ES2189345T3 - Derivados de la 9-amino y 9-nitrocamptotecina, procedimiento para su preparacion y su aplicacion como agentes antitumorales. - Google Patents

Derivados de la 9-amino y 9-nitrocamptotecina, procedimiento para su preparacion y su aplicacion como agentes antitumorales.

Info

Publication number
ES2189345T3
ES2189345T3 ES99202203T ES99202203T ES2189345T3 ES 2189345 T3 ES2189345 T3 ES 2189345T3 ES 99202203 T ES99202203 T ES 99202203T ES 99202203 T ES99202203 T ES 99202203T ES 2189345 T3 ES2189345 T3 ES 2189345T3
Authority
ES
Spain
Prior art keywords
formula
compound
amino
nitrocamptotecine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99202203T
Other languages
English (en)
Inventor
Walter Cabri
Ilaria Candiani
Franco Zarini
Angelo Bedeschi
Sergio Penco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Application granted granted Critical
Publication of ES2189345T3 publication Critical patent/ES2189345T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F23—COMBUSTION APPARATUS; COMBUSTION PROCESSES
    • F23C—METHODS OR APPARATUS FOR COMBUSTION USING FLUID FUEL OR SOLID FUEL SUSPENDED IN  A CARRIER GAS OR AIR 
    • F23C5/00—Disposition of burners with respect to the combustion chamber or to one another; Mounting of burners in combustion apparatus
    • F23C5/02—Structural details of mounting

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento de preparación de 9-amino camptotecina de fórmula (I) *fórmula *. Dicho procedimiento comprende: (1) hacer reaccionar un compuesto de fórmula (III) *fórmula * en la que el grupo hidroxi en el anillo A está en posición 10 o 12, con un agente de nitración, obteniéndose el compuesto correspondiente de fórmula (IV) *fórmula *, (2) se convierte el compuesto de fórmula (IV) en el correspondiente compuesto de fórmula (V) *fórmula * en la que XO es un grupo que se puede eliminar de manera reductora; y (3) se elimina de manera reductora dicho grupo XO y se reduce el grupo nitro del compuesto de fórmula (V), obteniéndose la 9-amino camptotecina de fórmula (I), que es un compuesto antitumoral conocido. La presente invención incluye también entre sus objetivos compuestos que tienen la fórmula (V) anterior y compuestos de fórmula (VII) que están dotados con actividad antitumoral.
ES99202203T 1993-09-28 1994-09-15 Derivados de la 9-amino y 9-nitrocamptotecina, procedimiento para su preparacion y su aplicacion como agentes antitumorales. Expired - Lifetime ES2189345T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939319944A GB9319944D0 (en) 1993-09-28 1993-09-28 Process for the preparation of 9-amino camptothecin

Publications (1)

Publication Number Publication Date
ES2189345T3 true ES2189345T3 (es) 2003-07-01

Family

ID=10742611

Family Applications (2)

Application Number Title Priority Date Filing Date
ES94927618T Expired - Lifetime ES2144059T3 (es) 1993-09-28 1994-09-15 Procedimiento de preparacion de la 9-amino camptotecina.
ES99202203T Expired - Lifetime ES2189345T3 (es) 1993-09-28 1994-09-15 Derivados de la 9-amino y 9-nitrocamptotecina, procedimiento para su preparacion y su aplicacion como agentes antitumorales.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES94927618T Expired - Lifetime ES2144059T3 (es) 1993-09-28 1994-09-15 Procedimiento de preparacion de la 9-amino camptotecina.

Country Status (21)

Country Link
US (2) US5614628A (es)
EP (2) EP0982307B1 (es)
JP (3) JP3754068B2 (es)
KR (1) KR950704323A (es)
CN (2) CN1046283C (es)
AT (2) ATE229022T1 (es)
AU (1) AU676089B2 (es)
CA (1) CA2150382C (es)
DE (2) DE69422795T2 (es)
DK (2) DK0670839T3 (es)
ES (2) ES2144059T3 (es)
FI (1) FI952549A7 (es)
GB (1) GB9319944D0 (es)
GR (1) GR3033197T3 (es)
HU (1) HUT71267A (es)
IL (3) IL120073A (es)
MY (1) MY131618A (es)
PT (2) PT670839E (es)
RU (1) RU2137774C1 (es)
WO (1) WO1995009169A1 (es)
ZA (1) ZA947522B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
GB9410388D0 (en) * 1994-05-24 1994-07-13 Erba Carlo Spa Method for the preparation of 9-amino camptothecin
TW438775B (en) * 1995-04-07 2001-06-07 Pharmacia & Upjohn Co Llc Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
US6504029B1 (en) * 1995-04-10 2003-01-07 Daiichi Pharmaceutical Co., Ltd. Condensed-hexacyclic compounds and a process therefor
GB9510716D0 (en) * 1995-05-26 1995-07-19 Pharmacia Spa Substituted camptothecin derivatives and process for their preparation
GB9600438D0 (en) * 1996-01-10 1996-03-13 Pharmacia Spa Hexacyclic camptothecin analogues, and process for preparing them
GB9601779D0 (en) * 1996-01-30 1996-04-03 Pharmacia Spa 9, 10 Disubstituted camptothecin derivatives
US5731316A (en) * 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6395541B1 (en) 1996-05-23 2002-05-28 The Rockefeller University Methods for the identification of compounds capable of inhibiting HIV-1 viral replication employing murine cell lines expressing human topoisomerase I
GB9702807D0 (en) 1997-02-12 1997-04-02 Pharmacia & Upjohn Spa Alkynyl-substituted camptothecins and process for their preparation
GB9715821D0 (en) * 1997-07-25 1997-10-01 Pharmacia & Upjohn Spa Amidino-camptothecin derivatives
US5922877A (en) * 1997-08-05 1999-07-13 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
USRE38408E1 (en) 1997-08-05 2004-01-27 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7049322B2 (en) * 2002-02-21 2006-05-23 Supergen, Inc. Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor
CN100334089C (zh) * 2004-07-21 2007-08-29 王洋 一种9－硝基喜树碱的生产方法
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
CN1312155C (zh) * 2005-01-21 2007-04-25 华东理工大学 一种分离纯化9－硝基喜树碱的方法
CA2765630C (en) 2009-06-26 2016-07-05 Taris Biomedical, Inc. Solid drug tablets for implantable drug delivery devices

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
GB9316352D0 (en) * 1993-08-06 1993-09-22 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation

Also Published As

Publication number Publication date
AU7696994A (en) 1995-04-18
CN1115181A (zh) 1996-01-17
KR950704323A (ko) 1995-11-17
IL120073A (en) 1999-07-14
ES2144059T3 (es) 2000-06-01
CA2150382A1 (en) 1995-04-06
US5916897A (en) 1999-06-29
FI952549A7 (fi) 1995-07-21
DE69431856T2 (de) 2003-08-21
JPH08506834A (ja) 1996-07-23
EP0982307A2 (en) 2000-03-01
US5614628A (en) 1997-03-25
HUT71267A (en) 1995-11-28
DK0982307T3 (da) 2003-03-24
EP0982307B1 (en) 2002-12-04
IL111066A0 (en) 1994-12-29
JP2005036004A (ja) 2005-02-10
JP3754068B2 (ja) 2006-03-08
DE69422795T2 (de) 2000-07-20
IL111066A (en) 1999-12-31
AU676089B2 (en) 1997-02-27
ATE229022T1 (de) 2002-12-15
RU95112485A (ru) 1997-04-20
CA2150382C (en) 2006-12-05
DE69422795D1 (de) 2000-03-02
PT670839E (pt) 2000-05-31
DK0670839T3 (da) 2002-12-23
PT982307E (pt) 2003-04-30
JP2005036003A (ja) 2005-02-10
EP0670839B1 (en) 2000-01-26
GR3033197T3 (en) 2000-08-31
RU2137774C1 (ru) 1999-09-20
ATE189221T1 (de) 2000-02-15
WO1995009169A1 (en) 1995-04-06
DE69431856D1 (de) 2003-01-16
GB9319944D0 (en) 1993-11-17
EP0982307A3 (en) 2000-07-26
CN1273974A (zh) 2000-11-22
FI952549A0 (fi) 1995-05-24
MY131618A (en) 2007-08-30
ZA947522B (en) 1995-05-29
EP0670839A1 (en) 1995-09-13
HU9501898D0 (en) 1995-08-28
IL120073A0 (en) 1997-04-15
CN1046283C (zh) 1999-11-10

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