ATE235514T1 - Monoklonaler anti-idiotypischer antikörper 3h1 aus maus - Google Patents

Monoklonaler anti-idiotypischer antikörper 3h1 aus maus

Info

Publication number
ATE235514T1
ATE235514T1 AT95944582T AT95944582T ATE235514T1 AT E235514 T1 ATE235514 T1 AT E235514T1 AT 95944582 T AT95944582 T AT 95944582T AT 95944582 T AT95944582 T AT 95944582T AT E235514 T1 ATE235514 T1 AT E235514T1
Authority
AT
Austria
Prior art keywords
monoclonal anti
cea
mouse
idiotypic antibody
provides
Prior art date
Application number
AT95944582T
Other languages
English (en)
Inventor
Malaya Chatterjee
Heinz Kohler
Sunil K Chatterjee
Kenneth A Foon
Original Assignee
Univ Kentucky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kentucky filed Critical Univ Kentucky
Application granted granted Critical
Publication of ATE235514T1 publication Critical patent/ATE235514T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • C07K16/4266—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/023—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a poxvirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95944582T 1994-12-28 1995-12-28 Monoklonaler anti-idiotypischer antikörper 3h1 aus maus ATE235514T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36548494A 1994-12-28 1994-12-28
PCT/US1995/017105 WO1996020219A2 (en) 1994-12-28 1995-12-28 Murine monoclonal anti-idiotype antibody 3h1

Publications (1)

Publication Number Publication Date
ATE235514T1 true ATE235514T1 (de) 2003-04-15

Family

ID=23439088

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95944450T ATE237687T1 (de) 1994-12-28 1995-12-28 Rekombinierte sequenzen des monoklonalen anti- idiotypischen antikörpers 3h1, diean dem menschlichen karzioembyonischen antigen liiert sind
AT95944582T ATE235514T1 (de) 1994-12-28 1995-12-28 Monoklonaler anti-idiotypischer antikörper 3h1 aus maus

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT95944450T ATE237687T1 (de) 1994-12-28 1995-12-28 Rekombinierte sequenzen des monoklonalen anti- idiotypischen antikörpers 3h1, diean dem menschlichen karzioembyonischen antigen liiert sind

Country Status (12)

Country Link
US (3) US5977315A (de)
EP (3) EP0796280B1 (de)
JP (2) JPH10511846A (de)
AT (2) ATE237687T1 (de)
AU (2) AU704829B2 (de)
CA (2) CA2209360C (de)
DE (2) DE69530415T2 (de)
DK (2) DK0796280T3 (de)
ES (2) ES2197217T3 (de)
MX (2) MX9704897A (de)
PT (2) PT796280E (de)
WO (2) WO1996020219A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796280B1 (de) * 1994-12-28 2003-03-26 University Of Kentucky Monoklonaler anti-idiotypischer antikörper 3h1 aus maus
US6235280B1 (en) * 1996-04-12 2001-05-22 Malaya Chatterjee Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1
US20020041872A1 (en) * 1996-04-12 2002-04-11 Malaya Chatterjee Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1
US7318921B2 (en) * 1996-05-15 2008-01-15 Altarex Medical Corp. Therapeutic compositions that alter the immune response
WO1997042973A1 (en) * 1996-05-15 1997-11-20 Altarex, Corp. Method and composition for reconforming multi-epitopic antigens to initiate an immune response
US20080220012A1 (en) * 1996-05-15 2008-09-11 Ragupathy Madiyalakan Therapeutic Compositions that alter the immune response
US20020098190A1 (en) * 1997-06-13 2002-07-25 Malaya Chatterjee Compositions and methods for treating tumors bearing HMFG and CEA antigens
WO1999002545A2 (en) * 1997-07-08 1999-01-21 Novopharm Biotech Inc. Antigen binding fragments, designated 4b5, that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
US7569674B2 (en) 1998-05-04 2009-08-04 Innexus Biotechnology International Limited Autophilic antibodies
US6355244B1 (en) 1997-11-17 2002-03-12 University Of Kentucky Research Foundation Methods and compositions for the treatment of psoriasis
AT409086B (de) * 1999-11-16 2002-05-27 Igeneon Krebs Immuntherapie Neue verwendung von antikörpern als impfstoffe
US6774209B1 (en) * 2000-04-03 2004-08-10 Dyax Corp. Binding peptides for carcinoembryonic antigen (CEA)
AU2001253479A1 (en) 2000-04-13 2001-10-30 Sts Biopolymers, Inc. Targeted therapeutic agent release devices and methods of making and using the same
DE20105649U1 (de) * 2001-03-30 2001-08-16 Wang, Ming-Theng, Chungho, Taipeh Kettenzahnrad und Ratschenanordnung geringer Reibung für die rückwärtige Nabe eines Zweirades
US8025873B2 (en) 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8029803B2 (en) * 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
AT500650B1 (de) * 2003-04-17 2009-11-15 Altropus Gmbh Immunogener rekombinanter antikörper
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
ZA200701787B (en) * 2004-08-05 2008-06-25 R & D Green Materials Llc Low temperature molding process for making solid biodegradable articles
JP2008521820A (ja) * 2004-11-24 2008-06-26 ヘルス リサーチ インコーポレイテッド 免疫原性ペプチドを同定および設計するための方法
EP1948802A4 (de) * 2005-10-13 2009-01-14 Virexx Medical Corp Chimäres antigen mit hepatitis-c-virus-polypeptid und fc-fragment zum hervorrufen einer immunantwort
US8603466B2 (en) * 2006-03-29 2013-12-10 King's College London Agonist antibodies against TSHR
TWI434855B (zh) * 2006-11-21 2014-04-21 Hoffmann La Roche 結合物及其在免疫分析中作為參考標準之用途
WO2009062050A2 (en) 2007-11-08 2009-05-14 Neogenix Oncology, Inc. Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
US8093018B2 (en) * 2008-05-20 2012-01-10 Otsuka Pharmaceutical Co., Ltd. Antibody identifying an antigen-bound antibody and an antigen-unbound antibody, and method for preparing the same
CN104634955B (zh) 2009-10-26 2016-09-14 雀巢产品技术援助有限公司 检测抗-tnf药物和自身抗体的试验
WO2012054532A1 (en) 2010-10-18 2012-04-26 Prometheus Laboratories Inc. Methods for determining anti-drug antibody isotypes
WO2013006810A1 (en) 2011-07-06 2013-01-10 Nestec Sa Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha
MA40094B1 (fr) * 2014-08-06 2022-05-31 Univ Miami Protéines de fusion de l'interleukine-2/récepteur alpha de l'interleukine-2 et procédés d'utilisation
RU2017122720A (ru) 2014-12-05 2019-01-10 Нестек С.А. Непрямые однородные анализы по изменению подвижности для детекции биологических препаратов в образцах пациента
PE20210313A1 (es) 2018-03-28 2021-02-12 Bristol Myers Squibb Co Proteinas de fusion interleucina-2/receptor alfa de interleucina-2 y metodos de uso
US20240060970A1 (en) * 2020-12-25 2024-02-22 Denka Company Limited Method for Measuring Target Antigen, and Insoluble Particles and Kit for Target Antigen Measurement Used Therein
CN119708155B (zh) * 2024-12-30 2025-12-09 中国药科大学 地龙抗血小板寡肽及其应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
JPS54140710A (en) * 1978-03-10 1979-11-01 Mitsui Toatsu Chem Inc Anti-tumor substance and its preparation
JPS56145222A (en) * 1980-04-28 1981-11-11 Toshiyuki Hamaoka Improved antibody and its preparation
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies
US4436728A (en) 1982-05-26 1984-03-13 Ribi Immunochem Research, Inc. Refined detoxified endotoxin product
US5053224A (en) 1983-11-07 1991-10-01 Hilary Koprowski Induction of antibody response to solid tumors with anti-idiotype antibodies
ATE45285T1 (de) 1983-11-07 1989-08-15 Wistar Inst Durch antiidiotype antikoerper induzierte immune antwort zu tumoren und viren.
US5180814A (en) * 1984-01-31 1993-01-19 Akzo N.V. Tumor specific monoclonal antibodies
US4828991A (en) * 1984-01-31 1989-05-09 Akzo N.V. Tumor specific monoclonal antibodies
US5106738A (en) 1984-01-31 1992-04-21 Akzo Nv Tumor specific monoclonal antibodies
US5171568A (en) * 1984-04-06 1992-12-15 Chiron Corporation Recombinant herpes simplex gb-gd vaccine
US4722840A (en) 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
US5160723A (en) * 1985-04-19 1992-11-03 Sloan-Kettering Institute For Cancer Research Method of imaging colorectal carcinoma lesion and composition for use therein
GB2202017A (en) * 1987-03-07 1988-09-14 Alvan Michael Judson Anti-lock electric braking
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
JP2517343B2 (ja) * 1988-01-26 1996-07-24 富士写真フイルム株式会社 熱現像感光材料
JPH01207920A (ja) 1988-02-16 1989-08-21 Oki Electric Ind Co Ltd ＩｎＰ半導体薄膜の製造方法
GB8812137D0 (en) 1988-05-23 1988-06-29 Imp Cancer Res Tech Antibodies
US5183756A (en) 1988-08-19 1993-02-02 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibody (D612) having selective reactivity for gastrointestinal caricinomas and method for employing the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5077284A (en) 1988-12-30 1991-12-31 Loria Roger M Use of dehydroepiandrosterone to improve immune response
US5407684A (en) * 1988-12-30 1995-04-18 Virginia Commonwealth University Use of DHEA as a medicinal
GB8928874D0 (en) * 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
US5244801A (en) * 1989-12-28 1993-09-14 Martin Tobi Process for producing monoclonal antibodies which specifically bind to benign colonic adenomatous polyps of human origin and hybridomas and monoclonal antibodies produced by said process
DE69030172T2 (de) 1990-01-26 1997-06-19 Immunomedics Inc Impfstoffe gegen Krebs und Infektionskrankheiten
US5200316A (en) * 1990-02-15 1993-04-06 Miles Inc. Immunoassay methods using noncross reactive cea gene family members antibodies
ATE147990T1 (de) 1990-05-10 1997-02-15 Dana Farber Cancer Inst Inc Erhöhung der assoziation exogener peptide mit mhci-molekülen auf zellen des immunsystems
US5608039A (en) * 1990-10-12 1997-03-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Single chain B3 antibody fusion proteins and their uses
GB9105992D0 (en) * 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccine
WO1993006233A1 (en) 1991-09-19 1993-04-01 Manson Lionel A Tumor immunotherapy utilizing a method of overcoming the resistance of a progressively growing tumor
US5227471A (en) 1992-01-30 1993-07-13 Eastern Virginia Medical School Of The Medical College Of Hampton Roads Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma
WO1994005329A1 (en) 1992-08-31 1994-03-17 Jenner Technologies Stimulation of an antitumor t-cell response using anti-idiotypic antibodies
EP0796280B1 (de) * 1994-12-28 2003-03-26 University Of Kentucky Monoklonaler anti-idiotypischer antikörper 3h1 aus maus

Also Published As

Publication number Publication date
MX9704897A (es) 1998-06-28
US5977315A (en) 1999-11-02
ES2197217T3 (es) 2004-01-01
US20010047083A1 (en) 2001-11-29
DK0800578T3 (da) 2003-08-11
DE69530107T2 (de) 2003-10-16
WO1996020277A3 (en) 1996-09-06
WO1996020219A2 (en) 1996-07-04
EP0800578B1 (de) 2003-04-16
JPH11500607A (ja) 1999-01-19
AU717779C (en) 2002-12-05
CA2209172C (en) 2007-04-10
EP1298144A3 (de) 2006-05-31
US7090842B1 (en) 2006-08-15
AU4692796A (en) 1996-07-19
EP0796280A2 (de) 1997-09-24
AU717779B2 (en) 2000-03-30
WO1996020219A3 (en) 1996-09-06
DE69530415T2 (de) 2004-02-12
MX9704898A (es) 1998-06-28
AU4649896A (en) 1996-07-19
CA2209172A1 (en) 1996-07-04
CA2209360C (en) 2010-07-06
PT796280E (pt) 2003-08-29
JPH10511846A (ja) 1998-11-17
WO1996020277A2 (en) 1996-07-04
EP0800578A2 (de) 1997-10-15
ES2196098T3 (es) 2003-12-16
ATE237687T1 (de) 2003-05-15
AU704829B2 (en) 1999-05-06
PT800578E (pt) 2003-09-30
DE69530415D1 (de) 2003-05-22
EP0796280B1 (de) 2003-03-26
EP1298144A2 (de) 2003-04-02
DK0796280T3 (da) 2003-04-22
DE69530107D1 (de) 2003-04-30
CA2209360A1 (en) 1996-07-04

Similar Documents

Publication Publication Date Title
DE69530107D1 (de) Monoklonaler anti-idiotypischer antikörper 3h1 aus maus
DE3574730D1 (de) Monoklonaler antikoerper gegen ein humanes tumor-karzinom-assoziiertes antigen.
ATE303160T1 (de) Impfstoff gegen prostatakrebs
ES2124533T3 (es) Anticuerpos monoclonales inmunoestimulantes.
ATE318312T1 (de) Monoklonaler anti-idiotypischer antikörper 11d10 aus der maus und methoden zu dessen verwendung
EP0966485A4 (de) Mutierte nicht aktivierende igg2 domäne und diese sequenz enthaltende anti-cd3 antikörper
DE3783277D1 (de) Monoklonaler antikoerper gegen humanes lungenkarzinom.
DE3484520D1 (de) Monoklonale antikoerper gegen menschlichen dickdarmkrebs und verfahren.
DE68918497D1 (de) Monoklonale Mäuseantikörper gegen HIV-IP24 und ihre Verwendung in Diagnostika.
IT8320550A0 (it) Procedimento di purificazione peraffinita' in cui si impiegano anticorpi monoclonali.
DE3854502D1 (de) Gegen hiv-antigene spezifischer monoklonaler antikörper.
DE69128543D1 (de) Monoklonale antikörper der maus
OA08485A (fr) Monoclonal antibodies and antigen for human non-small cell lung carcinoma and certain other human carcinomas.
DE3482905D1 (de) Monoklonale antikoerper gegen lungenkrebs des "nicht-kleine-zellen"-typs.
DE3586216D1 (de) Brusttumorassoziiertes antigen und monoklonale antikoerper dazu.
DK191989A (da) Tumor-associeret glycoproteinantigen, antistoffer mod antigenet samt hybridoma-cellelinie, der producerer antistofferne
ID20117A (id) Antibodi anti-fas
DE3485712D1 (de) Monoklonale antikoerper gegen menschliche nierenkrebsantigene und verfahren.
NO883501D0 (no) Slekt-spesifikt listeria-antigen identifisert med monoklonale antistoffer.
ATE77243T1 (de) E87ag-antigen des pseudomonas aeruginosa, monoklonale antikoerper dagegen und hybridom.
ATE359091T1 (de) Monoklonaler antikörper gegen menschlische nierenkarzinomzellen
DE3785795D1 (de) Monoklonale anti-menschliche magenkrebs-antikoerper.
ATE263784T1 (de) Anti-megakaryozyten monoklonaler antikörper 97a6
FI925638A7 (fi) Kasvainten yhteydessä esiintyvää antigeenia vastaan suunnattu monoklonaalinen vasta-aine 88BV59
NO165510C (no) Monoklonale antistoffer, samt anvendelse av dem in vitro for bestemmelse av naervaer av neoplasmer.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0796280

Country of ref document: EP

REN Ceased due to non-payment of the annual fee