ATE237327T1 - Bizyclische pyrrolverbindungen, deren pharmazeutische zusammensetzungen und ihre verwendung als entzündungshemmende und immunmodulierende mittel - Google Patents

Bizyclische pyrrolverbindungen, deren pharmazeutische zusammensetzungen und ihre verwendung als entzündungshemmende und immunmodulierende mittel

Info

Publication number: ATE237327T1
Authority: AT; Austria
Prior art keywords: bizyclic; inflammatory; pharmaceutical compositions; immunomodulating agents; pyrrole compounds
Prior art date: 1998-02-17

Application number

AT99903807T

Other languages

English (en)

Inventor

Andrew John Barker

Jason Grant Kettle

Alan Wellington Faull

Original Assignee

Astrazeneca Uk Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-17

Filing date

1999-02-02

Publication date

2003-05-15

1999-02-02 Application filed by Astrazeneca Uk Ltd filed Critical Astrazeneca Uk Ltd

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE237327T1 publication Critical patent/ATE237327T1/de

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
230000003110 anti-inflammatory effect Effects 0.000 title 1
239000002955 immunomodulating agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
125000000962 organic group Chemical group 0.000 abstract 2
101710155857 C-C motif chemokine 2 Proteins 0.000 abstract 1
102000000018 Chemokine CCL2 Human genes 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
External Artificial Organs (AREA)
Mechanical Coupling Of Light Guides (AREA)

AT99903807T 1998-02-17 1999-02-02 Bizyclische pyrrolverbindungen, deren pharmazeutische zusammensetzungen und ihre verwendung als entzündungshemmende und immunmodulierende mittel ATE237327T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9803226.1A GB9803226D0 (en)	1998-02-17	1998-02-17	Chemical compounds
PCT/GB1999/000332 WO1999040913A1 (en)	1998-02-17	1999-02-02	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE237327T1 true ATE237327T1 (de)	2003-05-15

Family

ID=10827054

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99903807T ATE237327T1 (de)	1998-02-17	1999-02-02	Bizyclische pyrrolverbindungen, deren pharmazeutische zusammensetzungen und ihre verwendung als entzündungshemmende und immunmodulierende mittel

Country Status (14)

Country	Link
US (1)	US6291507B1 (de)
EP (1)	EP1054667B1 (de)
JP (1)	JP2002502873A (de)
KR (1)	KR20010040996A (de)
CN (1)	CN1291095A (de)
AT (1)	ATE237327T1 (de)
AU (1)	AU745772B2 (de)
BR (1)	BR9907962A (de)
CA (1)	CA2317456A1 (de)
DE (1)	DE69906940T2 (de)
GB (1)	GB9803226D0 (de)
NO (1)	NO20004090L (de)
NZ (1)	NZ505586A (de)
WO (1)	WO1999040913A1 (de)

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JP5257068B2 (ja)	2006-05-16	2013-08-07	小野薬品工業株式会社	保護されていてもよい酸性基を含有する化合物およびその用途
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1998
- 1998-02-17 GB GBGB9803226.1A patent/GB9803226D0/en not_active Ceased
1999
- 1999-02-02 AU AU24327/99A patent/AU745772B2/en not_active Ceased
- 1999-02-02 DE DE69906940T patent/DE69906940T2/de not_active Expired - Fee Related
- 1999-02-02 JP JP2000531165A patent/JP2002502873A/ja active Pending
- 1999-02-02 AT AT99903807T patent/ATE237327T1/de not_active IP Right Cessation
- 1999-02-02 WO PCT/GB1999/000332 patent/WO1999040913A1/en not_active Ceased
- 1999-02-02 CN CN99803038A patent/CN1291095A/zh active Pending
- 1999-02-02 NZ NZ505586A patent/NZ505586A/xx unknown
- 1999-02-02 CA CA002317456A patent/CA2317456A1/en not_active Abandoned
- 1999-02-02 BR BR9907962-3A patent/BR9907962A/pt not_active IP Right Cessation
- 1999-02-02 EP EP99903807A patent/EP1054667B1/de not_active Expired - Lifetime
- 1999-02-02 KR KR1020007009017A patent/KR20010040996A/ko not_active Withdrawn
2000
- 2000-07-26 US US09/626,241 patent/US6291507B1/en not_active Expired - Fee Related
- 2000-08-16 NO NO20004090A patent/NO20004090L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2432799A (en)	1999-08-30
NO20004090D0 (no)	2000-08-16
DE69906940D1 (de)	2003-05-22
US6291507B1 (en)	2001-09-18
CN1291095A (zh)	2001-04-11
KR20010040996A (ko)	2001-05-15
BR9907962A (pt)	2000-10-24
EP1054667B1 (de)	2003-04-16
WO1999040913A1 (en)	1999-08-19
DE69906940T2 (de)	2003-12-24
GB9803226D0 (en)	1998-04-08
AU745772B2 (en)	2002-03-28
CA2317456A1 (en)	1999-08-19
EP1054667A1 (de)	2000-11-29
NO20004090L (no)	2000-10-16
NZ505586A (en)	2002-11-26
JP2002502873A (ja)	2002-01-29

Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69906940D1 (de)	2003-05-22	Bizyclische pyrrolverbindungen, deren pharmazeutische zusammensetzungen und ihre verwendung als entzündungshemmende und immunmodulierende mittel
ATE227570T1 (de)	2002-11-15	Bizyklische pyrrolderivate als mcp-1 inhibitoren
IS6309A (is)	2002-03-19	Kínasólínafleiður
DE60036611D1 (de)	2007-11-15	Indol-derivate als antientzündungs wirkstoffe
WO2000046198A8 (en)	2001-04-19	Anti-inflammatory indole derivatives
ES2189968T3 (es)	2003-07-16	Amidinofenil-pirrolidinas,-pirrolinas,e -isoxazolidinas y derivadOS DE LOS MISMOS.
NO904377D0 (no)	1990-10-10	Tricykliske karbapenemforbindelser.
IL110151A0 (en)	1994-10-07	Amide and urea derivatives and pharmaceutical compositions containing the same
ATE374773T1 (de)	2007-10-15	Polycyclische verbindungen als potenten alpha2- adrenoceptor antagonisten
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