ZA801770B - Novel heterocyclic substituted pyrazinoylguanidines and a process for preparing same - Google Patents
Novel heterocyclic substituted pyrazinoylguanidines and a process for preparing sameInfo
- Publication number
- ZA801770B ZA801770B ZA00801770A ZA801770A ZA801770B ZA 801770 B ZA801770 B ZA 801770B ZA 00801770 A ZA00801770 A ZA 00801770A ZA 801770 A ZA801770 A ZA 801770A ZA 801770 B ZA801770 B ZA 801770B
- Authority
- ZA
- South Africa
- Prior art keywords
- preparing same
- pyrazinoylguanidines
- heterocyclic substituted
- novel heterocyclic
- substituted pyrazinoylguanidines
- Prior art date
Links
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- WNBSDCKJFDZMHT-UHFFFAOYSA-N n-(diaminomethylidene)pyrazine-2-carboxamide Chemical class NC(N)=NC(=O)C1=CN=CC=N1 WNBSDCKJFDZMHT-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- -1 heterocyclic pyrazinoylguanidines Chemical class 0.000 abstract 1
- 230000001452 natriuretic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/024,293 US4246406A (en) | 1979-03-27 | 1979-03-27 | Heterocyclic substituted pyrazinoylguanidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA801770B true ZA801770B (en) | 1981-11-25 |
Family
ID=21819847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00801770A ZA801770B (en) | 1979-03-27 | 1980-03-25 | Novel heterocyclic substituted pyrazinoylguanidines and a process for preparing same |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4246406A (de) |
| EP (1) | EP0017152B1 (de) |
| JP (2) | JPS55130965A (de) |
| AT (1) | ATE2323T1 (de) |
| AU (1) | AU533298B2 (de) |
| DE (1) | DE3061733D1 (de) |
| DK (1) | DK129180A (de) |
| IE (1) | IE49578B1 (de) |
| NO (1) | NO152560C (de) |
| ZA (1) | ZA801770B (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4594349A (en) * | 1982-01-04 | 1986-06-10 | Beyer Jr Karl H | Hyperuretic agents |
| US4496573A (en) * | 1982-08-24 | 1985-01-29 | William H. Rorer, Inc. | 1-Pyridylmethyl-3-acyl guanidines |
| US4512991A (en) * | 1982-12-27 | 1985-04-23 | Merck & Co., Inc. | 3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds |
| US6858614B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| US6858615B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| AU2003295402A1 (en) * | 2002-11-06 | 2004-06-03 | Bristol-Myers Squibb Company | Acyl guanidine compounds and use thereof |
| US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| AU2004266704B2 (en) * | 2003-08-18 | 2012-02-23 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| US20070021439A1 (en) * | 2005-07-25 | 2007-01-25 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers |
| GB0526244D0 (en) | 2005-12-22 | 2006-02-01 | Novartis Ag | Organic compounds |
| CN101687851B (zh) | 2007-05-07 | 2013-02-27 | 诺瓦提斯公司 | 有机化合物 |
| CL2008003651A1 (es) | 2007-12-10 | 2009-06-19 | Novartis Ag | Compuestos derivados de 3,5-diamino-6-cloropirazinamida sustituida; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de una condición inflamatoria o alergica, en particular una enfermedad inflamatoria u obstructiva de las vias respiratorias. |
| US20110098311A1 (en) | 2009-10-22 | 2011-04-28 | Vertex Pharmaceuticals Incorported | Compositions for treatment of cystic fibrosis and other chronic diseases |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| SG10201708931XA (en) | 2012-12-17 | 2017-12-28 | Parion Sciences Inc | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
| RU2018138195A (ru) | 2012-12-17 | 2018-12-18 | Пэрион Сайенсиз, Инк. | Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| WO2025133218A1 (en) * | 2023-12-21 | 2025-06-26 | Phamri Norden Ab | Pyrazine derivatives for the treatment of skin disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6409714A (de) * | 1962-10-30 | 1965-10-01 | ||
| BE639386A (de) * | 1962-10-30 | |||
| US3328404A (en) * | 1966-08-25 | 1967-06-27 | Merck & Co Inc | Derivatives of pyrazine |
| US3432502A (en) * | 1966-08-25 | 1969-03-11 | Merck & Co Inc | Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products |
| NL6707564A (de) * | 1966-08-25 | 1968-02-26 | ||
| US4087526A (en) * | 1976-07-23 | 1978-05-02 | Merck & Co., Inc. | (3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens |
-
1979
- 1979-03-27 US US06/024,293 patent/US4246406A/en not_active Expired - Lifetime
-
1980
- 1980-03-18 AU AU56536/80A patent/AU533298B2/en not_active Ceased
- 1980-03-25 IE IE608/80A patent/IE49578B1/en unknown
- 1980-03-25 ZA ZA00801770A patent/ZA801770B/xx unknown
- 1980-03-26 EP EP80101589A patent/EP0017152B1/de not_active Expired
- 1980-03-26 AT AT80101589T patent/ATE2323T1/de not_active IP Right Cessation
- 1980-03-26 DE DE8080101589T patent/DE3061733D1/de not_active Expired
- 1980-03-26 DK DK129180A patent/DK129180A/da not_active IP Right Cessation
- 1980-03-26 NO NO800878A patent/NO152560C/no unknown
- 1980-03-27 JP JP8038319A patent/JPS55130965A/ja active Pending
-
1981
- 1981-03-18 JP JP3804081A patent/JPS56158771A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU533298B2 (en) | 1983-11-17 |
| NO152560C (no) | 1985-10-16 |
| NO800878L (no) | 1980-09-29 |
| IE49578B1 (en) | 1985-10-30 |
| NO152560B (no) | 1985-07-08 |
| ATE2323T1 (de) | 1983-02-15 |
| JPS55130965A (de) | 1980-10-11 |
| DK129180A (da) | 1980-09-28 |
| JPS56158771A (en) | 1981-12-07 |
| IE800608L (en) | 1980-09-27 |
| EP0017152A1 (de) | 1980-10-15 |
| US4246406A (en) | 1981-01-20 |
| EP0017152B1 (de) | 1983-01-26 |
| DE3061733D1 (en) | 1983-03-03 |
| AU5653680A (en) | 1980-10-02 |
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