DK0568651T3 - Bionedbrydelige polymerblandinger til afgivelse af lægemidler - Google Patents

Bionedbrydelige polymerblandinger til afgivelse af lægemidler

Info

Publication number
DK0568651T3
DK0568651T3 DK92908387T DK92908387T DK0568651T3 DK 0568651 T3 DK0568651 T3 DK 0568651T3 DK 92908387 T DK92908387 T DK 92908387T DK 92908387 T DK92908387 T DK 92908387T DK 0568651 T3 DK0568651 T3 DK 0568651T3
Authority
DK
Denmark
Prior art keywords
blends
polyesters
polyanhydrides
polymers
drug delivery
Prior art date
Application number
DK92908387T
Other languages
English (en)
Inventor
Abraham J Domb
Manoj Maniar
Andrew T S Haffer
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Application granted granted Critical
Publication of DK0568651T3 publication Critical patent/DK0568651T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/02—Polyesters derived from dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L73/00—Compositions of macromolecular compounds obtained by reactions forming a linkage containing oxygen or oxygen and carbon in the main chain, not provided for in groups C08L59/00 - C08L71/00; Compositions of derivatives of such polymers
    • C08L73/02—Polyanhydrides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK92908387T 1991-02-01 1992-01-31 Bionedbrydelige polymerblandinger til afgivelse af lægemidler DK0568651T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64892791A 1991-02-01 1991-02-01
PCT/US1992/000877 WO1992013567A1 (en) 1991-02-01 1992-01-31 Biodegradable polymer blends for drug delivery

Publications (1)

Publication Number Publication Date
DK0568651T3 true DK0568651T3 (da) 2002-08-05

Family

ID=24602790

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92908387T DK0568651T3 (da) 1991-02-01 1992-01-31 Bionedbrydelige polymerblandinger til afgivelse af lægemidler

Country Status (10)

Country Link
US (1) US5919835A (da)
EP (1) EP0568651B1 (da)
JP (1) JP3137337B2 (da)
AT (1) ATE216262T1 (da)
AU (1) AU669479B2 (da)
CA (1) CA2101742C (da)
DE (1) DE69232555T2 (da)
DK (1) DK0568651T3 (da)
ES (1) ES2176189T3 (da)
WO (1) WO1992013567A1 (da)

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EP0633907A1 (en) * 1992-03-30 1995-01-18 Alza Corporation Additives for bioerodible polymers to regulate degradation
US5321113A (en) * 1993-05-14 1994-06-14 Ethicon, Inc. Copolymers of an aromatic anhydride and aliphatic ester
ATE183092T1 (de) 1995-10-28 1999-08-15 Braun Melsungen Ag Lokalanästhetika und/oder zentralanalgetika enthaltende pharmazeutische zusammensetzungen
US20030077317A1 (en) * 1996-06-25 2003-04-24 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
JP2002542349A (ja) * 1999-04-16 2002-12-10 ダブリューエム・マーシュ・ライス・ユニバーシティー ポリ（プロピレンフマラート）−ジアクリレートマクロマーで交差結合された生体分解性のポリ（プロピレンフマラート）ネットワーク
US6113678A (en) * 1999-09-23 2000-09-05 Xerox Corporation Hot melt inks containing polyanhydrides
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
EP1446100B1 (en) * 2001-11-14 2011-05-04 Durect Corporation Injectable depot compositions and uses thereof
KR20040058101A (ko) * 2001-11-14 2004-07-03 알자 코포레이션 카테터 주입가능한 데포 조성물 및 그의 용도
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
JP2006503004A (ja) * 2002-07-31 2006-01-26 アルザ・コーポレーション 射出可能なデポ組成物及びその使用
DE60325742D1 (de) * 2002-07-31 2009-02-26 Alza Corp Injizierbare multimodale polymere depotzusammensetzungen und ihre verwendungen
US20040047911A1 (en) * 2002-08-13 2004-03-11 Medtronic, Inc. Active agent delivery system including a poly(ethylene-co-(meth)Acrylate), medical device, and method
ATE374049T1 (de) * 2002-08-13 2007-10-15 Medtronic Inc System zur abgabe von wirkstoffen mit einem hydrophoben cellulose-derivat
AU2003265446A1 (en) * 2002-08-13 2004-02-25 Medtronic, Inc. Active agent delivery system including a hydrophilic polymer, medical device, and method
DE60333566D1 (de) * 2002-08-13 2010-09-09 Medtronic Inc Medizinische vorrichtung mit verbesserter haftung zwischen einem polymeren berzug und einem substrat
EP1530491A1 (en) * 2002-08-13 2005-05-18 Medtronic, Inc. Active agent delivery systems, medical devices, and methods
US6911400B2 (en) * 2002-11-05 2005-06-28 International Business Machines Corporation Nonlithographic method to produce self-aligned mask, articles produced by same and compositions for same
US20050064005A1 (en) * 2003-08-13 2005-03-24 Dinh Thomas Q. Active agent delivery systems including a miscible polymer blend, medical devices, and methods
CA2535346A1 (en) * 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods
FR2859909B1 (fr) * 2003-09-22 2007-09-07 Biomerieux Sa Procede de preparation de microparticules bioresorbables, microparticules obtenues et utilisation
WO2006031658A2 (en) * 2004-09-10 2006-03-23 Allergan, Inc. Therapeutic lacrimal canalicular inserts and related methods
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US7432069B2 (en) 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
US20070200271A1 (en) * 2006-02-24 2007-08-30 Vipul Dave Implantable device prepared from melt processing
US20070200268A1 (en) * 2006-02-24 2007-08-30 Vipul Dave Implantable device prepared from solution processing
RU2444980C2 (ru) 2007-03-07 2012-03-20 Эко Терапьютикс, Инк. Трансдермальная система мониторинга аналита и способы детекции аналита
JP2010525881A (ja) * 2007-04-27 2010-07-29 エコー セラピューティクス， インコーポレイテッド 被検体の検知または経皮的薬物送達のための皮膚透過装置
JP5139003B2 (ja) * 2007-08-17 2013-02-06 国立大学法人京都工芸繊維大学 組成物およびフィルム
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
TWI501781B (zh) * 2010-12-10 2015-10-01 Ind Tech Res Inst 可控制釋放的組合物及其製造方法
JP6564369B2 (ja) 2013-12-09 2019-08-21 デュレクト コーポレイション 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法
CN109021215B (zh) * 2018-07-11 2021-03-02 中山大学 一种pH敏感型聚扁桃酸纳米药物载体及其制备方法和应用
CA3108431A1 (en) * 2018-08-10 2020-02-13 Ephemeral Solutions, Inc. Particles containing coloring agents and methods of using the same
JP2023515918A (ja) 2020-01-13 2023-04-17 デュレクト コーポレーション 不純物が低減された徐放性薬物送達システム及び関連の方法
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods

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US4522804A (en) * 1983-01-03 1985-06-11 Verex Laboratories, Inc. Constant release rate solid oral dosage formulations of propranolol
US4757128A (en) * 1986-08-01 1988-07-12 Massachusetts Institute Of Technology High molecular weight polyanhydride and preparation thereof
US4888176A (en) * 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
US4891225A (en) * 1984-05-21 1990-01-02 Massachusetts Institute Of Technology Bioerodible polyanhydrides for controlled drug delivery
US4886870A (en) * 1984-05-21 1989-12-12 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
US4764364A (en) * 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4841968A (en) * 1986-09-26 1989-06-27 Southern Research Institute Antithrombotic/thrombolytic suture and methods of making and using the same
US4789724A (en) * 1986-10-17 1988-12-06 Massachusetts Institute Of Technology Preparation of anhydride copolymers
US4863457A (en) * 1986-11-24 1989-09-05 Lee David A Drug delivery device
FR2612198A1 (fr) * 1987-03-27 1988-09-16 Tyndale Plains Hunter Ltd Composition de polyurethane hydrophile et article qui en est produit
US4857311A (en) * 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
WO1990009783A1 (en) * 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US5356630A (en) * 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
DK0476045T3 (da) * 1989-06-05 1996-09-16 Massachusetts Inst Technology Bionedbrydelige polymerer til lægemiddel-afgivelse i knogler
US4997904A (en) * 1989-08-25 1991-03-05 Nova Pharmaceutical Corporation Aromatic polyanhydride compositions
EP0423484B1 (de) * 1989-10-16 1993-11-03 PCD-Polymere Gesellschaft m.b.H. Pressling mit retardierter Wirkstofffreisetzung

Also Published As

Publication number Publication date
AU669479B2 (en) 1996-06-13
EP0568651B1 (en) 2002-04-17
AU1643292A (en) 1992-09-07
JPH06508863A (ja) 1994-10-06
DE69232555D1 (de) 2002-05-23
DE69232555T2 (de) 2002-10-31
CA2101742A1 (en) 1992-08-02
ES2176189T3 (es) 2002-12-01
JP3137337B2 (ja) 2001-02-19
EP0568651A1 (en) 1993-11-10
CA2101742C (en) 2005-04-12
US5919835A (en) 1999-07-06
EP0568651A4 (en) 1996-11-27
ATE216262T1 (de) 2002-05-15
WO1992013567A1 (en) 1992-08-20

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