not_active Expired - Fee Related
- 1995-07-12 EP EP95926857A patent/EP0775159B1/de not_active Expired - Lifetime
- 1995-07-12 PT PT95926857T patent/PT775159E/pt unknown
- 1995-07-12 HU HU9700210A patent/HU222830B1/hu not_active IP Right Cessation
- 1995-07-12 WO PCT/EP1995/002718 patent/WO1996003432A1/en not_active Ceased
- 1995-07-12 AU AU31095/95A patent/AU690311B2/en not_active Ceased
- 1995-07-12 CA CA002194582A patent/CA2194582C/en not_active Expired - Fee Related
- 1995-07-12 NZ NZ290373A patent/NZ290373A/en not_active IP Right Cessation
- 1995-07-12 AT AT95926857T patent/ATE207933T1/de not_active IP Right Cessation
- 1995-07-12 ES ES95926857T patent/ES2166401T3/es not_active Expired - Lifetime
- 1995-07-12 DE DE69523605T patent/DE69523605T2/de not_active Expired - Lifetime
- 1995-07-24 IL IL11470195A patent/IL114701A/xx not_active IP Right Cessation
- 1995-07-24 ZA ZA956138A patent/ZA956138B/xx unknown
1997
- 1997-01-20 FI FI970229A patent/FI118083B/fi active IP Right Grant
- 1997-01-24 NO NO19970325A patent/NO316926B1/no not_active IP Right Cessation
1998
- 1998-07-28 US US09/123,233 patent/US6057430A/en not_active Expired - Fee Related
2006
- 2006-11-09 JP JP2006304295A patent/JP2007031453A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
DE69523605T2 (de)	2002-07-11
FI118083B (fi)	2007-06-29
PT775159E (pt)	2002-04-29
JP3923516B2 (ja)	2007-06-06
IL114701A0 (en)	1995-11-27
TW440566B (en)	2001-06-16
NO970325D0 (no)	1997-01-24
US6057430A (en)	2000-05-02
WO1996003432A1 (en)	1996-02-08
DK0775159T3 (da)	2002-02-11
NO316926B1 (no)	2004-06-28
CA2194582C (en)	2008-09-02
DE69523605D1 (de)	2001-12-06
CA2194582A1 (en)	1996-02-08
KR100432839B1 (ko)	2004-08-30
AU690311B2 (en)	1998-04-23
ATE207933T1 (de)	2001-11-15
FI970229A0 (fi)	1997-01-20
HU222830B1 (hu)	2003-11-28
NO970325L (no)	1997-03-06
JP2007031453A (ja)	2007-02-08
ES2166401T3 (es)	2002-04-16
FI970229L (fi)	1997-01-20
EP0775159B1 (de)	2001-10-31
HUT76668A (en)	1997-10-28
EP0775159A1 (de)	1997-05-28
JPH11505506A (ja)	1999-05-21
NZ290373A (en)	1998-04-27
AU3109595A (en)	1996-02-22
ZA956138B (en)	1996-03-07

Similar Documents

Publication	Publication Date	Title
ZA956139B (en)	1996-03-07	New process for the production of biologically active protein
IL114701A0 (en)	1995-11-27	Process for the production of biologically active dimeric protein
UA43348C2 (uk)	2001-12-17	Водна фармацевтична композиція, що включає фактор росту нерва (варіанти) та ліофілізований фармацевтичний склад
HUT66485A (en)	1994-11-28	Lyposomal enzyme-cleavable antitumor drug conjugates,pharmaceutical compositions containing them, and process for producing them
LTIP1652A (en)	1995-08-25	Protein, biologically active hormone, method for protein production, pharmaceutical preparation
IL112539A0 (en)	1995-05-26	Pyrimidine derivatives and their preparation
IL116856A0 (en)	1996-07-23	Stable-lipid- comprising drug delivery complexes and methods for their production
HUP0002392A3 (en)	2000-11-28	Diazole and oxazole derivatives as growth hormone secretagogues, process for producing them and pharmaceutical compositions containing them
IL117091A (en)	2000-07-26	Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation threreof
CA2213322A1 (en)	1996-08-22	Thiols to promote hematopoietic progenitor cell growth
NZ325235A (en)	2000-01-28	New phenylamidine derivatives, a process for preparing the same and their use as medicaments
SI0785950T1 (en)	2003-08-31	Keratinocyte growth factor analogs
ATE234636T1 (de)	2003-04-15	Konjugat, umfassend einen wirkstoff, ein polypeptid und einen polyether
IL117943A0 (en)	1996-08-04	Dihalopropene compounds, insecticides containing them as active ingredients and intermediates for their production
IN172427B (de)	1993-07-24
MX9700656A (es)	1998-01-31	Proceso novedoso para la produccion de proteina dimerica biologicamente activa.
MX9700657A (es)	1998-01-31	Nuevo proceso para la produccion de proteina biologicamente activa.
AUPP031897A0 (en)	1997-12-04	Mammalian milk growth factor
CA2328832A1 (en)	1999-10-28	Processes for preparing pesticidal intermediates
AU1681895A (en)	1995-08-08	Process for preparing 4,4-dialkyl-6-halo-chromans or thiochromans useful as pharmaceutical intermediates
AU2121188A (en)	1989-01-30	Bactericidal and/or bacteriostatic peptides, process for their isolation, their production and their applications
AU6343086A (en)	1987-04-16	Fibrous wick comprising growth regulant, for plants
UA5743C2 (uk)	1994-12-29	Препарат тканинних біологічно активних речовин, який має регенаторну дію, та спосіб його одержання
HU210797A9 (en)	1995-07-28	Novel biologically active eburnamenine derivatives, pharmaceutical compositions containing them and process for preparing same
GB9613638D0 (en)	1996-08-28	Protein gene product 9.5 purified to homogeneity, process for its preparation and use

Legal Events

Date	Code	Title
2006-02-21	FF	Patent granted
2010-02-14	KB	Patent renewed
2014-03-31	MM9K	Patent not in force due to non-payment of renewal fees