ATE222245T1 - Verfahren zur herstellung von benzyl- substituierten rhodanin derivaten - Google Patents
Verfahren zur herstellung von benzyl- substituierten rhodanin derivatenInfo
- Publication number
- ATE222245T1 ATE222245T1 AT95943829T AT95943829T ATE222245T1 AT E222245 T1 ATE222245 T1 AT E222245T1 AT 95943829 T AT95943829 T AT 95943829T AT 95943829 T AT95943829 T AT 95943829T AT E222245 T1 ATE222245 T1 AT E222245T1
- Authority
- AT
- Austria
- Prior art keywords
- benzyl
- substituted
- derivatives
- novel
- rhodanine derivatives
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KIWUVOGUEXMXSV-UHFFFAOYSA-N rhodanine Chemical class O=C1CSC(=S)N1 KIWUVOGUEXMXSV-UHFFFAOYSA-N 0.000 title abstract 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 2
- -1 benzyl-substituted mercaptopropanoic acids Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/361,281 US5563277A (en) | 1994-12-21 | 1994-12-21 | Process for preparing benzyl-substituted rhodanine derivatives |
| PCT/US1995/016372 WO1996019466A1 (en) | 1994-12-21 | 1995-12-14 | Process for preparing benzyl-substituted rhodanine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE222245T1 true ATE222245T1 (de) | 2002-08-15 |
Family
ID=23421401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95943829T ATE222245T1 (de) | 1994-12-21 | 1995-12-14 | Verfahren zur herstellung von benzyl- substituierten rhodanin derivaten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5563277A (de) |
| EP (1) | EP0799215B1 (de) |
| JP (1) | JPH10511352A (de) |
| AT (1) | ATE222245T1 (de) |
| AU (1) | AU4520596A (de) |
| CA (1) | CA2207901A1 (de) |
| DE (1) | DE69527802T2 (de) |
| ES (1) | ES2181809T3 (de) |
| WO (1) | WO1996019466A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69608512T2 (de) * | 1995-09-07 | 2001-01-25 | Eli Lilly And Co., Indianapolis | Verfahren zur Herstellung von benzylsubstituierten Rhodaninederivaten |
| US6063799A (en) * | 1996-09-03 | 2000-05-16 | Eli Lilly And Company | Alternate crystal form of Tazofelone |
| US6005142A (en) * | 1996-09-03 | 1999-12-21 | Eli Lilly And Company | Process for preparing benzyl-substituted rhodanine derivatives |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0048159A3 (de) * | 1980-09-17 | 1982-05-12 | University Of Miami | Carboxyalkyl-Peptide und Thioäther und Äther von Peptiden als antihypertensive Mittel |
| IE940525L (en) * | 1988-05-25 | 1989-11-25 | Warner Lambert Co | Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents |
| ZA902520B (en) * | 1989-04-07 | 1991-12-24 | Lilly Co Eli | Aryl-substituted rhodanine derivatives |
| US5216002A (en) * | 1989-12-21 | 1993-06-01 | Eli Lilly And Company | Method of treating inflammatory bowel disease |
| IL96654A (en) * | 1989-12-21 | 1995-06-29 | Lilly Co Eli | Hydroxybenzyl substituted sulfur containing heterocyclic derivatives their preparation and pharmaceutical compositions containing them |
| FI922867A7 (fi) * | 1991-06-21 | 1992-12-22 | Tanabe Seiyaku Co | Dikarbonsyraderivat och foerfarande foer framstaellning av dem |
| GB9213934D0 (en) * | 1992-06-30 | 1992-08-12 | Smithkline Beecham Corp | Chemical compounds |
| CA2100376A1 (en) * | 1992-07-14 | 1994-01-15 | Mitsuo Masaki | Alkylenediamine derivatives |
| CZ181493A3 (en) * | 1992-09-10 | 1994-03-16 | Lilly Co Eli | The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease |
| JPH06234630A (ja) * | 1992-12-17 | 1994-08-23 | Tanabe Seiyaku Co Ltd | 中性メタロエンドペプチダーゼ阻害剤 |
| US5476865A (en) * | 1994-07-06 | 1995-12-19 | Eli Lilly And Company | Methods of inhibiting bone loss |
-
1994
- 1994-12-21 US US08/361,281 patent/US5563277A/en not_active Expired - Fee Related
-
1995
- 1995-12-14 CA CA002207901A patent/CA2207901A1/en not_active Abandoned
- 1995-12-14 AU AU45205/96A patent/AU4520596A/en not_active Abandoned
- 1995-12-14 AT AT95943829T patent/ATE222245T1/de not_active IP Right Cessation
- 1995-12-14 ES ES95943829T patent/ES2181809T3/es not_active Expired - Lifetime
- 1995-12-14 WO PCT/US1995/016372 patent/WO1996019466A1/en not_active Ceased
- 1995-12-14 JP JP8519911A patent/JPH10511352A/ja not_active Ceased
- 1995-12-14 DE DE69527802T patent/DE69527802T2/de not_active Expired - Fee Related
- 1995-12-14 EP EP95943829A patent/EP0799215B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0799215A1 (de) | 1997-10-08 |
| US5563277A (en) | 1996-10-08 |
| DE69527802D1 (de) | 2002-09-19 |
| WO1996019466A1 (en) | 1996-06-27 |
| DE69527802T2 (de) | 2003-04-10 |
| JPH10511352A (ja) | 1998-11-04 |
| EP0799215A4 (de) | 1998-03-11 |
| EP0799215B1 (de) | 2002-08-14 |
| CA2207901A1 (en) | 1996-06-27 |
| AU4520596A (en) | 1996-07-10 |
| ES2181809T3 (es) | 2003-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |