ATE212981T1 - 1-acyl-4-aliphatische aminopiperidin verbindungen - Google Patents

1-acyl-4-aliphatische aminopiperidin verbindungen

Info

Publication number: ATE212981T1
Authority: AT; Austria
Prior art keywords: alkyl; amino; substituted; alkylene; lower alkyl
Prior art date: 1994-09-30

Application number

AT95933394T

Other languages

English (en)

Inventor

Silvio Ofner

Siem Jacob Veenstra

Original Assignee

Novartis Erfind Verwalt Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-30

Filing date

1995-09-19

Publication date

2002-02-15

1995-09-19 Application filed by Novartis Erfind Verwalt Gmbh filed Critical Novartis Erfind Verwalt Gmbh

2002-02-15 Application granted granted Critical

2002-02-15 Publication of ATE212981T1 publication Critical patent/ATE212981T1/de

Links

LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical class NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 13
125000002947 alkylene group Chemical group 0.000 abstract 8
125000003545 alkoxy group Chemical group 0.000 abstract 5
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 3
125000003277 amino group Chemical group 0.000 abstract 3
125000001589 carboacyl group Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
239000005977 Ethylene Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000000033 alkoxyamino group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
-1 hydroxymethylene group Chemical group 0.000 abstract 1
125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)

AT95933394T 1994-09-30 1995-09-19 1-acyl-4-aliphatische aminopiperidin verbindungen ATE212981T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH296694		1994-09-30
PCT/EP1995/003681 WO1996010562A1 (en)	1994-09-30	1995-09-19	1-acyl-4-aliphatylaminopiperidine compounds

Publications (1)

Publication Number	Publication Date
ATE212981T1 true ATE212981T1 (de)	2002-02-15

Family

ID=4245651

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95933394T ATE212981T1 (de)	1994-09-30	1995-09-19	1-acyl-4-aliphatische aminopiperidin verbindungen

Country Status (14)

Country	Link
US (1)	US5935951A (de)
EP (1)	EP0783490B1 (de)
JP (1)	JPH10506399A (de)
AT (1)	ATE212981T1 (de)
AU (1)	AU3607895A (de)
CA (1)	CA2198382A1 (de)
DE (1)	DE69525355T2 (de)
DK (1)	DK0783490T3 (de)
ES (1)	ES2172595T3 (de)
FI (1)	FI971260A7 (de)
HU (1)	HUT77318A (de)
NO (1)	NO971383L (de)
PT (1)	PT783490E (de)
WO (1)	WO1996010562A1 (de)

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AU2005274927B2 (en)	2004-07-15	2011-11-03	Albany Molecular Research, Inc.	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
DE602006016244D1 (de)	2005-03-08	2010-09-30	Janssen Pharmaceutica Nv	Diazaspiro-ä4,4ü-nonanderivate als neurokinin-(nk1)-antagonisten
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JP5319518B2 (ja)	2007-04-02	2013-10-16	Ｍｓｄ株式会社	インドールジオン誘導体
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CN102014631A (zh)	2008-03-03	2011-04-13	泰格尔医药科技公司	酪氨酸激酶抑制剂
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
EP3026052A1 (de)	2009-04-20	2016-06-01	Auspex Pharmaceuticals, Inc.	Vobereitung von deuterierte piperidinhemmer der janus-kinase 3
CN102458123A (zh)	2009-05-12	2012-05-16	阿尔巴尼分子研究公司	芳基、杂芳基和杂环取代的四氢异喹啉及其用途
US8802696B2 (en)	2009-05-12	2014-08-12	Albany Molecular Research, Inc.	7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof
WO2010132487A1 (en)	2009-05-12	2010-11-18	Bristol-Myers Squibb Company	CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
JP5099731B1 (ja)	2009-10-14	2012-12-19	メルク・シャープ・アンド・ドーム・コーポレーション	ｐ５３活性を増大する置換ピペリジン及びその使用
EP2584903B1 (de)	2010-06-24	2018-10-24	Merck Sharp & Dohme Corp.	Neue heterozyklische verbindungen als erk-hemmer
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1995
- 1995-09-19 ES ES95933394T patent/ES2172595T3/es not_active Expired - Lifetime
- 1995-09-19 WO PCT/EP1995/003681 patent/WO1996010562A1/en not_active Ceased
- 1995-09-19 DK DK95933394T patent/DK0783490T3/da active
- 1995-09-19 PT PT95933394T patent/PT783490E/pt unknown
- 1995-09-19 AT AT95933394T patent/ATE212981T1/de not_active IP Right Cessation
- 1995-09-19 AU AU36078/95A patent/AU3607895A/en not_active Abandoned
- 1995-09-19 DE DE69525355T patent/DE69525355T2/de not_active Expired - Fee Related
- 1995-09-19 US US08/809,277 patent/US5935951A/en not_active Expired - Fee Related
- 1995-09-19 CA CA002198382A patent/CA2198382A1/en not_active Abandoned
- 1995-09-19 JP JP8511331A patent/JPH10506399A/ja not_active Ceased
- 1995-09-19 EP EP95933394A patent/EP0783490B1/de not_active Expired - Lifetime
- 1995-09-19 HU HU9701800A patent/HUT77318A/hu unknown
1997
- 1997-03-24 NO NO971383A patent/NO971383L/no unknown
- 1997-03-26 FI FI971260A patent/FI971260A7/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
DK0783490T3 (da)	2002-05-13
AU3607895A (en)	1996-04-26
FI971260A0 (fi)	1997-03-26
ES2172595T3 (es)	2002-10-01
JPH10506399A (ja)	1998-06-23
NO971383D0 (no)	1997-03-24
HUT77318A (hu)	1998-03-30
MX9702092A (es)	1997-10-31
US5935951A (en)	1999-08-10
DE69525355D1 (de)	2002-03-21
CA2198382A1 (en)	1996-04-11
FI971260A7 (fi)	1997-03-26
EP0783490B1 (de)	2002-02-06
NO971383L (no)	1997-05-14
EP0783490A1 (de)	1997-07-16
DE69525355T2 (de)	2002-09-19
PT783490E (pt)	2002-06-28
WO1996010562A1 (en)	1996-04-11

Legal Events

Date	Code	Title	Description
2004-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69525355D1 (de)	2002-03-21	1-acyl-4-aliphatische aminopiperidin verbindungen
BG100946A (bg)	1997-07-31	Нови аминокиселинни производни, метод за получаването им и фармацевтични състави съдържащи ги
MX9803407A (es)	1998-09-30	Derivados de piperazina 1-(1,2-disustituido piperidinil)-4-sustituidos.
MY117557A (en)	2004-07-31	1-(1,2-disubstituted piperidinyl)-4- substituted piperidine derivatives
FI941987A0 (fi)	1994-04-29	Uudet aminohappojohdannaiset, menetelmät niiden valmistamiseksi ja näitä yhdisteitä sisältävät farmaseuttiset koostumukset
UA41875C2 (uk)	2001-10-15	Спосіб інгібування естрогензалежних пухлин з використанням стероїдних сульфатовмісних інгібіторів
DE69310501D1 (de)	1997-06-12	Chinolylbenzofuran derivate als leukotrien-antagonisten
EA199900242A1 (ru)	1999-08-26	Аралкил- и аралкилиден-гетероциклические лактамы и имиды
KR960013370A (ko)	1996-05-22	트리글리세리드 과다 방지 조성물
EA200300044A1 (ru)	2003-06-26	Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции
MX9306310A (es)	1994-04-29	Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
FR2696466B1 (fr)	1994-11-25	Dérivés de 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, leur préparation et les médicaments les contenant.
AR018632A1 (es)	2001-11-28	Compuestos derivados de acido 1,2,3,4-tetrahidroquinolin-2-carboxilico, su uso en la fabricacion de medicamentos, composicion farmaceutica que los contiene, proceso para su preparacion.
IT1196423B (it)	1988-11-16	Benzotiazolin-composti
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DK0871626T3 (da)	2002-02-25	Triazoloner som apolipoprotein-B syntheseinhibitorer
GB1104145A (en)	1968-02-21	Pyrazolo-pyridine derivatives
ATE38987T1 (de)	1988-12-15	Neue 2h-1-benzopyran-2-on-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten.
SE8303913L (sv)	1984-01-09	Heterocykliska foreningar
DK558786A (da)	1987-05-24	Basisk substituerede pyridinforbindelser, fremstilling deraf, samt laegemidler, indeholdende disse
BR0013375A (pt)	2002-07-23	Composições farmacêuticas contendo derivados tiazolidinodiona e processo para sua preparação
EA200000116A1 (ru)	2000-08-28	Противогрибковые соединения на основе 2,4,4-тризамещенных-1,3-диоксоланов
BE896635A (fr)	1983-09-01	Compositions pharmaceutiques analgesiques contenant des 5-phenyl-1,4-benzodiazepines.
DE3166645D1 (en)	1984-11-15	Dibenzoxazonine, dibenzoxazecine, dibenzoxaazacycloundecane derivatives and their corresponding thia- and aza derivatives, their preparation and pharmaceutical compositions
RU94028266A (ru)	1996-07-10	Бициклические производные имидазола, метод их получения, новые полученные промежуточные продукты, их применение в качестве медикаментов и содержащие их фармацевтические соединения