DK129180A - Femgangsmaade til fremstilling af pyrazinoylguanidiner - Google Patents

Femgangsmaade til fremstilling af pyrazinoylguanidiner

Info

Publication number: DK129180A
Authority: DK; Denmark
Prior art keywords: pyrazinoylguanidines; preparing; heterocyclic; eukalemic; preparing same
Prior art date: 1979-03-27

Application number

DK129180A

Other languages

Danish (da)

English (en)

Inventor

E J Cragoe

O W Woltersdorf

S J D Solms

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-27

Filing date

1980-03-26

Publication date

1980-09-28

1980-03-26 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1980-09-28 Publication of DK129180A publication Critical patent/DK129180A/da

Links

239000003795 chemical substances by application Substances 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000001882 diuretic effect Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
-1 heterocyclic pyrazinoylguanidines Chemical class 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
WNBSDCKJFDZMHT-UHFFFAOYSA-N n-(diaminomethylidene)pyrazine-2-carboxamide Chemical class NC(N)=NC(=O)C1=CN=CC=N1 WNBSDCKJFDZMHT-UHFFFAOYSA-N 0.000 abstract 1
230000001452 natriuretic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Glass Compositions (AREA)
Iron Core Of Rotating Electric Machines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK129180A 1979-03-27 1980-03-26 Femgangsmaade til fremstilling af pyrazinoylguanidiner DK129180A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/024,293 US4246406A (en)	1979-03-27	1979-03-27	Heterocyclic substituted pyrazinoylguanidines

Publications (1)

Publication Number	Publication Date
DK129180A true DK129180A (da)	1980-09-28

Family

ID=21819847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK129180A DK129180A (da)	1979-03-27	1980-03-26	Femgangsmaade til fremstilling af pyrazinoylguanidiner

Country Status (10)

Country	Link
US (1)	US4246406A (de)
EP (1)	EP0017152B1 (de)
JP (2)	JPS55130965A (de)
AT (1)	ATE2323T1 (de)
AU (1)	AU533298B2 (de)
DE (1)	DE3061733D1 (de)
DK (1)	DK129180A (de)
IE (1)	IE49578B1 (de)
NO (1)	NO152560C (de)
ZA (1)	ZA801770B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4594349A (en) *	1982-01-04	1986-06-10	Beyer Jr Karl H	Hyperuretic agents
US4496573A (en) *	1982-08-24	1985-01-29	William H. Rorer, Inc.	1-Pyridylmethyl-3-acyl guanidines
US4512991A (en) *	1982-12-27	1985-04-23	Merck & Co., Inc.	3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds
US6858614B2 (en)	2002-02-19	2005-02-22	Parion Sciences, Inc.	Phenolic guanidine sodium channel blockers
US6858615B2 (en)	2002-02-19	2005-02-22	Parion Sciences, Inc.	Phenyl guanidine sodium channel blockers
AU2003295402A1 (en) *	2002-11-06	2004-06-03	Bristol-Myers Squibb Company	Acyl guanidine compounds and use thereof
US6903105B2 (en) *	2003-02-19	2005-06-07	Parion Sciences, Inc.	Sodium channel blockers
SI1663235T1 (sl) *	2003-08-18	2013-12-31	Parion Sciences, Inc.	ZaĹˇÄŤiteni pirazinoilgvanidinski blokatorji natrijevega kanala
US7745442B2 (en)	2003-08-20	2010-06-29	Parion Sciences, Inc.	Methods of reducing risk of infection from pathogens
US20090253714A1 (en) *	2003-08-20	2009-10-08	Johnson Michael R	Methods of reducing risk of infection from pathogens
US7399766B2 (en) *	2004-08-18	2008-07-15	Parion Sciences, Inc.	Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US20070021439A1 (en) *	2005-07-25	2007-01-25	Parion Sciences, Inc.	Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
GB0526244D0 (en)	2005-12-22	2006-02-01	Novartis Ag	Organic compounds
KR20100005730A (ko)	2007-05-07	2010-01-15	노파르티스 아게	유기 화합물
EA017919B1 (ru)	2007-12-10	2013-04-30	Новартис Аг	Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов
EP2813227A1 (de)	2009-10-22	2014-12-17	Vertex Pharmaceuticals Incorporated	Zusammensetzungen für die Behandlung von Mukoviszidose und anderen chronischen Erkrankungen
AR086745A1 (es)	2011-06-27	2014-01-22	Parion Sciences Inc	3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
PE20151054A1 (es)	2012-12-17	2015-08-07	Parion Sciences Inc	Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales
MX2015007797A (es)	2012-12-17	2015-10-05	Parion Sciences Inc	Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida.
US9102633B2 (en)	2013-12-13	2015-08-11	Parion Sciences, Inc.	Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
WO2025133218A1 (en) *	2023-12-21	2025-06-26	Phamri Norden Ab	Pyrazine derivatives for the treatment of skin disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE639386A (de) *	1962-10-30
NL6409714A (de) *	1962-10-30	1965-10-01
NL6707564A (de) *	1966-08-25	1968-02-26
US3328404A (en) *	1966-08-25	1967-06-27	Merck & Co Inc	Derivatives of pyrazine
US3432502A (en) *	1966-08-25	1969-03-11	Merck & Co Inc	Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products
US4087526A (en) *	1976-07-23	1978-05-02	Merck & Co., Inc.	(3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens

1979
- 1979-03-27 US US06/024,293 patent/US4246406A/en not_active Expired - Lifetime
1980
- 1980-03-18 AU AU56536/80A patent/AU533298B2/en not_active Ceased
- 1980-03-25 IE IE608/80A patent/IE49578B1/en unknown
- 1980-03-25 ZA ZA00801770A patent/ZA801770B/xx unknown
- 1980-03-26 DE DE8080101589T patent/DE3061733D1/de not_active Expired
- 1980-03-26 AT AT80101589T patent/ATE2323T1/de not_active IP Right Cessation
- 1980-03-26 EP EP80101589A patent/EP0017152B1/de not_active Expired
- 1980-03-26 NO NO800878A patent/NO152560C/no unknown
- 1980-03-26 DK DK129180A patent/DK129180A/da not_active IP Right Cessation
- 1980-03-27 JP JP8038319A patent/JPS55130965A/ja active Pending
1981
- 1981-03-18 JP JP3804081A patent/JPS56158771A/ja active Pending

Also Published As

Publication number	Publication date
IE800608L (en)	1980-09-27
EP0017152B1 (de)	1983-01-26
IE49578B1 (en)	1985-10-30
NO800878L (no)	1980-09-29
EP0017152A1 (de)	1980-10-15
JPS55130965A (de)	1980-10-11
AU5653680A (en)	1980-10-02
DE3061733D1 (en)	1983-03-03
NO152560B (no)	1985-07-08
JPS56158771A (en)	1981-12-07
ZA801770B (en)	1981-11-25
NO152560C (no)	1985-10-16
AU533298B2 (en)	1983-11-17
ATE2323T1 (de)	1983-02-15
US4246406A (en)	1981-01-20

Legal Events

Date	Code	Title	Description
1985-12-02	AHB	Application shelved due to non-payment
1989-01-16	PBP	Patent lapsed

Publication	Publication Date	Title
JPS55130965A (de)	1980-10-11
DK233880A (da)	1980-12-02	Fremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4,-triaziner
NO791553L (no)	1979-11-13	Stroempe.
NL161666C (nl)	1980-03-17	Schoudergewrichtprothese.
NO802619L (no)	1981-03-09	Kolofoniumdispersjoner.
FI803639A7 (fi)	1981-05-28	Liitoskappale.
NL185265C (nl)	1990-03-01	Urineerhulpmiddel.
DK147379A (da)	1979-10-12	Fremgangsmaade til fremstilling af histaminantagonister
DK153379A (da)	1979-10-15	Fremgangsmaade til fremstilling af n,n,n!,n!-tetraacetylethylendiamin
IT7924119A0 (it)	1979-07-05	Mandrino espandibile.
DK412280A (da)	1980-09-30	Fremgangsmaade til komprimering af formsand
FI803127A7 (fi)	1981-04-04	Heterosyklisiä yhdisteitä.
NL178738C (nl)	1986-11-17	Instelschakeling.
DK129280A (da)	1980-09-28	Fremgangsmaade til fremstilling af pyrazincarboxamider
NO153703C (no)	1986-05-07	Ladebord.
NO802453L (no)	1981-02-18	Heterocykliske forbindelser.
FI801242A7 (fi)	1981-01-01	Hylsylukko.
DK238280A (da)	1980-12-05	Fremgangsmaade til fremstilling af 10,11-dihydro5h-dibenzo(a,d)cyclohepten-5,10-iminer
NL7901561A (nl)	1979-08-29	Temperatuur-gestabiliseerde resonator.
DK40479A (da)	1979-08-02	Fremgangsmaade til fremstilling af monorden
NO144471C (no)	1981-09-09	Trinse for skistav.
DK214479A (da)	1979-11-25	Fremgangsmaade til fremstilling af 2,4-diamono-5-(3,5-dialkyl-4-hydroxybenzyl) pyrimidiner
DK93180A (da)	1980-10-09	Fremgangsmaade til fremstilling af trazenforbindelser
DK212080A (da)	1980-11-30	Fremgangsmaade til fremstilling af 2,2-dialkyl-4-methyl-5,5-dialkyl-3-formyl-3-pyrrolin
IT8023142A0 (it)	1980-06-30	Derivati prostaciclinici.