ATE239024T1 - Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung - Google Patents

Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung

Info

Publication number: ATE239024T1
Authority: AT; Austria
Prior art keywords: macrocyclic lactone; production; lactone compounds; compound; lactone compound
Prior art date: 1994-11-10

Application number

AT95932876T

Other languages

English (en)

Inventor

H Nishida

Y Yamauchi

T Inagaki

Y Kojima

N Kojima

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-10

Filing date

1995-10-13

Publication date

2003-05-15

1995-10-13 Application filed by Pfizer filed Critical Pfizer

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE239024T1 publication Critical patent/ATE239024T1/de

Links

-1 LACTONE COMPOUNDS Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
XJLSEXAGTJCILF-RXMQYKEDSA-N (R)-nipecotic acid zwitterion Chemical compound OC(=O)[C@@H]1CCCNC1 XJLSEXAGTJCILF-RXMQYKEDSA-N 0.000 abstract 1
241000187712 Actinoplanes sp. Species 0.000 abstract 1
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 abstract 1
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
229930182821 L-proline Natural products 0.000 abstract 1
230000001857 anti-mycotic effect Effects 0.000 abstract 1
239000002543 antimycotic Substances 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
238000000855 fermentation Methods 0.000 abstract 1
230000004151 fermentation Effects 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229960002429 proline Drugs 0.000 abstract 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Communicable Diseases (AREA)
Transplantation (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pyrane Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Epoxy Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Polyesters Or Polycarbonates (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT95932876T 1994-11-10 1995-10-13 Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung ATE239024T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP9401896		1994-11-10
PCT/IB1995/000870 WO1996015131A1 (en)	1994-11-10	1995-10-13	Macrocyclic lactone compounds and their production process

Publications (1)

Publication Number	Publication Date
ATE239024T1 true ATE239024T1 (de)	2003-05-15

Family

ID=1341416

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95932876T ATE239024T1 (de)	1994-11-10	1995-10-13	Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung

Country Status (12)

Country	Link
US (2)	US6001998A (de)
EP (1)	EP0854874B1 (de)
JP (1)	JP3061863B2 (de)
AT (1)	ATE239024T1 (de)
CA (1)	CA2204739C (de)
DE (1)	DE69530616T2 (de)
DK (1)	DK0854874T3 (de)
ES (1)	ES2194054T3 (de)
FI (1)	FI971995A0 (de)
MX (1)	MX9703484A (de)
PT (1)	PT854874E (de)
WO (1)	WO1996015131A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6001998A (en) *	1994-11-10	1999-12-14	Pfizer Inc	Macrocyclic lactone compounds and their production process
WO2002087423A2 (en) *	2001-05-02	2002-11-07	Blanchette Rockefeller Neurosciences Institute	Carbonic anhydrase activators for enhancing learning and memory
US6551591B1 (en)	2001-09-07	2003-04-22	Essential Therapeutics, Inc.	Antibiotics from microbispora
US20050065205A1 (en) *	2002-03-07	2005-03-24	Daniel Alkon	Methods for Alzheimer's disease treatment and cognitive enhance
US20080004332A1 (en) *	2002-03-07	2008-01-03	Alkon Daniel L	Methods for alzheimer's disease treatment and cognitive enhancement
US6825229B2 (en)	2002-03-07	2004-11-30	Blanchette Rockefeller Neurosciences Institute	Methods for Alzheimer's Disease treatment and cognitive enhancement
JP2008504225A (ja) *	2004-02-17	2008-02-14	ジョンソン，トーマス，イー．	大環状化合物を形成するための方法、組成物および装置
TW201207390A (en) *	2004-05-18	2012-02-16	Brni Neurosciences Inst	Method for screening agent for antidepressant activity
EP1768662A2 (de)	2004-06-24	2007-04-04	Novartis Vaccines and Diagnostics, Inc.	Immunstimulatoren kleiner moleküle und assays für deren nachweis
CA2598805A1 (en) *	2005-02-24	2006-08-31	Biocern, Inc.	Sperm cell separation methods and compositions
WO2006119211A2 (en) *	2005-05-02	2006-11-09	Genaera Corporation	Methods and compositions for treating ocular disorders
US20070054890A1 (en) *	2005-07-29	2007-03-08	Alkon Daniel L	Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
EP2762136A1 (de)	2006-07-28	2014-08-06	Blanchette Rockefeller Neurosciences, Institute	Verfahren zur Stimulierung von Zellwachstum, synaptischer Umformung und Verfestigung des Langzeitgedächtnisses
EP2061478A4 (de) *	2006-08-30	2010-07-07	Biocern Inc	Spermazellen-trennverfahren und zusammensetzungen mit aptameren oder nukleinsäuresequenzen zur verwendung darin
US7867988B2 (en) *	2006-09-13	2011-01-11	Elixir Medical Corporation	Macrocyclic lactone compounds and methods for their use
US10695327B2 (en)	2006-09-13	2020-06-30	Elixir Medical Corporation	Macrocyclic lactone compounds and methods for their use
US8088789B2 (en)	2006-09-13	2012-01-03	Elixir Medical Corporation	Macrocyclic lactone compounds and methods for their use
CN101848726A (zh)	2007-02-09	2010-09-29	布朗歇特洛克菲勒神经科学研究所	苔藓抑素、苔藓抑素类似物和其它相关物质对头部创伤引起的记忆缺陷和脑损伤的疗效
ES2528033T3 (es)	2007-02-09	2015-02-03	Blanchette Rockefeller Neurosciences Institute	Efectos terapéuticos de las briostatinas sobre la alteración de la memoria inducida por isquemia/accidente vascular cerebral y lesiones cerebrales
AU2010241807B2 (en) *	2009-05-01	2014-08-14	Glycomimetics, Inc.	Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US9364485B2 (en) *	2009-08-31	2016-06-14	Dr. Reddy's Laboratories Ltd.	Topical formulations comprising a steroid
EP2590642B1 (de)	2010-07-08	2018-03-14	Daniel L. Alkon	Pkc-aktivatoren und antikoagulans für einen therapieplan zur behandlung von apoplexie
JP6062362B2 (ja)	2010-08-19	2017-01-18	ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート	Ｐｋｃ活性化剤を使用した、異常な樹状突起棘に関連した認知障害の治療
WO2013071282A1 (en)	2011-11-13	2013-05-16	Blanchette Rockefeller Neurosciences Institute	Pkc activators and combinations thereof
US20180217163A1 (en)	2015-05-11	2018-08-02	Daniel L. Alkon	Treatment of neurodegenerative conditions using pkc activators after determining the presence of the apoe4 allele
CN107827803A (zh) *	2017-11-28	2018-03-23	绍兴厚普生物科技有限责任公司	一种从发酵液中提取l‑羟脯氨酸的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1910715A1 (de) *	1968-03-04	1969-10-09	Stanley Drug Products Inc	Antimikrobielle Faktoren und deren Verwendung
US5091389A (en) *	1991-04-23	1992-02-25	Merck & Co., Inc.	Lipophilic macrolide useful as an immunosuppressant
US5674732A (en) *	1992-04-27	1997-10-07	Pfizer Inc.	Rapamycin producer
CA2106034A1 (en) *	1992-09-24	1994-03-25	Ralph J. Russo	21-norrapamycin
US6001998A (en) *	1994-11-10	1999-12-14	Pfizer Inc	Macrocyclic lactone compounds and their production process

1995
- 1995-10-13 US US08/836,213 patent/US6001998A/en not_active Expired - Fee Related
- 1995-10-13 EP EP95932876A patent/EP0854874B1/de not_active Expired - Lifetime
- 1995-10-13 DE DE69530616T patent/DE69530616T2/de not_active Expired - Fee Related
- 1995-10-13 CA CA002204739A patent/CA2204739C/en not_active Expired - Fee Related
- 1995-10-13 AT AT95932876T patent/ATE239024T1/de not_active IP Right Cessation
- 1995-10-13 DK DK95932876T patent/DK0854874T3/da active
- 1995-10-13 FI FI971995A patent/FI971995A0/fi not_active IP Right Cessation
- 1995-10-13 PT PT95932876T patent/PT854874E/pt unknown
- 1995-10-13 JP JP8515869A patent/JP3061863B2/ja not_active Expired - Lifetime
- 1995-10-13 ES ES95932876T patent/ES2194054T3/es not_active Expired - Lifetime
- 1995-10-13 WO PCT/IB1995/000870 patent/WO1996015131A1/en not_active Ceased
- 1995-10-13 MX MX9703484A patent/MX9703484A/es not_active IP Right Cessation
1999
- 1999-08-20 US US09/378,062 patent/US6187568B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP3061863B2 (ja)	2000-07-10
WO1996015131A1 (en)	1996-05-23
FI971995L (fi)	1997-05-09
FI971995A7 (fi)	1997-05-09
PT854874E (pt)	2003-07-31
EP0854874A1 (de)	1998-07-29
DK0854874T3 (da)	2003-06-02
DE69530616T2 (de)	2004-04-01
ES2194054T3 (es)	2003-11-16
US6187568B1 (en)	2001-02-13
FI971995A0 (fi)	1997-05-09
US6001998A (en)	1999-12-14
EP0854874B1 (de)	2003-05-02
JPH11507907A (ja)	1999-07-13
MX9703484A (es)	1997-08-30
CA2204739C (en)	2000-04-04
DE69530616D1 (de)	2003-06-05

Legal Events

Date

Code

Title

Description

2003-09-15

UEP

Publication of translation of european patent specification

Ref document number: 0854874

Country of ref document: EP

2007-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69530616D1 (de)	2003-06-05	Macrocyklische lactonverbindungen und verfahren zu ihrer herstellung
DE69018529D1 (de)	1995-05-18	Phospholipase A2-Inhibitor, Mikroorganismen, die diesen Inhibitor erzeugen und mehrere Verfahren zu seiner Herstellung.
DE69623960D1 (de)	2002-10-31	Zwischenprodukte und verfahren zur herstellung von camptothecin-derivate (cpt-11) und verwandte verbindungen
MY140677A (en)	2010-01-15	Modified amino acids, pharmaceuticals containing these compounds and method for their production
ATE219499T1 (de)	2002-07-15	Lipopeptid-derivate, verfahren zu ihrer herstellung und ihre verwendung
MX9804046A (es)	1998-09-30	6-0-metil eritromicina d y proceso para hacerla.
ATE430160T1 (de)	2009-05-15	Lipopeptid-stereoisomere, verfahren zu ihrer herstellung und nützliche zwischenprodukte
MY145819A (en)	2012-04-30	Process and intermediates useful in the preparation of pharmaceutical compounds as fulvestrant
ATE231850T1 (de)	2003-02-15	Isochroman verbindungen und verfahren zu deren produktion
ATE211474T1 (de)	2002-01-15	Galanthamin derivate, verfahren zu ihrer herstellung und ihre verwendung als medikamente
AT380471B (de)	1986-05-26	Verfahren zur herstellung von neuen 2-oxoazetidin-derivate
ATE521600T1 (de)	2011-09-15	Verfahren zur herstellung von statinen
ATE475653T1 (de)	2010-08-15	Verfahren zur herstellung von valsartan
CA2019799A1 (en)	1990-12-27	Fucosidase inhibitor
DE3672361D1 (de)	1990-08-09	Ein neues ansamycin-antibiotikum, ein mikrobielles verfahren zu seiner herstellung und seine verwendung als arzneimittel.
DE60006690D1 (de)	2003-12-24	Antibiotische caprazamycine und verfahren zu deren herstellung
ATE250057T1 (de)	2003-10-15	Verfahren zur herstellung von 1-(1h)- benzoquinolizin-3-on derivaten
ATE236895T1 (de)	2003-04-15	Ringannelierte dihydropyrane, verfahren zur herstellung sowie deren verwendung
PL301862A1 (en)	1994-07-25	Novel 17,20-epoxy derivatives of pregnane, method of obtaining them and their application in obtaining cortisone derivatives and intermediate products
CA2223360A1 (en)	1998-06-04	Cyclic peptide compounds and their production process
ATE299851T1 (de)	2005-08-15	Verfahren zur herstellung von zwischenprodukten
ATE201874T1 (de)	2001-06-15	Verbessertes verfahren zur herstellung von carbapenem zwischenprodukten
BG103704A (en)	2000-05-31	New compounds
CA2257095A1 (en)	1997-12-11	Process for purifying sterically hindered 4-amino piperidines
EP0638125A1 (de)	1995-02-15	Neuartiger erzeuger von rapamycin.