ATE238998T1 - Substituierte benzimidazole als nicht-nucleoside reverse transcriptase inhibitore - Google Patents

Substituierte benzimidazole als nicht-nucleoside reverse transcriptase inhibitore

Info

Publication number
ATE238998T1
ATE238998T1 AT98907608T AT98907608T ATE238998T1 AT E238998 T1 ATE238998 T1 AT E238998T1 AT 98907608 T AT98907608 T AT 98907608T AT 98907608 T AT98907608 T AT 98907608T AT E238998 T1 ATE238998 T1 AT E238998T1
Authority
AT
Austria
Prior art keywords
reverse transcriptase
inhibitores
substituted benzimidazoles
nucleoside reverse
present
Prior art date
Application number
AT98907608T
Other languages
English (en)
Inventor
Christopher J Michejda
Marshall Morningstar
Thomas Roth
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE238998T1 publication Critical patent/ATE238998T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98907608T 1997-02-25 1998-02-24 Substituierte benzimidazole als nicht-nucleoside reverse transcriptase inhibitore ATE238998T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3850997P 1997-02-25 1997-02-25
PCT/US1998/003588 WO1998037072A1 (en) 1997-02-25 1998-02-24 Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase

Publications (1)

Publication Number Publication Date
ATE238998T1 true ATE238998T1 (de) 2003-05-15

Family

ID=21900368

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98907608T ATE238998T1 (de) 1997-02-25 1998-02-24 Substituierte benzimidazole als nicht-nucleoside reverse transcriptase inhibitore

Country Status (8)

Country Link
US (2) US6369235B1 (de)
EP (1) EP0963371B1 (de)
JP (1) JP2001513084A (de)
AT (1) ATE238998T1 (de)
AU (1) AU741772B2 (de)
CA (1) CA2281927C (de)
DE (1) DE69814049T2 (de)
WO (1) WO1998037072A1 (de)

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* Cited by examiner, † Cited by third party
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DE60034578D1 (de) * 1999-08-26 2007-06-06 Us Health Substituierte benzimidazole als nicht-nucleosid-inhibitoren von reverser transcriptase
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
NZ514403A (en) 1999-12-27 2002-10-25 Japan Tobacco Inc Fused-ring compounds and use thereof as drugs
US6242461B1 (en) * 2000-01-25 2001-06-05 Pfizer Inc. Use of aryl substituted azabenzimidazoles in the treatment of HIV and AIDS related diseases
GB0005366D0 (en) * 2000-03-06 2000-04-26 Xenova Ltd Pharmaceutical compounds
JP2004532797A (ja) * 2000-10-12 2004-10-28 スミスクライン・ビーチャム・コーポレイション ＮＦ−κＢ阻害剤
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
JP4730574B2 (ja) * 2001-05-18 2011-07-20 山田化学工業株式会社 ベンズイミダゾール化合物、アゾベンズイミダゾール化合物とそのキレート化合物
EP1516873A1 (de) * 2003-09-22 2005-03-23 Facultés Universitaires Notre-Dame de la Paix 2-Pyridinon-Derivate als HIV Inhibitoren
CA2612419C (en) * 2005-06-23 2017-06-13 Array Biopharma Inc. Process for preparing benzimidazole compounds
AR063311A1 (es) 2006-10-18 2009-01-21 Novartis Ag Compuestos organicos
TW200831085A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
US20080173808A1 (en) * 2007-01-18 2008-07-24 Schering Corporation Process and device for response normalized liquid chromatography nanospray ionization mass spectrometry (rnlc-nsi-ms)
DE102007008420A1 (de) * 2007-02-21 2008-08-28 Merck Patent Gmbh Benzimidazolderivate
US20080249305A1 (en) * 2007-03-27 2008-10-09 Calderwood David J Novel imidazole based heterocycles
WO2008118485A1 (en) * 2007-03-27 2008-10-02 Abbott Laboratories Novel imidazo based heterocycles
WO2008153701A1 (en) * 2007-05-24 2008-12-18 Schering Corporation Compounds for inhibiting ksp kinesin activity
JP5715820B2 (ja) * 2007-09-18 2015-05-13 スタンフォード ユニバーシティー フラビウイルス科ファミリーのウイルスへの感染を治療する方法ならびに、フラビウイルス科ファミリーのウイルスへの感染を治療するための組成物
US9101628B2 (en) * 2007-09-18 2015-08-11 The Board Of Trustees Of The Leland Stanford Junior University Methods and composition of treating a flaviviridae family viral infection
US8940730B2 (en) 2007-09-18 2015-01-27 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions of treating a Flaviviridae family viral infection
US9149463B2 (en) * 2007-09-18 2015-10-06 The Board Of Trustees Of The Leland Standford Junior University Methods and compositions of treating a Flaviviridae family viral infection
EP2408449A4 (de) 2009-03-18 2012-08-08 Univ Leland Stanford Junior Verfahren und zusammensetzungen zur behandlung von flaviviridae-virusinfektionen
BR112014030940B1 (pt) * 2012-06-11 2022-09-06 UCB Biopharma SRL Benzimidazóis que modulam tnf-alfa e composição farmacêutica compreendendo os mesmos
CA2982446A1 (en) 2015-03-18 2016-09-22 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds useful as inhibitors of tnf
AU2016233288A1 (en) 2015-03-18 2017-11-09 Bristol-Myers Squibb Company Substituted tricyclic heterocyclic compounds
MX2017011577A (es) 2015-03-18 2017-10-26 Bristol Myers Squibb Co Compuestos heterociclicos utiles como inhibidores de factor de necrosis tumoral (tnf).
KR102679517B1 (ko) 2015-08-03 2024-06-27 브리스톨-마이어스 스큅 컴퍼니 Tnf 알파의 조정제로서 유용한 시클릭 화합물

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
FR2096648B1 (de) * 1970-04-17 1973-08-10 Gen Electric
FR2092648A1 (en) * 1970-06-04 1972-01-28 Fuveau Sa 2-(fluorophenyl) benzimidazoles - as antiinflammatory and analgesic agents
US3825537A (en) 1972-02-28 1974-07-23 Squibb & Sons Inc 1-thiazolin-2-yl(or thiazin-2-yl)-2-aminobenzimidazoles and derivatives thereof
US4214089A (en) 1978-07-18 1980-07-22 American Home Products Corporation Thiazolo[3,2-a]benzimidazoles, imidazo [2,1-b]thiazoles, and related compounds as antineoplastic agents, and enhancers of the immune response
US4434288A (en) 1982-04-08 1984-02-28 Eli Lilly And Company Preparation of substituted 1-thiazinyl or 1-thiazolyl-2-aminobenzimidazoles
US5356917A (en) 1985-08-09 1994-10-18 Eli Lilly And Company Aryl-substituted rhodanine derivatives
FR2587029B1 (fr) 1985-09-11 1987-10-30 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
IT1243362B (it) * 1990-07-25 1994-06-10 Pietro Monforte Sintesi di attivita' anti-hiv di 1h, 3h-tiazolo 3,4-a benzimidazoli 1-sostituiti
US5248672A (en) 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
GB9205368D0 (en) 1992-03-12 1992-04-22 Pfizer Ltd Benzimidozole anthelmintic agents
US5622960A (en) 1992-04-14 1997-04-22 The United States Of America As Represented By The Department Of Health And Human Services Topoisomerase II inhibitors and therapeutic uses therefor
JPH09506335A (ja) 1993-09-22 1997-06-24 ザ、ウェルカム、ファンデーション、リミテッド 抗ウイルス剤としてのビス（アミノベンズイミダゾリル）アルカン
US6815461B1 (en) 1994-01-20 2004-11-09 The University Of North Carolina At Chapel Hill Method of inhibiting retroviral integrase
US5545653A (en) 1995-06-07 1996-08-13 Eli Lilly And Company Anti-viral compounds
GB9600143D0 (en) 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
US5821242A (en) 1996-06-06 1998-10-13 Eli Lilly And Company Anti-viral compounds
CA2293508A1 (en) 1997-06-04 1998-12-10 Louis Nickolaus Jungheim Anti-viral compounds

Also Published As

Publication number Publication date
US6894068B2 (en) 2005-05-17
JP2001513084A (ja) 2001-08-28
DE69814049D1 (de) 2003-06-05
EP0963371A1 (de) 1999-12-15
US20030191160A1 (en) 2003-10-09
DE69814049T2 (de) 2004-02-19
AU6337198A (en) 1998-09-09
WO1998037072A1 (en) 1998-08-27
US6369235B1 (en) 2002-04-09
CA2281927C (en) 2004-01-27
AU741772B2 (en) 2001-12-06
CA2281927A1 (en) 1998-08-27
EP0963371B1 (de) 2003-05-02

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