ES2187660T3 - Derivados de rapamicina. - Google Patents

Derivados de rapamicina.

Info

Publication number
ES2187660T3
ES2187660T3 ES96921931T ES96921931T ES2187660T3 ES 2187660 T3 ES2187660 T3 ES 2187660T3 ES 96921931 T ES96921931 T ES 96921931T ES 96921931 T ES96921931 T ES 96921931T ES 2187660 T3 ES2187660 T3 ES 2187660T3
Authority
ES
Spain
Prior art keywords
rapamycin derivatives
formula
rapamycin
derivatives
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96921931T
Other languages
English (en)
Inventor
Sylvain Cottens
Richard Sedrani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9511704.0A external-priority patent/GB9511704D0/en
Priority claimed from GBGB9513754.3A external-priority patent/GB9513754D0/en
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2187660T3 publication Critical patent/ES2187660T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LOS COMPUESTOS DE FORMULA (I), EN DONDE R SUB,2} SE HA SELECCIONADO DE LA FORMULA (II) O DE LA FORMULA (III), Y DONDE X ES OH O H, MUESTRAN ACTIVIDAD INMUNOSUPRESORA.
ES96921931T 1995-06-09 1996-06-05 Derivados de rapamicina. Expired - Lifetime ES2187660T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9511704.0A GB9511704D0 (en) 1995-06-09 1995-06-09 Organic compounds
GBGB9513754.3A GB9513754D0 (en) 1995-07-06 1995-07-06 Organic compounds

Publications (1)

Publication Number Publication Date
ES2187660T3 true ES2187660T3 (es) 2003-06-16

Family

ID=26307190

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96921931T Expired - Lifetime ES2187660T3 (es) 1995-06-09 1996-06-05 Derivados de rapamicina.

Country Status (29)

Country Link
US (2) US5985890A (es)
EP (1) EP0833828B1 (es)
JP (1) JP3226545B2 (es)
KR (1) KR100400620B1 (es)
CN (1) CN1124276C (es)
AR (1) AR003426A1 (es)
AT (1) ATE228135T1 (es)
AU (1) AU712193B2 (es)
BR (1) BR9609260A (es)
CA (1) CA2219659C (es)
CO (1) CO4440629A1 (es)
CZ (1) CZ292233B6 (es)
DE (1) DE69624921T2 (es)
DK (1) DK0833828T3 (es)
ES (1) ES2187660T3 (es)
FI (1) FI113051B (es)
HU (1) HU228234B1 (es)
IL (1) IL122212A (es)
MY (1) MY145291A (es)
NO (1) NO317058B1 (es)
NZ (1) NZ311647A (es)
PE (1) PE4598A1 (es)
PL (1) PL184731B1 (es)
PT (1) PT833828E (es)
RU (1) RU2158267C2 (es)
SK (1) SK284529B6 (es)
TR (1) TR199701567T1 (es)
TW (1) TW410226B (es)
WO (1) WO1996041807A1 (es)

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RU2158267C2 (ru) 2000-10-27
ATE228135T1 (de) 2002-12-15
KR19990022780A (ko) 1999-03-25
PT833828E (pt) 2003-02-28
EP0833828B1 (en) 2002-11-20
MX9709555A (es) 1998-03-31
DK0833828T3 (da) 2003-03-17
KR100400620B1 (ko) 2004-02-18
JP2000510815A (ja) 2000-08-22
SK284529B6 (sk) 2005-05-05
TW410226B (en) 2000-11-01
DE69624921T2 (de) 2003-09-11
TR199701567T1 (xx) 1998-04-21
PE4598A1 (es) 1998-02-19
SK168297A3 (en) 1998-05-06
HU228234B1 (en) 2013-02-28
CZ292233B6 (cs) 2003-08-13
WO1996041807A1 (en) 1996-12-27
FI973991L (fi) 1997-12-09
HK1014949A1 (en) 1999-10-08
US5985890A (en) 1999-11-16
PL323310A1 (en) 1998-03-16
BR9609260A (pt) 1999-05-18
FI973991A0 (fi) 1997-10-17
CO4440629A1 (es) 1997-05-07
AU712193B2 (en) 1999-10-28
NO975432L (no) 1997-11-26
CA2219659A1 (en) 1996-12-27
CN1124276C (zh) 2003-10-15
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US6200985B1 (en) 2001-03-13
HUP9802200A3 (en) 2000-05-29
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NO317058B1 (no) 2004-08-02
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