ATE234626T1 - Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten - Google Patents

Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten

Info

Publication number: ATE234626T1
Authority: AT; Austria
Prior art keywords: deoxynojirimycin; treatment; medication; producing; long chain
Prior art date: 1999-07-26

Application number

AT00946807T

Other languages

English (en)

Inventor

Gary S Jacob

Raymond A Dwek

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-26

Filing date

2000-07-24

Publication date

2003-04-15

2000-07-24 Application filed by Searle & Co filed Critical Searle & Co

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE234626T1 publication Critical patent/ATE234626T1/de

Links

HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 title abstract 3
229930186217 Glycolipid Natural products 0.000 title abstract 3
201000010099 disease Diseases 0.000 title abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
102000004547 Glucosylceramidase Human genes 0.000 title abstract 2
108010017544 Glucosylceramidase Proteins 0.000 title abstract 2
LXBIFEVIBLOUGU-JGWLITMVSA-N duvoglustat Chemical class OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O LXBIFEVIBLOUGU-JGWLITMVSA-N 0.000 title abstract 2
238000011282 treatment Methods 0.000 title abstract 2
238000009825 accumulation Methods 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
LXBIFEVIBLOUGU-UHFFFAOYSA-N Deoxymannojirimycin Natural products OCC1NCC(O)C(O)C1O LXBIFEVIBLOUGU-UHFFFAOYSA-N 0.000 abstract 2
208000015872 Gaucher disease Diseases 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229940000425 combination drug Drugs 0.000 abstract 1
125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
238000002651 drug therapy Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT00946807T 1999-07-26 2000-07-24 Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten ATE234626T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14556899P	1999-07-26	1999-07-26
PCT/US2000/016340 WO2001007078A1 (en)	1999-07-26	2000-07-24	Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidase enzyme for the manufacture of medicament for the treatment of glycolipid storage diseases

Publications (1)

Publication Number	Publication Date
ATE234626T1 true ATE234626T1 (de)	2003-04-15

Family

ID=22513679

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00946807T ATE234626T1 (de)	1999-07-26	2000-07-24	Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten

Country Status (8)

Country	Link
US (2)	US6495570B2 (de)
EP (1)	EP1196190B1 (de)
JP (1)	JP2003505430A (de)
AT (1)	ATE234626T1 (de)
AU (1)	AU6050600A (de)
CA (1)	CA2378776A1 (de)
DE (1)	DE60001745T2 (de)
WO (1)	WO2001007078A1 (de)

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ATE526991T1 (de) *	2005-10-24	2011-10-15	Univ Massachusetts	Zusammensetzungen und ihre verwendungen für die gentherapeutische behandlung von knochenerkrankungen
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EP2400843B1 (de) *	2009-02-24	2015-11-11	United Therapeutics Corporation	Iminozucker und verfahren zur behandlung von arenaviridae-erkrankungen
ES2524361T3 (es)	2009-06-12	2014-12-05	United Therapeutics Corporation	Iminoazúcares para su uso en el tratamiento de enfermedades por bunyavirus y togavirus
NZ713967A (en)	2009-07-28	2017-01-27	Shire Human Genetic Therapies	Compositions and methods for treating gaucher disease
CA2772807A1 (en) *	2009-09-04	2011-03-10	The Chancellor, Masters And Scholars Of The University Of Oxford	Methods of treating poxviral infections
CA2772813A1 (en) *	2009-09-04	2011-03-10	The Chancellor, Masters And Scholars Of The University Of Oxford	Iminosugars and methods of treating filoviral diseases
JP5653438B2 (ja) *	2009-09-04	2015-01-14	ユナイテッドセラピューティクスコーポレイション	オルトミクソウイルス感染の治療方法
WO2012001641A1 (en) *	2010-06-30	2012-01-05	Actelion Pharmaceuticals Ltd	Stable pharmaceutical compositions
CN104519905A (zh)	2012-03-02	2015-04-15	夏尔人类遗传性治疗公司	用于治疗iii型戈谢病的组合物和方法
KR20230066482A (ko)	2012-03-07	2023-05-15	아미쿠스 세라퓨틱스, 인코포레이티드	폼페병의 치료를 위한 고농도 알파-글루코시다제 조성물
CN106102464A (zh) *	2013-05-02	2016-11-09	牛津大学之校长及学者	采用亚氨基糖的糖脂抑制
CN114540327B (zh)	2014-09-30	2026-03-24	阿米库斯治疗学公司	具有增强的碳水化合物的高强度酸性α-葡糖苷酶
KR20250007693A (ko)	2015-12-30	2025-01-14	아미쿠스 세라퓨틱스, 인코포레이티드	폼페병 치료용의 강화된 산 알파-글루코시다제
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2000
- 2000-07-24 EP EP00946807A patent/EP1196190B1/de not_active Expired - Lifetime
- 2000-07-24 AU AU60506/00A patent/AU6050600A/en not_active Abandoned
- 2000-07-24 CA CA002378776A patent/CA2378776A1/en not_active Abandoned
- 2000-07-24 WO PCT/US2000/016340 patent/WO2001007078A1/en not_active Ceased
- 2000-07-24 JP JP2001511961A patent/JP2003505430A/ja active Pending
- 2000-07-24 AT AT00946807T patent/ATE234626T1/de not_active IP Right Cessation
- 2000-07-24 DE DE60001745T patent/DE60001745T2/de not_active Expired - Fee Related
2001
- 2001-05-17 US US09/859,928 patent/US6495570B2/en not_active Expired - Lifetime
2002
- 2002-01-22 US US10/054,802 patent/US6696059B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US6696059B2 (en)	2004-02-24
CA2378776A1 (en)	2001-02-01
US6495570B2 (en)	2002-12-17
DE60001745D1 (de)	2003-04-24
WO2001007078A1 (en)	2001-02-01
EP1196190A1 (de)	2002-04-17
EP1196190B1 (de)	2003-03-19
US20020127213A1 (en)	2002-09-12
JP2003505430A (ja)	2003-02-12
DE60001745T2 (de)	2004-03-04
US20010044453A1 (en)	2001-11-22
AU6050600A (en)	2001-02-13

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2003-11-15

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Publication	Publication Date	Title
ATE234626T1 (de)	2003-04-15	Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin mit glucocerebrosidase enzyme zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten
ATE226821T1 (de)	2002-11-15	Verwendung von langkettigen n-alkyl derivaten von deoxynojirimycin zur herstellung eines medikaments zur behandlung von mit glykolipiden akkumulation zusammenhängenden krankheiten
CA2278507A1 (en)	1998-07-16	Method for treatment of cns-involved lysosomal storage diseases
GEP20043269B (en)	2004-06-25	Purine Derivatives, Method for Their Production and Composition Containing the Same
TW200505900A (en)	2005-02-16	Muscarinic agonists
UA43391C2 (uk)	2001-12-17	Спосіб інгібування міжклітинного зчеплення і спосіб інгібування запального процесу та порушеного процесу нормальної коагуляції у пацієнтів з розладами васкулярного ендотелію
AU8155894A (en)	1995-06-29	Methods of inhibiting thrombin
ATE83659T1 (de)	1993-01-15	Verwendung von indolon-derivaten zur herstellung von arzneimitteln zur behandlung des parkinsonismus.
AU2003225617A1 (en)	2003-09-16	Thiadiazolylpiperazine derivatives useful for treating or preventing pain
MY137348A (en)	2009-01-30	Highly selective norepinephrine reuptake inhibitors and methods of using the same
GEP20053720B (en)	2006-01-10	Triamide-Substituted Indoles, Benzofuranes and Benzothiophenes as Inhibitors of Microsomal Triglyceride Transfer Protein (MTP) and/or Apolipoprotein B (Apo B) Secretion
IL128036A (en)	2005-08-31	Deoxynojirimycin derivatives comprising a polyclic alcohol group, pharmaceutical composition comprising a deoxynojirimycin derivative and uses thereof
ATE205712T1 (de)	2001-10-15	Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung der angiogenese und angiogene krankheiten
ATE199642T1 (de)	2001-03-15	Verwendung von 2-phenyl-3-aroylbenzothiophen derivaten zur herstellung eines medikaments zur hemmung des knorpelabbaus
DE69725879D1 (de)	2003-12-04	VERWENDUNG VON p-AMINOPHENOLDERIVATEN ZUR HERSTELLUNG VON PHARMAZEUTISCHEN ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN
ATE366107T1 (de)	2007-07-15	Verwendung von sulfodehydroabietinsäure zur behandlung entzündlicher darmerkrankungen
ATE161725T1 (de)	1998-01-15	Verwendung von phosphatdiestern zur behandlung von erkrankungen der retina
EP1006793A4 (de)	2002-10-09	Anti-arrhythmische zusammensetzungen und behandlungsverfahren
AU6932691A (en)	1991-07-25	Administration method of antithrombin
SE9702716D0 (sv)	1997-07-15	Substituted phenylazacycloalkanes in the treatment of cognitive disorders
WO2002017917A8 (en)	2002-07-04	Manzamines for treatment of drug resistant infection
IL126795A (en)	2003-05-29	Pharmaceutical compositions for the treatment of substance abuse disorders comprising pyridyl- and pyrimidyl-piperazines
BG106209A (en)	2002-09-30	Therapeutic agents
RU94044487A (ru)	1996-10-20	Применение 2-фенил-3-ароилбензотиофенов для лечения мужского бесплодия