ATE210439T1 - Verfahren und mittel zur inhibierung von proteinkinasen - Google Patents

Verfahren und mittel zur inhibierung von proteinkinasen

Info

Publication number
ATE210439T1
ATE210439T1 AT95941340T AT95941340T ATE210439T1 AT E210439 T1 ATE210439 T1 AT E210439T1 AT 95941340 T AT95941340 T AT 95941340T AT 95941340 T AT95941340 T AT 95941340T AT E210439 T1 ATE210439 T1 AT E210439T1
Authority
AT
Austria
Prior art keywords
independently represents
protein kinases
inhibiting protein
double bond
together represent
Prior art date
Application number
AT95941340T
Other languages
English (en)
Inventor
Neill A Giese
Nathalie Lokker
Original Assignee
Cor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc
Application granted granted Critical
Publication of ATE210439T1 publication Critical patent/ATE210439T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pyrane Compounds (AREA)
AT95941340T 1994-10-28 1995-10-26 Verfahren und mittel zur inhibierung von proteinkinasen ATE210439T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/332,597 US5795910A (en) 1994-10-28 1994-10-28 Method and compositions for inhibiting protein kinases
PCT/US1995/013882 WO1996013259A2 (en) 1994-10-28 1995-10-26 Method and compositions for inhibiting protein kinases

Publications (1)

Publication Number Publication Date
ATE210439T1 true ATE210439T1 (de) 2001-12-15

Family

ID=23298937

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95941340T ATE210439T1 (de) 1994-10-28 1995-10-26 Verfahren und mittel zur inhibierung von proteinkinasen

Country Status (14)

Country Link
US (3) US5795910A (de)
EP (1) EP0788356B9 (de)
JP (1) JPH10508024A (de)
KR (1) KR970706812A (de)
CN (1) CN1165481A (de)
AT (1) ATE210439T1 (de)
AU (1) AU706621B2 (de)
CA (1) CA2203757A1 (de)
DE (1) DE69524628T2 (de)
DK (1) DK0788356T3 (de)
ES (1) ES2170172T3 (de)
PT (1) PT788356E (de)
TW (1) TW467743B (de)
WO (1) WO1996013259A2 (de)

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US6699843B2 (en) * 1995-06-07 2004-03-02 Gilead Sciences, Inc. Method for treatment of tumors using nucleic acid ligands to PDGF
US6819376B1 (en) * 1996-08-06 2004-11-16 Seiko Epson Corporation Liquid crystal display device with a light-shielding portion
AU5675099A (en) * 1998-08-17 2000-03-06 William E. Trout Use of zeranol to modulate reproductive cycles
US20030219427A1 (en) * 1998-08-18 2003-11-27 Allen Hamish J. TPL-2/COT kinase and methods of use
EP1137427A1 (de) * 1998-12-07 2001-10-04 Ecosmart Technologies Inc. Krebsbehandlung zusammensetzung und verfahren mittels natürlicher pflanzlicher äetherischer öle mit signaltransduktion modulatoren
JP2002533389A (ja) 1998-12-24 2002-10-08 ノーベーション ファーマシューティカルズ インコーポレーテッド ｍＲＮＡ安定性に影響する化合物およびそのための使用
MXPA02001553A (es) * 1999-08-13 2003-05-23 Scripps Research Inst Metodos y composiciones utiles para modulacion de angiogenesis usando proteina cinasa raf y ras.
GB9925958D0 (en) * 1999-11-02 1999-12-29 Bundred Nigel J Therapeutic use
US7087608B2 (en) 2000-03-03 2006-08-08 Robert Charles Atkins Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
JP2004292314A (ja) * 2000-12-14 2004-10-21 Chugai Pharmaceut Co Ltd ケラチノサイト増殖抑制剤
US6565864B2 (en) 2000-12-28 2003-05-20 Unilever Home & Personal Care Usa, A Division Of Conopco, Inc. Skin care product containing retinoids and phytoestrogens in a dual compartment package
WO2002064809A2 (en) * 2001-02-09 2002-08-22 Unilever N.V. Process for the preparation of one or more statins by fermentation
US7553979B2 (en) * 2001-11-09 2009-06-30 Conforma Therapeutics Corporation HSP90-inhibiting zearalanol compounds and methods of producing and using same
FR2835252B1 (fr) * 2002-01-25 2005-08-05 Seppic Sa Utilisation d'un compose inactivant la proteine kinase a dans une composition contenant un milieu cosmetiquement acceptable, pour eclaicir la peau
US7799827B2 (en) 2002-03-08 2010-09-21 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
US7915306B2 (en) * 2002-03-08 2011-03-29 Eisai Co., Ltd. Macrocyclic compounds useful as pharmaceuticals
CN1652743A (zh) * 2002-04-17 2005-08-10 大正制药株式会社 毛发生长补剂
US8853376B2 (en) 2002-11-21 2014-10-07 Archemix Llc Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
US20060193902A1 (en) * 2003-04-02 2006-08-31 Celator Pharmaceuticals, Inc. Pharmaceutical compositions containing active agents having a lactone group and transition metal ions
NZ592039A (en) 2003-08-27 2013-03-28 Ophthotech Corp Combination therapy for the treatment of ocular neovascular disorders
US20060079494A1 (en) * 2004-09-27 2006-04-13 Santi Daniel V Specific kinase inhibitors
US20070149593A1 (en) * 2005-12-23 2007-06-28 Alcon, Inc. PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
US7601852B2 (en) * 2006-05-11 2009-10-13 Kosan Biosciences Incorporated Macrocyclic kinase inhibitors
EP2136799B1 (de) * 2006-08-11 2017-10-04 Universite De Strasbourg Makrocyclische verbindungen als hemmer von kinase und hsp90
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
AU2008279027B8 (en) 2007-07-25 2014-03-06 Eisai R & D Management Co., Ltd. Multikinase inhibitors for use in the treatment of cancer
ATE545023T1 (de) 2007-10-29 2012-02-15 Eisai R&D Man Co Ltd Verfahren zur vorhersage der fähigkeit einer zearalenon-analogverbindung für die krebsbehandlung
JP5496908B2 (ja) 2007-12-07 2014-05-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 ゼラレノンマクロライドアナログを作製するための中間体および方法
US20110190237A1 (en) * 2008-01-15 2011-08-04 Nexgenix Pharmaceuticals Macrocyclic Prodrug Compounds Useful as Therapeutics
WO2010099139A2 (en) 2009-02-25 2010-09-02 Osi Pharmaceuticals, Inc. Combination anti-cancer therapy
US8642834B2 (en) 2009-02-27 2014-02-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
CN101928700B (zh) * 2009-07-28 2012-05-02 北京恒宇视野生物科技有限公司 蛋白激酶pftk1单克隆抗体及其制备方法
WO2012021974A1 (en) * 2010-08-20 2012-02-23 The Hospital For Sick Children Compositions and methods for treatment of cystic fibrosis and diseases associated with aberrant protein cellular processing
JP2014519813A (ja) 2011-04-25 2014-08-21 オーエスアイ・ファーマシューティカルズ，エルエルシー 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
US10434085B2 (en) 2015-06-04 2019-10-08 University Of North Carolina At Greensboro Non-aromatic difluoro analogues of resorcylic acid lactones

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196019A (en) * 1964-04-06 1965-07-20 Purdue Research Foundation Anabolic and estrogenic compound and process of making
JPS6239558A (ja) * 1985-08-13 1987-02-20 Kanegafuchi Chem Ind Co Ltd α−シアノアクリル酸アミド誘導体
JPS6239523A (ja) * 1985-08-14 1987-02-20 Kanegafuchi Chem Ind Co Ltd 酵素阻害剤
JPS6242923A (ja) * 1985-08-19 1987-02-24 Kanegafuchi Chem Ind Co Ltd 酵素阻害剤
JPS6242925A (ja) * 1985-08-20 1987-02-24 Kanegafuchi Chem Ind Co Ltd 酵素阻害剤
US4842862A (en) * 1986-07-03 1989-06-27 International Minerals & Chemical Corp. Immunostimulating agents
GB9225396D0 (en) * 1992-12-04 1993-01-27 Sandoz Ltd Improvements in or relating to organic compounds

Also Published As

Publication number Publication date
ES2170172T3 (es) 2002-08-01
US5728726A (en) 1998-03-17
EP0788356A2 (de) 1997-08-13
CA2203757A1 (en) 1996-05-09
DE69524628D1 (de) 2002-01-24
KR970706812A (ko) 1997-12-01
AU706621B2 (en) 1999-06-17
CN1165481A (zh) 1997-11-19
DE69524628T2 (de) 2002-08-08
WO1996013259A3 (en) 1996-08-01
WO1996013259A2 (en) 1996-05-09
TW467743B (en) 2001-12-11
EP0788356B9 (de) 2002-10-02
DK0788356T3 (da) 2002-03-18
EP0788356B1 (de) 2001-12-12
MX9703113A (es) 1998-06-30
US5674892A (en) 1997-10-07
AU4278996A (en) 1996-05-23
PT788356E (pt) 2002-06-28
US5795910A (en) 1998-08-18
JPH10508024A (ja) 1998-08-04

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee