ATE215961T1 - 7.alpha.-methyl 19-nortestosteron undecanoat mit androgenischer aktivität - Google Patents

7.alpha.-methyl 19-nortestosteron undecanoat mit androgenischer aktivität

Info

Publication number: ATE215961T1
Authority: AT; Austria
Prior art keywords: methyl; undecanoate; nortestosterone; alpha; androgenic activity
Prior art date: 1998-06-19

Application number

AT99929208T

Other languages

English (en)

Inventor

Dirk Leysen

Der Voort Hendrikus Adrian Van

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-19

Filing date

1999-06-14

Publication date

2002-04-15

1999-06-14 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

2002-04-15 Application granted granted Critical

2002-04-15 Publication of ATE215961T1 publication Critical patent/ATE215961T1/de

Links

ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 title abstract 2
YSGQGNQWBLYHPE-UHFFFAOYSA-N 17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C1CC2(C)C(O)CCC2C2C(C)CC3=CC(=O)CCC3C21 YSGQGNQWBLYHPE-UHFFFAOYSA-N 0.000 title 1
230000001548 androgenic effect Effects 0.000 title 1
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
YSGQGNQWBLYHPE-CFUSNLFHSA-N (7r,8r,9s,10r,13s,14s,17s)-17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound C1C[C@]2(C)[C@@H](O)CC[C@H]2[C@@H]2[C@H](C)CC3=CC(=O)CC[C@@H]3[C@H]21 YSGQGNQWBLYHPE-CFUSNLFHSA-N 0.000 abstract 1
WRLOOHHQBLTCLM-QKLCDPPYSA-N [(7r,8r,9s,10r,13s,14s,17s)-7,13-dimethyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl] undecanoate Chemical compound C([C@H]1C)C2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCCCCCC)[C@@]1(C)CC2 WRLOOHHQBLTCLM-QKLCDPPYSA-N 0.000 abstract 1
239000003098 androgen Substances 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
229960003604 testosterone Drugs 0.000 abstract 1
150000003515 testosterones Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Cultivation Receptacles Or Flower-Pots, Or Pots For Seedlings (AREA)
Percussion Or Vibration Massage (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

AT99929208T 1998-06-19 1999-06-14 7.alpha.-methyl 19-nortestosteron undecanoat mit androgenischer aktivität ATE215961T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98202052		1998-06-19
PCT/EP1999/004102 WO1999067271A1 (en)	1998-06-19	1999-06-14	Testosterone derivative

Publications (1)

Publication Number	Publication Date
ATE215961T1 true ATE215961T1 (de)	2002-04-15

Family

ID=8233831

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99929208T ATE215961T1 (de)	1998-06-19	1999-06-14	7.alpha.-methyl 19-nortestosteron undecanoat mit androgenischer aktivität

Country Status (25)

Country	Link
US (3)	US6437158B1 (de)
EP (1)	EP1087986B1 (de)
JP (1)	JP2002518514A (de)
KR (1)	KR100596649B1 (de)
CN (1)	CN1172949C (de)
AT (1)	ATE215961T1 (de)
AU (1)	AU756739B2 (de)
BR (1)	BR9911344A (de)
CA (1)	CA2333985C (de)
CZ (1)	CZ293319B6 (de)
DE (1)	DE69901250T2 (de)
DK (1)	DK1087986T3 (de)
ES (1)	ES2175989T3 (de)
HU (1)	HUP0102274A3 (de)
ID (1)	ID27260A (de)
IL (1)	IL139689A (de)
NO (1)	NO316518B1 (de)
NZ (1)	NZ508299A (de)
PL (1)	PL191285B1 (de)
PT (1)	PT1087986E (de)
RU (1)	RU2216546C2 (de)
SK (1)	SK282796B6 (de)
TR (1)	TR200003743T2 (de)
WO (1)	WO1999067271A1 (de)
ZA (1)	ZA200006813B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6756366B1 (en) *	1999-04-06	2004-06-29	Akzo Nobel N.V.	Orally active androgens
HRP20030060A2 (en) *	2000-07-28	2004-06-30	Akzo Nobel Nv	16alpha-methyl or ethyl substituted estrogens
JP3774888B2 (ja) *	2001-11-28	2006-05-17	日本化薬株式会社	ステロイド類化合物のｌｃ−ｍｓによる高感度検出法
TW200404552A (en) *	2002-05-30	2004-04-01	Akzo Nobel Nv	Self administered contraception
TW200400041A (en) *	2002-05-30	2004-01-01	Akzo Nobel Nv	Use of new etonogestrel esters
TW200403065A (en)	2002-05-30	2004-03-01	Akzo Nobel Nv	New etonogestrel esters
GB0304927D0 (en)	2003-03-04	2003-04-09	Resolution Chemicals Ltd	Process for the production of tibolone
JO2505B1 (en) *	2003-03-14	2009-10-05	باير شيرنغ فارما اكتنجيسيلشافت	Pharmacy methods and formulations for obtaining acceptable serum testosterone levels
JO2492B1 (en)	2003-04-28	2009-10-05	شيرينج ايه جي	A pharmaceutical formula in the form of aqueous gel for the skin use of its active ingredients
PE20050677A1 (es)	2003-12-22	2005-10-04	Akzo Nobel Nv	Esteroides con perfil androgenico y progestagenico mixto
UA89964C2 (ru)	2004-09-08	2010-03-25	Н.В. Органон	15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
EP1879382B1 (de)	2006-07-10	2017-09-06	Samsung Electronics Co., Ltd.	Mehrschirmanzeigevorrichtung und Verfahren für ein digitales Rundfunkempfangsgerät
WO2008101030A1 (en) *	2007-02-13	2008-08-21	The Regents Of The University Of California	Methods for amplifying steroid hormone effects
US20090018107A1 (en) *	2007-07-13	2009-01-15	Oral Delivery Technology Ltd.	Novel composition to increase muscle strength
US20090017107A1 (en) *	2007-07-13	2009-01-15	Oral Delivery Technology Ltd.	Novel composition to increase libido
US20100303937A1 (en) *	2009-06-01	2010-12-02	Michael Farber	Novel composition to increase testosterone levels
CN102558267A (zh) *	2012-01-13	2012-07-11	宜城市共同药业有限公司	庚酸睾酮的制备方法
EP2833944A4 (de)	2012-04-06	2016-05-25	Antares Pharma Inc	Verabreichung von testosteron-zusammensetzungen durch nadelgestützte düseninjektion
PT2953667T (pt) *	2013-02-11	2020-01-28	Antares Pharma Inc	Dispositivo de injeção a jato auxiliado por agulha tendo força de gatilho reduzida

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5342834A (en) *	1989-04-07	1994-08-30	The Population Council, Inc.	Method for androgen supplementation

1999
- 1999-06-14 RU RU2001101892/04A patent/RU2216546C2/ru not_active IP Right Cessation
- 1999-06-14 DK DK99929208T patent/DK1087986T3/da active
- 1999-06-14 CN CNB998075175A patent/CN1172949C/zh not_active Expired - Fee Related
- 1999-06-14 BR BR9911344-9A patent/BR9911344A/pt not_active Application Discontinuation
- 1999-06-14 NZ NZ508299A patent/NZ508299A/xx unknown
- 1999-06-14 TR TR2000/03743T patent/TR200003743T2/xx unknown
- 1999-06-14 WO PCT/EP1999/004102 patent/WO1999067271A1/en not_active Ceased
- 1999-06-14 AU AU46101/99A patent/AU756739B2/en not_active Ceased
- 1999-06-14 CA CA002333985A patent/CA2333985C/en not_active Expired - Fee Related
- 1999-06-14 CZ CZ20004779A patent/CZ293319B6/cs not_active IP Right Cessation
- 1999-06-14 ID IDW20002632A patent/ID27260A/id unknown
- 1999-06-14 HU HU0102274A patent/HUP0102274A3/hu unknown
- 1999-06-14 IL IL13968999A patent/IL139689A/en not_active IP Right Cessation
- 1999-06-14 KR KR1020007014182A patent/KR100596649B1/ko not_active Expired - Fee Related
- 1999-06-14 SK SK1940-2000A patent/SK282796B6/sk not_active IP Right Cessation
- 1999-06-14 JP JP2000555922A patent/JP2002518514A/ja active Pending
- 1999-06-14 EP EP99929208A patent/EP1087986B1/de not_active Expired - Lifetime
- 1999-06-14 US US09/719,927 patent/US6437158B1/en not_active Expired - Fee Related
- 1999-06-14 DE DE69901250T patent/DE69901250T2/de not_active Expired - Fee Related
- 1999-06-14 PL PL344987A patent/PL191285B1/pl not_active IP Right Cessation
- 1999-06-14 AT AT99929208T patent/ATE215961T1/de not_active IP Right Cessation
- 1999-06-14 PT PT99929208T patent/PT1087986E/pt unknown
- 1999-06-14 ES ES99929208T patent/ES2175989T3/es not_active Expired - Lifetime
2000
- 2000-11-21 ZA ZA200006813A patent/ZA200006813B/en unknown
- 2000-12-18 NO NO20006455A patent/NO316518B1/no unknown
2002
- 2002-06-21 US US10/177,989 patent/US20040033999A1/en not_active Abandoned
2004
- 2004-10-13 US US10/964,076 patent/US6989378B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR9911344A (pt)	2001-03-13
CA2333985A1 (en)	1999-12-29
JP2002518514A (ja)	2002-06-25
TR200003743T2 (tr)	2001-07-23
US20050153949A1 (en)	2005-07-14
CN1172949C (zh)	2004-10-27
NZ508299A (en)	2003-04-29
DE69901250T2 (de)	2002-10-17
DK1087986T3 (da)	2002-06-17
SK282796B6 (sk)	2002-12-03
US6989378B2 (en)	2006-01-24
ID27260A (id)	2001-03-22
US20040033999A1 (en)	2004-02-19
KR100596649B1 (ko)	2006-07-06
NO316518B1 (no)	2004-02-02
ZA200006813B (en)	2002-02-21
HK1034263A1 (en)	2001-10-19
DE69901250D1 (de)	2002-05-16
US6437158B1 (en)	2002-08-20
NO20006455D0 (no)	2000-12-18
IL139689A0 (en)	2002-02-10
CZ20004779A3 (en)	2001-06-13
HUP0102274A2 (hu)	2001-12-28
WO1999067271A1 (en)	1999-12-29
CA2333985C (en)	2007-04-10
CZ293319B6 (cs)	2004-04-14
AU4610199A (en)	2000-01-10
EP1087986A1 (de)	2001-04-04
ES2175989T3 (es)	2002-11-16
AU756739B2 (en)	2003-01-23
RU2216546C2 (ru)	2003-11-20
KR20010052850A (ko)	2001-06-25
CN1305488A (zh)	2001-07-25
SK19402000A3 (sk)	2001-07-10
PL191285B1 (pl)	2006-04-28
NO20006455L (no)	2000-12-18
EP1087986B1 (de)	2002-04-10
IL139689A (en)	2004-09-27
PL344987A1 (en)	2001-11-19
PT1087986E (pt)	2002-08-30
HUP0102274A3 (en)	2002-08-28

Legal Events

Date	Code	Title	Description
2002-09-15	UEP	Publication of translation of european patent specification
2010-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69901250D1 (de)	2002-05-16	7.alpha.-methyl 19-nortestosteron undecanoat mit androgenischer aktivität
ES2134847T3 (es)	1999-10-16	Derivados de taxol.
ES2114931T3 (es)	1998-06-16	Nuevos esteres esteroidales.
ES2194446T3 (es)	2003-11-16	Derivados de bibiclooctano utilizados como plastificantes.
NL1002835A1 (nl)	1996-10-14	Synergistisch stabilisatormengsel.
YU11997A (sh)	1999-09-27	Laktamski derivati i njihove farmaceutske kompozicije
MX9301032A (es)	1993-09-01	Compuestos farmaceuticos y procedimento para su preparacion
AR038431A2 (es)	2005-01-12	Derivados 2-desoxo-15-alquilo de marcfortina
CO5231161A1 (es)	2002-12-27	4-aminopicolinatos y su uso como herbicidas
EA200300337A1 (ru)	2003-08-28	Полиарилкарбоксамиды, применимые в качестве агентов, снижающих содержание липидов
ES2193730T3 (es)	2003-11-01	Ligandos de receptores de la hormona tiroidea y de glucocortioides para el tratamiento de desordenes metabolicos.
ZA200108124B (en)	2003-03-26	Pharmaceutical compounds.
DE69331721D1 (de)	2002-04-25	Neue carbamazepin hapten Analoge
MY128392A (en)	2007-01-31	6ALPHA, 9ALPHA-DIFLUORO-17ALPHA-(2-FURANYLCARBOXYL)OXY]-11ß-HYDROXY-16ALPHA-METHYL-3-OXO-ANDROST-1,4,-DIENE-17-CARBOTHIOIC ACID S-FLUOROMETHYL ESTER AS AN ANTI-INFLAMMATORY AGENT
DK1073447T3 (da)	2007-09-03	N1-modificerede glycopeptider
MX9900914A (de)	1999-05-31
AR018888A1 (es)	2001-12-12	Un derivado de testosterona, uso del mismo, una formulacion farmaceutica que comprende a dicho derivado y un kit para la anticoncepcion masculina
PL346643A1 (en)	2002-02-25	Medicament containing platinum complex compounds and the use thereof
KR970704463A (ko)	1997-09-06	스트렙토그라민 유도체, 이의 제조 방법 및 이를 함유하는 약학 조성물(streptogramine derivatives, preparation of same and pharmaceutical compositions containing same)
EP1232740A3 (de)	2003-07-02	Haarwuchsmittel
MY120189A (en)	2005-09-30	Sultam and sultone derived oxazolidinones
BR9809436A (pt)	2000-06-13	Derivados estrogênicos de 19-noradnrost-17-ona com um anel aromático b
ECSP993023A (es)	1999-09-09	Derivados de la testosterona
AR036462A1 (es)	2004-09-08	Un compuesto esteroidal y su uso para la fabricacion de un medicamento
ZA200205362B (en)	2003-10-06	Unsaturated 14, 15-cyclopropane-androstanes, a method for their production and pharmaceutical compositions containing these compounds.