ATE233320T1 - Antagonisten von humanem interleukin-6, welche zur bindung mit gp 130 unfähig sind und ihre verwendung in der herstellung von pharmazeutische zusammensetzungen - Google Patents

Antagonisten von humanem interleukin-6, welche zur bindung mit gp 130 unfähig sind und ihre verwendung in der herstellung von pharmazeutische zusammensetzungen

Info

Publication number
ATE233320T1
ATE233320T1 AT96912205T AT96912205T ATE233320T1 AT E233320 T1 ATE233320 T1 AT E233320T1 AT 96912205 T AT96912205 T AT 96912205T AT 96912205 T AT96912205 T AT 96912205T AT E233320 T1 ATE233320 T1 AT E233320T1
Authority
AT
Austria
Prior art keywords
human interleukin
binding
pct
antagonists
inapable
Prior art date
Application number
AT96912205T
Other languages
English (en)
Inventor
Gennaro Ciliberto
Rocco Savino
Giacomo Paonessa
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of ATE233320T1 publication Critical patent/ATE233320T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT96912205T 1995-04-28 1996-04-26 Antagonisten von humanem interleukin-6, welche zur bindung mit gp 130 unfähig sind und ihre verwendung in der herstellung von pharmazeutische zusammensetzungen ATE233320T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95RM000273A IT1276555B1 (it) 1995-04-28 1995-04-28 Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni
PCT/IT1996/000084 WO1996034104A1 (en) 1995-04-28 1996-04-26 Antagonists of human interleukin-6 that are totally incapable of binding gp 130, and their use in the preparation of pharmaceutical compounds

Publications (1)

Publication Number Publication Date
ATE233320T1 true ATE233320T1 (de) 2003-03-15

Family

ID=11403338

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96912205T ATE233320T1 (de) 1995-04-28 1996-04-26 Antagonisten von humanem interleukin-6, welche zur bindung mit gp 130 unfähig sind und ihre verwendung in der herstellung von pharmazeutische zusammensetzungen

Country Status (11)

Country Link
US (1) US5972902A (de)
EP (1) EP0822986B1 (de)
JP (2) JP3373856B2 (de)
AT (1) ATE233320T1 (de)
CA (1) CA2218372C (de)
DE (1) DE69626387T2 (de)
DK (1) DK0822986T3 (de)
ES (1) ES2191096T3 (de)
IT (1) IT1276555B1 (de)
PT (1) PT822986E (de)
WO (1) WO1996034104A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0869176A4 (de) * 1995-11-07 2000-09-20 Kaneka Corp Autoantigene
DE19704979A1 (de) * 1996-02-07 1997-08-14 Max Delbrueck Centrum Retroviraler Vektor für den Gentransfer eines IL6-Antagonisten in humane hämatopoetische Stammzellen
AU736282B2 (en) 1997-03-21 2001-07-26 Chugai Seiyaku Kabushiki Kaisha A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient
IT1291932B1 (it) * 1997-06-20 1999-01-21 Angeletti P Ist Richerche Bio Composizioni farmaceutiche antitumorali capaci anche di ridurre la farmacoresistenza in cellule tumorali, in particolare di carcinoma
DE60020269T2 (de) 2000-03-06 2006-01-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Verwendung von interleukin-6 antagonisten zur behandlung von oestrogen-abhängigen krebs
BRPI0214168B8 (pt) * 2001-11-14 2021-05-25 Centocor Inc anticorpos anti-il-6, moléculas de ácido nucleico codificando os mesmos, vetores compreendendo as referidas moléculas, composições e formulações compreendendo os referidos anticorpos, bem como métodos de produção dos mesmos
US20050100550A1 (en) * 2003-11-10 2005-05-12 Mohit Trikha Anti-angiogenic uses of IL-6 antagonists
ITRM20050103A1 (it) * 2005-03-10 2006-09-11 Rocco Savino Associazione di antagonisti della interleuchina 6 e farmaci antiproliferativi.
PA8672101A1 (es) 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
US8188235B2 (en) * 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses
CN113698467A (zh) * 2020-05-19 2021-11-26 甘李药业股份有限公司 Il-6变体及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU687763B2 (en) * 1992-10-20 1998-03-05 Central Laboratory Of The Netherlands Red Cross Blood Transfusion Service Interleukin-6 receptor antagonists
IT1261787B (it) * 1993-06-23 1996-06-03 Angeletti P Ist Richerche Bio Metodologia per la selezione di superagonisti, antagonisti e super- antagonisti di ormoni del cui complesso recettoriale fa parte gp 130.

Also Published As

Publication number Publication date
IT1276555B1 (it) 1997-11-03
ITRM950273A1 (it) 1996-10-28
DE69626387T2 (de) 2003-12-11
US5972902A (en) 1999-10-26
EP0822986A1 (de) 1998-02-11
EP0822986B1 (de) 2003-02-26
WO1996034104A1 (en) 1996-10-31
ITRM950273A0 (it) 1995-04-28
JPH10506538A (ja) 1998-06-30
PT822986E (pt) 2003-07-31
ES2191096T3 (es) 2003-09-01
JP3373856B2 (ja) 2003-02-04
DE69626387D1 (de) 2003-04-03
JP2003153691A (ja) 2003-05-27
CA2218372A1 (en) 1996-10-31
DK0822986T3 (da) 2003-04-28
CA2218372C (en) 2001-07-31

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