ATE228821T1 - Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung - Google Patents

Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung

Info

Publication number
ATE228821T1
ATE228821T1 AT94909393T AT94909393T ATE228821T1 AT E228821 T1 ATE228821 T1 AT E228821T1 AT 94909393 T AT94909393 T AT 94909393T AT 94909393 T AT94909393 T AT 94909393T AT E228821 T1 ATE228821 T1 AT E228821T1
Authority
AT
Austria
Prior art keywords
particles
suspensions
lipid
solid lipid
delivery systems
Prior art date
Application number
AT94909393T
Other languages
English (en)
Inventor
Kirsten Westesen
Britta Siekmann
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Application granted granted Critical
Publication of ATE228821T1 publication Critical patent/ATE228821T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/044—Suspensions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0245—Specific shapes or structures not provided for by any of the groups of A61K8/0241
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/48—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids
    • B01F23/482—Mixing liquids with liquids; Emulsifying characterised by the nature of the liquids using molten solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/50—Mixing liquids with solids
    • B01F23/51—Methods thereof
    • B01F23/511—Methods thereof characterised by the composition of the liquids or solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Dentistry (AREA)
  • Medical Informatics (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Geometry (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT94909393T 1993-03-05 1994-03-04 Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung ATE228821T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2750193A 1993-03-05 1993-03-05
CA002091152A CA2091152C (en) 1993-03-05 1993-03-05 Solid lipid particles, particles of bioactive agents and methods for the manfuacture and use thereof
PCT/SE1994/000185 WO1994020072A1 (en) 1993-03-05 1994-03-04 Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof

Publications (1)

Publication Number Publication Date
ATE228821T1 true ATE228821T1 (de) 2002-12-15

Family

ID=25675967

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94909393T ATE228821T1 (de) 1993-03-05 1994-03-04 Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung

Country Status (13)

Country Link
EP (1) EP0687172B1 (de)
JP (2) JP3916249B2 (de)
AT (1) ATE228821T1 (de)
AU (1) AU676279B2 (de)
CA (1) CA2091152C (de)
DE (1) DE69431831T2 (de)
DK (1) DK0687172T3 (de)
ES (1) ES2190439T3 (de)
FI (1) FI114006B (de)
NO (1) NO314285B1 (de)
NZ (1) NZ262541A (de)
PT (1) PT687172E (de)
WO (1) WO1994020072A1 (de)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5885486A (en) * 1993-03-05 1999-03-23 Pharmaciaand Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
US5785976A (en) * 1993-03-05 1998-07-28 Pharmacia & Upjohn Ab Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof
PT101422B (pt) * 1993-12-06 1997-06-30 Ineti Inst Biotec Q F E Tecnol Formulacoes lipossomicas contendo vidarabina e/ou derivados, com indice terapeutico elevado e processo para a sua preparacao
DE4440337A1 (de) * 1994-11-11 1996-05-15 Dds Drug Delivery Services Ges Pharmazeutische Nanosuspensionen zur Arzneistoffapplikation als Systeme mit erhöhter Sättigungslöslichkeit und Lösungsgeschwindigkeit
US5747001A (en) * 1995-02-24 1998-05-05 Nanosystems, L.L.C. Aerosols containing beclomethazone nanoparticle dispersions
WO1996025918A1 (en) 1995-02-24 1996-08-29 Nanosystems L.L.C. Aerosols containing nanoparticle dispersions
DE19517147C2 (de) * 1995-05-10 1999-07-01 Hexal Pharmaforschung Gmbh Aciclovir-Zubereitung
US7255877B2 (en) 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
CZ299790B6 (cs) * 1996-08-22 2008-11-26 Skyepharma Canada Inc. Kompozice mikrocástic ve vode nerozpustné látky, farmaceutická kompozice, zpusob prípravy stabilních cástic, mikrocástice ve vode nerozpustné nebo slabe rozpustné slouceniny, kompozice obsahující tyto mikrocástice a zpusob prípravy mikrocástic
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
DE19641259A1 (de) * 1996-10-07 1998-04-16 Kade Pharma Fab Gmbh Arzneimittel auf Basis von Diclofenac
PT936860E (pt) * 1996-10-25 2002-07-31 Monsanto Technology Llc Composicao e metodo para tratamento de plantas com quimicos exogenos
ES2182048T3 (es) 1996-10-25 2003-03-01 Monsanto Technology Llc Composicion y procedimiento para tratar plantas con sustancias quimicas exogenas.
GB9624615D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Chrystallisation process
GB9625589D0 (en) * 1996-12-10 1997-01-29 Boots Co Plc Therapeutic agents
IT1292142B1 (it) * 1997-06-12 1999-01-25 Maria Rosa Gasco Composizione farmaceutica in forma di microparticelle lipidiche solide atte alla somministrazione parenterale
US6423363B1 (en) * 1997-08-22 2002-07-23 Lipton, Division Of Conopco, Inc. Aqueous dispersion
AU1809499A (en) * 1997-12-10 1999-06-28 Awadhesh K. Mishra Self-emulsifying fenofibrate formulations
IT1298575B1 (it) * 1998-02-06 2000-01-12 Vectorpharma Int Composizioni farmaceutiche in forma di nanoparticelle comprendenti sostanze lipidiche e sostanze antifiliche e relativo processo di
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
SE512958C2 (sv) † 1998-04-30 2000-06-12 Triple Crown Ab Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning
GB9810859D0 (en) * 1998-05-20 1998-07-22 Zeneca Ltd Crystallisation process
AU3776999A (en) * 1998-06-17 2000-01-05 Uniroyal Chemical Company, Inc. Biologically-active microdispersion composition
ITMI981528A1 (it) * 1998-07-03 2000-01-03 Recordati Ind Chimica E Farma Formulazioni topiche di aciclovir
JP4198318B2 (ja) 1998-08-19 2008-12-17 ヤーゴテック アクチェンゲゼルシャフト プロポフォールの注射可能水性分散物
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US7939105B2 (en) 1998-11-20 2011-05-10 Jagotec Ag Process for preparing a rapidly dispersing solid drug dosage form
IT1303787B1 (it) 1998-11-25 2001-02-23 Maria Rosa Gasco "nanosfere lipidiche solide atte ad una rapida internalizzazione nellecellule"
DE19919770A1 (de) * 1999-04-30 2000-11-02 Henkel Kgaa Verwendung nanoskaliger antimikrobieller Wirkstoffe in der Mund- und/oder Zahnpflege
SE517769C2 (sv) 1999-10-29 2002-07-16 Triple Crown Ab Kolesterol och blodfettsänkande komposition, innehållande fytosteroler, blandade med monoglycerider
KR20020026053A (ko) 2000-09-30 2002-04-06 노승권 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료
US20040077604A1 (en) 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6607784B2 (en) 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
AU2002337692B2 (en) 2001-09-26 2007-09-13 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
AU2003223852A1 (en) 2002-02-28 2003-09-09 Wolf-Dieter Juelich Micro/nanoparticle obtained from lipid-containing marine organisms for use in pharmaceutics and cosmetics
CN1289005C (zh) * 2002-03-20 2006-12-13 优俊科学公司 包含植物甾醇的食物及其制备方法
JP4452970B2 (ja) 2002-03-27 2010-04-21 日本臓器製薬株式会社 ジクロフェナクナトリウム経口製剤
EP2283864A1 (de) * 2002-07-16 2011-02-16 Elan Pharma International Ltd. Flüssige Zusammensetzung enthaltend stabilisierte Wirkstoff-Nanopartikeln
ITMI20021725A1 (it) * 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.
EP1585548B1 (de) 2002-12-09 2018-06-27 Abraxis BioScience, LLC Zusammensetzungen, pharmakologisch wirksame agenzien enthaltend und wirkstofffreigabemethoden
DE10312763A1 (de) * 2003-03-21 2004-09-30 IFAC Institut für angewandte Colloidtechnologie GmbH & Co. KG Verfahren zur Herstellung einer SLN-Dispersion
FR2852843B1 (fr) 2003-03-24 2008-05-23 Karim Ioualalen Systeme galenique permettant le masquage du gout
JP2004323444A (ja) * 2003-04-25 2004-11-18 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai 凍結乾燥微粒子製剤およびその製法
US7438903B2 (en) * 2003-06-06 2008-10-21 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
JP2007503418A (ja) 2003-08-27 2007-02-22 バイヤースドルフ・アクチエンゲゼルシヤフト 局所使用中に個別には感知不能になる外皮を有するカプセル
US8741320B2 (en) 2003-08-27 2014-06-03 Beiersdorf Ag Spherical cosmetic preparations for topical application
DE10357640A1 (de) 2003-08-27 2005-03-24 Beiersdorf Ag Kosmetische kugelförmige Zubereitungen zur topischen Anwendung
JP2005097295A (ja) * 2003-09-01 2005-04-14 Wakunaga Pharmaceut Co Ltd ビタミン安定液剤
CA2560900A1 (en) 2004-03-26 2005-10-06 Cell Therapeutics Europe S.R.L. Nanoparticle formulations of platinum compounds
US7803366B2 (en) 2004-05-07 2010-09-28 Nbty, Inc. Methods and compositions that enhance bioavailability of coenzyme-Q10
EP1674085A1 (de) * 2004-12-22 2006-06-28 Universite Libre De Bruxelles Feste Lipidteilchen als pharmazeutische annehmbare Füllstoffe oder Träger zur Inhalation
KR20130079645A (ko) 2005-07-18 2013-07-10 유니버시티 오브 메사츄세츠 로웰 나노에멀젼 조성물 및 이의 제조 및 사용 방법
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
US7943666B2 (en) 2006-07-24 2011-05-17 Trinity Laboratories, Inc. Esters of capsaicin for treating pain
WO2008070538A2 (en) 2006-12-01 2008-06-12 Anterios, Inc. Micellar nanoparticles comprising botulinum toxin
SG10201607909WA (en) 2006-12-01 2016-11-29 Anterios Inc Peptide nanoparticles and uses therefor
WO2008102065A1 (fr) * 2007-02-14 2008-08-28 Commissariat A L'energie Atomique Emulsions fluorescentes pour l'imagerie optique
WO2008131170A1 (en) 2007-04-18 2008-10-30 Particle Sciences, Inc, Aerosol dispersions of particles with active pharmaceutical ingredients
CN101765423B (zh) 2007-05-31 2014-08-06 安特里奥公司 核酸纳米粒子和其用途
JP5468271B2 (ja) * 2008-02-08 2014-04-09 花王株式会社 微粒子分散液の製造方法
DE102008035442A1 (de) 2008-07-26 2010-01-28 Ernst-Moritz-Arndt-Universität Greifswald Zubereitungen aus Artemisia Annua, ihre Umwandlung in Mikro- und Nanopartikel und ihre Verwendung
FR2934955B1 (fr) 2008-08-14 2011-07-08 Commissariat Energie Atomique Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions
FR2934953B1 (fr) 2008-08-14 2011-01-21 Commissariat Energie Atomique Nanoemulsions de nanocristaux
FR2934954B1 (fr) * 2008-08-14 2011-07-22 Commissariat Energie Atomique Emulsion fluorescente de vert d'indocyanine
MX2011002847A (es) 2008-09-19 2011-04-07 Activus Pharma Co Ltd Polvo de compuesto organico combinado para uso medico y metodo de produccion y suspension del mismo.
WO2010138539A2 (en) 2009-05-27 2010-12-02 Elan Pharma International Ltd. Reduction of flake-like aggregation in nanoparticulate active agent compositions
JP5824511B2 (ja) 2010-05-03 2015-11-25 テイコク ファーマ ユーエスエー インコーポレーテッド 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法
WO2012059936A1 (en) 2010-11-03 2012-05-10 Padma Venkitachalam Devarajan Pharmaceutical compositions for colloidal drug delivery
WO2013105026A1 (en) * 2012-01-09 2013-07-18 Department Of Biotechnology (Dbt) A process for preparing solid lipid sustained release nanoparticles for delivery of vitamins
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
WO2014054172A1 (ja) * 2012-10-05 2014-04-10 株式会社原田食品 ゾル状低カロリー食品素材および包装容器体入ゾル状低カロリー食品素材およびそれらの製造方法
JP6357481B2 (ja) * 2012-11-30 2018-07-11 インスメッド， インコーポレイテッド プロスタサイクリン化合物およびプロスタサイクリン化合物を使用する方法
EP2823811A1 (de) * 2013-07-09 2015-01-14 OTC GmbH Gerichtetes aktives Freisetzungssystem mit festen Lipidnanopartikeln
SI3060041T1 (sl) 2013-10-25 2021-04-30 Insmed Incorporated Spojine prostaciklina
US11458096B2 (en) 2014-04-09 2022-10-04 Pulse Pharmaceuticals Pvt. Ltd. Composition and method of producing nanoformulation of water insoluble bioactives in aqueous base
EP3904326A1 (de) 2014-11-18 2021-11-03 Insmed Incorporated Verfahren zur herstellung von treprostinil und treprostinilderivat-prodrugs
EP3510161A4 (de) 2016-08-23 2020-04-22 Akouos, Inc. Zusammensetzungen und verfahren zur behandlung von nicht altersbedingten hörschäden bei einer person
EP3541358A1 (de) 2016-11-21 2019-09-25 Eirion Therapeutics, Inc. Transdermale verabreichung von grossen wirkstoffen
CN114072136B (zh) 2019-04-29 2024-11-29 英斯梅德股份有限公司 曲前列素前药的干粉组合物及其使用方法
EP4054348B1 (de) 2019-12-10 2026-01-28 Lonza Sales AG Partikel mit einem lipid-matrix-kern und einem wirkstoff
CN116096905A (zh) 2020-02-21 2023-05-09 阿库斯股份有限公司 用于治疗人受试者的非年龄相关性听力损伤的组合物和方法
AU2022248850A1 (en) * 2021-03-27 2023-11-09 TRx Biosciences Limited Compositions having improved bioavailability of therapeutics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421468A1 (de) * 1984-06-08 1985-12-19 Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung
DE3702029A1 (de) * 1987-01-24 1988-08-04 Basf Ag Waessriges oder pulverfoermiges, wasserdispergierbares praeparat eines in wasser schwerloeslichen pharmazeutischen wirkstoffs und verfahren zu seiner herstellung
CA2068216C (en) * 1989-11-13 1999-04-13 Abraham J. Domb Lipospheres for controlled delivery of substances
AU658608B2 (en) * 1991-03-25 1995-04-27 Astellas Pharma Europe B.V. Topical preparation containing a suspension of solid lipid particles

Also Published As

Publication number Publication date
DE69431831D1 (de) 2003-01-16
FI954143L (fi) 1995-10-19
FI954143A0 (fi) 1995-09-04
EP0687172B1 (de) 2002-12-04
WO1994020072A1 (en) 1994-09-15
JPH08507515A (ja) 1996-08-13
PT687172E (pt) 2003-04-30
JP2007023051A (ja) 2007-02-01
JP3916249B2 (ja) 2007-05-16
CA2091152C (en) 2005-05-03
NO314285B1 (no) 2003-03-03
CA2091152A1 (en) 1994-09-06
ES2190439T3 (es) 2003-08-01
DK0687172T3 (da) 2003-03-17
FI114006B (fi) 2004-07-30
NZ262541A (en) 1997-04-24
NO953461D0 (no) 1995-09-04
AU676279B2 (en) 1997-03-06
DE69431831T2 (de) 2003-04-10
AU6225394A (en) 1994-09-26
EP0687172A1 (de) 1995-12-20
NO953461L (no) 1995-11-06

Similar Documents

Publication Publication Date Title
DE69431831D1 (de) Feste lipidpartikel, partikel von bioaktiven wirkstoffen und verfahren für ihre herstellung und verwendung
DE69124357T2 (de) Protein Nanomatrizen und Verfahren zur Herstellung
Xue et al. Polymer–protein conjugate particles with biocatalytic activity for stabilization of water-in-water emulsions
CA2294172C (en) Pharmaceutical composition in form of solid lipidic microparticles suitable to parenteral administration
DE3783958T2 (de) Verzoegerte abgabe von makromolekularen polypeptiden.
US5405616A (en) Means for containing active substances, having a shell of hydrophilic macromolecules, active substances and process for preparation thereof
DE69609222T2 (de) Partikel auf Polyaminosäure(n)basis zur Verwendung als Wirkstoffträger sowie deren Herstellungsverfahren
KR102385203B1 (ko) 골 형태 발생 단백질 및 폴리-l-락틱산 필러와 히알루론산 필러 결합체를 함유하는 서방성 주사제제 및 그 제조방법
LU91613I2 (fr) Paclitaxel albumin (Abraxane - paclitaxel)
MX337149B (es) Nuevas formulaciones de agentes farmacologicos, metodos para su preparacion y metodos para el uso de los mismos.
DE69415684T2 (de) Verfahren zur herstellung von mikrospharen mit einer wirbelschichtstufe
GB2237510B (en) Small particle drug compositions for nasal administration
NO962088D0 (no) Preparat for in vivo-produksjon av terapeutiske produkter
HUT63954A (en) Process for producing active ingredient containing microparticldes from hydrolytically degredable polymers
BR0007985A (pt) Processo para a preparação de derivados multiplamente reticulados do ácido hialurÈnico (ha), ha multiplamente reticulado, ha reticulado em um ou mais polìmeros diferentes de ha, ha reticulado em um segundo polìmero, produto, e, uso de um derivado de ha multiplamente reticulado
DE3486029T2 (de) Ifn-praeparat mit verzoegerter abgabe fuer parentale verabreichung.
DE69104539D1 (de) Granulare Zubereitungen und Verfahren zur ihrer Herstellung.
Clements et al. Injectable biomaterials for delivery of interleukin-1 receptor antagonist: toward improving its therapeutic effect
NO960232L (no) Fremgangsmåte for belegging av dråper eller nanopartikler
JPH062224B2 (ja) 極小粒子形の蛋白質の分散性コロイド系の調製方法
JP4121372B2 (ja) 生分解性ポリマー型薬物放出システム
DE69904701T2 (de) Physiologisch aktives polypeptid enthaltende zubereitung mit verzögerter freisetzung und deren herstellung
Cui et al. Surface entrapment of polylysine in biodegradable poly (DL-lactide-co-glycolide) microparticles
Rao et al. Controlled release systems for proteins based on gelatin microspheres
ATE453400T1 (de) Pharmazeutische formulierungen für die verzögerte freisetzung von interferonen und ihre therapeutischen anwendungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0687172

Country of ref document: EP

REN Ceased due to non-payment of the annual fee