ATE239700T1 - 24,24-difluorierte analogen von 1-alpha,25- dihydroxy vitamin d3 - Google Patents

24,24-difluorierte analogen von 1-alpha,25- dihydroxy vitamin d3

Info

Publication number: ATE239700T1
Authority: AT; Austria
Prior art keywords: alpha; difluorinated; ring; analogues; dihydroxy vitamin
Prior art date: 1998-06-03

Application number

AT99933481T

Other languages

English (en)

Inventor

Gary H Posner

Jae Kyoo Lee

Qiang Wang

Original Assignee

Univ Johns Hopkins

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-03

Filing date

1999-06-02

Publication date

2003-05-15

1999-06-02 Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE239700T1 publication Critical patent/ATE239700T1/de

Links

GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 title abstract 2
GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
-1 1-hydroxymethyl group Chemical group 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
230000000125 calcaemic effect Effects 0.000 abstract 1
235000020964 calcitriol Nutrition 0.000 abstract 1
239000011612 calcitriol Substances 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
238000000338 in vitro Methods 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
230000002103 transcriptional effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99933481T 1998-06-03 1999-06-02 24,24-difluorierte analogen von 1-alpha,25- dihydroxy vitamin d3 ATE239700T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US8803598P	1998-06-03	1998-06-03
US09/323,106 US6043386A (en)	1998-06-03	1999-06-01	Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1α,-25-dihydroxy vitamin D3
PCT/US1999/012190 WO1999062876A1 (en)	1998-06-03	1999-06-02	24,24-difluorinated analogs of 1-alpha,25-dihydroxy vitamin d3

Publications (1)

Publication Number	Publication Date
ATE239700T1 true ATE239700T1 (de)	2003-05-15

Family

ID=26777918

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99933481T ATE239700T1 (de)	1998-06-03	1999-06-02	24,24-difluorierte analogen von 1-alpha,25- dihydroxy vitamin d3

Country Status (6)

Country	Link
US (1)	US6043386A (de)
EP (1)	EP1095017B1 (de)
AT (1)	ATE239700T1 (de)
CA (1)	CA2334347C (de)
DE (2)	DE69907681T4 (de)
WO (1)	WO1999062876A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000051554A2 (en) *	1999-03-05	2000-09-08	Johns Hopkins University	Regulating skin appearance and composition with a fluorinated vitamin d3 analog compound
ES2274785T3 (es)	1999-04-01	2007-06-01	Johns Hopkins University	Analogos de 1-alfa,25-dihidroxi vitamina d3 no calcemicos, antiproliferativos, transcripcionalmente activos que contienen azufre.
US20020137731A1 (en)	2000-05-30	2002-09-26	Gewirtz David A.	Combination of radiation and vitamin D3 analogs for the treatment of cancer
US20020041902A1 (en) *	2000-09-29	2002-04-11	Steiner Gregory Gene	Fluoride as a chemoprotective and chemotheraputic agent for cancer in mammals
US6559138B1 (en) *	2001-09-21	2003-05-06	Syntex (U.S.A.) Llc	3-Desoxy-vitamin D3 analog esters
US20040258801A1 (en) *	2001-09-27	2004-12-23	Alvin Ling	Vitamin fortification of foodstuffs
US7101865B2 (en) *	2002-06-13	2006-09-05	Cytochroma Inc.	24-sulfoximine vitamin D3 compounds
CA2510228C (en) *	2002-12-18	2012-10-30	Johns Hopkins University	25-so2-substituted analogs of 1.alpha.,25-dihydroxyvitamin d3

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4421690A (en) *	1982-05-17	1983-12-20	Hoffmann-La Roche Inc.	Process for the preparation of 24,24-difluoro-1α,25-dihydroxy vitamin D3 and intermediates obtained therefrom
US4599330A (en) *	1982-05-17	1986-07-08	Hoffmann-La Roche Inc.	Method of treating milk fever
JPS6253960A (ja) *	1985-05-30	1987-03-09	Taisho Pharmaceut Co Ltd	ビタミンｄ↓３の誘導体
US4853378A (en) *	1986-10-20	1989-08-01	Sumitomo Chemical Company, Limited	Fluorine derivatives of vitamin D3 and process for producing the same
US4970203A (en) *	1988-12-09	1990-11-13	Deluca Hector F	Method for improving reproductive functions in mammals
US5830885A (en) *	1992-03-12	1998-11-03	The Johns Hopkins University	Antiproliferative vitamin D3 hybrids
US5428029A (en) *	1993-11-24	1995-06-27	Hoffmann-La Roche Inc.	Vitamin D3 fluorinated analogs
JPH0873425A (ja) *	1994-09-03	1996-03-19	Nippon Oil & Fats Co Ltd	フッ素化ビタミンｄ誘導体および製造方法

1999
- 1999-06-01 US US09/323,106 patent/US6043386A/en not_active Expired - Lifetime
- 1999-06-02 DE DE69907681T patent/DE69907681T4/de not_active Expired - Lifetime
- 1999-06-02 WO PCT/US1999/012190 patent/WO1999062876A1/en not_active Ceased
- 1999-06-02 EP EP99933481A patent/EP1095017B1/de not_active Expired - Lifetime
- 1999-06-02 CA CA002334347A patent/CA2334347C/en not_active Expired - Fee Related
- 1999-06-02 AT AT99933481T patent/ATE239700T1/de not_active IP Right Cessation
- 1999-06-02 DE DE69907681A patent/DE69907681D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1999062876A1 (en)	1999-12-09
DE69907681T2 (de)	2004-03-25
EP1095017B1 (de)	2003-05-07
CA2334347C (en)	2009-01-13
DE69907681T4 (de)	2007-04-12
WO1999062876A8 (en)	2000-09-14
US6043386A (en)	2000-03-28
WO1999062876A9 (en)	2000-10-26
DE69907681D1 (de)	2003-06-12
EP1095017A1 (de)	2001-05-02
CA2334347A1 (en)	1999-12-09

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Legal Events

Date	Code	Title	Description
2003-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties