ATE215125T1 - ßHEAT SHOCKß-PROTEINE UND BEHANDLUNG VON TUMOREN - Google Patents

ßHEAT SHOCKß-PROTEINE UND BEHANDLUNG VON TUMOREN

Info

Publication number
ATE215125T1
ATE215125T1 AT93924762T AT93924762T ATE215125T1 AT E215125 T1 ATE215125 T1 AT E215125T1 AT 93924762 T AT93924762 T AT 93924762T AT 93924762 T AT93924762 T AT 93924762T AT E215125 T1 ATE215125 T1 AT E215125T1
Authority
AT
Austria
Prior art keywords
treatment
ßheat
shockß
tumors
proteins
Prior art date
Application number
AT93924762T
Other languages
English (en)
Inventor
Michael Joseph Colston
Douglas Lowrie
Katalin Veronika Lukacs
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of ATE215125T1 publication Critical patent/ATE215125T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Processing Of Solid Wastes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93924762T 1992-11-13 1993-11-15 ßHEAT SHOCKß-PROTEINE UND BEHANDLUNG VON TUMOREN ATE215125T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929223816A GB9223816D0 (en) 1992-11-13 1992-11-13 Heat shock proteins and the treatment of tumours
PCT/GB1993/002339 WO1994011513A1 (en) 1992-11-13 1993-11-15 Heat shock proteins and the treatment of tumours

Publications (1)

Publication Number Publication Date
ATE215125T1 true ATE215125T1 (de) 2002-04-15

Family

ID=10725030

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93924762T ATE215125T1 (de) 1992-11-13 1993-11-15 ßHEAT SHOCKß-PROTEINE UND BEHANDLUNG VON TUMOREN

Country Status (12)

Country Link
US (1) US6328957B1 (de)
EP (1) EP0670899B1 (de)
JP (1) JP3520086B2 (de)
AT (1) ATE215125T1 (de)
AU (1) AU690085B2 (de)
CA (1) CA2149309A1 (de)
DE (1) DE69331762T2 (de)
DK (1) DK0670899T3 (de)
ES (1) ES2174856T3 (de)
GB (1) GB9223816D0 (de)
PT (1) PT670899E (de)
WO (1) WO1994011513A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6348449B1 (en) 1993-09-21 2002-02-19 The Trustees Of The University Of Pennsylvania Methods of inducing mucosal immunity
US5750119A (en) * 1994-01-13 1998-05-12 Mount Sinai School Of Medicine Of The City University Of New York Immunotherapeutic stress protein-peptide complexes against cancer
US5997873A (en) * 1994-01-13 1999-12-07 Mount Sinai School Of Medicine Of The City University Of New York Method of preparation of heat shock protein 70-peptide complexes
US6310194B1 (en) 1994-09-26 2001-10-30 Carnegie Institution Of Washington Plant fatty acid hydroxylases
US5688651A (en) * 1994-12-16 1997-11-18 Ramot University Authority For Applied Research And Development Ltd. Prevention of protein aggregation
DE19510344C1 (de) * 1995-03-22 1996-11-07 Boehringer Ingelheim Int Verwendung einer Tumorvakzine
US6331299B1 (en) 1995-08-18 2001-12-18 Sloan-Kettering Institute For Cancer Research Method for treatment of cancer and infectious disease and compositions useful in same
US6719974B1 (en) 1995-08-18 2004-04-13 Sloan-Kettering Institute For Cancer Research Heat shock protein-based vaccines and immunotherapies
US6761892B1 (en) 1995-08-18 2004-07-13 Sloan-Kettering Institute For Cancer Research Heat shock protein-based vaccines and immunotherapies
US6773707B1 (en) 1995-08-18 2004-08-10 Sloan-Kettering Institute For Cancer Research Heat shock protein-based vaccines and immunotherapies
AU724399B2 (en) * 1995-08-18 2000-09-21 Sloan-Kettering Institute For Cancer Research Heat shock protein-based vaccines and immunotherapies
US5837251A (en) * 1995-09-13 1998-11-17 Fordham University Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases
US5935576A (en) 1995-09-13 1999-08-10 Fordham University Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens
US5985270A (en) * 1995-09-13 1999-11-16 Fordham University Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes
WO1997026910A2 (de) * 1996-01-27 1997-07-31 Max-Delbrück-Centrum für Molekulare Medizin Tumorimpfstoff für die immuntherapie von malignen tumoren
US5830464A (en) * 1997-02-07 1998-11-03 Fordham University Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy
US6017540A (en) 1997-02-07 2000-01-25 Fordham University Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes
US7276488B2 (en) 1997-06-04 2007-10-02 Oxford Biomedica (Uk) Limited Vector system
AU747602B2 (en) 1997-06-04 2002-05-16 Oxford Biomedica (Uk) Limited Vector
AU1045199A (en) * 1997-11-05 1999-05-24 Isis Innovation Limited Cancer gene
US5948646A (en) 1997-12-11 1999-09-07 Fordham University Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes
ES2439014T3 (es) 1998-02-20 2014-01-21 The University Of Miami Complejo de péptido antigénico-proteína de choque térmico modificada
ES2246566T5 (es) * 1998-03-27 2010-10-26 Gabriele Prof. Dr. Multhoff Aplicacion de proteinas hsp70.
US6495360B1 (en) * 1999-05-28 2002-12-17 Photogen, Inc. Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins
CN1423660A (zh) 1999-11-18 2003-06-11 牛津生物医学（英国）有限公司 抗体
AU6669401A (en) 2000-06-02 2001-12-11 Univ Connecticut Health Ct Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy
PL375043A1 (en) 2001-08-20 2005-11-14 University Of Connecticut Health Center Methods for preparing compositions comprising heat shock proteins or alpha-2-macroglobulin, useful for the treatment of cancer and infectious disease
CN1304559C (zh) * 2001-10-09 2007-03-14 杭州康科生物技术有限公司 表达热休克蛋白的溶瘤微生物及其应用
UA79952C2 (en) * 2001-12-10 2007-08-10 Kabulesh Mafatlal Khamar MYCOBACTERIUM w APPLICATIONS FOR CANCER TREATMENT
US7420037B2 (en) 2003-02-13 2008-09-02 Antigenics Inc. Heat shock protein-based vaccines and immunotherapies
AU2003227265A1 (en) * 2003-03-27 2004-10-25 Takeshi Kobayashi Thermotherapeutic for malignant tumor comprising heat shock protein and fine magnetic particles
US7309491B2 (en) 2003-04-11 2007-12-18 Antigenics Inc. Heat shock protein-based vaccines and immunotherapies
EP2257301B1 (de) 2008-03-03 2014-01-22 The University of Miami Auf allogenen krebszellen basierende immuntherapie
AU2009226077B2 (en) 2008-03-20 2012-04-19 University Of Miami Heat shock protein gp96 vaccination and methods of using same
WO2010060026A1 (en) * 2008-11-21 2010-05-27 University Of Miami Hiv/siv vaccines for the generation of mucosal and systemic immunity
AU2010232490B2 (en) 2009-04-03 2016-08-11 Agenus Inc. Methods for preparing and using multichaperone-antigen complexes
KR20170109582A (ko) 2015-02-06 2017-09-29 히트 바이오로직스, 인코퍼레이티드 벡터 공동 발현 백신 및 공동 자극 분자
CA3040123A1 (en) 2016-10-11 2018-04-19 University Of Miami Vectors and vaccine cells for immunity against zika virus
US11548930B2 (en) 2017-04-04 2023-01-10 Heat Biologics, Inc. Intratumoral vaccination

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0419569B1 (de) * 1988-06-15 1995-09-06 Whitehead Institute For Biomedical Research Stressproteine und verwendungen dafür
PT92079B (pt) 1988-10-24 1995-09-12 Univ Iowa State Res Found Inc Processo de preparacao de proteina 60 de choque termico de levedura e de reuniao de sub-unidades de proteina nao funcional
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
NL9102009A (nl) 1991-11-29 1993-06-16 Stichting Katholieke Univ Produktie van bioactieve peptiden met recombinante cellen.
AU3766593A (en) * 1992-03-09 1993-10-05 Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Fondazione Giovanni Pascale Protein compound capable of inhibiting tumoral growth
AU3752793A (en) 1992-03-11 1993-10-05 Marja Makarow A method for production of proteins in yeast

Also Published As

Publication number Publication date
AU5430794A (en) 1994-06-08
US6328957B1 (en) 2001-12-11
EP0670899A1 (de) 1995-09-13
WO1994011513A1 (en) 1994-05-26
EP0670899B1 (de) 2002-03-27
DE69331762T2 (de) 2002-07-25
ES2174856T3 (es) 2002-11-16
DK0670899T3 (da) 2002-07-22
PT670899E (pt) 2002-09-30
CA2149309A1 (en) 1994-05-26
JP3520086B2 (ja) 2004-04-19
DE69331762D1 (de) 2002-05-02
JPH08503132A (ja) 1996-04-09
GB9223816D0 (en) 1993-01-06
AU690085B2 (en) 1998-04-23

Similar Documents

Publication Publication Date Title
DE69331762D1 (de) "heat shock"-proteine und behandlung von tumoren
DE69122346D1 (de) Amplifikation von Midivariant-DNS-Templaten
DE3851121D1 (de) Filamentlose Magnetron-Ionenquelle und Verwendungsverfahren.
ATE96840T1 (de) Fuer die direkte expression von aktiviertem menschlichen protein-c verwendbare vektoren und zusammensetzungen.
NO910720D0 (no) Vektorer og forbindelser for ekspresjon av zymogene former av humant protein c.
DE3785388D1 (de) Antivirale peptide und mittel zur behandlung von herpes.
PT839194E (pt) Variantesda proteina p53 e utilizacoes terapeuticas.
DE3872754D1 (de) Nachweis von antikoerpern humaner immundefizienz-viren.
PT817851E (pt) Dna codificador do virus do papiloma humano tipo 18
DE3685651D1 (de) Den antigenischen und immunogenischen determinanten von wichtigen neutralisierenden proteinen des rotavirus entsprechende peptide.
DE3751576D1 (de) Virale Inaktivierung und Reinigung von aktiven Proteinen.
DE69533359D1 (de) Veränderte menschliche c3-proteine
NO883834D0 (no) Fremgangsmaate for fremstilling av nye hiv-proteiner og peptider.
EP0209543A4 (de) Peptidfragmente menschlicher apolipoproteine, typspezifische antikörper und verwendungsverfahren.
ITRM920350A0 (it) Epitopi immunologicamente omologhi di hla e proteine del virus hiv.
DE3852625D1 (de) Vektoren und Verbindungen zur Expression von Zymogen-Formen von menschlichem Protein C.
DK0538341T3 (da) EHV-4-gycoproteinvaccine.
ATE41773T1 (de) 4,5-dihydro-4-oxo-2((2-transphenylcyclopropyl)amino>-3-furancarbonsaeuren und derivate davon.
ATE310828T1 (de) Implantat und vektor zur behandlung von erworbenen krankheiten
NO892269L (no) Ikke-hyperglykosylerte hepatitt b-virus-proteiner samt ekspresjons-"kassetter" og fremgangsmaate for fremstilling avproteinene.
ATE45675T1 (de) Verwendung von interferon gamma (ifn-gamma) zur herstellung von praeparationen zur behandlung rheumatischer erkrankungen.
NO881502L (no) Rekombinante htlv-111-proteiner og anvendelser av disse.
ATE70181T1 (de) Verwendung von oxochinazolinderivaten bei der behandlung von hyperurikaemie.
DE3880226D1 (de) Derivate von calcitonin verwandten gen-peptiden.
ATE82124T1 (de) Anwendung von n-(2-(diaethylamino)aethyl>-2-methoxy-4((1-h-4,5ihydro-2-imidazolyl)amino>-5- chlorobenzamid als anxiolytisches und antipsychotisches mittel.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee