ATE208380T1 - Verfahren zur herstellung von (2-(4-((4- chlorophenyl)phenylmethyl)-1-piperazinyl)- ethoxy)essigsäure-estern - Google Patents
Verfahren zur herstellung von (2-(4-((4- chlorophenyl)phenylmethyl)-1-piperazinyl)- ethoxy)essigsäure-esternInfo
- Publication number
- ATE208380T1 ATE208380T1 AT99302979T AT99302979T ATE208380T1 AT E208380 T1 ATE208380 T1 AT E208380T1 AT 99302979 T AT99302979 T AT 99302979T AT 99302979 T AT99302979 T AT 99302979T AT E208380 T1 ATE208380 T1 AT E208380T1
- Authority
- AT
- Austria
- Prior art keywords
- chlorophenyl
- phenylmethyl
- piperazinyl
- ethoxy
- producing
- Prior art date
Links
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical class C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 229910052801 chlorine Chemical group 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000002516 radical scavenger Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12419598A IL124195A (en) | 1998-04-23 | 1998-04-23 | Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE208380T1 true ATE208380T1 (de) | 2001-11-15 |
Family
ID=11071431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99302979T ATE208380T1 (de) | 1998-04-23 | 1999-04-16 | Verfahren zur herstellung von (2-(4-((4- chlorophenyl)phenylmethyl)-1-piperazinyl)- ethoxy)essigsäure-estern |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6100400A (de) |
| EP (1) | EP0952153B1 (de) |
| KR (1) | KR19990081747A (de) |
| AT (1) | ATE208380T1 (de) |
| CA (1) | CA2269394C (de) |
| CZ (1) | CZ141599A3 (de) |
| DE (1) | DE69900424T2 (de) |
| DK (1) | DK0952153T3 (de) |
| ES (1) | ES2165223T3 (de) |
| HU (1) | HUP9901337A3 (de) |
| IL (1) | IL124195A (de) |
| PL (1) | PL332521A1 (de) |
| SI (1) | SI9900098A (de) |
| SK (1) | SK282710B6 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239277B1 (en) * | 1999-10-20 | 2001-05-29 | Salsbury Chemicals, Inc. | Process for preparing piperazine-substituted aliphatic carboxylates |
| KR100503443B1 (ko) * | 2004-02-02 | 2005-07-22 | 한림제약(주) | 광학적으로 활성인 세티리진 또는 그의 염의 제조방법 |
| KR100669824B1 (ko) | 2005-04-18 | 2007-01-16 | 경동제약 주식회사 | (-)-2-[2-[4-[(4-클로로페닐)페닐메틸]-1-피페라지닐]에톡시]-아세트산의 제조방법 |
| HU227325B1 (en) * | 2005-12-08 | 2011-03-28 | Egis Gyogyszergyar Nyrt | Process for the production of an intermediate of (dextro- and levo)- cetirizine |
| WO2009022327A2 (en) * | 2007-08-15 | 2009-02-19 | Chemagis Ltd. | Novel process for preparing highly pure levocetirizine and salts thereof |
| CN101928263A (zh) * | 2010-07-06 | 2010-12-29 | 四川大学 | 一种制备盐酸乙氟利嗪的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI75816C (fi) * | 1981-02-06 | 1988-08-08 | Ucb Sa | Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid. |
| GB8827390D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
| GB8827391D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride |
| NO304832B1 (no) * | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| DE4233963A1 (de) * | 1992-10-08 | 1994-04-14 | Schwabe Willmar Gmbh & Co | Neue Benzopyranone, Verfahren zu ihrer Herstellung und Verwendung |
| GB9305282D0 (en) * | 1993-03-15 | 1993-05-05 | Ucb Sa | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine |
| BE1010095A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels. |
| BE1010094A3 (fr) * | 1996-04-10 | 1997-12-02 | Ucb Sa | Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues. |
-
1998
- 1998-04-23 IL IL12419598A patent/IL124195A/xx not_active IP Right Cessation
- 1998-08-21 KR KR1019980033931A patent/KR19990081747A/ko not_active Withdrawn
-
1999
- 1999-04-14 PL PL99332521A patent/PL332521A1/xx unknown
- 1999-04-15 CA CA002269394A patent/CA2269394C/en not_active Expired - Fee Related
- 1999-04-15 US US09/292,318 patent/US6100400A/en not_active Expired - Lifetime
- 1999-04-16 DK DK99302979T patent/DK0952153T3/da active
- 1999-04-16 EP EP99302979A patent/EP0952153B1/de not_active Expired - Lifetime
- 1999-04-16 DE DE69900424T patent/DE69900424T2/de not_active Expired - Lifetime
- 1999-04-16 ES ES99302979T patent/ES2165223T3/es not_active Expired - Lifetime
- 1999-04-16 AT AT99302979T patent/ATE208380T1/de not_active IP Right Cessation
- 1999-04-20 SI SI9900098A patent/SI9900098A/sl not_active IP Right Cessation
- 1999-04-21 CZ CZ991415A patent/CZ141599A3/cs unknown
- 1999-04-21 SK SK522-99A patent/SK282710B6/sk unknown
- 1999-04-22 HU HU9901337A patent/HUP9901337A3/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0952153B1 (de) | 2001-11-07 |
| CA2269394C (en) | 2003-12-09 |
| SK52299A3 (en) | 2000-02-14 |
| SI9900098A (sl) | 1999-12-31 |
| US6100400A (en) | 2000-08-08 |
| KR19990081747A (ko) | 1999-11-15 |
| HUP9901337A2 (hu) | 2000-04-28 |
| CZ141599A3 (cs) | 1999-11-17 |
| DE69900424D1 (de) | 2001-12-13 |
| PL332521A1 (en) | 1999-10-25 |
| EP0952153A3 (de) | 2000-01-12 |
| ES2165223T3 (es) | 2002-03-01 |
| IL124195A (en) | 2000-08-31 |
| CA2269394A1 (en) | 1999-10-23 |
| HU9901337D0 (en) | 1999-07-28 |
| DE69900424T2 (de) | 2002-07-18 |
| HUP9901337A3 (en) | 2001-02-28 |
| SK282710B6 (sk) | 2002-11-06 |
| EP0952153A2 (de) | 1999-10-27 |
| DK0952153T3 (da) | 2003-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |