ATE208827T1 - Konjugate von dns und pns und verfahren zu deren herstellung - Google Patents
Konjugate von dns und pns und verfahren zu deren herstellungInfo
- Publication number
- ATE208827T1 ATE208827T1 AT99905934T AT99905934T ATE208827T1 AT E208827 T1 ATE208827 T1 AT E208827T1 AT 99905934 T AT99905934 T AT 99905934T AT 99905934 T AT99905934 T AT 99905934T AT E208827 T1 ATE208827 T1 AT E208827T1
- Authority
- AT
- Austria
- Prior art keywords
- carboxylic acid
- disclosed
- methods
- conjugates
- dna
- Prior art date
Links
- 150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 3
- 108020003215 DNA Probes Proteins 0.000 abstract 2
- 239000003298 DNA probe Substances 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 2
- -1 aminooxyacetyl moiety Chemical group 0.000 abstract 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7438898P | 1998-02-11 | 1998-02-11 | |
| PCT/US1999/002908 WO1999041273A2 (en) | 1998-02-11 | 1999-02-10 | Pna and dna conjugates and methods for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE208827T1 true ATE208827T1 (de) | 2001-11-15 |
Family
ID=22119288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99905934T ATE208827T1 (de) | 1998-02-11 | 1999-02-10 | Konjugate von dns und pns und verfahren zu deren herstellung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6197513B1 (de) |
| EP (1) | EP1053355B1 (de) |
| JP (1) | JP2002503456A (de) |
| AT (1) | ATE208827T1 (de) |
| AU (1) | AU742241B2 (de) |
| CA (1) | CA2320390C (de) |
| DE (1) | DE69900462T2 (de) |
| DK (1) | DK1053355T3 (de) |
| WO (1) | WO1999041273A2 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2288760T3 (es) | 1996-04-25 | 2008-01-16 | Bioarray Solutions Ltd. | Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies. |
| US7060432B1 (en) | 1999-06-15 | 2006-06-13 | Applera Corporation | Methods for the detection, identification, and/or enumeration of yeast, particularly in wine |
| US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
| DE60216468T2 (de) | 2001-03-09 | 2007-09-27 | Boston Probes, Inc., Bedford | Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen |
| US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
| CA2497740C (en) | 2001-10-15 | 2011-06-21 | Bioarray Solutions, Ltd. | Multiplexed analysis of polymorphic loci by probe elongation-mediated detection |
| US6942972B2 (en) | 2001-10-24 | 2005-09-13 | Beckman Coulter, Inc. | Efficient synthesis of protein-oligonucleotide conjugates |
| AU2003228649A1 (en) * | 2002-04-23 | 2003-11-10 | U.S.Genomics, Inc. | Compositions and methods related to two-arm nucleic acid probes |
| WO2004007692A2 (en) * | 2002-07-17 | 2004-01-22 | U.S.Genomics, Inc. | Methods and compositions for analyzing polymers using chimeric tags |
| US7041453B2 (en) | 2002-08-22 | 2006-05-09 | Bioarray Solutions Ltd. | Molecular constructs and methods of use for detection of biochemical reactions |
| US20040038331A1 (en) * | 2002-08-23 | 2004-02-26 | Reddy M. Parameswara | Solid phase synthesis of biomolecule conjugates |
| WO2004047007A1 (en) | 2002-11-15 | 2004-06-03 | Bioarray Solutions, Ltd. | Analysis, secure access to, and transmission of array images |
| US20050123944A1 (en) * | 2003-08-01 | 2005-06-09 | U.S. Genomics, Inc. | Methods and compositions related to the use of sequence-specific endonucleases for analyzing nucleic acids under non-cleaving conditions |
| JP4564959B2 (ja) | 2003-09-22 | 2010-10-20 | バイオアレイ ソリューションズ リミテッド | 生体分子に共有結合できる、複数の官能基を持つ表面固定化高分子電解質 |
| US7563569B2 (en) | 2003-10-28 | 2009-07-21 | Michael Seul | Optimization of gene expression analysis using immobilized capture probes |
| US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
| US20060292559A1 (en) * | 2005-06-23 | 2006-12-28 | Beckman Coulter, Inc. | Cell-based microarrays, and methods for their preparation and use |
| JP2009525048A (ja) * | 2006-02-01 | 2009-07-09 | ザ ジョンズ ホプキンス ユニバーシティー | 腫瘍性障害または感染症に対する免疫学的予防法または免疫療法のためのポリペプチド−核酸複合体 |
| CA2695385A1 (en) * | 2007-07-31 | 2009-02-05 | Atul Bedi | Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders |
| US7767441B2 (en) | 2007-10-25 | 2010-08-03 | Industrial Technology Research Institute | Bioassay system including optical detection apparatuses, and method for detecting biomolecules |
| US7811810B2 (en) | 2007-10-25 | 2010-10-12 | Industrial Technology Research Institute | Bioassay system including optical detection apparatuses, and method for detecting biomolecules |
| US9778188B2 (en) | 2009-03-11 | 2017-10-03 | Industrial Technology Research Institute | Apparatus and method for detection and discrimination molecular object |
| US8927271B1 (en) | 2010-01-21 | 2015-01-06 | Jack T. Johansen | Compositions and methods for detecting target analytes |
| US9482615B2 (en) | 2010-03-15 | 2016-11-01 | Industrial Technology Research Institute | Single-molecule detection system and methods |
| US9670243B2 (en) | 2010-06-02 | 2017-06-06 | Industrial Technology Research Institute | Compositions and methods for sequencing nucleic acids |
| US8865077B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| US8865078B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| CN110121364A (zh) | 2016-12-19 | 2019-08-13 | 文塔纳医疗系统公司 | 肽核酸缀合物 |
| WO2019120635A1 (en) | 2017-12-18 | 2019-06-27 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992000989A1 (en) | 1990-07-10 | 1992-01-23 | Imperial Chemical Industries Plc | Non-isotopic nucleic acid labelling method |
| AU681997B2 (en) * | 1991-09-05 | 1997-09-18 | University Of Connecticut, The | Targeted delivery of poly- or oligonucleotides to cells |
| WO1994004550A1 (en) * | 1992-08-21 | 1994-03-03 | Triplex Pharmaceutical Corporation | Cholesteryl-modified triple-helix forming oligonucleotides and uses thereof |
| US5574142A (en) | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| US6133444A (en) | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
| US5705333A (en) * | 1994-08-05 | 1998-01-06 | The Regents Of The University Of California | Peptide-based nucleic acid mimics(PENAMS) |
| US5580731A (en) * | 1994-08-25 | 1996-12-03 | Chiron Corporation | N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith |
| AU3999495A (en) | 1994-10-06 | 1996-05-02 | Buchardt, Dorte | Peptide nucleic acid conjugates |
| WO1996040709A1 (en) | 1995-06-07 | 1996-12-19 | Perseptive Biosystems, Inc. | Pna-dna chimeras and pna synthons for their preparation |
| US6110676A (en) | 1996-12-04 | 2000-08-29 | Boston Probes, Inc. | Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays |
| CA2298067A1 (en) | 1997-07-24 | 1999-02-04 | Ulo Langel | Conjugates of transporter peptides and nucleic acid analogs, and their use |
-
1999
- 1999-02-10 CA CA2320390A patent/CA2320390C/en not_active Expired - Lifetime
- 1999-02-10 WO PCT/US1999/002908 patent/WO1999041273A2/en not_active Ceased
- 1999-02-10 DE DE69900462T patent/DE69900462T2/de not_active Expired - Lifetime
- 1999-02-10 DK DK99905934T patent/DK1053355T3/da active
- 1999-02-10 JP JP2000531464A patent/JP2002503456A/ja not_active Withdrawn
- 1999-02-10 US US09/247,996 patent/US6197513B1/en not_active Expired - Lifetime
- 1999-02-10 AT AT99905934T patent/ATE208827T1/de not_active IP Right Cessation
- 1999-02-10 AU AU25973/99A patent/AU742241B2/en not_active Ceased
- 1999-02-10 EP EP99905934A patent/EP1053355B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1053355B1 (de) | 2001-11-14 |
| DE69900462D1 (de) | 2001-12-20 |
| JP2002503456A (ja) | 2002-02-05 |
| AU2597399A (en) | 1999-08-30 |
| CA2320390C (en) | 2010-06-08 |
| WO1999041273A2 (en) | 1999-08-19 |
| WO1999041273A3 (en) | 1999-09-23 |
| DK1053355T3 (da) | 2002-02-11 |
| US6197513B1 (en) | 2001-03-06 |
| AU742241B2 (en) | 2001-12-20 |
| CA2320390A1 (en) | 1999-08-19 |
| DE69900462T2 (de) | 2002-07-11 |
| EP1053355A2 (de) | 2000-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |