ATE230738T1 - Verfahren zur herstellung von citalopram - Google Patents
Verfahren zur herstellung von citalopramInfo
- Publication number
- ATE230738T1 ATE230738T1 AT99950506T AT99950506T ATE230738T1 AT E230738 T1 ATE230738 T1 AT E230738T1 AT 99950506 T AT99950506 T AT 99950506T AT 99950506 T AT99950506 T AT 99950506T AT E230738 T1 ATE230738 T1 AT E230738T1
- Authority
- AT
- Austria
- Prior art keywords
- producing citalopram
- citalopram
- producing
- Prior art date
Links
- WSEQXVZVJXJVFP-UHFFFAOYSA-N 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile Chemical compound O1CC2=CC(C#N)=CC=C2C1(CCCN(C)C)C1=CC=C(F)C=C1 WSEQXVZVJXJVFP-UHFFFAOYSA-N 0.000 title 1
- 229960001653 citalopram Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002242 IT1302700B1 (it) | 1998-10-20 | 1998-10-20 | Procedimento per la preparazione di un derivato dell'isobenzofurano |
| IT1999MI001152 IT1312319B1 (it) | 1999-05-25 | 1999-05-25 | Procedimento per la preparazione del citalopram. |
| IT1999MI001724 IT1313587B1 (it) | 1999-08-02 | 1999-08-02 | Procedimento per la preparazione di un derivato del5-cianoisobenzofurano. |
| PCT/DK1999/000576 WO2000023431A1 (en) | 1998-10-20 | 1999-10-19 | Method for the preparation of citalopram |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE230738T1 true ATE230738T1 (de) | 2003-01-15 |
Family
ID=27274104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99950506T ATE230738T1 (de) | 1998-10-20 | 1999-10-19 | Verfahren zur herstellung von citalopram |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6365747B1 (de) |
| EP (1) | EP1123284B1 (de) |
| JP (1) | JP3892667B2 (de) |
| KR (1) | KR100411505B1 (de) |
| CN (1) | CN1129592C (de) |
| AR (1) | AR018693A1 (de) |
| AT (1) | ATE230738T1 (de) |
| AU (1) | AU746665B2 (de) |
| BG (1) | BG64704B1 (de) |
| BR (1) | BR9915158B1 (de) |
| CA (1) | CA2291134C (de) |
| CZ (1) | CZ299920B6 (de) |
| DE (1) | DE69904853T2 (de) |
| DK (1) | DK1123284T3 (de) |
| EA (1) | EA002977B1 (de) |
| ES (1) | ES2189502T3 (de) |
| HK (1) | HK1042297B (de) |
| HU (1) | HU228576B1 (de) |
| IL (1) | IL142346A0 (de) |
| IS (1) | IS2256B (de) |
| NO (1) | NO327038B1 (de) |
| NZ (1) | NZ510858A (de) |
| PL (1) | PL199423B1 (de) |
| SK (1) | SK285719B6 (de) |
| WO (1) | WO2000023431A1 (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL143422A0 (en) | 1998-12-23 | 2002-04-21 | Lundbeck & Co As H | Method for the preparation of 5-cyanophthalide |
| AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
| DK1173431T4 (da) † | 1999-04-14 | 2010-01-04 | Lundbeck & Co As H | Fremgangsmåde til fremstilling af citalopram |
| ITMI991581A1 (it) * | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| AR021155A1 (es) * | 1999-07-08 | 2002-06-12 | Lundbeck & Co As H | Tratamiento de desordenes neuroticos |
| HRP20020344B1 (hr) | 1999-10-25 | 2010-10-31 | H. Lundbeck A/S | Način priprave citaloprama |
| GB2360281B (en) | 1999-10-25 | 2002-01-16 | Lundbeck & Co As H | Method for the preparation of citalopram |
| AR026063A1 (es) | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
| HUP0203635A3 (en) | 1999-12-28 | 2005-02-28 | Lundbeck & Co As H | Method for the preparation of citalopram |
| PT1246813E (pt) | 1999-12-30 | 2004-02-27 | Lundbeck & Co As H | Metodo para a preparacao de citalopram |
| CN1195749C (zh) * | 2000-01-14 | 2005-04-06 | H.隆德贝克有限公司 | 制备5－氰基2－苯并[c]呋喃酮的方法 |
| IT1317729B1 (it) * | 2000-01-18 | 2003-07-15 | Norpharma S P A | Procedimento per la preparazione della 5-carbossiftalide. |
| NL1017415C1 (nl) | 2000-02-24 | 2001-05-18 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
| NL1017417C1 (nl) | 2000-03-03 | 2001-03-16 | Lundbeck & Co As H | Werkwijze voor de bereiding van Citalopram. |
| GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
| IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| CN1427835A (zh) | 2000-03-13 | 2003-07-02 | H·隆德贝克有限公司 | 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化 |
| KR20020080481A (ko) | 2000-03-13 | 2002-10-23 | 하. 룬트벡 아크티에 셀스카브 | 시탈로프람의 제조 방법 |
| GB2357762B (en) | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
| TR200202155T2 (tr) | 2000-03-14 | 2002-12-23 | H. Lundbeck A/S | Sitalopramin preparasyon metodu |
| DE10190485T1 (de) * | 2000-03-16 | 2002-03-21 | Lundbeck & Co As H | Verfahren zur Herstellung von 5-Cyano-1-(4-fluorphenyl)-1,3-dihydroisobenzofuranen |
| US6977306B2 (en) | 2000-05-02 | 2005-12-20 | Sumitomo Chemical Company, Limited | Citalopram hydrobromide crystal and method for crystallization thereof |
| AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
| CA2354877C (en) | 2000-08-18 | 2006-05-02 | H. Lundbeck A/S | Method for the preparation of citalopram |
| WO2001045483A2 (en) * | 2000-12-22 | 2001-06-28 | H. Lundbeck A/S | Method for the preparation of pure citalopram |
| JP2003519121A (ja) * | 2000-12-28 | 2003-06-17 | ハー・ルンドベック・アクチエゼルスカベット | 純粋なシタロプラムの製造方法 |
| EP1355897A1 (de) | 2001-01-30 | 2003-10-29 | Orion Corporation Fermion | Verfahren zur herstellung von 1-(3-dimethylaminopropyl)-1-(4-fluorphenyl)-1,3-dihydrobenzofuran-5-carbonitrile |
| WO2002087566A1 (en) * | 2001-05-01 | 2002-11-07 | H. Lundbeck A/S | The use of enantiomeric pure escitalopram |
| IL159326A0 (en) | 2001-07-31 | 2004-06-01 | Lundbeck & Co As H | Crystalline composition containing escitalopram |
| IS7239A (is) * | 2001-12-14 | 2004-04-29 | H. Lundbeck A/S | Aðferð til framleiðslu á essítalóprami |
| US7148364B2 (en) | 2002-01-07 | 2006-12-12 | Sun Pharmaceutical Industries | Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile |
| US7192939B2 (en) * | 2002-01-30 | 2007-03-20 | Montana State University | Pestalotiopsis microsporia isolates and compounds derived therefrom |
| CA2381341A1 (en) * | 2002-04-09 | 2003-10-09 | Torcan Chemical Ltd. | Process and intermediates for preparing escitalopram |
| AR040970A1 (es) | 2002-08-12 | 2005-04-27 | Lundbeck & Co As H | Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram |
| US6812355B2 (en) | 2002-10-22 | 2004-11-02 | Sekhsaria Chemicals Limited | Process for the manufacture of citalopram hydrobromide from 5-bromophthalide |
| AU2003287919B2 (en) * | 2002-12-23 | 2009-11-12 | H. Lundbeck A/S | Escitalopram hydrobromide and a method for the preparation thereof |
| US7019153B2 (en) | 2003-06-10 | 2006-03-28 | Sun Pharmaceutical Industries Limited | Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid |
| CN100569765C (zh) * | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
| TWI339651B (en) | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| ITMI20040717A1 (it) * | 2004-04-09 | 2004-07-09 | Adorkem Technology Spa | Procedimento chemo-enzimatico per la preparazione dell'escitalopram |
| JP2006008603A (ja) * | 2004-06-25 | 2006-01-12 | Sumitomo Chemical Co Ltd | 光学活性シタロプラムの製造方法、その中間体およびその製造方法 |
| ES2285972T1 (es) | 2004-08-23 | 2007-12-01 | Sun Pharmaceutical Industries Limited | Procedimiento de fabricacion de citalopram y enantiomeros. |
| WO2006090409A1 (en) * | 2005-02-28 | 2006-08-31 | Kekule Pharma Ltd., | An improved process for the preparation of 5 - carboxyphthalide |
| GB2442619B (en) * | 2005-05-04 | 2010-05-26 | Pharmed Medicare Pvt Ltd | Chlorination of sucrose acylates using triphosgene |
| CN101157674B (zh) * | 2005-07-12 | 2010-04-14 | 西陇化工股份有限公司 | 西酞普兰盐的提纯方法 |
| US8258291B2 (en) * | 2006-10-25 | 2012-09-04 | Mamtek International Limited | Process for the preparation of sucralose by the chlorination of sugar with triphosgene (BTC) |
| US9339500B2 (en) * | 2008-03-04 | 2016-05-17 | Intra-Cellular Therapies, Inc. | Methods of treating vasomotor symptoms |
| US9346777B2 (en) * | 2012-09-06 | 2016-05-24 | MediSynergics, LLC | Antiprotozoal compounds |
| US9284291B2 (en) * | 2014-07-29 | 2016-03-15 | MediSynergies, LLC | Kappa opioid receptor compounds |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1143703A (de) | 1965-03-18 | |||
| GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8419963D0 (en) | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| DK213290D0 (da) * | 1990-09-06 | 1990-09-06 | Lundbeck & Co As H | Treatment of cerebrovascular disorders |
| DE19626659A1 (de) | 1996-07-03 | 1998-01-08 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
| DE19627697A1 (de) | 1996-07-10 | 1998-01-15 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
| ES2148120T3 (es) | 1997-07-08 | 2002-01-16 | Lundbeck & Co As H | Metodo para la preparacion de citalopram. |
| UA62985C2 (en) * | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
| EA002770B1 (ru) | 1997-11-11 | 2002-08-29 | Х.Лундбекк А/С | Способ получения циталопрама |
| IL143422A0 (en) | 1998-12-23 | 2002-04-21 | Lundbeck & Co As H | Method for the preparation of 5-cyanophthalide |
| AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
| DK1173431T4 (da) | 1999-04-14 | 2010-01-04 | Lundbeck & Co As H | Fremgangsmåde til fremstilling af citalopram |
| GB2360281B (en) | 1999-10-25 | 2002-01-16 | Lundbeck & Co As H | Method for the preparation of citalopram |
| US6310222B1 (en) | 1999-11-01 | 2001-10-30 | Sumika Fine Chemicals Co., Ltd. | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate |
-
1999
- 1999-10-19 PL PL347189A patent/PL199423B1/pl not_active IP Right Cessation
- 1999-10-19 IL IL14234699A patent/IL142346A0/xx not_active IP Right Cessation
- 1999-10-19 KR KR10-2001-7004889A patent/KR100411505B1/ko not_active Expired - Fee Related
- 1999-10-19 EP EP99950506A patent/EP1123284B1/de not_active Expired - Lifetime
- 1999-10-19 ES ES99950506T patent/ES2189502T3/es not_active Expired - Lifetime
- 1999-10-19 AT AT99950506T patent/ATE230738T1/de active
- 1999-10-19 JP JP2000577159A patent/JP3892667B2/ja not_active Expired - Fee Related
- 1999-10-19 NZ NZ510858A patent/NZ510858A/en not_active IP Right Cessation
- 1999-10-19 SK SK535-2001A patent/SK285719B6/sk not_active IP Right Cessation
- 1999-10-19 US US09/830,109 patent/US6365747B1/en not_active Expired - Lifetime
- 1999-10-19 DE DE69904853T patent/DE69904853T2/de not_active Expired - Lifetime
- 1999-10-19 BR BRPI9915158-8A patent/BR9915158B1/pt not_active IP Right Cessation
- 1999-10-19 CN CN99812369A patent/CN1129592C/zh not_active Expired - Fee Related
- 1999-10-19 WO PCT/DK1999/000576 patent/WO2000023431A1/en not_active Ceased
- 1999-10-19 HU HU0104128A patent/HU228576B1/hu unknown
- 1999-10-19 AU AU63260/99A patent/AU746665B2/en not_active Ceased
- 1999-10-19 CZ CZ20011418A patent/CZ299920B6/cs not_active IP Right Cessation
- 1999-10-19 HK HK02103712.9A patent/HK1042297B/zh not_active IP Right Cessation
- 1999-10-19 EA EA200100457A patent/EA002977B1/ru not_active IP Right Cessation
- 1999-10-19 DK DK99950506T patent/DK1123284T3/da active
- 1999-10-19 CA CA002291134A patent/CA2291134C/en not_active Expired - Fee Related
- 1999-10-20 AR ARP990105305A patent/AR018693A1/es active IP Right Grant
-
2001
- 2001-03-30 IS IS5911A patent/IS2256B/is unknown
- 2001-04-19 NO NO20011936A patent/NO327038B1/no not_active IP Right Cessation
- 2001-04-20 BG BG105457A patent/BG64704B1/bg unknown
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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