ATE212341T1 - N-benzyldioxothiazolidylbenzamid-derivate und verfahren zu ihrer herstellung - Google Patents
N-benzyldioxothiazolidylbenzamid-derivate und verfahren zu ihrer herstellungInfo
- Publication number
- ATE212341T1 ATE212341T1 AT96920002T AT96920002T ATE212341T1 AT E212341 T1 ATE212341 T1 AT E212341T1 AT 96920002 T AT96920002 T AT 96920002T AT 96920002 T AT96920002 T AT 96920002T AT E212341 T1 ATE212341 T1 AT E212341T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- groups
- group
- atoms
- preparing
- Prior art date
Links
- HNWXYYXDKGPQTJ-UHFFFAOYSA-N N-benzyl-3,4-dioxo-2-(2H-1,3-thiazol-2-id-4-yl)cyclohexa-1,5-diene-1-carboxamide Chemical class C(C1=CC=CC=C1)NC(C1=C(C(C(C=C1)=O)=O)C=1N=[C-]SC=1)=O HNWXYYXDKGPQTJ-UHFFFAOYSA-N 0.000 title abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- -1 methylenedioxy group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15978195 | 1995-06-02 | ||
| JP15313996A JP3144624B2 (ja) | 1995-06-02 | 1996-05-24 | N−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| PCT/JP1996/001459 WO1996038428A1 (en) | 1995-06-02 | 1996-05-30 | N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE212341T1 true ATE212341T1 (de) | 2002-02-15 |
Family
ID=26481850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96920002T ATE212341T1 (de) | 1995-06-02 | 1996-05-30 | N-benzyldioxothiazolidylbenzamid-derivate und verfahren zu ihrer herstellung |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6030990A (de) |
| EP (1) | EP0846693B1 (de) |
| JP (1) | JP3144624B2 (de) |
| KR (1) | KR100456177B1 (de) |
| CN (2) | CN1069901C (de) |
| AT (1) | ATE212341T1 (de) |
| AU (1) | AU698896B2 (de) |
| CA (1) | CA2220698C (de) |
| DE (1) | DE69618792T2 (de) |
| DK (1) | DK0846693T3 (de) |
| ES (1) | ES2170858T3 (de) |
| HU (1) | HU225039B1 (de) |
| PT (1) | PT846693E (de) |
| TW (1) | TW400328B (de) |
| WO (1) | WO1996038428A1 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703096A (en) * | 1994-10-07 | 1997-12-30 | Sankyo Company, Limited | Oxime derivatives, their preparation and their therapeutic use |
| CZ293016B6 (cs) * | 1995-06-01 | 2004-01-14 | Sankyo Company Limited | Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem |
| AU2231397A (en) * | 1996-03-08 | 1997-09-22 | Torii Pharmaceutical Co., Ltd. | Thiazolidine-2,4-dione derivatives |
| CA2344300A1 (en) | 1998-09-17 | 2000-03-23 | Jeffrey A. Robl | Method for treating atherosclerosis employing an ap2 inhibitor and combination |
| US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
| WO2001014349A1 (en) * | 1999-08-23 | 2001-03-01 | Kyorin Pharmaceutical Co., Ltd. | Substituted benzylthiazolidine-2,4-dione derivatives |
| EP1207156B1 (de) * | 1999-08-23 | 2005-05-18 | Kyorin Pharmaceutical Co., Ltd. | Substituierte benzylthiazolidin-2,4-dion derivate |
| AU781076B2 (en) * | 1999-08-23 | 2005-05-05 | Kyorin Pharmaceutical Co. Ltd. | Substituted benzylthiazolidine-2,4-dione derivatives |
| WO2001014351A1 (en) * | 1999-08-23 | 2001-03-01 | Kyorin Pharmaceutical Co., Ltd. | Substituted benzylthiazolidine-2,4-dione derivatives |
| DE60025621T2 (de) * | 1999-09-17 | 2006-11-23 | Kyorin Pharmaceutical Co., Ltd. | O-anisamid-derivate |
| TWI262185B (en) | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
| WO2001034148A1 (en) * | 1999-11-11 | 2001-05-17 | Kyorin Pharmaceutical Co., Ltd. | Solid preparations for oral use |
| EP1240174A2 (de) * | 1999-12-22 | 2002-09-18 | Metabasis Therapeutics, Inc. | Neue bisamidat phosphonat prodrogen |
| EP1253145B1 (de) * | 2000-02-01 | 2006-09-20 | Kyorin Pharmaceutical Co., Ltd. | Alkalimetallsalz von thiazolidin-2,4-dion-derivaten |
| AU2001236079A1 (en) * | 2000-03-07 | 2001-09-17 | Kyorin Pharmaceutical Co. Ltd. | Intermediate compounds |
| HUP0300475A3 (en) * | 2000-04-25 | 2004-10-28 | Kyorin Seiyaku Kk | Novel stable crystal of thiazolidinedione derivative and process for producing the same |
| WO2001096321A1 (en) * | 2000-06-14 | 2001-12-20 | Kyorin Pharmaceutical Co., Ltd. | Process for the preparation of thiazolidinedione derivatives |
| US7563774B2 (en) * | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| ATE341343T1 (de) * | 2000-12-26 | 2006-10-15 | Sankyo Co | Medizinische zusammensetzungen mit diuretischem und die insulinresistenz verbesserndem mittel |
| ATE369851T1 (de) * | 2001-01-26 | 2007-09-15 | Schering Corp | Kombinationen von gallensäuresequestriermitteln und hemmern der sterolabsorption zur behandlung von kardiovaskulären indikationen |
| US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| IL156488A0 (en) * | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
| RS20100015A (sr) | 2001-01-26 | 2010-12-31 | Schering Corporation | Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije |
| IL156585A0 (en) * | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions |
| PT1355644E (pt) * | 2001-01-26 | 2006-11-30 | Schering Corp | Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia |
| US20060287254A1 (en) * | 2001-01-26 | 2006-12-21 | Schering Corporation | Use of substituted azetidinone compounds for the treatment of sitosterolemia |
| EP1353695A2 (de) * | 2001-01-26 | 2003-10-22 | Schering Corporation | Kombinationen von einem hemmer der sterol-absorption und nicotinsäure zur behandlung von kardiovaskulären indikationen |
| US7253178B2 (en) | 2001-03-28 | 2007-08-07 | Eisai Co., Ltd. | Carboxylic acids |
| JP4549021B2 (ja) | 2001-03-30 | 2010-09-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ベンゼン化合物およびその塩 |
| TWI311133B (en) | 2001-04-20 | 2009-06-21 | Eisai R&D Man Co Ltd | Carboxylic acid derivativeand the salt thereof |
| DE60216275T2 (de) * | 2001-05-25 | 2007-06-21 | Schering Corp. | Verwendung von mit azetidinon substituierten derivaten bei der behandlung der alzheimer-krankheit |
| US7687664B2 (en) | 2001-06-04 | 2010-03-30 | Eisai R&D Management Co., Ltd. | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it |
| EP1452521A4 (de) | 2001-08-17 | 2007-03-14 | Eisai R&D Man Co Ltd | Cyclische verbindung und ppar-agonist |
| US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
| US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| EP1429756B1 (de) * | 2001-09-21 | 2006-11-22 | Schering Corporation | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
| PA8557501A1 (es) | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
| WO2003042190A1 (en) | 2001-11-12 | 2003-05-22 | Pfizer Products Inc. | N-alkyl-adamantyl derivatives as p2x7-receptor antagonists |
| ITRM20020016A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza |
| WO2003088962A1 (en) * | 2002-04-16 | 2003-10-30 | Merck & Co., Inc. | Combination therapy using a ppar alpha/gamma agonist |
| US6821524B2 (en) * | 2002-06-03 | 2004-11-23 | Jan Marini Skin Research, Inc. | Cosmetic skin care compositions |
| AU2003241579B9 (en) | 2002-06-19 | 2009-07-30 | Eli Lilly And Company | Amide linker peroxisome proliferator activated receptor modulators |
| JP2006508188A (ja) | 2002-11-06 | 2006-03-09 | シェーリング コーポレイション | 脱髄の処置のためのコレステロール吸収インヒビター |
| US7071223B1 (en) * | 2002-12-31 | 2006-07-04 | Pfizer, Inc. | Benzamide inhibitors of the P2X7 receptor |
| PA8591801A1 (es) | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
| DE10308355A1 (de) | 2003-02-27 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| US7148246B2 (en) | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
| DE10308351A1 (de) | 2003-02-27 | 2004-11-25 | Aventis Pharma Deutschland Gmbh | 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10308353A1 (de) | 2003-02-27 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE10308352A1 (de) | 2003-02-27 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| US7459442B2 (en) * | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| CN1756756A (zh) * | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| DE602004016123D1 (de) | 2003-03-07 | 2008-10-09 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| ES2281801T3 (es) * | 2003-05-12 | 2007-10-01 | Pfizer Products Inc. | Inhibidores benzamida del receptor p2x7. |
| EP1689383B1 (de) | 2003-11-19 | 2012-10-31 | Metabasis Therapeutics, Inc. | Neue phosphor enthaltende thyromimetika |
| EP1586573B1 (de) | 2004-04-01 | 2007-02-07 | Sanofi-Aventis Deutschland GmbH | Oxadiazolone, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Pharmazeutika |
| CA2572119A1 (en) * | 2004-06-29 | 2006-01-12 | Warner-Lambert Company Llc | Combination therapies utilizing benzamide inhibitors of the p2x7 receptor |
| BRPI0512781A (pt) * | 2004-06-29 | 2008-04-08 | Pfizer Prod Inc | método para preparação de derivados de 5-{4-(2-hidroxi-propil)-3,5-dioxo-4,5-diidro-3h-[1,2,4]tria zin-2-il}-benzamida através da desproteção dos precursores de protetores de hidroxila |
| JP2008504362A (ja) * | 2004-06-29 | 2008-02-14 | ファイザー・プロダクツ・インク | P2x7阻害活性をもつ5−[4−(2−ヒドロキシ−エチル)−3,5−ジオキソ−4,5−ジヒドロ−3h−[1,2,4]トリアジン−2−イル]−ベンズアミド誘導体を、トリアジンの4−位において置換されていない誘導体とオキシランをルイス酸の存在下で反応させることにより製造する方法 |
| WO2006023515A2 (en) * | 2004-08-18 | 2006-03-02 | Metabasis Therapeutics, Inc. | Novel thiazole inhibitors of fructose 1,6-bisphosphatase |
| DE102005026762A1 (de) | 2005-06-09 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
| KR100958831B1 (ko) * | 2006-09-19 | 2010-05-24 | 주식회사유한양행 | 헤테로아릴피리미딘 유도체, 이들의 제조방법, 및 이들을포함하는 조성물 |
| US20120046364A1 (en) | 2009-02-10 | 2012-02-23 | Metabasis Therapeutics, Inc. | Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989008650A1 (en) * | 1988-03-08 | 1989-09-21 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| FR2680512B1 (fr) * | 1991-08-20 | 1995-01-20 | Adir | Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| NO302519B1 (no) * | 1991-12-26 | 1998-03-16 | Sankyo Co | Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat |
-
1996
- 1996-05-24 JP JP15313996A patent/JP3144624B2/ja not_active Expired - Fee Related
- 1996-05-30 US US08/952,672 patent/US6030990A/en not_active Expired - Lifetime
- 1996-05-30 DK DK96920002T patent/DK0846693T3/da active
- 1996-05-30 AT AT96920002T patent/ATE212341T1/de not_active IP Right Cessation
- 1996-05-30 ES ES96920002T patent/ES2170858T3/es not_active Expired - Lifetime
- 1996-05-30 WO PCT/JP1996/001459 patent/WO1996038428A1/ja not_active Ceased
- 1996-05-30 EP EP96920002A patent/EP0846693B1/de not_active Expired - Lifetime
- 1996-05-30 CA CA002220698A patent/CA2220698C/en not_active Expired - Fee Related
- 1996-05-30 PT PT96920002T patent/PT846693E/pt unknown
- 1996-05-30 CN CN96194390A patent/CN1069901C/zh not_active Expired - Fee Related
- 1996-05-30 HU HU9802565A patent/HU225039B1/hu not_active IP Right Cessation
- 1996-05-30 KR KR1019970708916A patent/KR100456177B1/ko not_active Expired - Fee Related
- 1996-05-30 DE DE69618792T patent/DE69618792T2/de not_active Expired - Fee Related
- 1996-05-30 AU AU58446/96A patent/AU698896B2/en not_active Ceased
- 1996-06-01 TW TW085106555A patent/TW400328B/zh not_active IP Right Cessation
-
2000
- 2000-10-17 CN CNB001301381A patent/CN1133627C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69618792D1 (de) | 2002-03-14 |
| HUP9802565A3 (en) | 2000-01-28 |
| CA2220698A1 (en) | 1996-12-05 |
| CN1186489A (zh) | 1998-07-01 |
| DE69618792T2 (de) | 2002-10-10 |
| CA2220698C (en) | 2003-06-17 |
| EP0846693A1 (de) | 1998-06-10 |
| US6030990A (en) | 2000-02-29 |
| WO1996038428A1 (en) | 1996-12-05 |
| AU5844696A (en) | 1996-12-18 |
| ES2170858T3 (es) | 2002-08-16 |
| CN1336366A (zh) | 2002-02-20 |
| TW400328B (en) | 2000-08-01 |
| DK0846693T3 (da) | 2002-05-06 |
| JPH0948771A (ja) | 1997-02-18 |
| HUP9802565A2 (hu) | 1999-04-28 |
| CN1069901C (zh) | 2001-08-22 |
| PT846693E (pt) | 2002-05-31 |
| AU698896B2 (en) | 1998-11-12 |
| JP3144624B2 (ja) | 2001-03-12 |
| KR100456177B1 (ko) | 2004-12-30 |
| CN1133627C (zh) | 2004-01-07 |
| EP0846693B1 (de) | 2002-01-23 |
| EP0846693A4 (de) | 1999-03-03 |
| HU225039B1 (en) | 2006-05-29 |
| KR19990022435A (ko) | 1999-03-25 |
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