NO971383L - 1-acyl-4-alifatylaminopiperidinforbindelser - Google Patents
1-acyl-4-alifatylaminopiperidinforbindelserInfo
- Publication number
- NO971383L NO971383L NO971383A NO971383A NO971383L NO 971383 L NO971383 L NO 971383L NO 971383 A NO971383 A NO 971383A NO 971383 A NO971383 A NO 971383A NO 971383 L NO971383 L NO 971383L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- amino
- substituted
- alkylene
- lower alkyl
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 14
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000002947 alkylene group Chemical group 0.000 abstract 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 108700028369 Alleles Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- IYABWNGZIDDRAK-UHFFFAOYSA-N allene Chemical group C=C=C IYABWNGZIDDRAK-UHFFFAOYSA-N 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- -1 hydroxymethylene Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004205 trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Nye l-acyl-4-alifatylaminoplperldlnforblndelser med formel I R;------N R.¿X, (I). clerR-j^ er et benzoyl, naftoyl eller cykloalkanoylradikal som er usubstituert eller substituert med lavere alVtyl, lavire alkoksl, halogen og/eller trlfluormetyl; R2 er cykloalkyl eller et fenyl- eller naftylradlkal som er usulstltuert eller substituert med lavere alkyl, lavere alkoksl, halogen, nltro, cyano og/eller trlfluonnetyl; R3 »g R4 sannien er lavere alkylen eller aza-, oksa- eller tla-lavere alkylen; eller R3 er lavere alkyl, lavere alkjksi-lavere allqrl, di-lavere alkylamlno-lavere alkyl eller et radikal med formel -(CH2)n-C(-0)-Rg (la); og R^ er 'åydrogen, lavere alkyl eller et radikal ined formel -((3!2)n"'^("0)'K5 (^a); R5 er (i) hydrogen, alkyl eller alkjl som er substituert med halogen, lavere alkoksl, amlno eller aralnosubstltuert med lavere alkyl, amlno- lavire alkyl, mono- eller di-lavere alkylamlnoalkyl, lavere alkanoyl, lavere alkokslkarbonyl eller lavere alli^len eller aza-, oksa- eller tia-lavere alkylen, (11) l^ydroksyl, cykloalkoksl, lavere alkoksl eller lavere alkricsl som er substituert med lavere alkoksl, amlno eller amlno substituert med lavere alkyl, amlno-lavere alkfl, mono- eller di-lavere alkylamlnoalkyl, lavere alkanoyl, lavere alkokslkarbonyl eller lavere alkylen eller aza-, oksa- eller tla-lavere alkylen, eller (111) amlno eller amlno substituert med lavere alkyl, cykloalkyl, amlto-lavere alkyl, mono- eller dl-lavere alkylanilnoalkyl, lavere alkanoyl, lavere alkokslkarbonyl eller lavere alkjlen eller aza-, oksa-eller tla-lavere alkylen; Xj^ er metylen, etylen, en dlrekteblndlng, en fri eller ketallsert karbonylgruppe eller en fri eller foretret hydroksymetylengrtjppe; og n er 0 eller 1, og deres salter, fremgangsmåter for fremstilling av forbindelsene Ifølge oppfinnelsen, farmasøytiske samnensetnlnger som inneholder disse og deres anvendelse som farmasøytisk aktive ingredienser.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH296694 | 1994-09-30 | ||
| PCT/EP1995/003681 WO1996010562A1 (en) | 1994-09-30 | 1995-09-19 | 1-acyl-4-aliphatylaminopiperidine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO971383D0 NO971383D0 (no) | 1997-03-24 |
| NO971383L true NO971383L (no) | 1997-05-14 |
Family
ID=4245651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO971383A NO971383L (no) | 1994-09-30 | 1997-03-24 | 1-acyl-4-alifatylaminopiperidinforbindelser |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5935951A (no) |
| EP (1) | EP0783490B1 (no) |
| JP (1) | JPH10506399A (no) |
| AT (1) | ATE212981T1 (no) |
| AU (1) | AU3607895A (no) |
| CA (1) | CA2198382A1 (no) |
| DE (1) | DE69525355T2 (no) |
| DK (1) | DK0783490T3 (no) |
| ES (1) | ES2172595T3 (no) |
| FI (1) | FI971260A7 (no) |
| HU (1) | HUT77318A (no) |
| NO (1) | NO971383L (no) |
| PT (1) | PT783490E (no) |
| WO (1) | WO1996010562A1 (no) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW475930B (en) * | 1995-04-24 | 2002-02-11 | Novartis Ag | Novel compound, its use and pharmaceutical composition comprising it |
| NZ321575A (en) | 1995-10-30 | 1999-05-28 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives |
| TW429256B (en) * | 1995-12-27 | 2001-04-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives |
| TW531537B (en) | 1995-12-27 | 2003-05-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-substituted piperidine derivatives |
| MXPA02004330A (es) | 1999-11-03 | 2004-07-30 | Albany Molecular Res Inc | Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina.. |
| US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
| KR100821410B1 (ko) | 2000-07-11 | 2008-04-10 | 에이엠알 테크놀로지, 인크. | 4-페닐 치환된 테트라하이드로이소퀴놀린 및 이의치료학적 용도 |
| GB0025354D0 (en) | 2000-10-17 | 2000-11-29 | Glaxo Group Ltd | Chemical compounds |
| DE10112198A1 (de) * | 2001-03-14 | 2002-09-19 | Gruenenthal Gmbh | Substituierte Dimethyl-[1-(1-phenyl-cyclohexyl)-piperidin-3-ylmethyl]-amine |
| WO2003066589A1 (en) | 2002-02-08 | 2003-08-14 | Glaxo Group Limited | Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases |
| GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| GB0203022D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| NZ552397A (en) | 2004-07-15 | 2011-04-29 | Amr Technology Inc | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| NZ556628A (en) | 2005-03-08 | 2009-09-25 | Janssen Pharmaceutica Nv | Diaza-spiro-[4.4]-nonane derivatives as neurokinin (NK1) antagonists |
| ES2382814T3 (es) | 2005-05-17 | 2012-06-13 | Merck Sharp & Dohme Ltd. | Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer |
| KR101594898B1 (ko) | 2005-07-15 | 2016-02-18 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| EP1940842B1 (en) | 2005-09-29 | 2012-05-30 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| GB0603041D0 (en) | 2006-02-15 | 2006-03-29 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
| EP2060563A4 (en) * | 2006-09-08 | 2010-12-22 | Dainippon Sumitomo Pharma Co | CYCLIC AMINO ALKYL CY CARBOXYL AMIDE DERIVATIVE |
| US8173629B2 (en) | 2006-09-22 | 2012-05-08 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| JP4611444B2 (ja) | 2007-01-10 | 2011-01-12 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール |
| JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Ｍｓｄ株式会社 | インドールジオン誘導体 |
| AU2008269154B2 (en) | 2007-06-27 | 2014-06-12 | Merck Sharp & Dohme Llc | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| AU2009222122A1 (en) | 2008-03-03 | 2009-09-11 | Tiger Pharmatech | Tyrosine kinase inhibitors |
| US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
| WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
| AU2010239396B2 (en) * | 2009-04-20 | 2016-06-23 | Auspex Pharmaceuticals, Llc | Piperidine inhibitors of Janus Kinase 3 |
| AU2010247763B2 (en) | 2009-05-12 | 2015-12-24 | Albany Molecular Research, Inc. | 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof |
| WO2010132437A1 (en) | 2009-05-12 | 2010-11-18 | Albany Molecular Research, Inc. | Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof |
| AU2010247735B2 (en) | 2009-05-12 | 2015-07-16 | Albany Molecular Research, Inc. | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof |
| PE20121172A1 (es) | 2009-10-14 | 2012-09-05 | Merck Sharp & Dohme | Piperidinas sustituidas con actividad en la hdm2 |
| WO2011163330A1 (en) | 2010-06-24 | 2011-12-29 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
| EP3330377A1 (en) | 2010-08-02 | 2018-06-06 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina) |
| US9029341B2 (en) | 2010-08-17 | 2015-05-12 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA) |
| US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
| EP2613782B1 (en) | 2010-09-01 | 2016-11-02 | Merck Sharp & Dohme Corp. | Indazole derivatives useful as erk inhibitors |
| US9242981B2 (en) | 2010-09-16 | 2016-01-26 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel ERK inhibitors |
| WO2012058210A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA) |
| WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
| AU2012245971A1 (en) | 2011-04-21 | 2013-10-17 | Piramal Enterprises Limited | A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
| WO2013004766A1 (en) | 2011-07-04 | 2013-01-10 | Ferrari Giulio | Nk-1 receptor antagonists for treating corneal neovascularisation |
| EP2770987B1 (en) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
| RU2660429C2 (ru) | 2012-09-28 | 2018-07-06 | Мерк Шарп И Доум Корп. | Новые соединения, которые являются ингибиторами erk |
| RS56680B1 (sr) | 2012-11-28 | 2018-03-30 | Merck Sharp & Dohme | Kompozicije i postupci za lečenje kancera |
| KR102196882B1 (ko) | 2012-12-20 | 2020-12-30 | 머크 샤프 앤드 돔 코포레이션 | Hdm2 억제제로서의 치환된 이미다조피리딘 |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3525785B1 (en) | 2016-10-12 | 2025-08-27 | Merck Sharp & Dohme LLC | Kdm5 inhibitors |
| EP3706747B1 (en) | 2017-11-08 | 2025-09-03 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| US10947234B2 (en) | 2017-11-08 | 2021-03-16 | Merck Sharp & Dohme Corp. | PRMT5 inhibitors |
| US20210015834A1 (en) | 2018-02-26 | 2021-01-21 | Ospedale San Raffaele S.R.L. | Nk-1 antagonists for use in the treatment of ocular pain |
| US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| US12173026B2 (en) | 2018-08-07 | 2024-12-24 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| EP3833668B1 (en) | 2018-08-07 | 2025-03-19 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| WO2021180885A1 (en) | 2020-03-11 | 2021-09-16 | Ospedale San Raffaele S.R.L. | Treatment of stem cell deficiency |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8804104D0 (en) * | 1988-02-23 | 1988-03-23 | Glaxo Group Ltd | Chemical compounds |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| EP0600952B1 (en) * | 1991-08-20 | 1996-04-17 | MERCK SHARP & DOHME LTD. | Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them |
| WO1995011895A1 (en) * | 1993-10-26 | 1995-05-04 | Ciba-Geigy Ag | N-benzoyl-4-oxy/thio-2-substituted piperidines as substance-p receptor antagonists |
-
1995
- 1995-09-19 HU HU9701800A patent/HUT77318A/hu unknown
- 1995-09-19 DK DK95933394T patent/DK0783490T3/da active
- 1995-09-19 ES ES95933394T patent/ES2172595T3/es not_active Expired - Lifetime
- 1995-09-19 PT PT95933394T patent/PT783490E/pt unknown
- 1995-09-19 AT AT95933394T patent/ATE212981T1/de not_active IP Right Cessation
- 1995-09-19 US US08/809,277 patent/US5935951A/en not_active Expired - Fee Related
- 1995-09-19 EP EP95933394A patent/EP0783490B1/en not_active Expired - Lifetime
- 1995-09-19 WO PCT/EP1995/003681 patent/WO1996010562A1/en not_active Ceased
- 1995-09-19 DE DE69525355T patent/DE69525355T2/de not_active Expired - Fee Related
- 1995-09-19 AU AU36078/95A patent/AU3607895A/en not_active Abandoned
- 1995-09-19 CA CA002198382A patent/CA2198382A1/en not_active Abandoned
- 1995-09-19 JP JP8511331A patent/JPH10506399A/ja not_active Ceased
-
1997
- 1997-03-24 NO NO971383A patent/NO971383L/no unknown
- 1997-03-26 FI FI971260A patent/FI971260A7/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0783490B1 (en) | 2002-02-06 |
| AU3607895A (en) | 1996-04-26 |
| FI971260A0 (fi) | 1997-03-26 |
| CA2198382A1 (en) | 1996-04-11 |
| DE69525355D1 (de) | 2002-03-21 |
| HUT77318A (hu) | 1998-03-30 |
| DE69525355T2 (de) | 2002-09-19 |
| ATE212981T1 (de) | 2002-02-15 |
| PT783490E (pt) | 2002-06-28 |
| DK0783490T3 (da) | 2002-05-13 |
| FI971260A7 (fi) | 1997-03-26 |
| WO1996010562A1 (en) | 1996-04-11 |
| US5935951A (en) | 1999-08-10 |
| MX9702092A (es) | 1997-10-31 |
| ES2172595T3 (es) | 2002-10-01 |
| JPH10506399A (ja) | 1998-06-23 |
| NO971383D0 (no) | 1997-03-24 |
| EP0783490A1 (en) | 1997-07-16 |
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