ATE233316T1 - Verfahren zur herstellung von rdspa alpha1 - Google Patents

Verfahren zur herstellung von rdspa alpha1

Info

Publication number: ATE233316T1
Authority: AT; Austria
Prior art keywords: rdspa; alpha1; producing; chromatography; ending
Prior art date: 1996-02-05

Application number

AT97901624T

Other languages

English (en)

Inventor

Michael Mccaman

Erno Pungor

Carol Souders

Mei P Tan

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-05

Filing date

1997-01-31

Publication date

2003-03-15

1997-01-31 Application filed by Schering Ag filed Critical Schering Ag

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE233316T1 publication Critical patent/ATE233316T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
238000001042 affinity chromatography Methods 0.000 abstract 1
238000005277 cation exchange chromatography Methods 0.000 abstract 1
238000011210 chromatographic step Methods 0.000 abstract 1
238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Analytical Chemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Paper (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Control Of Motors That Do Not Use Commutators (AREA)
Electric Propulsion And Braking For Vehicles (AREA)

AT97901624T 1996-02-05 1997-01-31 Verfahren zur herstellung von rdspa alpha1 ATE233316T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/597,059 US5731186A (en)	1996-02-05	1996-02-05	Method for the production of rDSPA α1
PCT/EP1997/000441 WO1997029188A1 (en)	1996-02-05	1997-01-31	METHOD FOR THE PRODUCTION OF rDSPA α1

Publications (1)

Publication Number	Publication Date
ATE233316T1 true ATE233316T1 (de)	2003-03-15

Family

ID=24389906

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97901624T ATE233316T1 (de)	1996-02-05	1997-01-31	Verfahren zur herstellung von rdspa alpha1

Country Status (22)

Country	Link
US (1)	US5731186A (de)
EP (1)	EP1015568B1 (de)
JP (1)	JP3805378B2 (de)
KR (1)	KR100508043B1 (de)
CN (1)	CN1242059C (de)
AT (1)	ATE233316T1 (de)
AU (1)	AU706286B2 (de)
CZ (1)	CZ294827B6 (de)
DE (1)	DE69719382T2 (de)
DK (1)	DK1015568T3 (de)
ES (1)	ES2193349T3 (de)
HU (1)	HU223902B1 (de)
IL (1)	IL124952A (de)
NO (1)	NO322527B1 (de)
PL (1)	PL186410B1 (de)
PT (1)	PT1015568E (de)
RU (1)	RU2223315C2 (de)
SK (1)	SK284179B6 (de)
TW (1)	TW385313B (de)
UA (1)	UA62925C2 (de)
WO (1)	WO1997029188A1 (de)
ZA (1)	ZA97948B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100436655B1 (ko) *	2001-07-25	2004-06-22	(주)엘피스바이오텍	광범위한 단백질에 적용할 수 있는 단백질의 농축 및정제 방법
DE10153601A1 (de) *	2001-11-02	2003-05-22	Paion Gmbh	DSPA zur Behandlung von Schlaganfall
WO2007134617A1 (en) *	2006-05-19	2007-11-29	Paion Deutschland Gmbh	Use of desmodus salivary plasminogen activator (dspa) for treating venous thromboembolism
TWI482628B (zh) *	2007-10-18	2015-05-01	Lundbeck & Co As H	新穎之血栓溶解病患次群
WO2011107299A2 (en) *	2010-04-16	2011-09-09	Paion Deutschland Gmbh	Method for the manufacture of recombinant dspa alpha1
US20120258519A1 (en) *	2011-04-10	2012-10-11	Therapeutic Proteins Inc.	Protein Harvesting
CN107921407B (zh)	2015-06-05	2022-07-05	格雷斯公司	生物处理吸附澄清剂及其制备和使用方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3512910A1 (de) *	1985-04-11	1986-10-16	Behringwerke Ag, 3550 Marburg	Verfahren zur reinigung von plasminogenaktivatoren
US4721572A (en) *	1985-07-12	1988-01-26	Miles Laboratories, Inc.	Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices
US4898825A (en) *	1986-05-07	1990-02-06	Mitsui Toatsu Chemicals, Incorporated	Methods for purification of single-chain and double-chain tissue plasminogen activator
JPS6463378A (en) *	1986-08-11	1989-03-09	Mitsui Toatsu Chemicals	Separation of single stranded tpa and double standard tpa
US4929560A (en) *	1988-02-03	1990-05-29	Damon Biotech, Inc.	Recovery of tissue plasminogen activator
IE69054B1 (en) *	1988-07-20	1996-08-07	Schering Ag	Vampire bat salivary plasminogen activators
CA2046632C (en) *	1989-02-13	1999-05-11	Schering Aktiengesellschaft	Thrombolytic from vampire bat saliva
DE3943241A1 (de) *	1989-12-22	1991-06-27	Schering Ag	Thrombolytisch wirkendes kombinationspraeparat
US5141862A (en) *	1990-04-17	1992-08-25	Smithkline Beecham Corporation	Method of purifying tpa or plasminogen activator using a tripeptide of the formula: -X-Y-argininal wherein X and Y are selected from the group consisting of pro,phe,trp and tyr

1996
- 1996-02-05 US US08/597,059 patent/US5731186A/en not_active Expired - Lifetime
1997
- 1997-01-31 WO PCT/EP1997/000441 patent/WO1997029188A1/en not_active Ceased
- 1997-01-31 DK DK97901624T patent/DK1015568T3/da active
- 1997-01-31 CN CNB971920818A patent/CN1242059C/zh not_active Expired - Lifetime
- 1997-01-31 IL IL12495297A patent/IL124952A/en not_active IP Right Cessation
- 1997-01-31 RU RU98116622/12A patent/RU2223315C2/ru active
- 1997-01-31 AT AT97901624T patent/ATE233316T1/de active
- 1997-01-31 DE DE69719382T patent/DE69719382T2/de not_active Expired - Lifetime
- 1997-01-31 ES ES97901624T patent/ES2193349T3/es not_active Expired - Lifetime
- 1997-01-31 EP EP97901624A patent/EP1015568B1/de not_active Expired - Lifetime
- 1997-01-31 HU HU9901029A patent/HU223902B1/hu active IP Right Grant
- 1997-01-31 CZ CZ19982455A patent/CZ294827B6/cs not_active IP Right Cessation
- 1997-01-31 SK SK1032-98A patent/SK284179B6/sk not_active IP Right Cessation
- 1997-01-31 UA UA98094695A patent/UA62925C2/uk unknown
- 1997-01-31 JP JP52796297A patent/JP3805378B2/ja not_active Expired - Lifetime
- 1997-01-31 KR KR10-1998-0706036A patent/KR100508043B1/ko not_active Expired - Lifetime
- 1997-01-31 PL PL97328146A patent/PL186410B1/pl unknown
- 1997-01-31 AU AU15462/97A patent/AU706286B2/en not_active Expired
- 1997-01-31 PT PT97901624T patent/PT1015568E/pt unknown
- 1997-02-05 ZA ZA9700948A patent/ZA97948B/xx unknown
- 1997-08-12 TW TW086111545A patent/TW385313B/zh not_active IP Right Cessation
1998
- 1998-08-04 NO NO19983579A patent/NO322527B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ294827B6 (cs)	2005-03-16
PL328146A1 (en)	1999-01-18
RU2223315C2 (ru)	2004-02-10
CN1242059C (zh)	2006-02-15
JP2000504565A (ja)	2000-04-18
AU1546297A (en)	1997-08-28
KR19990082306A (ko)	1999-11-25
HK1018795A1 (en)	2000-01-07
NO983579L (no)	1998-10-05
HUP9901029A3 (en)	2001-10-29
IL124952A (en)	2002-08-14
CN1210559A (zh)	1999-03-10
AU706286B2 (en)	1999-06-10
NO322527B1 (no)	2006-10-16
KR100508043B1 (ko)	2005-12-21
DE69719382D1 (de)	2003-04-03
UA62925C2 (en)	2004-01-15
HU223902B1 (hu)	2005-03-29
PL186410B1 (pl)	2004-01-30
PT1015568E (pt)	2003-07-31
TW385313B (en)	2000-03-21
SK103298A3 (en)	1999-03-12
WO1997029188A1 (en)	1997-08-14
ES2193349T3 (es)	2003-11-01
NO983579D0 (no)	1998-08-04
SK284179B6 (sk)	2004-10-05
US5731186A (en)	1998-03-24
ZA97948B (en)	1997-08-19
HUP9901029A2 (hu)	1999-07-28
JP3805378B2 (ja)	2006-08-02
EP1015568B1 (de)	2003-02-26
IL124952A0 (en)	1999-01-26
DK1015568T3 (da)	2003-06-10
CZ245598A3 (cs)	1999-01-13
DE69719382T2 (de)	2003-11-27
EP1015568A1 (de)	2000-07-05

Legal Events

Date

Code

Title

Description

2003-09-15

UEP

Publication of translation of european patent specification

Ref document number: 1015568

Country of ref document: EP

2010-03-15

EEFA

Change of the company name

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