PL184824B1 - Pochodne amidynonaftylowe oraz ich sole oraz kompozycja farmaceutyczna zawierająca pochodną amidynonaftylową lub jej sól - Google Patents

Pochodne amidynonaftylowe oraz ich sole oraz kompozycja farmaceutyczna zawierająca pochodną amidynonaftylową lub jej sól

Info

Publication number
PL184824B1
PL184824B1 PL95320486A PL32048695A PL184824B1 PL 184824 B1 PL184824 B1 PL 184824B1 PL 95320486 A PL95320486 A PL 95320486A PL 32048695 A PL32048695 A PL 32048695A PL 184824 B1 PL184824 B1 PL 184824B1
Authority
PL
Poland
Prior art keywords
group
methyl
phenyl
naphthyl
oxy
Prior art date
Application number
PL95320486A
Other languages
English (en)
Polish (pl)
Other versions
PL320486A1 (en
Inventor
Fukushi Hirayama
Hiroyuki Koshio
Yuzo Matsumoto
Tomihisa Kawasaki
Seiji Kaku
Isao Yanagisawa
Original Assignee
Yamanouchi Pharmaceu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceu filed Critical Yamanouchi Pharmaceu
Publication of PL320486A1 publication Critical patent/PL320486A1/xx
Publication of PL184824B1 publication Critical patent/PL184824B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL95320486A 1994-12-02 1995-12-01 Pochodne amidynonaftylowe oraz ich sole oraz kompozycja farmaceutyczna zawierająca pochodną amidynonaftylową lub jej sól PL184824B1 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP29996394 1994-12-02
JP10520595 1995-04-28
JP19881695 1995-08-03
PCT/JP1995/002458 WO1996016940A1 (en) 1994-12-02 1995-12-01 Novel amidinonaphthyl derivative or salt thereof

Publications (2)

Publication Number Publication Date
PL320486A1 PL320486A1 (en) 1997-09-29
PL184824B1 true PL184824B1 (pl) 2002-12-31

Family

ID=27310425

Family Applications (1)

Application Number Title Priority Date Filing Date
PL95320486A PL184824B1 (pl) 1994-12-02 1995-12-01 Pochodne amidynonaftylowe oraz ich sole oraz kompozycja farmaceutyczna zawierająca pochodną amidynonaftylową lub jej sól

Country Status (20)

Country Link
US (1) US5869501A (de)
EP (1) EP0798295B1 (de)
JP (1) JP3004362B2 (de)
KR (1) KR100383161B1 (de)
CN (1) CN1087736C (de)
AT (1) ATE233240T1 (de)
AU (1) AU688628B2 (de)
CA (1) CA2206532C (de)
DE (1) DE69529770T2 (de)
ES (1) ES2193202T3 (de)
FI (1) FI115051B (de)
HU (1) HUT77313A (de)
MX (1) MX9704059A (de)
NO (1) NO309566B1 (de)
NZ (1) NZ296210A (de)
PL (1) PL184824B1 (de)
PT (1) PT798295E (de)
RU (1) RU2154633C2 (de)
TW (1) TW300888B (de)
WO (1) WO1996016940A1 (de)

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US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
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US6258822B1 (en) 1997-08-06 2001-07-10 Abbott Laboratories Urokinase inhibitors
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US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
DE19754490A1 (de) * 1997-12-09 1999-06-10 Boehringer Ingelheim Pharma Durch einen Aminocarbonylrest substituierte Bicyclen, ihre Herstellung und ihre Verwendung als Arzneimittel
CA2318351A1 (en) * 1997-12-26 1999-07-08 Hidemitsu Nishida Aromatic compounds having cyclic amino or salts thereof
WO1999037643A1 (en) * 1998-01-26 1999-07-29 Yamanouchi Pharmaceutical Co., Ltd. Novel benzene-fused heterocyclic derivatives or salts thereof
EP0937723A1 (de) * 1998-02-18 1999-08-25 Roche Diagnostics GmbH Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
EP1066272A4 (de) * 1998-03-27 2002-03-13 Biocryst Pharm Inc Neue verbindungen, die im komplement-, koagulat- und kallikrein-reaktionsweg nützlich sind und verfahren zu ihrer herstellung
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US6504031B1 (en) 1998-08-06 2003-01-07 Milan Bruncko Naphthamidine urokinase inhibitors
US6284796B1 (en) 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
EP1140862A4 (de) 1998-12-23 2004-07-28 Bristol Myers Squibb Pharma Co Inhibitoren von thrombin oder faktor-xa
CN100488947C (zh) 1999-01-13 2009-05-20 杰南技术公司 丝氨酸蛋白酶抑制剂
AU3074700A (en) * 1999-01-22 2000-08-07 Yamanouchi Pharmaceutical Co., Ltd. Medicinal compositions with improved oral absorption
WO2000051998A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
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US6858599B2 (en) 1999-06-30 2005-02-22 Mochida Pharmaceutical Co., Ltd. Tricyclic compound having spiro union
WO2001002356A1 (en) * 1999-07-01 2001-01-11 Sankyo Company, Limited Indoline or tetrahydroquinoline derivatives
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
MXPA02004218A (es) * 1999-10-28 2002-10-17 Sankyo Co Derivados de benzamidina.
EP1095933A1 (de) * 1999-10-30 2001-05-02 Aventis Pharma Deutschland GmbH N-Guanidinoalkylamide, Verfahren zu ihrer Herstellung, ihre Verwendung und pharmazeutische Zusammensetzungen, die sie enthalten
WO2001056989A2 (en) * 2000-02-01 2001-08-09 Cor Therapeutics, Inc. Inhibitors of factor xa
ES2254385T3 (es) 2000-02-29 2006-06-16 Millennium Pharmaceuticals, Inc. Benzamidas e inhibidores relacionados del factor xa.
AU2001249397A1 (en) * 2000-03-24 2001-10-08 Cor Therapeutics, Inc. Oxindole inhibitors of factor xa
AU776053B2 (en) 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
US6495562B1 (en) 2000-04-25 2002-12-17 Abbott Laboratories Naphthamidine urokinase inhibitors
AU2001288819A1 (en) 2000-09-11 2002-03-26 Genentech, Inc. Amidine inhibitors of serine proteases
WO2002042270A1 (en) 2000-11-22 2002-05-30 Yamanouchi Pharmaceutical Co., Ltd. Substituted benzene derivatives or salts thereof
US6710061B2 (en) 2001-03-09 2004-03-23 Ortho-Mcneil Pharamceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
CA2440389A1 (en) 2001-03-09 2002-10-03 Ortho-Mcneil Pharmaceutical, Inc. Aminopyrrolidine sulfonamides as serine protease inhibitors
US7312235B2 (en) 2001-03-30 2007-12-25 Millennium Pharmaceuticals, Inc. Benzamide inhibitors of factor Xa
PL363961A1 (en) 2001-04-05 2004-11-29 Sankyo Company, Limited Benzamidine derivative
HRP20040612A2 (en) * 2002-01-29 2005-04-30 Applied Research Systems Ars Holding N.V. Substituted methylene amide derivatives as modulators of protein tyrosine phosphatases (ptps)
RU2226392C1 (ru) * 2002-10-23 2004-04-10 Биологический факультет Московского государственного университета им. М.В. Ломоносова Способ ингибирования агрегации тромбоцитов
US20070004736A1 (en) 2002-11-22 2007-01-04 Keiji Kubo Imidazole derivative, process for producing the same, and use
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
MXPA05007012A (es) * 2002-12-24 2005-08-18 Daiichi Seiyaku Co Derivados novedosos de etilendiamina.
JP2007500221A (ja) 2003-05-20 2007-01-11 ジェネンテック・インコーポレーテッド 第ＶＩＩａ因子のベンゾフラン阻害剤
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WO2005034867A2 (en) 2003-10-09 2005-04-21 Millennium Pharmaceuticals, Inc. Thioether-substituted benzamides as inhibitors of factor xa
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
CA2565437A1 (en) 2004-06-18 2006-01-05 Millennium Pharmaceuticals, Inc. Factor xa inhibitors
WO2006055951A2 (en) 2004-11-19 2006-05-26 Portola Pharmaceuticals, Inc. Tetrahydroisoquinolines as factor xa inhibitors
WO2006063113A2 (en) 2004-12-07 2006-06-15 Portola Pharmaceuticals, Inc. Ureas as factor xa inhibitors
US20060160790A1 (en) * 2004-12-07 2006-07-20 Portola Pharmaceuticals, Inc. Thioureas as factor Xa inhibitors
EP1847527A4 (de) 2005-02-02 2009-04-08 Ajinomoto Kk Neue benzamidinverbindungen
DK1948608T3 (da) 2005-11-08 2012-07-02 Millennium Pharm Inc Farmaceutiske salte og polymorfe former af N-(5-chlor-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]-benzoyl]amino]-5-methoxybenzamid, en faktor xa-inhibitor
AU2007229637A1 (en) * 2006-03-28 2007-10-04 Novartis Ag Amide derivatives and their application for the treatment of G protein related diseases
US7884234B2 (en) * 2006-10-12 2011-02-08 Institute Of Medicinal Molecular Design, Inc. N-phenyloxamide derivatives
EP2077995B1 (de) 2006-11-02 2012-02-08 Millennium Pharmaceuticals, Inc. Verfahren zur synthetisierung pharmazeutischer salze aus einem faktor-xa-hemmer
EP2090300A4 (de) * 2006-11-30 2010-02-10 Takeda Pharmaceutical Präparat mit verzögerter freisetzung
US8633245B2 (en) * 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor
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EA015918B1 (ru) 2010-03-03 2011-12-30 Дмитрий Геннадьевич ТОВБИН УРЕТАНЫ, МОЧЕВИНЫ, АМИДЫ И РОДСТВЕННЫЕ ИНГИБИТОРЫ ФАКТОРА Xa
US11679093B2 (en) 2018-06-11 2023-06-20 The Regents Of The University Of Colorado, A Body Corporate 2-naphthimidamides, analogues thereof, and methods of treatment using same
CN117304076B (zh) * 2023-11-28 2024-02-20 苏州大学 一种n-磺酰基脒化合物的制备方法

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Also Published As

Publication number Publication date
TW300888B (de) 1997-03-21
ES2193202T3 (es) 2003-11-01
KR100383161B1 (ko) 2003-12-24
NO972482L (no) 1997-08-01
FI115051B (fi) 2005-02-28
MX9704059A (es) 1997-08-30
NO972482D0 (no) 1997-05-30
ATE233240T1 (de) 2003-03-15
EP0798295B1 (de) 2003-02-26
EP0798295A4 (de) 1998-03-04
FI972326A7 (fi) 1997-06-02
FI972326A0 (fi) 1997-06-02
CN1087736C (zh) 2002-07-17
CA2206532A1 (en) 1996-06-06
PT798295E (pt) 2003-07-31
US5869501A (en) 1999-02-09
WO1996016940A1 (en) 1996-06-06
CA2206532C (en) 2006-07-11
RU2154633C2 (ru) 2000-08-20
CN1167484A (zh) 1997-12-10
NO309566B1 (no) 2001-02-19
DE69529770T2 (de) 2003-12-24
HUT77313A (hu) 1998-03-30
DE69529770D1 (de) 2003-04-03
NZ296210A (en) 1998-05-27
JP3004362B2 (ja) 2000-01-31
AU3994295A (en) 1996-06-19
PL320486A1 (en) 1997-09-29
EP0798295A1 (de) 1997-10-01
AU688628B2 (en) 1998-03-12

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Legal Events

Date Code Title Description
LAPS Decisions on the lapse of the protection rights

Effective date: 20051201