ATE223911T1 - Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten - Google Patents

Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten

Info

Publication number: ATE223911T1
Authority: AT; Austria
Prior art keywords: antagonists containing; pgd2 antagonists; benzothiophenecarboxamide; derivatives; benzothiophenecarboxamide derivatives
Prior art date: 1996-12-13

Application number

AT97947866T

Other languages

English (en)

Inventor

Tsunetoshi Honma

Yoshiharu Hiramatsu

Akinori Arimura

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-13

Filing date

1997-12-10

Publication date

2002-09-15

1997-12-10 Application filed by Shionogi & Co filed Critical Shionogi & Co

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223911T1 publication Critical patent/ATE223911T1/de

Links

GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical class C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 title 1
102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 title 1
101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
BHMBVRSPMRCCGG-OUTUXVNYSA-N prostaglandin D2 Chemical compound CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)[C@@H](O)CC1=O BHMBVRSPMRCCGG-OUTUXVNYSA-N 0.000 title 1
BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT97947866T 1996-12-13 1997-12-10 Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten ATE223911T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP33349596		1996-12-13
JP25400197		1997-09-19
PCT/JP1997/004527 WO1998025919A1 (en)	1996-12-13	1997-12-10	Benzothiophenecarboxamide derivatives and pgd2 antagonists comprising them

Publications (1)

Publication Number	Publication Date
ATE223911T1 true ATE223911T1 (de)	2002-09-15

Family

ID=26541496

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97947866T ATE223911T1 (de)	1996-12-13	1997-12-10	Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten

Country Status (25)

Country	Link
US (1)	US6083974A (de)
EP (1)	EP0944614B1 (de)
JP (1)	JP3215441B2 (de)
KR (1)	KR100433568B1 (de)
CN (2)	CN1105112C (de)
AR (1)	AR008939A1 (de)
AT (1)	ATE223911T1 (de)
AU (1)	AU718958B2 (de)
BR (1)	BR9714016A (de)
CA (1)	CA2274591C (de)
CZ (1)	CZ297324B6 (de)
DE (1)	DE69715448T2 (de)
DK (1)	DK0944614T3 (de)
ES (1)	ES2181039T3 (de)
HU (1)	HU226458B1 (de)
ID (1)	ID22753A (de)
IL (1)	IL130660A (de)
NO (1)	NO992838L (de)
NZ (1)	NZ336143A (de)
PL (1)	PL191760B1 (de)
PT (1)	PT944614E (de)
RU (1)	RU2161617C1 (de)
TR (1)	TR199901280T2 (de)
TW (1)	TW438790B (de)
WO (1)	WO1998025919A1 (de)

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CN1198649C (zh) *	1998-06-03	2005-04-27	盐野义制药株式会社	用于治疗瘙痒的含pgd2受体拮抗剂的药物组合物
AU5430100A (en)	1999-07-02	2001-01-22	Shionogi & Co., Ltd.	Novel process for producing bicyclic amino alcohol
EP1262475A4 (de)	2000-03-09	2005-01-05	Ono Pharmaceutical Co	Indolderivate, verfahren zu ihrer herstellung und deren verwendung
ATE311200T1 (de) *	2000-04-12	2005-12-15	Merck Frosst Canada Inc	Verfahren und zusammensetzungen zur behandlung von allergischen zuständen mit pgd2 rezeptor antagonisten
US6410583B1 (en) *	2000-07-25	2002-06-25	Merck Frosst Canada & Co.	Cyclopentanoindoles, compositions containing such compounds and methods of treatment
US7273883B2 (en)	2000-09-14	2007-09-25	Allergan, Inc.	Prostaglandin EP4 antagonist
US7217725B2 (en)	2000-09-14	2007-05-15	Allergan, Inc.	Prostaglandin D2 antagonist
US6693203B2 (en)	2000-10-17	2004-02-17	Shionogi & Co., Ltd	Process for the preparation of PGD2 antagonist
US6933317B2 (en) *	2000-11-01	2005-08-23	Shionogi & Co. Ltd.	PGD2 receptor antagonistic pharmaceutical compositions
AR038136A1 (es)	2002-01-24	2004-12-29	Merck Frosst Canada Inc	Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
MXPA04009095A (es)	2002-03-19	2004-12-06	Ono Pharmaceutical Co	Compuesto de acido carboxilico y agente farmaceutico que comprende el compuesto como ingrediente activo.
AU2003252499B2 (en) *	2002-07-12	2007-11-08	Japan Science And Technology Agency	Drugs for improving the prognosis of brain injury and a method of screening the same
JPWO2004030674A1 (ja) *	2002-09-30	2006-01-26	塩野義製薬株式会社	プロスタグランジンｄ▲下２▼、プロスタグランジンｄ▲下２▼アゴニストおよびプロスタグランジンｄ▲下２▼アンタゴニストの新規用途
WO2004039807A1 (en)	2002-10-30	2004-05-13	Merck Frosst Canada & Co.	Pyridopyrrolizine and pyridoindolizine derivatives
US7714132B2 (en)	2004-03-11	2010-05-11	Actelion Pharmaceuticals, Ltd.	Tetrahydropyridoindole derivatives
JPWO2006068162A1 (ja) *	2004-12-24	2008-06-12	塩野義製薬株式会社	慢性閉塞性肺疾患の治療剤
TW200716093A (en) *	2005-04-28	2007-05-01	Shionogi & Co	An antiasthmatic agent containing PGD2 receptor antagonist and leukotriene receptor antagonist
TWI410410B (zh)	2007-08-10	2013-10-01	Ono Pharmaceutical Co	Phenylacetic acid compounds
JP5731538B2 (ja)	2009-12-23	2015-06-10	アイアンウッドファーマシューティカルズインコーポレイテッド	Ｃｒｔｈ２モジュレーター
WO2011115804A1 (en)	2010-03-17	2011-09-22	Ironwood Pharmaceuticals, Inc.	Sgc stimulators
EP2588465B1 (de)	2010-06-30	2017-01-25	Ironwood Pharmaceuticals, Inc.	Sgc-stimulatoren
US20130259830A1 (en)	2010-07-12	2013-10-03	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
WO2012009137A1 (en)	2010-07-12	2012-01-19	Ironwood Pharmaceuticals, Inc.	Crth2 modulators
CN107266433A (zh)	2010-11-09	2017-10-20	铁木医药有限公司	sGC刺激剂
CN106117194A (zh)	2011-12-27	2016-11-16	铁木医药有限公司	可用作sgc刺激剂的2‑苄基、3‑(嘧啶‑2‑基)取代的吡唑类
WO2014047111A1 (en)	2012-09-18	2014-03-27	Ironwood Pharmaceuticals, Inc.	Sgc stimulators
EP2897953B8 (de)	2012-09-19	2019-06-26	Cyclerion Therapeutics, Inc.	Sgc-stimulatoren
EA033168B1 (ru)	2013-03-15	2019-09-30	Сайклерион Терапьютикс, Инк.	СТИМУЛЯТОРЫ sGC
CA2933250A1 (en)	2013-12-11	2015-06-18	Ironwood Pharmaceuticals, Inc.	Sgc stimulators
EP3094327A1 (de)	2014-01-13	2016-11-23	Ironwood Pharmaceuticals, Inc.	Verwendung von sgc-stimulatoren zur behandlung von neuromuskulären störungen
EP3194382B1 (de)	2014-09-17	2021-09-08	Cyclerion Therapeutics, Inc.	Pyrazolderivate als sgc-stimulatoren
EP3194386A2 (de)	2014-09-17	2017-07-26	Ironwood Pharmaceuticals, Inc.	Sgc-stimulatoren
US20170298055A1 (en)	2014-09-17	2017-10-19	Ironwood Pharmaceuticals, Inc.	sGC STIMULATORS
JP6770522B2 (ja)	2015-02-13	2020-10-14	アンスティチュナショナルドゥラサンテエドゥラルシェルシュメディカル	全身性エリテマトーデスを予防し、及び／又は、治療するためのｐｔｇｄｒ−１及び／又はｐｔｇｄｒ−２アンタゴニスト
CN109563087A (zh)	2016-07-07	2019-04-02	铁木医药有限公司	sGC刺激剂的固体形式
EA039683B1 (ru)	2016-07-07	2022-02-28	Сайклерион Терапьютикс, Инк.	ФОСФОРСОДЕРЖАЩИЕ ПРОЛЕКАРСТВА СТИМУЛЯТОРОВ sGC

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CA2268164A1 (en) *	1996-10-08	1998-04-16	Yao-Chang Xu	New serotonin 5-ht1f agonists

1997
- 1997-12-10 PL PL334072A patent/PL191760B1/pl not_active IP Right Cessation
- 1997-12-10 AU AU54097/98A patent/AU718958B2/en not_active Ceased
- 1997-12-10 NZ NZ336143A patent/NZ336143A/en unknown
- 1997-12-10 EP EP97947866A patent/EP0944614B1/de not_active Expired - Lifetime
- 1997-12-10 TR TR1999/01280T patent/TR199901280T2/xx unknown
- 1997-12-10 CN CN97180628A patent/CN1105112C/zh not_active Expired - Fee Related
- 1997-12-10 CA CA002274591A patent/CA2274591C/en not_active Expired - Fee Related
- 1997-12-10 WO PCT/JP1997/004527 patent/WO1998025919A1/en not_active Ceased
- 1997-12-10 HU HU0002869A patent/HU226458B1/hu not_active IP Right Cessation
- 1997-12-10 ID IDW990472A patent/ID22753A/id unknown
- 1997-12-10 US US09/308,176 patent/US6083974A/en not_active Expired - Lifetime
- 1997-12-10 CZ CZ0206599A patent/CZ297324B6/cs not_active IP Right Cessation
- 1997-12-10 AT AT97947866T patent/ATE223911T1/de not_active IP Right Cessation
- 1997-12-10 JP JP52649298A patent/JP3215441B2/ja not_active Expired - Fee Related
- 1997-12-10 IL IL13066097A patent/IL130660A/en not_active IP Right Cessation
- 1997-12-10 ES ES97947866T patent/ES2181039T3/es not_active Expired - Lifetime
- 1997-12-10 DK DK97947866T patent/DK0944614T3/da active
- 1997-12-10 BR BR9714016-3A patent/BR9714016A/pt active Search and Examination
- 1997-12-10 DE DE69715448T patent/DE69715448T2/de not_active Expired - Lifetime
- 1997-12-10 RU RU99115766/04A patent/RU2161617C1/ru not_active IP Right Cessation
- 1997-12-10 KR KR10-1999-7005154A patent/KR100433568B1/ko not_active Expired - Fee Related
- 1997-12-10 PT PT97947866T patent/PT944614E/pt unknown
- 1997-12-11 TW TW086118667A patent/TW438790B/zh not_active IP Right Cessation
- 1997-12-12 AR ARP970105862A patent/AR008939A1/es active IP Right Grant
1999
- 1999-06-10 NO NO992838A patent/NO992838L/no unknown
2002
- 2002-06-11 CN CNB021227608A patent/CN1185226C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HUP0002869A2 (hu)	2001-06-28
BR9714016A (pt)	2000-02-29
CN1445225A (zh)	2003-10-01
ID22753A (id)	1999-12-09
HUP0002869A3 (en)	2003-01-28
TW438790B (en)	2001-06-07
AR008939A1 (es)	2000-02-23
RU2161617C1 (ru)	2001-01-10
DE69715448T2 (de)	2003-08-07
WO1998025919A1 (en)	1998-06-18
EP0944614B1 (de)	2002-09-11
HU226458B1 (en)	2008-12-29
CN1105112C (zh)	2003-04-09
PL334072A1 (en)	2000-01-31
IL130660A (en)	2002-03-10
CN1185226C (zh)	2005-01-19
AU5409798A (en)	1998-07-03
HK1020045A1 (en)	2000-03-10
ES2181039T3 (es)	2003-02-16
US6083974A (en)	2000-07-04
KR20000069402A (ko)	2000-11-25
DE69715448D1 (de)	2002-10-17
EP0944614A1 (de)	1999-09-29
CZ297324B6 (cs)	2006-11-15
AU718958B2 (en)	2000-05-04
CA2274591C (en)	2005-06-14
CZ206599A3 (cs)	1999-11-17
IL130660A0 (en)	2000-06-01
PT944614E (pt)	2003-01-31
JP2000514824A (ja)	2000-11-07
JP3215441B2 (ja)	2001-10-09
KR100433568B1 (ko)	2004-05-31
CN1240438A (zh)	2000-01-05
CA2274591A1 (en)	1998-06-18
NO992838D0 (no)	1999-06-10
TR199901280T2 (xx)	1999-10-21
DK0944614T3 (da)	2003-01-13
PL191760B1 (pl)	2006-06-30
NO992838L (no)	1999-07-20
NZ336143A (en)	2002-05-31

Legal Events

Date	Code	Title	Description
2003-01-15	UEP	Publication of translation of european patent specification
2010-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69715448D1 (de)	2002-10-17	Benzothiophenecarboxamid-derivate und diese enthaltende pgd2 antagonisten
ATE307887T1 (de)	2005-11-15	Ob-rezeptor und liganden
DE69828963D1 (de)	2005-03-17	Wirstoffabgabe und gentherapiesystem
DE69834616D1 (de)	2006-06-29	Tastsinnempfindlicher detektor und signalisierungseinheit
DE69825327D1 (de)	2004-09-02	Prüfanordnung und Prüfverfahren
FR11C0020I2 (fr)	2012-03-16	Dérives difluoroprostaglandines et leur application
DE69735732D1 (de)	2006-05-24	Beleuchtungsvorrichtung und diese verwendende Anzeigevorrichtung
DE69723398D1 (de)	2003-08-14	Polyalkylphenoxyaminoalkane und diese enthaltende freibstoffzusammensetzungen
DE69710335D1 (de)	2002-03-21	Wirkstoffabgebende zusatzmittel und diese enthaltende reinigungsmittelstücke
DE69728434D1 (de)	2004-05-06	Ankoppelvorrichtung und flaschen
FI964298A0 (fi)	1996-10-25	Faestningsanordning foer baerbar apparat
DE69607321D1 (de)	2000-04-27	Reinigungsverfahren und zusammensetzung
DE69831755D1 (de)	2006-02-09	Optoakustische kontrastmittel und anwendungsverfahren
DE69725961D1 (de)	2003-12-11	Befestigumgsvorrichtung und damit versehene prothese
DE69818248D1 (de)	2003-10-23	Chinolin- und chinazolin-derivate als crf antagonisten
DE69835254D1 (de)	2006-08-31	Empfangseinrichtungen und Empfangsverfahren
DE59711847D1 (de)	2004-09-16	Substituierte aza- und diazacycloheptan- und -cyclooctanverbindungen und deren verwendung
DE69417897D1 (de)	1999-05-20	2-hydroxypropandiaminderivate und diese enthaltende detergenzzubereitung
PT910462E (pt)	2002-06-28	Dispositivo misturador e distribuidor
DE69831750D1 (de)	2006-02-09	Biozide und biozide tücher
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