ATE209862T1 - Isolierung von lactoferrin aus milch - Google Patents

Isolierung von lactoferrin aus milch

Info

Publication number
ATE209862T1
ATE209862T1 AT95909735T AT95909735T ATE209862T1 AT E209862 T1 ATE209862 T1 AT E209862T1 AT 95909735 T AT95909735 T AT 95909735T AT 95909735 T AT95909735 T AT 95909735T AT E209862 T1 ATE209862 T1 AT E209862T1
Authority
AT
Austria
Prior art keywords
lactoferrin
milk
isolation
lactoferrins
eluted
Prior art date
Application number
AT95909735T
Other languages
English (en)
Inventor
Jan H Nuijens
Harry H Van Veen
Original Assignee
Pharming Intellectual Pty Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharming Intellectual Pty Bv filed Critical Pharming Intellectual Pty Bv
Application granted granted Critical
Publication of ATE209862T1 publication Critical patent/ATE209862T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/146—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by ion-exchange
    • A23C9/1465—Chromatographic separation of protein or lactose fraction; Adsorption of protein or lactose fraction followed by elution
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/832—Milk; colostrum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dairy Products (AREA)
AT95909735T 1994-02-16 1995-02-16 Isolierung von lactoferrin aus milch ATE209862T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19832194A 1994-02-16 1994-02-16
PCT/EP1995/000583 WO1995022258A2 (en) 1994-02-16 1995-02-16 Isolation of lactoferrin from milk

Publications (1)

Publication Number Publication Date
ATE209862T1 true ATE209862T1 (de) 2001-12-15

Family

ID=22732892

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95909735T ATE209862T1 (de) 1994-02-16 1995-02-16 Isolierung von lactoferrin aus milch

Country Status (11)

Country Link
US (3) US5861491A (de)
EP (2) EP0744901B1 (de)
JP (1) JPH09509165A (de)
AT (1) ATE209862T1 (de)
AU (1) AU1809895A (de)
CA (1) CA2183459A1 (de)
DE (1) DE69524386D1 (de)
FI (1) FI963197L (de)
NO (1) NO963163L (de)
NZ (1) NZ330484A (de)
WO (1) WO1995022258A2 (de)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268487B1 (en) 1996-05-13 2001-07-31 Genzyme Transgenics Corporation Purification of biologically active peptides from milk
US6333311B1 (en) * 1997-02-03 2001-12-25 Pharming Useful properties of human lactoferrin and variants thereof
JP2002508009A (ja) * 1998-04-13 2002-03-12 ニュー イングランド メディカル センター ホスピタル インク． ラクトフェリンおよび関連分子を用いた感染性因子を不活化する方法および組成物
US6399570B1 (en) * 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
US6537785B1 (en) 1999-09-14 2003-03-25 Genzyme Glycobiology Research Institute, Inc. Methods of treating lysosomal storage diseases
US6770468B1 (en) 1999-09-14 2004-08-03 Genzyme Glycobiology Research Institute, Inc. Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway
US7060677B1 (en) 1999-11-11 2006-06-13 Am-Pharma B.V. Antimicrobial activity of the first cationic cluster of human lactoferrin
EP1228097B1 (de) * 1999-11-11 2005-12-21 AM-Pharma B.V. Antimicrobielle wirkung des ersten kationischen cluster des menschlichen lactoferrins
NZ501675A (en) 1999-12-09 2002-12-20 New Zealand Dairy Board Translucent milk drink having a pH of 5.7 to 7.0 and a percentage transmission of at least 5% prepared by a cation exchange process
US6905856B2 (en) * 2001-12-21 2005-06-14 Genzyme Glycobiology Research Institute, Inc. Soluble GlcNAc phosphotransferase
US20030124652A1 (en) * 2001-12-21 2003-07-03 Novazyme Pharmaceuticals, Inc. Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells
US6800472B2 (en) * 2001-12-21 2004-10-05 Genzyme Glycobiology Research Institute, Inc. Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase
DK1480524T3 (da) * 2002-03-07 2013-07-15 Upfront Chromatography As Fremgangsmåde til isolering af lactoferrin
DE60335997D1 (de) 2002-09-16 2011-03-24 Agennix Inc Lactoferrin-zusammensetzungen und verfahren zur behandlung von diabetischen ulcus
AU2003296447A1 (en) 2002-12-10 2004-06-30 Agennix Incorporated Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
AU2003293500A1 (en) 2002-12-12 2004-07-09 Agennix Incorporated Lactoferrin in the reduction of pain
JP4263932B2 (ja) * 2003-04-01 2009-05-13 雪印乳業株式会社 ラクトフェリンの製造方法
WO2004103285A2 (en) * 2003-05-14 2004-12-02 Agennix Incorporated Lactoferrin in the treatment of diabetes mellitus
US8105615B2 (en) * 2003-06-06 2012-01-31 Agennix Incorporated Lactoferrin as an adjuvant in cancer vaccines
US20040259770A1 (en) * 2003-06-19 2004-12-23 Rush University Medical Center Method for determining leukocyte activation
CA2463301A1 (en) * 2004-04-22 2005-10-22 Atanas Iliev Lalev Method for detecting protein interactions - affinity purification with switching the ligand
EP1689348B1 (de) * 2003-12-05 2013-05-15 Children's Hospital Medical Center Oligosaccharid-Zusammensetzungen und ihre Verwendung bei der Behandlung von Infektionen
EP1712558A4 (de) * 2004-02-03 2007-02-21 Univ Kurume Verfahren zur trennung/ aufreinigung von kationischem protein
WO2005085287A1 (en) * 2004-03-03 2005-09-15 En-N-Tech, Inc. Treatments for contaminant reduction in lactoferrin preparations and lactoferrin-containing compositions
WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
US20090306350A1 (en) * 2005-05-13 2009-12-10 Crea Biopharma Inc. New purification method of lactoferrin
FR2901796A1 (fr) * 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
ITRM20060434A1 (it) * 2006-08-07 2008-02-08 Pietro Raimondi Prodotto da somministrare all organismo umano per isuoi effetti protettivi e curativi a base di latte di bufala autorricchito di lattoferrina oppure di lattoferrina tal quale ottenuto attraverso processi separativi di membrana
NZ555163A (en) 2007-05-14 2010-05-28 Fonterra Co Operative Group Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments
US7919589B2 (en) * 2007-07-10 2011-04-05 Glanbia Nutritionals (Ireland), Ltd. Method for removing endotoxin from proteins
AU2014201943B2 (en) * 2007-07-10 2016-07-28 Glanbia Nutritionals Method for removing endotoxin from proteins
JP5766947B2 (ja) 2007-09-07 2015-08-19 チルドレンズ ホスピタル メディカル センター 臨床サンプルにおける分泌性のルイス抗原およびシアル化抗原のレベルの疾患リスクの予測指標としての使用
EP2077273B1 (de) * 2007-12-31 2011-09-14 Animal Technology Institute Taiwan Verfahren zur Trennung von Casein aus löslichen Proteinen in einer Zusammensetzung
CN101672835B (zh) * 2008-09-09 2012-05-30 光明乳业股份有限公司 一种测定乳制品中乳铁蛋白的方法
FR2940655B1 (fr) 2008-12-31 2011-02-18 Lfb Biotechnologies Peptides isoles de facteur vii de lapin.
RU2579661C2 (ru) * 2009-01-28 2016-04-10 Жан-Поль ПЕРРОДЭН Способ производства лактоферрина, фракция, содержащая лактоферрин, и ее применения
EP2451462B1 (de) 2009-07-06 2017-09-06 Children's Hospital Medical Center Entzündungshemmung mit milch-oligosacchariden
EP2649442A1 (de) * 2010-12-09 2013-10-16 Nestec S.A. Quantifizierung von lactoferrin in säuglingsmilchnahrung durch elektrophorese mittels ir-fluoreszenzbildgebung
SG190781A1 (en) 2010-12-29 2013-07-31 Mjn Us Holdings Llc Method for inhibiting pathogens using a nutritional composition
CN107668721A (zh) 2010-12-29 2018-02-09 Mjn 美国控股有限责任公司 包含乳铁蛋白的营养组合物在支持抵抗疾病和状况中的用途
US8968722B2 (en) 2010-12-29 2015-03-03 Mead Johnson Nutrition Company Milk-based nutritional compositions containing lactoferrin and uses thereof
US20120171231A1 (en) 2010-12-29 2012-07-05 Anja Wittke Use of nutritional compositions including lactoferrin in stimulating immune cells
US8648036B2 (en) 2010-12-29 2014-02-11 Mead Johnson Nutrition Company Use of nutritional compositions including lactoferrin and one or more prebiotics in inhibiting adhesion of pathogens in the gastrointestinal tract
US20120171328A1 (en) 2011-01-05 2012-07-05 Dattatreya Banavara Composition comprising heat labile milk proteins and process for preparing same
US9351978B2 (en) 2012-02-29 2016-05-31 Mead Johnson Nutrition Company Neurogenesis screening method and uses thereof
WO2013138991A1 (en) * 2012-03-20 2013-09-26 Nestec S.A. Lactoferrin supplementation and diarrhea
AU2013204850B2 (en) * 2012-10-08 2015-06-25 Murray Goulburn Co-Operative Co. Limited Improved process for purifying milk proteins and products thereof
AU2013204858B2 (en) * 2012-10-08 2015-06-25 Saputo Dairy Australia Pty Limited Improved process for purifying milk proteins and products thereof
US10626460B2 (en) 2013-02-21 2020-04-21 Children's Hospital Medical Center Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease
US20140255365A1 (en) 2013-03-11 2014-09-11 Mead Johnson Nutrition Company Oral Electrolyte Solution Containing Lactoferrin and Uses Thereof
US20140271978A1 (en) 2013-03-15 2014-09-18 Mead Johnson Nutrition Company Low-buffer nutritional compositions and uses thereof
US9458225B2 (en) * 2013-06-26 2016-10-04 United Arab Emirates University Method for purifying lactoferrin
US9241923B2 (en) 2013-07-16 2016-01-26 Mead Johnson Nutrition Company Methods for promoting neuronal development and/or health
US9226914B2 (en) 2013-07-16 2016-01-05 Mead Johnson Nutrition Company Methods for promoting neuronal development and/or health
US9661868B2 (en) * 2013-07-16 2017-05-30 Mead Johnson Nutrition Company Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin
US10709770B2 (en) 2013-07-31 2020-07-14 Mead Johnson Nutrition Company Nutritional compositions containing a prebiotic and lactoferrin and uses thereof
US9609888B2 (en) 2013-07-31 2017-04-04 Mead Johnson Nutrition Company Nutritional compositions containing synergistic combination and uses thereof
WO2015050744A2 (en) 2013-10-03 2015-04-09 Mjn U.S. Holdings Llc Neurogenesis screening method and uses thereof
CZ2013885A3 (cs) 2013-11-15 2015-08-19 Univerzita PalackĂ©ho Způsob separace syrovátkových proteinů z mléčného média a zařízení k provádění tohoto způsobu
CN103709246B (zh) * 2013-11-25 2015-09-02 北京济福霖生物技术有限公司 一种乳铁蛋白及乳过氧化物酶的纯化方法
US20150157048A1 (en) 2013-12-11 2015-06-11 Mead Johnson Nutrition Company Nutritional compositions containing stearidonic acid and uses thereof
WO2015094532A1 (en) 2013-12-17 2015-06-25 Mjn U.S. Holdings Llc Nutritional composition containing a neurologic component of kaempferol and/or fisetin
US20150164833A1 (en) 2013-12-17 2015-06-18 Mead Johnson Nutrition Company Nutritional composition containing a neurologic component of ursolic acid and uses thereof
US10639334B2 (en) 2014-01-07 2020-05-05 Mead Johnson Nutrition Company Pediatric nutritional composition with milk peptides for healthy growth and development
US10028519B2 (en) 2014-03-05 2018-07-24 Mead Johnson Nutrition Company Nutritional compositions containing ceramide and uses thereof
US20150290261A1 (en) 2014-04-10 2015-10-15 Mead Johnson Nutrition Company Methods of use for probiotics and prebiotics
US20150305359A1 (en) 2014-04-24 2015-10-29 Mead Johnson Nutrition Company Nutritional compositions directed to subjects having cow's milk protein allergies
US20150305385A1 (en) 2014-04-25 2015-10-29 Mead Johnson Nutrition Company Pediatric nutritional composition with human milk oligosaccahrides, prebiotics and probiotics
US20160015068A1 (en) 2014-07-16 2016-01-21 Mead Johnson Nutrition Company Nutritional formulas containing oil blends and uses thereof
US20160029682A1 (en) 2014-08-01 2016-02-04 Mead Johnson Nutrition Company Hydrolyzed lactose-containing nutritional compositions and uses thereof
US20160095339A1 (en) 2014-10-01 2016-04-07 Mead Johnson Nutrition Company Nutritional composition for gastrointestinal environment to provide improved microbiome and metabolic profile
CA2962136A1 (en) 2014-11-07 2016-05-12 Mjn U.S. Holdings Llc Nutritional compositions containing a prebiotic and lactoferrin and uses thereof
WO2016176484A1 (en) 2015-04-28 2016-11-03 Children's Hospital Medical Center Use of oligosaccharide compositions to enhance weight gain
US10525016B2 (en) 2015-06-03 2020-01-07 Mead Johnson Nutrition Company Nutritional compositions containing an elevated level of inositol and uses thereof
US20170006897A1 (en) 2015-07-10 2017-01-12 Mead Johnson Nutrition Company Nutritional compositions and methods for promoting cognitive development
US10617701B2 (en) 2015-07-10 2020-04-14 Mead Johnson Nutrition Company Nutritional compositions containing phosphatidylethanolamine, sphingomyelin and docosahexaenoic acid
US10582714B2 (en) 2015-07-10 2020-03-10 Mead Johnson Nutrition Company Nutritional compositions and methods for promoting cognitive development
US20170020950A1 (en) 2015-07-23 2017-01-26 Mead Johnson Nutrition Company Methods for modulating kinases
US9730969B2 (en) 2015-11-06 2017-08-15 Mead Johnson Nutrition Company Nutritional compositions for promoting gut barrier function and ameliorating visceral pain
US10034937B2 (en) 2015-12-04 2018-07-31 Mead Johnson Nutrition Company Synergistic nutritional compositions and uses thereof
CN109564204B (zh) * 2016-03-18 2021-12-10 真克里斯公司 变态反应的分子起源
US20180064739A1 (en) 2016-09-06 2018-03-08 Mead Johnson Nutrition Company Nutritional composition with human milk oligosaccharides and uses thereof
US20180103675A1 (en) 2016-10-14 2018-04-19 Mead Johnson Nutrition Company Personalized pediatric nutrition products comprising human milk oligosaccharides
US20180133287A1 (en) 2016-11-14 2018-05-17 Mead Johnson Nutrition Company Nutritional compositions providing dietary management of colic
US20180153951A1 (en) 2016-12-05 2018-06-07 Mead Johnson Nutrition Company Methods for Inducing Adipocyte Browning, Improving Metabolic Flexibility, and Reducing Detrimental White Adipocyte Tissue Deposition and Dysfunction
US10980269B2 (en) 2016-12-12 2021-04-20 Mead Johnson Nutrition Company Protein hydrolysates and methods of making same
US20180160714A1 (en) 2016-12-12 2018-06-14 Mead Johnson Nutrition Company Nutritional compositions containing butyrate and uses thereof
US20180161292A1 (en) 2016-12-12 2018-06-14 Mead Johnson Nutrition Company Nutritional compositions containing butyrate and uses thereof
US20180168215A1 (en) 2016-12-21 2018-06-21 Mead Johnson Nutrition Company Nutritional compositions containing inositol and uses thereof
US20180333426A1 (en) 2017-05-17 2018-11-22 Mead Johnson Nutrition Company Nutritional composition with human milk oligosaccharides and uses thereof
US20180332881A1 (en) 2017-05-17 2018-11-22 Mead Johnson Nutrition Company Preterm infant formula containing butyrate and uses thereof
US20190208807A1 (en) 2018-01-05 2019-07-11 Mead Johnson Nutrition Company Nutritional compositions containing milk-derived peptides and uses thereof
GB2573538B (en) 2018-05-09 2023-01-04 Mjn Us Holdings Llc Pediatric nutritional compositions and methods for infants delivered by C-section
JP2022513594A (ja) 2018-11-06 2022-02-09 アルヘル プロジェクティランジェ イン インゼニリング ディー．オー．オー． 乳、初乳及び酸性又は甘性ホエーから高度に精製されたラクトフェリン及びラクトペルオキシダーゼを製造する方法
JP7370224B2 (ja) * 2019-11-08 2023-10-27 ライオン株式会社 ラクトフェリン含有腸溶製剤
FR3115037B1 (fr) * 2020-10-12 2025-02-21 Cie Laitiere Europeenne Procédé de purification de fraction de protéines cationiques et fraction ainsi obtenue
CA3229787A1 (en) * 2021-08-23 2023-03-02 Christopher HLUBB Lactoferrin compositions and methods of use
CN114414687A (zh) * 2022-01-13 2022-04-29 北京美正生物科技有限公司 一种乳铁蛋白提取用结合缓冲液及其制备方法和应用、牛乳铁蛋白的检测方法
CN116200463A (zh) * 2023-01-31 2023-06-02 陕西科技大学 不同来源乳及乳制品中活性乳铁蛋白含量的快速检测方法及试剂盒
DE202023102334U1 (de) * 2023-04-28 2023-06-07 Mercurius Production Gmbh Lactoferrin und Vorrichtung zu dessen Herstellung
WO2025213137A1 (en) 2024-04-05 2025-10-09 ByHeart, Inc. Formulation comprising heat-treated lactoferrin for nutritional support in subjects in need thereof
WO2025213143A1 (en) 2024-04-05 2025-10-09 ByHeart, Inc. Nutritional supplement comprising lactoferrin protein complexes in subjects in need thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2505615A1 (fr) * 1981-05-15 1982-11-19 Elf Aquitaine Procede d'extraction de lactoferrine et d'immunoglobulines du lait
JPS61145200A (ja) * 1984-12-19 1986-07-02 Snow Brand Milk Prod Co Ltd ウシラクトフェリンの分離精製法
IE61701B1 (en) * 1986-07-17 1994-11-30 Morinaga Milk Industry Co Ltd Process for producing bovine lactoferrin in high purity
JPH0725800B2 (ja) * 1987-04-10 1995-03-22 雪印乳業株式会社 硫酸エステル化物を用いて乳からラクトフエリンを分離、精製する方法
US4977137B1 (en) * 1987-06-03 1994-06-28 Baylor College Medicine Lactoferrin as a dietary ingredient promoting the growth of the gastrointestinal tract
SE458818B (sv) * 1987-11-27 1989-05-16 Svenska Mejeriernas Riksforeni Foerfarande foer utvinning av rena fraktioner av laktoperoxidas och laktoferrin ur mjoelkserum
NZ230031A (en) * 1988-07-27 1991-10-25 Snow Brand Milk Products Co Ltd Separation of proteins (e.g. lactoferrin) using affinity gel carrier in a rotary column
US5169936A (en) * 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
CA2075206C (en) * 1989-12-01 2006-05-23 Herbert L. Heyneker Production of recombinant polypeptides by bovine species and transgenic methods
US5240909B1 (en) * 1990-03-14 1998-01-20 Dietrich Nitsche Use of lactoferrin for treatment of toxic effects of endotoxins
WO1993002098A1 (en) * 1991-07-25 1993-02-04 Commonwealth Scientific And Industrial Research Organisation Isolation of charged particles from fluids
ATE129125T1 (de) * 1992-01-15 1995-11-15 Campina Melkunie Bv Verfahren zur isolierung von lactoferrin und lactoperoxidase aus milch und milchprodukten.
JPH05202098A (ja) * 1992-01-29 1993-08-10 Snow Brand Milk Prod Co Ltd 乳質原料から生理活性物質の製造法
WO1995030339A1 (en) * 1994-05-05 1995-11-16 Ferrodynamics, Inc. Cloning, expression, and uses of human lactoferrin

Also Published As

Publication number Publication date
WO1995022258A2 (en) 1995-08-24
WO1995022258A3 (en) 1995-11-16
NZ330484A (en) 1999-11-29
EP1142484A2 (de) 2001-10-10
FI963197A7 (fi) 1996-08-15
NO963163L (no) 1996-09-16
MX9603369A (es) 1997-12-31
CA2183459A1 (en) 1995-08-24
JPH09509165A (ja) 1997-09-16
NO963163D0 (no) 1996-07-29
FI963197A0 (fi) 1996-08-15
AU1809895A (en) 1995-09-04
EP0744901A1 (de) 1996-12-04
US5919913A (en) 1999-07-06
FI963197L (fi) 1996-08-15
EP0744901B1 (de) 2001-12-05
US5861491A (en) 1999-01-19
DE69524386D1 (de) 2002-01-17
US5849885A (en) 1998-12-15

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