DK0910399T3 - Stabilt farmaceutisk BDNF-præparat - Google Patents
Stabilt farmaceutisk BDNF-præparatInfo
- Publication number
- DK0910399T3 DK0910399T3 DK97922156T DK97922156T DK0910399T3 DK 0910399 T3 DK0910399 T3 DK 0910399T3 DK 97922156 T DK97922156 T DK 97922156T DK 97922156 T DK97922156 T DK 97922156T DK 0910399 T3 DK0910399 T3 DK 0910399T3
- Authority
- DK
- Denmark
- Prior art keywords
- bdnf
- pct
- stable pharmaceutical
- preparation
- sec
- Prior art date
Links
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 title abstract 5
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 title abstract 5
- 229940077737 brain-derived neurotrophic factor Drugs 0.000 abstract 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000036425 denaturation Effects 0.000 abstract 1
- 238000004925 denaturation Methods 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8156070A JPH10212241A (ja) | 1996-05-27 | 1996-05-27 | Ｂｄｎｆを安定に含有する製剤 |
| PCT/JP1997/001746 WO1997045135A1 (en) | 1996-05-27 | 1997-05-26 | Stable pharmaceutical composition of bdnf |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0910399T3 true DK0910399T3 (da) | 2003-01-06 |
Family
ID=15619654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97922156T DK0910399T3 (da) | 1996-05-27 | 1997-05-26 | Stabilt farmaceutisk BDNF-præparat |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6077829A (da) |
| EP (1) | EP0910399B1 (da) |
| JP (1) | JPH10212241A (da) |
| AT (1) | ATE223728T1 (da) |
| AU (1) | AU715571B2 (da) |
| CA (1) | CA2256410C (da) |
| DE (1) | DE69715414T2 (da) |
| DK (1) | DK0910399T3 (da) |
| ES (1) | ES2183170T3 (da) |
| PT (1) | PT910399E (da) |
| WO (1) | WO1997045135A1 (da) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998010785A1 (en) * | 1996-09-13 | 1998-03-19 | Advanced Medicine Research Institute | Ophthalmic compositions of neurotrophic factors, remedies for optic nerve function disorders and method for treating optic nerve function disorders |
| US20040120891A1 (en) * | 1998-12-21 | 2004-06-24 | Craig Hill | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
| AU5105100A (en) * | 1999-06-03 | 2000-12-28 | Eisai Co. Ltd. | Crystals of carbapenem derivatives and pharmaceutical preparations for injection |
| AUPQ084899A0 (en) * | 1999-06-08 | 1999-07-01 | University Of Melbourne, The | Neurotrophin agonists |
| AU2001271037A1 (en) * | 2000-07-13 | 2002-01-30 | Daiichi Pharmaceutical Co., Ltd. | Pharmaceutical compositions containing dds compounds |
| US6852323B2 (en) | 2000-07-21 | 2005-02-08 | The Regents Of The University Of California | Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder |
| US7223406B2 (en) * | 2000-07-21 | 2007-05-29 | The Regents Of The University Of California | Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder |
| WO2002096356A2 (en) * | 2001-05-25 | 2002-12-05 | Cornell Research Foundation, Inc. | HIGH AFFINITY LIGAND FOR p75 NEUROTROPHIN RECEPTOR |
| DE10149030A1 (de) * | 2001-10-05 | 2003-04-10 | Viscum Ag | Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin |
| US20040096828A1 (en) * | 2002-01-04 | 2004-05-20 | Lu Dyung Aina M | Cytoskeleton-associated proteins |
| US20030219696A1 (en) * | 2002-05-23 | 2003-11-27 | Moreland Gerald W. | Method and apparatus for preventing backflow in dental saliva evacuators |
| CA2513226A1 (en) * | 2003-01-13 | 2004-07-29 | Mahendra S. Rao | Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products |
| US20050048041A1 (en) * | 2003-01-13 | 2005-03-03 | Rao Mahendra S. | Persistent expression of candidate molecule in proliferating stem and progenitor cells for delivery of therapeutic products |
| MX2007015292A (es) | 2005-06-06 | 2008-02-21 | Wyeth Corp | Anticuerpos monoclonales anti-trkb y sus usos. |
| CN103301475B (zh) | 2005-12-28 | 2016-08-03 | 斯克里普斯研究所 | 药物组合物和表达载体以及调节基因表达的方法和核酸分子的应用 |
| WO2008019431A1 (en) * | 2006-08-14 | 2008-02-21 | Brc Operations Pty Limited | Method and compositions for simultaneously regulating memory and mood |
| IT1396607B1 (it) | 2009-11-16 | 2012-12-14 | Hmfra Hungary Ltd Liability Company | Preparazioni oftalmiche a base di bdnf (brain-derived neurotrophic factor) e loro uso. |
| CA2781666C (en) | 2009-11-23 | 2017-02-21 | Cubist Pharmaceuticals, Inc. | Lipopeptide compositions and related methods |
| ES2694592T3 (es) | 2012-03-15 | 2018-12-21 | Curna, Inc. | Tratamiento de enfermedades relacionadas con el factor neurotrófico derivado del cerebro (BDNF) por inhibición del transcrito antisentido natural de BDNF |
| MX2021000644A (es) | 2018-07-18 | 2021-08-19 | Manzanita Pharmaceuticals Inc | Conjugados para suministrar un agente contra el cancer a las celulas nerviosas, metodos de uso y metodos para la elaboracion de los mismos. |
| JP2021019532A (ja) * | 2019-07-26 | 2021-02-18 | 花王株式会社 | 血液脳関門保護剤 |
| EP4117625A1 (en) | 2020-03-12 | 2023-01-18 | Baxter International Inc. | Daptomycin formulations containing a combination of sorbitol and mannitol |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
| AU6909091A (en) * | 1989-12-05 | 1991-06-26 | Ramsey Foundation | Neurologic agents for nasal administration to the brain |
| US5604202A (en) * | 1990-11-13 | 1997-02-18 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Use of NGF growth factors to treat drug-induced neuropathy |
| US5770577A (en) * | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
-
1996
- 1996-05-27 JP JP8156070A patent/JPH10212241A/ja active Pending
-
1997
- 1997-05-26 US US09/180,884 patent/US6077829A/en not_active Expired - Fee Related
- 1997-05-26 WO PCT/JP1997/001746 patent/WO1997045135A1/en not_active Ceased
- 1997-05-26 EP EP97922156A patent/EP0910399B1/en not_active Expired - Lifetime
- 1997-05-26 ES ES97922156T patent/ES2183170T3/es not_active Expired - Lifetime
- 1997-05-26 PT PT97922156T patent/PT910399E/pt unknown
- 1997-05-26 AU AU27923/97A patent/AU715571B2/en not_active Ceased
- 1997-05-26 DK DK97922156T patent/DK0910399T3/da active
- 1997-05-26 DE DE69715414T patent/DE69715414T2/de not_active Expired - Lifetime
- 1997-05-26 AT AT97922156T patent/ATE223728T1/de not_active IP Right Cessation
- 1997-05-26 CA CA002256410A patent/CA2256410C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE223728T1 (de) | 2002-09-15 |
| DE69715414T2 (de) | 2003-05-15 |
| CA2256410C (en) | 2007-02-27 |
| AU2792397A (en) | 1998-01-05 |
| US6077829A (en) | 2000-06-20 |
| EP0910399A1 (en) | 1999-04-28 |
| CA2256410A1 (en) | 1997-12-04 |
| PT910399E (pt) | 2002-11-29 |
| AU715571B2 (en) | 2000-02-03 |
| WO1997045135A1 (en) | 1997-12-04 |
| DE69715414D1 (de) | 2002-10-17 |
| ES2183170T3 (es) | 2003-03-16 |
| EP0910399B1 (en) | 2002-09-11 |
| JPH10212241A (ja) | 1998-08-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2183170T3 (es) | Composicion farmaceutica estable del factor bdnf. | |
| SE9201073D0 (sv) | Protein formulation | |
| ES2563677T3 (es) | Composiciones de combinaciones de Neisseria | |
| BR0315645A (pt) | Polipetìdeos de fusão de actrib e seus usos | |
| BR9508088A (pt) | Composição de limpeza antimicrobiana processo para desinfetar superfícies não vivas e uso em um processo para a preparação de uma coposição desinfetante | |
| ATE410441T1 (de) | Zusammensetzungen und methoden zur behandlung von infektionen unter verwendung von indolicidinanalogen | |
| ATE146360T1 (de) | Gonadotropin enthaltende gefriergetrocknete troepfen | |
| DE59905954D1 (de) | Dialkylfumarate zur behandlung von autoimmunerkrankungen | |
| BR0004884A (pt) | Composições acaricidas | |
| NO971889D0 (no) | Forbindelser og sammensetninger for levering av aktive midler | |
| KR890004718A (ko) | 안정한 인체 단백질의 제조 | |
| NO20031159D0 (no) | Melkesyrebakterier som er i stand til å redusere et individs tendens til åutvikle allergiske reaksjoner | |
| HUP0303278A2 (hu) | Fagyasztva szárított pantoprazol készítmény, eljárás az előállítására és pantoprazol injekció | |
| DK1149910T3 (da) | Farmaceutisk præparat til behandling af papillomavirustumorer og -infektion | |
| ES2187820T3 (es) | Formulaciones farmaceuticas de factor de liberacion de la corticotrop ina que tiene una estabilidad en su forma liquida. | |
| DK0641216T3 (da) | Farmaceutisk præparat indeholdende IL-6 | |
| BR9809103A (pt) | Forma farmacêutica estável de administração para peptìdeos, proteìnas e ácidos nucléicos | |
| AU679581B2 (en) | Method of stabilizing protein C or activated protein C and stabilized composition | |
| DE69315388D1 (de) | Aus bakteriellen Proteinen bestehender Extrakt, Verfahren zur dessen Herstellung und diesen Extrakt enthaltende pharmazeutische Zusammensetzung | |
| DK1165102T3 (da) | Matrixproteinpræparater til podning i ikke-mineraliseret væv | |
| ATE303816T1 (de) | Neue therapeutische verwendung eines eine virale ansteckung modulierendes protein zur verhinderung von abstossung von fremdtransplantaten | |
| DK1074264T3 (da) | Inhibitorer for neovaskularisering | |
| PT94685A (pt) | Processo para a preparacao de 2-imidazolinas substituidas e de composicoes farmaceuticas que as contem | |
| DK0722325T3 (da) | Præparat til behandling eller forebyggelse af herpes | |
| EP1174439A3 (en) | Compositions and methods for treating infections using analogues of indolicidin |