ES2178640T3 - Proteina de transferencia de trigliceridos micro9somicos. - Google Patents

Proteina de transferencia de trigliceridos micro9somicos.

Info

Publication number
ES2178640T3
ES2178640T3 ES93103697T ES93103697T ES2178640T3 ES 2178640 T3 ES2178640 T3 ES 2178640T3 ES 93103697 T ES93103697 T ES 93103697T ES 93103697 T ES93103697 T ES 93103697T ES 2178640 T3 ES2178640 T3 ES 2178640T3
Authority
ES
Spain
Prior art keywords
transfer protein
methods
activity
molecular weight
high molecular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93103697T
Other languages
English (en)
Other versions
ES2178640T5 (es
Inventor
Ii John R Wetterau
Daru Young Sharp
Richard E Gregg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25300790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2178640(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES2178640T3 publication Critical patent/ES2178640T3/es
Application granted granted Critical
Publication of ES2178640T5 publication Critical patent/ES2178640T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

SECUENCIAS DE ACIDO NUCLEICO PARTICULARMENTE SECUENCIAS DE ADN, QUE CODIFICAN TODA O PARTE DE LA SUBUNIDAD DE PESO MOLECULAR ELEVADO DE PROTEINA DE TRANSFERENCIA DE TRIGLICERIDO MICROSOMAL, VECTORES DE EXPRESION QUE CONTIENEN LAS SECUENCIAS DE ADN, CELULAS HUESPED QUE CONTIENEN LOS VECTORES DE EXPRESION, Y METODOS QUE UTILIZAN ESTOS MATERIALES. LA INVENCION TAMBIEN SE REFIERE A MOLECULAS DE POLIPEPTIDO QUE COMPRENDEN TODA O PARTE DE LA SUBUNIDAD DE PESO MOLECULAR ELEVADO DE PROTEINA DE TRANSFERENCIA DE TRIGLIRECIDO MICROSOMAL, Y METODOS PARA PRODUCIR ESTAS MOLECULAS. LA INVENCION SE REFIERE TAMBIEN A NUEVOS METODOS PARA PREVENIR, ESTABILIZAR O CAUSAR LA REGRESION DE ARTEROSCLEROSIS Y AGENTES TERAPEUTICOS QUE TIENEN TAL ACTIVIDAD. LA PREVENCION SE REFIERE ADICIONALMENTE A NUEVOS METODOS PARA REDUCIR LOS NIVELES DE LIQUIDO DE SUERO Y AGENTES TERAPEUTICOS QUE TIENEN TAL ACTIVIDAD.
ES93103697T 1992-03-06 1993-03-08 Proteina de transferencia de trigliceridos microsomicos. Expired - Lifetime ES2178640T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84750392A 1992-03-06 1992-03-06
US847503 1992-03-06

Publications (2)

Publication Number Publication Date
ES2178640T3 true ES2178640T3 (es) 2003-01-01
ES2178640T5 ES2178640T5 (es) 2010-06-01

Family

ID=25300790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93103697T Expired - Lifetime ES2178640T5 (es) 1992-03-06 1993-03-08 Proteina de transferencia de trigliceridos microsomicos.

Country Status (12)

Country Link
EP (1) EP0584446B2 (es)
JP (1) JP4298801B2 (es)
AT (1) ATE219514T1 (es)
AU (1) AU670930B2 (es)
CA (1) CA2091102C (es)
DE (1) DE69332041T3 (es)
DK (1) DK0584446T4 (es)
ES (1) ES2178640T5 (es)
HU (1) HU218419B (es)
MX (1) MX9301269A (es)
PT (1) PT584446E (es)
ZA (1) ZA931601B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
ZA961340B (en) 1995-02-21 1997-09-11 Bristol Myers Squibb Co Inhibitors of microsomal triglyceride transfer protein and method.
DK0902785T3 (da) * 1996-04-30 2002-10-07 Pfizer Fremgangsmåder og mellemprodukter til fremstilling af 4'-trifluormethylbiphenyl-2-carboxylsyre-[2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]amid
US5885983A (en) * 1996-05-10 1999-03-23 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5827875A (en) * 1996-05-10 1998-10-27 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5883109A (en) * 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
EP0954313A4 (en) * 1996-07-24 2003-07-02 Bristol Myers Squibb Co METHOD FOR TREATING TUMORS WITH LOW DENSITY LIPOPROTEIN (LDL) NEEDS USING MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) INHIBITORS
US5760246A (en) 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method
CA2276467A1 (en) * 1997-01-17 1998-07-23 Bristol-Myers Squibb Company Method for treating atherosclerosis with an mpt inhibitor and cholesterol lowering drugs
JP2001527551A (ja) * 1997-05-01 2001-12-25 ブリストル−マイヤーズ・スクイブ・カンパニー Ｍｔｐインヒビターと脂溶性ビタミンの組合せおよび該組合せを用いる血清脂質レベルの降下法
US5968950A (en) * 1997-06-23 1999-10-19 Pfizer Inc Apo B-secretion/MTP inhibitor hydrochloride salt
JP2959765B2 (ja) 1997-12-12 1999-10-06 日本たばこ産業株式会社 ３−ピペリジル−４−オキソキナゾリン誘導体及びそれを含有してなる医薬組成物
JP4790178B2 (ja) * 1999-07-06 2011-10-12 アンドルシェルシュ・インコーポレイテッド 体重増加の処置方法および／または抑制方法
CA2324800A1 (en) * 1999-11-10 2001-05-10 Mary Anne Hickman Use of apo b secretion/mtp inhibitors
EP1294943A2 (en) * 2000-01-20 2003-03-26 Genome Therapeutics Corporation RAPID DETERMINATION OF GENE STRUCTURE USING cDNA SEQUENCE
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
JO2390B1 (en) 2001-04-06 2007-06-17 شركة جانسين فارماسوتيكا ان. في Diphenylcarboxamides act as lipid-lowering agents
BR0210616A (pt) 2001-06-28 2004-09-28 Pfizer Prod Inc Indóis, benzofuranos e benzotiofenos substituìdos com triamida, composição farmacêutica, uso dos referidos compostos, bem como processo para preparação dos mesmos
CA2505471A1 (en) * 2003-06-27 2005-05-12 The Research Foundation Of State University Of New York Fluorescence assay for mtp activity
KR100799802B1 (ko) 2004-02-04 2008-01-31 화이자 프로덕츠 인크. 치환된 퀴놀린 화합물
PT1725234E (pt) 2004-03-05 2013-03-04 Univ Pennsylvania Métodos com efeitos secundários reduzidos para tratamento de patologias ou doenças associadas a hiperlipidemia e hipercolesterolemia
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
BR112023000808A2 (pt) 2020-07-29 2023-02-07 Amryt Pharmaceuticals Inc Lomitapida para uso em métodos para tratar hiperlipidemia e hipercolesterolemia em pacientes pediátricos

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291205B1 (en) * 1992-06-12 2001-09-18 Merck & Co., Inc. Method of increasing production of disulfide bonded recombinant proteins by saccharomyces cerevisiae

Also Published As

Publication number Publication date
EP0584446B2 (en) 2010-03-10
HUT67962A (en) 1995-05-29
HU9300627D0 (en) 1993-05-28
MX9301269A (es) 1993-09-01
EP0584446A2 (en) 1994-03-02
CA2091102A1 (en) 1993-09-07
CA2091102C (en) 2009-05-26
EP0584446A3 (en) 1995-04-26
DK0584446T3 (da) 2002-10-14
DE69332041D1 (de) 2002-07-25
JP4298801B2 (ja) 2009-07-22
JPH0638761A (ja) 1994-02-15
AU670930B2 (en) 1996-08-08
HU218419B (hu) 2000-08-28
ZA931601B (en) 1993-10-05
ATE219514T1 (de) 2002-07-15
AU3406493A (en) 1993-09-09
EP0584446B1 (en) 2002-06-19
DE69332041T3 (de) 2011-05-05
PT584446E (pt) 2002-09-30
DE69332041T2 (de) 2004-04-29
DK0584446T4 (da) 2010-05-17
ES2178640T5 (es) 2010-06-01

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