ATE223911T1 - Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten - Google Patents

Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten

Info

Publication number: ATE223911T1
Authority: AT; Austria
Prior art keywords: antagonists containing; pgd2 antagonists; benzothiophenecarboxamide; derivatives; benzothiophenecarboxamide derivatives
Prior art date: 1996-12-13

Application number

AT97947866T

Other languages

English (en)

Inventor

Tsunetoshi Honma

Yoshiharu Hiramatsu

Akinori Arimura

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-13

Filing date

1997-12-10

Publication date

2002-09-15

1997-12-10 Application filed by Shionogi & Co filed Critical Shionogi & Co

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223911T1 publication Critical patent/ATE223911T1/de

Links

GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical class C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 title 1
102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 title 1
101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 title 1
BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

AT97947866T 1996-12-13 1997-12-10 Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten ATE223911T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP33349596		1996-12-13
JP25400197		1997-09-19
PCT/JP1997/004527 WO1998025919A1 (en)	1996-12-13	1997-12-10	Benzothiophenecarboxamide derivatives and pgd2 antagonists comprising them

Publications (1)

Publication Number	Publication Date
ATE223911T1 true ATE223911T1 (de)	2002-09-15

Family

ID=26541496

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97947866T ATE223911T1 (de)	1996-12-13	1997-12-10	Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten

Country Status (25)

Country	Link
US (1)	US6083974A (de)
EP (1)	EP0944614B1 (de)
JP (1)	JP3215441B2 (de)
KR (1)	KR100433568B1 (de)
CN (2)	CN1105112C (de)
AR (1)	AR008939A1 (de)
AT (1)	ATE223911T1 (de)
AU (1)	AU718958B2 (de)
BR (1)	BR9714016A (de)
CA (1)	CA2274591C (de)
CZ (1)	CZ297324B6 (de)
DE (1)	DE69715448T2 (de)
DK (1)	DK0944614T3 (de)
ES (1)	ES2181039T3 (de)
HU (1)	HU226458B1 (de)
ID (1)	ID22753A (de)
IL (1)	IL130660A (de)
NO (1)	NO992838L (de)
NZ (1)	NZ336143A (de)
PL (1)	PL191760B1 (de)
PT (1)	PT944614E (de)
RU (1)	RU2161617C1 (de)
TR (1)	TR199901280T2 (de)
TW (1)	TW438790B (de)
WO (1)	WO1998025919A1 (de)

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CN1198649C (zh) *	1998-06-03	2005-04-27	盐野义制药株式会社	用于治疗瘙痒的含pgd2受体拮抗剂的药物组合物
ATE404524T1 (de) *	1999-07-02	2008-08-15	Shionogi & Co	Neuartiges verfahren zur herstellung bicyclischer amino-alkohole
HUP0301493A2 (hu)	2000-03-09	2003-08-28	Ono Pharmaceutical Co., Ltd.	Indolszármazékok, eljárás előállításukra és alkalmazásuk
DE60115411D1 (de) *	2000-04-12	2006-01-05	Merck Frosst Canada & Co Kirkl	Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten
US6410583B1 (en) *	2000-07-25	2002-06-25	Merck Frosst Canada & Co.	Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7273883B2 (en)	2000-09-14	2007-09-25	Allergan, Inc.	Prostaglandin EP4 antagonist
US7217725B2 (en)	2000-09-14	2007-05-15	Allergan, Inc.	Prostaglandin D2 antagonist
DE60108515T2 (de) *	2000-10-17	2006-01-12	Shionogi & Co., Ltd.	Verfahren zur herstellung eines pgd2-antagonisten
US6933317B2 (en) *	2000-11-01	2005-08-23	Shionogi & Co. Ltd.	PGD2 receptor antagonistic pharmaceutical compositions
AR038136A1 (es)	2002-01-24	2004-12-29	Merck Frosst Canada Inc	Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
ATE516277T1 (de) *	2002-03-19	2011-07-15	Ono Pharmaceutical Co	Carbonsäureverbindungen und arzneimittel, die diese verbindungen als wirkstoffe enthalten
AU2003252499B2 (en) *	2002-07-12	2007-11-08	Japan Science And Technology Agency	Drugs for improving the prognosis of brain injury and a method of screening the same
WO2004030674A1 (ja) *	2002-09-30	2004-04-15	Shionogi & Co., Ltd.	プロスタグランジンｄ２、プロスタグランジンｄ２アゴニストおよびプロスタグランジンｄ２アンタゴニストの新規用途
EP1558614B1 (de)	2002-10-30	2010-09-01	Merck Frosst Canada Ltd.	Pyridopyrrolizin- und pyridoindolizinderivate
AU2005229356B2 (en)	2004-03-11	2011-06-09	Idorsia Pharmaceuticals Ltd	Tetrahydropyridoindole derivatives
WO2006068162A1 (ja) *	2004-12-24	2006-06-29	Shionogi & Co., Ltd.	慢性閉塞性肺疾患の治療剤
TW200716093A (en) *	2005-04-28	2007-05-01	Shionogi & Co	An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh)	2007-08-10	2013-10-01	Ono Pharmaceutical Co	Phenylacetic acid compounds
SG181900A1 (en)	2009-12-23	2012-08-30	Ironwood Pharmaceuticals Inc	Crth2 modulators
US20130178475A1 (en)	2010-03-17	2013-07-11	Ironwood Pharmaceuticals, Inc.	sGC STIMULATORS
AR088020A1 (es)	2010-06-30	2014-05-07	Ironwood Pharmaceuticals Inc	Compuestos heterociclicos como estimuladores de sgc
WO2012009134A1 (en)	2010-07-12	2012-01-19	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
US20130216552A1 (en)	2010-07-12	2013-08-22	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
EP2637659B1 (de)	2010-11-09	2016-05-18	Ironwood Pharmaceuticals, Inc.	Sgc-stimulatoren
CN106117194A (zh)	2011-12-27	2016-11-16	铁木医药有限公司	可用作sgc刺激剂的2‑苄基、3‑(嘧啶‑2‑基)取代的吡唑类
US9309235B2 (en)	2012-09-18	2016-04-12	Ironwood Pharmaceuticals, Inc.	SGC stimulators
US9487508B2 (en)	2012-09-19	2016-11-08	Ironwood Pharmaceuticals, Inc.	SGC stimulators
SI2970243T1 (sl)	2013-03-15	2020-04-30	Cyclerion Therapeutics, Inc.	SGC stimulatorji
JP2016540017A (ja)	2013-12-11	2016-12-22	アイアンウッドファーマシューティカルズインコーポレイテッド	ｓＧＣ刺激物質
WO2015106268A1 (en)	2014-01-13	2015-07-16	Ironwood Pharmaceuticals, Inc.	USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
US20170298055A1 (en)	2014-09-17	2017-10-19	Ironwood Pharmaceuticals, Inc.	sGC STIMULATORS
EP3194386A2 (de)	2014-09-17	2017-07-26	Ironwood Pharmaceuticals, Inc.	Sgc-stimulatoren
US20170291889A1 (en)	2014-09-17	2017-10-12	Ironwood Pharmaceuticals, Inc.	Pyrazole derivatives as sgc stimulators
ES2991300T3 (es)	2015-02-13	2024-12-03	Inserm Institut Nat De La Sante Et De Larecherche Medicale	Antagonistas de PTGDR-1 y/o PTGDR-2 para prevenir y/o tratar lupus eritematoso sistémico
CN109476686B (zh)	2016-07-07	2022-01-18	赛克里翁治疗有限公司	sGC刺激剂的磷前药
MX389964B (es)	2016-07-07	2025-03-19	Cyclerion Therapeutics Inc	Formas sólidas de un estimulador de guanilato ciclasa soluble (sgc).

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JPS6149A (ja) *	1984-06-12	1986-01-06	Ono Pharmaceut Co Ltd	新規な１３―アザ―１４―オキソ―ＴｘＡ２類似化合物およびそれらを有効成分として含有するトロンボキサン起因疾患治療剤
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1997
- 1997-12-10 CZ CZ0206599A patent/CZ297324B6/cs not_active IP Right Cessation
- 1997-12-10 WO PCT/JP1997/004527 patent/WO1998025919A1/en not_active Ceased
- 1997-12-10 CN CN97180628A patent/CN1105112C/zh not_active Expired - Fee Related
- 1997-12-10 RU RU99115766/04A patent/RU2161617C1/ru not_active IP Right Cessation
- 1997-12-10 KR KR10-1999-7005154A patent/KR100433568B1/ko not_active Expired - Fee Related
- 1997-12-10 BR BR9714016-3A patent/BR9714016A/pt active Search and Examination
- 1997-12-10 AU AU54097/98A patent/AU718958B2/en not_active Ceased
- 1997-12-10 NZ NZ336143A patent/NZ336143A/en unknown
- 1997-12-10 ID IDW990472A patent/ID22753A/id unknown
- 1997-12-10 CA CA002274591A patent/CA2274591C/en not_active Expired - Fee Related
- 1997-12-10 DK DK97947866T patent/DK0944614T3/da active
- 1997-12-10 AT AT97947866T patent/ATE223911T1/de not_active IP Right Cessation
- 1997-12-10 IL IL13066097A patent/IL130660A/en not_active IP Right Cessation
- 1997-12-10 DE DE69715448T patent/DE69715448T2/de not_active Expired - Lifetime
- 1997-12-10 US US09/308,176 patent/US6083974A/en not_active Expired - Lifetime
- 1997-12-10 EP EP97947866A patent/EP0944614B1/de not_active Expired - Lifetime
- 1997-12-10 PT PT97947866T patent/PT944614E/pt unknown
- 1997-12-10 TR TR1999/01280T patent/TR199901280T2/xx unknown
- 1997-12-10 PL PL334072A patent/PL191760B1/pl not_active IP Right Cessation
- 1997-12-10 JP JP52649298A patent/JP3215441B2/ja not_active Expired - Fee Related
- 1997-12-10 HU HU0002869A patent/HU226458B1/hu not_active IP Right Cessation
- 1997-12-10 ES ES97947866T patent/ES2181039T3/es not_active Expired - Lifetime
- 1997-12-11 TW TW086118667A patent/TW438790B/zh not_active IP Right Cessation
- 1997-12-12 AR ARP970105862A patent/AR008939A1/es active IP Right Grant
1999
- 1999-06-10 NO NO992838A patent/NO992838L/no unknown
2002
- 2002-06-11 CN CNB021227608A patent/CN1185226C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2181039T3 (es)	2003-02-16
HU226458B1 (en)	2008-12-29
CZ297324B6 (cs)	2006-11-15
NZ336143A (en)	2002-05-31
KR20000069402A (ko)	2000-11-25
EP0944614B1 (de)	2002-09-11
IL130660A (en)	2002-03-10
CN1105112C (zh)	2003-04-09
KR100433568B1 (ko)	2004-05-31
RU2161617C1 (ru)	2001-01-10
CN1240438A (zh)	2000-01-05
DE69715448D1 (de)	2002-10-17
DE69715448T2 (de)	2003-08-07
ID22753A (id)	1999-12-09
AR008939A1 (es)	2000-02-23
CN1185226C (zh)	2005-01-19
PT944614E (pt)	2003-01-31
CA2274591A1 (en)	1998-06-18
AU718958B2 (en)	2000-05-04
TW438790B (en)	2001-06-07
NO992838D0 (no)	1999-06-10
AU5409798A (en)	1998-07-03
PL191760B1 (pl)	2006-06-30
JP2000514824A (ja)	2000-11-07
BR9714016A (pt)	2000-02-29
CZ206599A3 (cs)	1999-11-17
DK0944614T3 (da)	2003-01-13
EP0944614A1 (de)	1999-09-29
TR199901280T2 (xx)	1999-10-21
WO1998025919A1 (en)	1998-06-18
HUP0002869A3 (en)	2003-01-28
NO992838L (no)	1999-07-20
CA2274591C (en)	2005-06-14
CN1445225A (zh)	2003-10-01
PL334072A1 (en)	2000-01-31
IL130660A0 (en)	2000-06-01
HUP0002869A2 (hu)	2001-06-28
US6083974A (en)	2000-07-04
JP3215441B2 (ja)	2001-10-09
HK1020045A1 (en)	2000-03-10

Legal Events

Date	Code	Title	Description
2003-01-15	UEP	Publication of translation of european patent specification
2010-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69715448D1 (de)	2002-10-17	Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten
ATE307887T1 (de)	2005-11-15	Ob-rezeptor und liganden
DE69828963D1 (de)	2005-03-17	Wirstoffabgabe und gentherapiesystem
DE69834616D1 (de)	2006-06-29	Tastsinnempfindlicher detektor und signalisierungseinheit
DE69825327D1 (de)	2004-09-02	Prüfanordnung und Prüfverfahren
FR11C0020I2 (fr)	2012-03-16	Dérives difluoroprostaglandines et leur application
DE69735732D1 (de)	2006-05-24	Beleuchtungsvorrichtung und diese verwendende Anzeigevorrichtung
DE69723398D1 (de)	2003-08-14	Polyalkylphenoxyaminoalkane und diese enthaltende freibstoffzusammensetzungen
DE69728434D1 (de)	2004-05-06	Ankoppelvorrichtung und flaschen
FI964298A0 (fi)	1996-10-25	Faestningsanordning foer baerbar apparat
DE69607321D1 (de)	2000-04-27	Reinigungsverfahren und zusammensetzung
DE69831755D1 (de)	2006-02-09	Optoakustische kontrastmittel und anwendungsverfahren
DE69832657D1 (de)	2006-01-12	Empfangseinrichtungen und Empfangsverfahren
DE69725961D1 (de)	2003-12-11	Befestigumgsvorrichtung und damit versehene prothese
DE69818248D1 (de)	2003-10-23	Chinolin- und chinazolin-derivate als crf antagonisten
DE69835254D1 (de)	2006-08-31	Empfangseinrichtungen und Empfangsverfahren
DE59711847D1 (de)	2004-09-16	Substituierte aza- und diazacycloheptan- und -cyclooctanverbindungen und deren verwendung
DE69417897D1 (de)	1999-05-20	2-hydroxypropandiaminderivate und diese enthaltende detergenzzubereitung
PT910462E (pt)	2002-06-28	Dispositivo misturador e distribuidor
DE69831750D1 (de)	2006-02-09	Biozide und biozide tücher
DE69716062D1 (de)	2002-11-07	Benzofuran-derivate und deren verwendung
FI963154A0 (fi)	1996-08-12	Foerfarande foer upploesning av zinkslig under atmosfaeriska foer haollanden
DE59705120D1 (de)	2001-12-06	Häckselmaschine und Fördervorrichtung
DE69903961D1 (de)	2002-12-19	Muscarinagonisten und antagonisten
DE69513831D1 (de)	2000-01-13	Semicarbazid-derivate und diese enthaltende coatings