ATE212847T1 - Verwendung von phenol substituierten diphosphonaten als antineoplastische substanten - Google Patents

Verwendung von phenol substituierten diphosphonaten als antineoplastische substanten

Info

Publication number
ATE212847T1
ATE212847T1 AT96928381T AT96928381T ATE212847T1 AT E212847 T1 ATE212847 T1 AT E212847T1 AT 96928381 T AT96928381 T AT 96928381T AT 96928381 T AT96928381 T AT 96928381T AT E212847 T1 ATE212847 T1 AT E212847T1
Authority
AT
Austria
Prior art keywords
pct
substants
antineoplastic
phenol substituted
sec
Prior art date
Application number
AT96928381T
Other languages
English (en)
Inventor
Eric Niesor
Craig Leigh Bentzen
Lan Mong Nguyen
Jean-Luc Thuillard
Hieu Trung Phan
Jean Flach
Original Assignee
Symphar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphar Sa filed Critical Symphar Sa
Application granted granted Critical
Publication of ATE212847T1 publication Critical patent/ATE212847T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT96928381T 1995-07-28 1996-07-26 Verwendung von phenol substituierten diphosphonaten als antineoplastische substanten ATE212847T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH02213/95A CH690163A5 (fr) 1995-07-28 1995-07-28 Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
PCT/EP1996/003301 WO1997004785A1 (en) 1995-07-28 1996-07-26 Use of phenol substituted diphosphonates as antineoplastic agents

Publications (1)

Publication Number Publication Date
ATE212847T1 true ATE212847T1 (de) 2002-02-15

Family

ID=4228513

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96928381T ATE212847T1 (de) 1995-07-28 1996-07-26 Verwendung von phenol substituierten diphosphonaten als antineoplastische substanten

Country Status (14)

Country Link
US (1) US6127350A (de)
EP (1) EP0845991B1 (de)
JP (1) JPH11511127A (de)
CN (1) CN1091601C (de)
AT (1) ATE212847T1 (de)
AU (1) AU723094B2 (de)
CA (1) CA2228212A1 (de)
CH (1) CH690163A5 (de)
DE (1) DE69619117T2 (de)
DK (1) DK0845991T3 (de)
ES (1) ES2172675T3 (de)
PT (1) PT845991E (de)
WO (1) WO1997004785A1 (de)
ZA (1) ZA966364B (de)

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CA2747954C (en) 1999-12-03 2014-02-25 The Regents Of The University Of California Phosphonate compounds
GB0019272D0 (en) * 2000-08-04 2000-09-27 Symphar Sa Pharmaceutical compounds
FR2827289B1 (fr) * 2001-07-16 2004-07-23 Univ Paris 13 Nouveau derive d'acide diphosphonique, son application en therapeutique et procede de preparation
ES2336312T3 (es) 2001-07-16 2010-04-12 Universite Paris 13 Procedimiento de preparacion de derivados de bisfosfonatos.
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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH675422A5 (de) * 1988-03-31 1990-09-28 Symphar Sa
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物

Also Published As

Publication number Publication date
AU723094B2 (en) 2000-08-17
CN1192148A (zh) 1998-09-02
JPH11511127A (ja) 1999-09-28
EP0845991A2 (de) 1998-06-10
ES2172675T3 (es) 2002-10-01
PT845991E (pt) 2002-07-31
DE69619117T2 (de) 2002-09-19
DE69619117D1 (de) 2002-03-21
CA2228212A1 (en) 1997-02-13
CH690163A5 (fr) 2000-05-31
HK1015686A1 (en) 1999-10-22
ZA966364B (en) 1997-02-11
WO1997004785A1 (en) 1997-02-13
AU6787496A (en) 1997-02-26
DK0845991T3 (da) 2002-05-27
CN1091601C (zh) 2002-10-02
EP0845991B1 (de) 2002-02-06
US6127350A (en) 2000-10-03

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