ATE210128T1 - Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotiden - Google Patents
Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotidenInfo
- Publication number
- ATE210128T1 ATE210128T1 AT94914724T AT94914724T ATE210128T1 AT E210128 T1 ATE210128 T1 AT E210128T1 AT 94914724 T AT94914724 T AT 94914724T AT 94914724 T AT94914724 T AT 94914724T AT E210128 T1 ATE210128 T1 AT E210128T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleosidic
- polynucleotides
- crosslinking
- reagents
- cumarin derivatives
- Prior art date
Links
- 238000004132 cross linking Methods 0.000 title abstract 2
- 102000040430 polynucleotide Human genes 0.000 title abstract 2
- 108091033319 polynucleotide Proteins 0.000 title abstract 2
- 239000002157 polynucleotide Substances 0.000 title abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical class C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 150000001893 coumarin derivatives Chemical class 0.000 abstract 1
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007899 nucleic acid hybridization Methods 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
- C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Silicon Polymers (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4656893A | 1993-04-13 | 1993-04-13 | |
| PCT/US1994/003160 WO1994024120A1 (en) | 1993-04-13 | 1994-03-23 | Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE210128T1 true ATE210128T1 (de) | 2001-12-15 |
Family
ID=21944142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94914724T ATE210128T1 (de) | 1993-04-13 | 1994-03-23 | Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotiden |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6005093A (de) |
| EP (1) | EP0693065B1 (de) |
| JP (1) | JPH08511002A (de) |
| AT (1) | ATE210128T1 (de) |
| CA (1) | CA2159356A1 (de) |
| DE (1) | DE69429338T2 (de) |
| DK (1) | DK0693065T3 (de) |
| ES (1) | ES2169071T3 (de) |
| PT (1) | PT693065E (de) |
| WO (1) | WO1994024120A1 (de) |
Families Citing this family (43)
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| JPH08511002A (ja) * | 1993-04-13 | 1996-11-19 | ナクスコー | ポリヌクレオチド架橋剤としての非ヌクレオシドクマリン誘導体 |
| US6277570B1 (en) | 1993-04-13 | 2001-08-21 | Naxcor | Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents |
| US5767259A (en) | 1994-12-27 | 1998-06-16 | Naxcor | Oligonucleotides containing base-free linking groups with photoactivatable side chains |
| US6495676B1 (en) * | 1993-04-13 | 2002-12-17 | Naxcor | Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents |
| AU719277B2 (en) * | 1995-03-09 | 2000-05-04 | Naxcor | Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents |
| CA2236675A1 (en) * | 1995-11-03 | 1997-05-09 | Naxcor | Double-stranded conformational polymorphism analysis |
| US20040266706A1 (en) * | 2002-11-05 | 2004-12-30 | Muthiah Manoharan | Cross-linked oligomeric compounds and their use in gene modulation |
| US6124099A (en) * | 1998-06-22 | 2000-09-26 | The University Of Vermont And State Agricultural College | Method for placing a photo-cross-linking agent at specific internal sites within the sequence of synthetic strands of ribonucleic acids |
| MXPA01001894A (es) | 1998-08-21 | 2002-04-24 | Naxcor | Ensayos utilizando acidos nucleicos inmovilizados reticulables. |
| US6303799B1 (en) | 1998-11-10 | 2001-10-16 | Naxcor | Polynucleotide crosslinking agents |
| US20060275782A1 (en) | 1999-04-20 | 2006-12-07 | Illumina, Inc. | Detection of nucleic acid reactions on bead arrays |
| US6573048B1 (en) | 2000-04-18 | 2003-06-03 | Naxcor | Degradable nucleic acid probes and nucleic acid detection methods |
| US20050013996A1 (en) * | 2002-03-08 | 2005-01-20 | Hatfield Stephen F. | Hot melt pressure sensitive adhesives for disposable articles |
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| ES2864086T3 (es) | 2002-08-23 | 2021-10-13 | Illumina Cambridge Ltd | Nucleótidos etiquetados |
| US11008359B2 (en) | 2002-08-23 | 2021-05-18 | Illumina Cambridge Limited | Labelled nucleotides |
| AU2003268269A1 (en) * | 2002-08-29 | 2004-03-19 | Naxcor | Polymorphism detection among homologous sequences |
| US6800768B1 (en) * | 2002-09-06 | 2004-10-05 | Naxcor, Inc. | Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents |
| AU2003265482A1 (en) * | 2002-09-06 | 2004-03-29 | Naxcor, Inc. | Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents |
| US6943768B2 (en) | 2003-02-21 | 2005-09-13 | Xtellus Inc. | Thermal control system for liquid crystal cell |
| US20050136414A1 (en) * | 2003-12-23 | 2005-06-23 | Kevin Gunderson | Methods and compositions for making locus-specific arrays |
| JP5850746B2 (ja) * | 2008-11-17 | 2016-02-03 | ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. | 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物 |
| EP2358898B1 (de) * | 2008-11-17 | 2016-08-31 | Headway Technologies, Inc. | Verfahren und zusammensetzungen bei dem nachweis von zielmolekülen auf partikelbasis unter verwendung von kovalente bindungen ausbildenden reaktiven paaren |
| US9365897B2 (en) | 2011-02-08 | 2016-06-14 | Illumina, Inc. | Selective enrichment of nucleic acids |
| JP6126997B2 (ja) | 2011-02-16 | 2017-05-10 | ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. | 検出可能な標識の標的限局性の係留のための方法及び組成物 |
| ITMI20130162A1 (it) * | 2013-02-06 | 2014-08-07 | Fidia Farmaceutici | Derivati fotoreticolati di acido ialuronico, loro processo di preparazione ed impiego |
| JP6190534B2 (ja) * | 2013-08-22 | 2017-08-30 | ソニー株式会社 | 水溶性蛍光染料又は有色染料及びその使用方法 |
| AU2017240154B2 (en) | 2016-04-01 | 2021-08-12 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| EP3440136B1 (de) | 2016-04-06 | 2025-07-23 | Sony Group Corporation | Ultrahelle dimere oder polymere farbstoffe mit abstandslinkergruppen |
| CN105837544B (zh) * | 2016-04-27 | 2018-01-30 | 广西师范大学 | 一种有机叠氮与香豆素合成3‑氨基苯并吡喃‑2‑酮类衍生物的新方法 |
| WO2018013999A1 (en) | 2016-07-15 | 2018-01-18 | Am Chemicals Llc | Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis |
| JP7312929B2 (ja) | 2016-07-29 | 2023-07-24 | ソニーグループ株式会社 | 超明色二量体またはポリマー色素およびその調製のための方法 |
| CN111315415A (zh) | 2017-10-05 | 2020-06-19 | 索尼公司 | 可编程的聚合药物 |
| EP3691689A1 (de) | 2017-10-05 | 2020-08-12 | Sony Corporation | Programmierbare dendritische arzneimittel |
| EP3737419B1 (de) | 2018-01-12 | 2024-04-10 | Sony Group Corporation | Phosphoalkylpolymere mit biologisch aktiven verbindungen |
| JP7813098B2 (ja) | 2018-01-12 | 2026-02-12 | ソニーグループ株式会社 | 生物学的に活性な化合物を含む剛性間隔基を有するポリマー |
| JP2021510698A (ja) | 2018-01-12 | 2021-04-30 | ソニー株式会社 | 生物学的に活性な化合物を含むホスホアルキルリボースポリマー |
| EP3768689A1 (de) | 2018-03-21 | 2021-01-27 | Sony Corporation | Polymere tandemfarbstoffe mit linkergruppen |
| CN112313242A (zh) | 2018-06-27 | 2021-02-02 | 索尼公司 | 具有含脱氧核糖的连接体基团的聚合物染料 |
| KR20210032434A (ko) | 2018-07-13 | 2021-03-24 | 소니 주식회사 | 유기인산염 단위를 포함하는 백본을 갖는 중합체성 염료 |
| CN113383043A (zh) | 2019-09-26 | 2021-09-10 | 索尼集团公司 | 具有连接体基团的聚合物串联染料 |
| JP2023552448A (ja) | 2020-12-07 | 2023-12-15 | ソニーグループ株式会社 | 二量体色素又はポリマー色素における輝度を増強するためのスペーシングリンカー基の設計 |
| CN116120269A (zh) * | 2023-01-04 | 2023-05-16 | 山东滨州金盛新材料科技有限责任公司 | 一种水溶性聚甘油基生育酚及其制备方法 |
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| US4196281A (en) * | 1976-10-20 | 1980-04-01 | Regents Of The University Of California | Psoralens |
| US4378458A (en) * | 1981-03-30 | 1983-03-29 | Baker Instruments Corporation | Novel chromogenic and/or fluorogenic substrates for monitoring catalytic or enzymatic activity |
| US4713326A (en) * | 1983-07-05 | 1987-12-15 | Molecular Diagnostics, Inc. | Coupling of nucleic acids to solid support by photochemical methods |
| US4737454A (en) * | 1983-07-14 | 1988-04-12 | Molecular Diagnostics, Inc. | Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays |
| US4599303A (en) * | 1983-12-12 | 1986-07-08 | Hri Associates, Inc. | Nucleic acid hybridization assay employing probes crosslinkable to target sequences |
| US4617261A (en) * | 1984-03-21 | 1986-10-14 | Cetus Corporation | Process for labeling nucleic acids and hybridization probes |
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| JPS61254855A (ja) * | 1985-05-08 | 1986-11-12 | Yoshinori Nagai | 螢光色素による化学修飾を目印としたｄｎａ断片の螢光検出方法 |
| US4822731A (en) * | 1986-01-09 | 1989-04-18 | Cetus Corporation | Process for labeling single-stranded nucleic acids and hybridizaiton probes |
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| US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| DE3738460A1 (de) * | 1987-11-12 | 1989-05-24 | Max Planck Gesellschaft | Modifizierte oligonukleotide |
| US5449602A (en) * | 1988-01-13 | 1995-09-12 | Amoco Corporation | Template-directed photoligation |
| JPH0812168B2 (ja) * | 1988-04-04 | 1996-02-07 | 株式会社ナカボーテック | コンクリート中の鉄筋に対する分極低抗測定方法 |
| FR2642074B1 (fr) * | 1989-01-20 | 1994-04-29 | Oris Ind | Derives de molecules polyhydroxylees permettant l'introduction d'au moins une ramification dans un oligonucleotide |
| US5082934A (en) * | 1989-04-05 | 1992-01-21 | Naxcor | Coumarin derivatives for use as nucleotide crosslinking reagents |
| WO1992013629A1 (en) * | 1991-01-31 | 1992-08-20 | Wayne State University | A method for analyzing an organic sample |
| DE4114482A1 (de) * | 1991-05-03 | 1992-11-05 | Bayer Ag | Polymere farbstoffe, verfahren zu deren herstellung und deren verwendung |
| JPH08511002A (ja) * | 1993-04-13 | 1996-11-19 | ナクスコー | ポリヌクレオチド架橋剤としての非ヌクレオシドクマリン誘導体 |
-
1994
- 1994-03-23 JP JP6523201A patent/JPH08511002A/ja not_active Ceased
- 1994-03-23 CA CA002159356A patent/CA2159356A1/en not_active Abandoned
- 1994-03-23 DE DE69429338T patent/DE69429338T2/de not_active Expired - Fee Related
- 1994-03-23 ES ES94914724T patent/ES2169071T3/es not_active Expired - Lifetime
- 1994-03-23 EP EP94914724A patent/EP0693065B1/de not_active Expired - Lifetime
- 1994-03-23 AT AT94914724T patent/ATE210128T1/de not_active IP Right Cessation
- 1994-03-23 PT PT94914724T patent/PT693065E/pt unknown
- 1994-03-23 DK DK94914724T patent/DK0693065T3/da active
- 1994-03-23 WO PCT/US1994/003160 patent/WO1994024120A1/en not_active Ceased
-
1995
- 1995-03-09 US US08/401,630 patent/US6005093A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69429338D1 (de) | 2002-01-17 |
| US6005093A (en) | 1999-12-21 |
| CA2159356A1 (en) | 1994-10-27 |
| DE69429338T2 (de) | 2002-08-14 |
| EP0693065A4 (de) | 1996-03-20 |
| DK0693065T3 (da) | 2002-03-04 |
| EP0693065B1 (de) | 2001-12-05 |
| EP0693065A1 (de) | 1996-01-24 |
| ES2169071T3 (es) | 2002-07-01 |
| JPH08511002A (ja) | 1996-11-19 |
| PT693065E (pt) | 2002-05-31 |
| AU6697494A (en) | 1994-11-08 |
| AU688765B2 (en) | 1998-03-19 |
| WO1994024120A1 (en) | 1994-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |