ATE214098T1 - Neue cephalosporin-c-acylase - Google Patents

Neue cephalosporin-c-acylase

Info

Publication number: ATE214098T1
Authority: AT; Austria
Prior art keywords: acylase; pct; date; amino acid; mutant
Prior art date: 1993-11-01

Application number

AT94931165T

Other languages

English (en)

Inventor

Mineo Niwa

Yoshimasa Saito

Takao Fujimura

Yoshinori Ishii

Yuji Noguchi

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-01

Filing date

1994-10-26

Publication date

2002-03-15

1993-11-01 Priority claimed from GB939322508A external-priority patent/GB9322508D0/en

1993-12-29 Priority claimed from GB9326519A external-priority patent/GB9326519D0/en

1994-10-26 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

2002-03-15 Application granted granted Critical

2002-03-15 Publication of ATE214098T1 publication Critical patent/ATE214098T1/de

Links

HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title 2
150000001413 amino acids Chemical class 0.000 abstract 2
239000013604 expression vector Substances 0.000 abstract 2
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
230000004075 alteration Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000012258 culturing Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cephalosporin Compounds (AREA)

AT94931165T 1993-11-01 1994-10-26 Neue cephalosporin-c-acylase ATE214098T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB939322508A GB9322508D0 (en)	1993-11-01	1993-11-01	A new cephalosporin c acylase
GB9326519A GB9326519D0 (en)	1993-12-29	1993-12-29	A new cephalosporin C acylase
PCT/JP1994/001799 WO1995012680A1 (en)	1993-11-01	1994-10-26	A new cephalosporin c acylase

Publications (1)

Publication Number	Publication Date
ATE214098T1 true ATE214098T1 (de)	2002-03-15

Family

ID=26303776

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94931165T ATE214098T1 (de)	1993-11-01	1994-10-26	Neue cephalosporin-c-acylase

Country Status (12)

Country	Link
US (1)	US5804429A (de)
EP (1)	EP0726958B1 (de)
JP (1)	JPH09505732A (de)
KR (1)	KR960705932A (de)
CN (1)	CN1150823A (de)
AT (1)	ATE214098T1 (de)
CA (1)	CA2175338A1 (de)
DE (1)	DE69430067T2 (de)
ES (1)	ES2170107T3 (de)
HU (1)	HUT76084A (de)
TW (1)	TW400384B (de)
WO (1)	WO1995012680A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991016435A1 (en) *	1990-04-18	1991-10-31	Gist-Brocades N.V.	Mutated beta-lactam acylase genes
WO1996005318A1 (en) *	1994-08-12	1996-02-22	Gist-Brocades B.V.	Mutated penicillin g acylase genes
DE69738873D1 (de)	1996-11-05	2008-09-11	Bristol Myers Squibb Co	Mutierte penicillin g acylasen
AU2002316862A1 (en)	2001-04-19	2002-11-05	Bioferma Murcia, S.A.	Enzymatic process for preparing cephalosporin derivatives
KR100530299B1 (ko) *	2003-08-11	2005-11-22	산도즈 게엠베하	변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
ITMI20040016A1 (it) *	2004-01-12	2004-04-12	Antibiotics S P A	Cefalosporina c acilasi
BRPI0621278A2 (pt)	2005-12-28	2011-12-06	Dsm Ip Assests Bv	acilases mutantes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9019724D0 (en) *	1990-09-10	1990-10-24	Fujisawa Pharmaceutical Co	Cephalosporin c acylase
GB9022907D0 (en) *	1990-10-22	1990-12-05	Fujisawa Pharmaceutical Co	Novel gl-7aca acylase
GB9204439D0 (en) *	1992-02-27	1992-04-15	Fujisawa Pharmaceutical Co	A new cephalosporin c acylase

1994
- 1994-10-21 TW TW083109758A patent/TW400384B/zh not_active IP Right Cessation
- 1994-10-26 AT AT94931165T patent/ATE214098T1/de not_active IP Right Cessation
- 1994-10-26 KR KR1019960702230A patent/KR960705932A/ko not_active Ceased
- 1994-10-26 WO PCT/JP1994/001799 patent/WO1995012680A1/en not_active Ceased
- 1994-10-26 DE DE69430067T patent/DE69430067T2/de not_active Expired - Fee Related
- 1994-10-26 US US08/633,760 patent/US5804429A/en not_active Expired - Fee Related
- 1994-10-26 EP EP94931165A patent/EP0726958B1/de not_active Expired - Lifetime
- 1994-10-26 HU HU9601151A patent/HUT76084A/hu unknown
- 1994-10-26 ES ES94931165T patent/ES2170107T3/es not_active Expired - Lifetime
- 1994-10-26 JP JP7513119A patent/JPH09505732A/ja active Pending
- 1994-10-26 CN CN94194758A patent/CN1150823A/zh active Pending
- 1994-10-26 CA CA002175338A patent/CA2175338A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69430067D1 (de)	2002-04-11
TW400384B (en)	2000-08-01
CA2175338A1 (en)	1995-05-11
EP0726958A1 (de)	1996-08-21
US5804429A (en)	1998-09-08
JPH09505732A (ja)	1997-06-10
CN1150823A (zh)	1997-05-28
ES2170107T3 (es)	2002-08-01
EP0726958B1 (de)	2002-03-06
HU9601151D0 (en)	1996-06-28
WO1995012680A1 (en)	1995-05-11
KR960705932A (ko)	1996-11-08
HUT76084A (en)	1997-06-30
DE69430067T2 (de)	2002-08-14

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Legal Events

Date	Code	Title	Description
2002-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties