ATE216262T1 - Biologisch abbaubare polymermischungen zur arzneistoffabgabe - Google Patents

Biologisch abbaubare polymermischungen zur arzneistoffabgabe

Info

Publication number
ATE216262T1
ATE216262T1 AT92908387T AT92908387T ATE216262T1 AT E216262 T1 ATE216262 T1 AT E216262T1 AT 92908387 T AT92908387 T AT 92908387T AT 92908387 T AT92908387 T AT 92908387T AT E216262 T1 ATE216262 T1 AT E216262T1
Authority
AT
Austria
Prior art keywords
blends
polyesters
polyanhydrides
polymers
drug delivery
Prior art date
Application number
AT92908387T
Other languages
English (en)
Inventor
Abraham J Domb
Manoj Maniar
Andrew T S Haffer
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of ATE216262T1 publication Critical patent/ATE216262T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/02—Polyesters derived from dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L73/00—Compositions of macromolecular compounds obtained by reactions forming a linkage containing oxygen or oxygen and carbon in the main chain, not provided for in groups C08L59/00 - C08L71/00; Compositions of derivatives of such polymers
    • C08L73/02—Polyanhydrides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT92908387T 1991-02-01 1992-01-31 Biologisch abbaubare polymermischungen zur arzneistoffabgabe ATE216262T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64892791A 1991-02-01 1991-02-01
PCT/US1992/000877 WO1992013567A1 (en) 1991-02-01 1992-01-31 Biodegradable polymer blends for drug delivery

Publications (1)

Publication Number Publication Date
ATE216262T1 true ATE216262T1 (de) 2002-05-15

Family

ID=24602790

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92908387T ATE216262T1 (de) 1991-02-01 1992-01-31 Biologisch abbaubare polymermischungen zur arzneistoffabgabe

Country Status (10)

Country Link
US (1) US5919835A (de)
EP (1) EP0568651B1 (de)
JP (1) JP3137337B2 (de)
AT (1) ATE216262T1 (de)
AU (1) AU669479B2 (de)
CA (1) CA2101742C (de)
DE (1) DE69232555T2 (de)
DK (1) DK0568651T3 (de)
ES (1) ES2176189T3 (de)
WO (1) WO1992013567A1 (de)

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ES2138130T3 (es) 1995-10-28 2000-01-01 Braun Melsungen Ag Composicion farmaceutica que contiene un anestesico local y/o un analgesico de accion central.
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
JP2002542349A (ja) * 1999-04-16 2002-12-10 ダブリューエム・マーシュ・ライス・ユニバーシティー ポリ（プロピレンフマラート）−ジアクリレートマクロマーで交差結合された生体分解性のポリ（プロピレンフマラート）ネットワーク
US6113678A (en) * 1999-09-23 2000-09-05 Xerox Corporation Hot melt inks containing polyanhydrides
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
WO2003041757A2 (en) * 2001-11-14 2003-05-22 Alza Corporation Catheter injectable depot compositions and uses thereof
CA2466632C (en) * 2001-11-14 2014-02-11 Alza Corporation Injectable depot compositions and uses thereof
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
WO2004011054A2 (en) * 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
KR20050038008A (ko) * 2002-07-31 2005-04-25 알자 코포레이션 주사용 저장형 조성물 및 이의 용도
AU2003258230A1 (en) * 2002-08-13 2004-02-25 Medtronic, Inc Medical device exhibiting improved adhesion between polymeric coating and substrate
WO2004014451A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery systems, medical devices, and methods
DE60316579T2 (de) * 2002-08-13 2008-07-03 Medtronic, Inc., Minneapolis System zur abgabe von wirkstoffen mit einem hydrophoben cellulose-derivat
EP1531875B1 (de) * 2002-08-13 2010-03-03 Medtronic, Inc. Darreichungssysteme von wirkstoffen mit poly(ethylene-co(meth)akrylate, medizinische vorrichtung und verfahren
WO2004014448A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a hydrophilic polymer, medical device, and method
US6911400B2 (en) * 2002-11-05 2005-06-28 International Business Machines Corporation Nonlithographic method to produce self-aligned mask, articles produced by same and compositions for same
EP1660145A2 (de) * 2003-08-13 2006-05-31 Medtronic, Inc. Wirkstoff-abgabesysteme mit einer einzelnen schicht aus einer polymermischung, medizinprodukte und verfahren
US20050064005A1 (en) * 2003-08-13 2005-03-24 Dinh Thomas Q. Active agent delivery systems including a miscible polymer blend, medical devices, and methods
FR2859909B1 (fr) * 2003-09-22 2007-09-07 Biomerieux Sa Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation
WO2006031658A2 (en) * 2004-09-10 2006-03-23 Allergan, Inc. Therapeutic lacrimal canalicular inserts and related methods
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US7432069B2 (en) 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
US20070200271A1 (en) * 2006-02-24 2007-08-30 Vipul Dave Implantable device prepared from melt processing
US20070200268A1 (en) * 2006-02-24 2007-08-30 Vipul Dave Implantable device prepared from solution processing
US8812071B2 (en) 2007-03-07 2014-08-19 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
PT2152358E (pt) * 2007-04-27 2011-06-07 Echo Therapeutics Inc Dispositivo de permeação da pele para detecção de analito ou distribuição transdérmica de droga
JP5139003B2 (ja) * 2007-08-17 2013-02-06 国立大学法人京都工芸繊維大学 組成物およびフィルム
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
TWI501781B (zh) * 2010-12-10 2015-10-01 Ind Tech Res Inst 可控制釋放的組合物及其製造方法
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
CN109021215B (zh) * 2018-07-11 2021-03-02 中山大学 一种pH敏感型聚扁桃酸纳米药物载体及其制备方法和应用
CA3108431A1 (en) * 2018-08-10 2020-02-13 Ephemeral Solutions, Inc. Particles containing coloring agents and methods of using the same
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
CN116940358A (zh) 2021-01-12 2023-10-24 度勒科特公司 持续释放药物递送系统和有关的方法

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US4522804A (en) * 1983-01-03 1985-06-11 Verex Laboratories, Inc. Constant release rate solid oral dosage formulations of propranolol
US4888176A (en) * 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US4757128A (en) * 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4891225A (en) * 1984-05-21 1990-01-02 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4886870A (en) * 1984-05-21 1989-12-12 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
US4764364A (en) * 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4789724A (en) * 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US4863457A (en) * 1986-11-24 1989-09-05 Lee David A Drug delivery device
FR2612198A1 (fr) * 1987-03-27 1988-09-16 Tyndale Plains Hunter Ltd Composition de polyurethane hydrophile et article qui en est produit
US4857311A (en) * 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
WO1990009783A1 (en) * 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
DK0476045T3 (da) * 1989-06-05 1996-09-16 Massachusetts Inst Technology Bionedbrydelige polymerer til lægemiddel-afgivelse i knogler
US4997904A (en) * 1989-08-25 1991-03-05 Nova Pharmaceutical Corporation Aromatic polyanhydride compositions
EP0423484B1 (de) * 1989-10-16 1993-11-03 PCD-Polymere Gesellschaft m.b.H. Pressling mit retardierter Wirkstofffreisetzung

Also Published As

Publication number Publication date
DE69232555T2 (de) 2002-10-31
CA2101742A1 (en) 1992-08-02
AU669479B2 (en) 1996-06-13
ES2176189T3 (es) 2002-12-01
EP0568651A4 (en) 1996-11-27
CA2101742C (en) 2005-04-12
DK0568651T3 (da) 2002-08-05
EP0568651A1 (de) 1993-11-10
AU1643292A (en) 1992-09-07
EP0568651B1 (de) 2002-04-17
JPH06508863A (ja) 1994-10-06
US5919835A (en) 1999-07-06
WO1992013567A1 (en) 1992-08-20
JP3137337B2 (ja) 2001-02-19
DE69232555D1 (de) 2002-05-23

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee