ATE219054T1 - Omega-zykloalkyl-prostaglandin e2 derivate - Google Patents

Omega-zykloalkyl-prostaglandin e2 derivate

Info

Publication number: ATE219054T1
Authority: AT; Austria
Prior art keywords: cycloalkyl; alkoxy; alkyl; halogen atom; prostaglandin
Prior art date: 1997-02-04

Application number

AT98300769T

Other languages

English (en)

Inventor

Kousuke Tani

Shuichi Ohuchida

Original Assignee

Ono Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-04

Filing date

1998-02-03

Publication date

2002-06-15

1998-02-03 Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE219054T1 publication Critical patent/ATE219054T1/de

Links

125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 2
125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 2
125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
229920000858 Cyclodextrin Polymers 0.000 abstract 1
208000010412 Glaucoma Diseases 0.000 abstract 1
206010067125 Liver injury Diseases 0.000 abstract 1
208000005107 Premature Birth Diseases 0.000 abstract 1
206010036590 Premature baby Diseases 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
206010000210 abortion Diseases 0.000 abstract 1
231100000176 abortion Toxicity 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
231100000234 hepatic damage Toxicity 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
230000008818 liver damage Effects 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
230000016273 neuron death Effects 0.000 abstract 1
201000001119 neuropathy Diseases 0.000 abstract 1
230000007823 neuropathy Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
210000000056 organ Anatomy 0.000 abstract 1
230000011164 ossification Effects 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
208000033808 peripheral neuropathy Diseases 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
210000001525 retina Anatomy 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT98300769T 1997-02-04 1998-02-03 Omega-zykloalkyl-prostaglandin e2 derivate ATE219054T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP3549997		1997-02-04
JP31916997		1997-11-06

Publications (1)

Publication Number	Publication Date
ATE219054T1 true ATE219054T1 (de)	2002-06-15

Family

ID=26374500

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98300769T ATE219054T1 (de)	1997-02-04	1998-02-03	Omega-zykloalkyl-prostaglandin e2 derivate

Country Status (13)

Country	Link
US (3)	US6110969A (de)
EP (1)	EP0860430B1 (de)
KR (1)	KR100573535B1 (de)
AT (1)	ATE219054T1 (de)
AU (1)	AU736271B2 (de)
CA (1)	CA2228828A1 (de)
DE (1)	DE69805874T2 (de)
DK (1)	DK0860430T3 (de)
ES (1)	ES2178808T3 (de)
HU (1)	HUP9800208A3 (de)
NO (1)	NO317155B1 (de)
PT (1)	PT860430E (de)
TW (1)	TW581756B (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2303341T3 (es)	1996-12-20	2008-08-01	Pfizer Inc.	Prevencion y tratamiento de trastorno del esqueleto con agonistas de la prostaglandina e2 selectivos del subtipo de receptor ep2.
US6235780B1 (en) *	1998-07-21	2001-05-22	Ono Pharmaceutical Co., Ltd.	ω-cycloalkyl-prostaglandin E1 derivatives
ATE281432T1 (de)	1999-03-05	2004-11-15	Univ Duke	C-16 ungesätigte fp-selektive prostaglandin analoge
US20020172693A1 (en) *	2000-03-31	2002-11-21	Delong Michell Anthony	Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en)	2000-03-31	2002-01-31	Delong Mitchell Anthony	Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en)	2000-03-31	2002-03-28	Delong Mitchell Anthony	Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
KR20030019628A (ko) *	2000-07-31	2003-03-06	오노 야꾸힝 고교 가부시키가이샤	프로스타글란딘 유도체를 유효 성분으로 하는 발기부전치료제
US6410591B1 (en) *	2001-05-08	2002-06-25	Allergan Sales, Inc.	3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
US20030027853A1 (en)	2001-06-14	2003-02-06	Allergan Sales, Inc.	3, 7or3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure
US7872045B2 (en)	2001-06-14	2011-01-18	Allergan, Inc.	Combination therapy for glaucoma treatment
JP2006021998A (ja) *	2002-07-18	2006-01-26	Ono Pharmaceut Co Ltd	Ｅｐ２アゴニストを有効成分とする月経困難症治療剤
JP3678366B2 (ja)	2002-08-09	2005-08-03	大正製薬株式会社	止痒剤
US7737182B2 (en)	2002-08-09	2010-06-15	Taisho Pharmaceutical Co., Ltd.	Pharmaceuticals for xerosis
ES2584606T3 (es)	2002-10-10	2016-09-28	Ono Pharmaceutical Co., Ltd.	Microesferas que comprenden ONO-1301
AU2003301900A1 (en) *	2002-11-13	2004-06-03	Fumie Sato	Antipruritic drug
WO2004073591A2 (en) *	2003-02-24	2004-09-02	Bayer Healthcare Ag	Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep2 (prostaglandin e2 ep2)
US20070167403A1 (en) *	2003-04-03	2007-07-19	Yoshifumi Takenobu	Remedy for spinal canal stenosis
EP2422814A1 (de)	2003-07-25	2012-02-29	Ono Pharmaceutical Co., Ltd.	Heilmittel für Knorpelerkrankungen
JP4893999B2 (ja) *	2004-10-22	2012-03-07	小野薬品工業株式会社	吸入用医薬組成物
AR053710A1 (es) *	2005-04-11	2007-05-16	Xenon Pharmaceuticals Inc	Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
AR056968A1 (es) *	2005-04-11	2007-11-07	Xenon Pharmaceuticals Inc	Compuestos espiro-oxindol y composiciones farmacéuticas
RU2420316C2 (ru)	2005-06-03	2011-06-10	Оно Фармасьютикал Ко., Лтд.	Агент для регенерации и/или защиты нервов
US7563924B2 (en) *	2005-11-21	2009-07-21	Schering Aktiengesellschaft	9-chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments
LT1976828T (lt)	2005-12-29	2017-04-25	Celtaxsys, Inc.	Diamino dariniai, kaip leukotrieno a4 hidrolazės inhibitoriai
US20110294842A9 (en) *	2006-10-12	2011-12-01	Xenon Pharmaceuticals Inc.	Spiro (furo [3, 2-c] pyridine-3-3' -indol) -2' (1'h)-one derivatives and related compounds for the treatment of sodium-channel mediated diseases, such as pain
WO2008060789A2 (en)	2006-10-12	2008-05-22	Xenon Pharmaceuticals Inc.	Use of spiro-oxindole compounds as therapeutic agents
EP2269611B1 (de)	2006-11-16	2016-03-23	Gemmus Pharma Inc.	EP2- und EP4-Agonisten als Wirkstoffe zur Behandlung von Influenza A Virusinfektionen
US7960378B2 (en) *	2008-03-18	2011-06-14	Allergan, Inc.	Therapeutic compounds
EP2149554A1 (de)	2008-07-30	2010-02-03	Bayer Schering Pharma Aktiengesellschaft	Indolylamide als Modulatoren des EP2-Rezeptors
EP2149552A1 (de)	2008-07-30	2010-02-03	Bayer Schering Pharma AG	5,6 substituierte Benzamid-Derivate als Modulatoren des EP2-Rezeptors
EP2149551A1 (de)	2008-07-30	2010-02-03	Bayer Schering Pharma AG	N-(Indol-3-ylalkyl)-(hetero)arylamidderivate als Modulatoren des EP2-Rezeptors
JO3032B1 (ar) *	2008-10-17	2016-09-05	Xenon Pharmaceuticals Inc	مركبات سبيرو – اوكسندول وإستعمالاتها كعوامل علاجية.
CA2741024A1 (en) *	2008-10-17	2010-04-22	Xenon Pharmaceuticals Inc.	Spiro-oxindole compounds and their use as therapeutic agents
US8722739B2 (en)	2008-10-29	2014-05-13	Novaer Holdings, Inc.	Amino acid salts of prostaglandins
US8623918B2 (en)	2008-10-29	2014-01-07	Novaer Holdings, Inc.	Amino acid salts of prostaglandins
AR077252A1 (es)	2009-06-29	2011-08-10	Xenon Pharmaceuticals Inc	Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
KR20120099429A (ko)	2009-10-14	2012-09-10	제논 파마슈티칼스 인크.	스피로-옥스인돌 화합물의 합성 방법
US20110086899A1 (en) *	2009-10-14	2011-04-14	Xenon Pharmaceuticals Inc.	Pharmaceutical compositions for oral administration
WO2011106729A2 (en)	2010-02-26	2011-09-01	Xenon Pharmaceuticals Inc.	Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
TW201311630A (zh)	2011-08-05	2013-03-16	Ono Pharmaceutical Co	軟骨疾病治療用化合物
BR112014003802A2 (pt) *	2011-08-19	2017-06-13	Merck Sharp & Dohme	composto, composto composição farmacêutica, uso de um composto, método para fabricar um composto, e, preparação de um medicamento
RU2474426C1 (ru) *	2011-12-26	2013-02-10	Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН	Простамиды и их аналоги, обладающие нейрозащитным действием
HK1205114A1 (en)	2012-04-12	2015-12-11	Xenon Pharmaceuticals Inc.	Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents
EP2913047B1 (de)	2012-10-29	2019-05-08	Cardio Incorporated	Spezifisches therapeutikum für pulmonale erkrankungen
CA2906035A1 (en)	2013-03-14	2014-09-25	Celtaxsys, Inc.	Inhibitors of leukotriene a4 hydrolase
EP2818484A1 (de)	2013-06-28	2014-12-31	Universitat Autònoma de Barcelona	Synergistische Kombination eines Anti-IgE-Antikörpers und eines EP2-Rezeptoragonisten
US9968716B2 (en)	2013-10-15	2018-05-15	Ono Pharmaceutical Co., Ltd.	Drug-eluting stent graft
WO2016127068A1 (en)	2015-02-05	2016-08-11	Teva Pharmaceuticals International Gmbh	Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound
US10100060B2 (en)	2016-06-16	2018-10-16	Xenon Pharmaceuticals Inc.	Asymmetric synthesis of funapide
US10385007B2 (en)	2016-12-09	2019-08-20	Celtaxsys, Inc.	Monamine and monoamine derivatives as inhibitors of leukotriene A4 hydrolase
AU2017371348B2 (en)	2016-12-09	2022-02-03	Celltaxis, Llc	Inhibitors of leukotriene A4 hydrolase
US10202334B2 (en)	2016-12-09	2019-02-12	Celtaxsys, Inc.	Pendant amines and derivatives as inhibitors of leukotriene A4 hydrolase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4061670A (en) *	1976-07-19	1977-12-06	American Cyanamid Company	15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners
US4132738A (en) *	1978-02-23	1979-01-02	Miles Laboratories, Inc.	Preparation of 15-deoxy-16-hydroxyprostaglandins
US4336404A (en) *	1979-05-14	1982-06-22	Miles Laboratories, Inc.	1-Acyloxy-15-deoxy-16-hydroxy-analogs of prostaglandin E1
US4363817A (en) *	1981-08-27	1982-12-14	Miles Laboratories, Inc.	Enol acylate analogs of E1 and E2 prostaglandins
US5698598A (en) *	1995-08-04	1997-12-16	Allergan	EP2 -receptor agonists as agents for lowering intraocular pressure

1998
- 1998-02-02 NO NO19980442A patent/NO317155B1/no unknown
- 1998-02-03 DK DK98300769T patent/DK0860430T3/da active
- 1998-02-03 PT PT98300769T patent/PT860430E/pt unknown
- 1998-02-03 HU HU9800208A patent/HUP9800208A3/hu unknown
- 1998-02-03 EP EP98300769A patent/EP0860430B1/de not_active Expired - Lifetime
- 1998-02-03 ES ES98300769T patent/ES2178808T3/es not_active Expired - Lifetime
- 1998-02-03 DE DE69805874T patent/DE69805874T2/de not_active Expired - Lifetime
- 1998-02-03 TW TW087101279A patent/TW581756B/zh not_active IP Right Cessation
- 1998-02-03 KR KR1019980002882A patent/KR100573535B1/ko not_active Expired - Fee Related
- 1998-02-03 AT AT98300769T patent/ATE219054T1/de not_active IP Right Cessation
- 1998-02-04 US US09/018,565 patent/US6110969A/en not_active Expired - Lifetime
- 1998-02-04 CA CA002228828A patent/CA2228828A1/en not_active Abandoned
- 1998-02-04 AU AU52892/98A patent/AU736271B2/en not_active Ceased
2000
- 2000-05-12 US US09/570,728 patent/US6576785B1/en not_active Expired - Fee Related
2002
- 2002-09-11 US US10/238,623 patent/US20030186939A1/en not_active Abandoned

Also Published As

Publication number	Publication date
NO980442L (no)	1998-08-05
HUP9800208A3 (en)	2000-04-28
NO980442D0 (no)	1998-02-02
PT860430E (pt)	2002-11-29
ES2178808T3 (es)	2003-01-01
EP0860430B1 (de)	2002-06-12
AU5289298A (en)	1998-08-06
AU736271B2 (en)	2001-07-26
US6110969A (en)	2000-08-29
EP0860430A2 (de)	1998-08-26
HU9800208D0 (en)	1998-03-30
KR100573535B1 (ko)	2006-12-15
EP0860430A3 (de)	1999-06-23
US20030186939A1 (en)	2003-10-02
TW581756B (en)	2004-04-01
DE69805874T2 (de)	2002-12-19
US6576785B1 (en)	2003-06-10
NO317155B1 (no)	2004-08-30
DE69805874D1 (de)	2002-07-18
DK0860430T3 (da)	2002-09-09
KR19980071021A (ko)	1998-10-26
CA2228828A1 (en)	1998-08-04
HUP9800208A2 (hu)	1998-09-28

Legal Events

Date	Code	Title	Description
2002-12-15	UEP	Publication of translation of european patent specification
2007-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE219054T1 (de)	2002-06-15	Omega-zykloalkyl-prostaglandin e2 derivate
DE69901658D1 (de)	2002-07-11	Omega-Zykloalkyl-Prostaglandin E1 Derivate
DE69821987D1 (de)	2004-04-01	Omega-cycloalkyl-prostaglandin e2 derivate
AR044403A1 (es)	2005-09-14	Derivados de oximas y su uso como inmunodepresores. composiciones farmaceuticas que los contienen.
AR036032A1 (es)	2004-08-04	Compuesto derivado de quinolina, composicion que lo comprende; uso del mismo en la fabricacion de medicamentos, proceso para prepararlo, y metodo para detectar y seleccionar un agente que module la actividad del mif
DK1201678T3 (da)	2004-10-18	Hidtil ukendte bicyklonukleosidanaloger
DE69132713D1 (de)	2001-10-11	Benzylidenthiazolidinderivate, ihre Herstellung und ihre Anwendung als Lipidperoxid-Inhibitoren
EP0806416A4 (de)	1998-04-15	Huperzin-derivate, ihre herstellung und ihre verwendung
HUP9601176A2 (hu)	1998-07-28	Adhéziós receptor antagonista amidinszármazékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
DK0918776T3 (da)	2004-07-12	Totalsyntese af antitumor acylfulvener
EA200000400A1 (ru)	2000-10-30	Галогензамещенные тетрациклические производные тетрагидрофурана
AU2888892A (en)	1993-05-03	3-ureido-benzodiazepinones useful as antagonists of cck or of gastrine
DE69931051D1 (de)	2006-06-01	Neue vinylbenzolderivate
ATE223411T1 (de)	2002-09-15	1-methylcarbapenem-derivate
ATE239741T1 (de)	2003-05-15	Derivate der phosphonsäure zur inhibierung von carboxypeptidase b
ES2089041T5 (es)	2000-07-16	Compuestos de piridinasulfonamida sustituida, composiciones herbicidas que los contienen, y procedimiento para su preparacion.
ATE293616T1 (de)	2005-05-15	2-fluoro-(oxido-thiopyran-4-yl)benzol derivate
ATE147073T1 (de)	1997-01-15	Hydantoin-derivate
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KR950703575A (ko)	1995-09-20	신규의 옥사 또는 아자스테로이드 7위치 치환 화합물 [novel 7-sunstituted oxa-or azasteroid compound]
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ATE225366T1 (de)	2002-10-15	22s-hydroxycholesta-8,14-dien derivate mit meiose regulierende aktivität
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