ATE240095T1 - Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation - Google Patents

Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation

Info

Publication number
ATE240095T1
ATE240095T1 AT95942357T AT95942357T ATE240095T1 AT E240095 T1 ATE240095 T1 AT E240095T1 AT 95942357 T AT95942357 T AT 95942357T AT 95942357 T AT95942357 T AT 95942357T AT E240095 T1 ATE240095 T1 AT E240095T1
Authority
AT
Austria
Prior art keywords
inhalation
pharmaceutical composition
composition containing
proliposome powder
proliposome
Prior art date
Application number
AT95942357T
Other languages
English (en)
Inventor
Katarina Bystroem
Per-Gunnar Nilsson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9404466A external-priority patent/SE9404466D0/xx
Priority claimed from SE9502369A external-priority patent/SE9502369D0/xx
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE240095T1 publication Critical patent/ATE240095T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95942357T 1994-12-22 1995-12-20 Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation ATE240095T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9404466A SE9404466D0 (sv) 1994-12-22 1994-12-22 Process for the preparation of powders for inhalation
SE9502369A SE9502369D0 (sv) 1995-06-30 1995-06-30 Process for the preparation of compositions for inhalation
PCT/SE1995/001560 WO1996019199A1 (en) 1994-12-22 1995-12-20 Proliposome powders for inhalation

Publications (1)

Publication Number Publication Date
ATE240095T1 true ATE240095T1 (de) 2003-05-15

Family

ID=26662194

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95942357T ATE240095T1 (de) 1994-12-22 1995-12-20 Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation

Country Status (32)

Country Link
US (1) US6045828A (de)
EP (1) EP0800383B1 (de)
JP (1) JPH10510830A (de)
KR (1) KR100432461B1 (de)
CN (1) CN1087932C (de)
AR (1) AR002009A1 (de)
AT (1) ATE240095T1 (de)
AU (1) AU693632B2 (de)
BR (1) BR9510512A (de)
CA (1) CA2208517A1 (de)
CZ (1) CZ286469B6 (de)
DE (1) DE69530792T2 (de)
DK (1) DK0800383T3 (de)
EE (1) EE03592B1 (de)
EG (1) EG23683A (de)
ES (1) ES2194931T3 (de)
FI (1) FI972653A7 (de)
HU (1) HUT77628A (de)
IL (1) IL116454A (de)
IS (1) IS1978B (de)
MY (1) MY114114A (de)
NO (1) NO320434B1 (de)
NZ (1) NZ298180A (de)
PL (1) PL184393B1 (de)
PT (1) PT800383E (de)
RU (1) RU2162689C2 (de)
SA (1) SA95160463B1 (de)
SK (1) SK284918B6 (de)
TR (1) TR199501633A1 (de)
TW (1) TW508248B (de)
UA (1) UA43886C2 (de)
WO (1) WO1996019199A1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR002009A1 (es) * 1994-12-22 1998-01-07 Astra Ab Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
TW497974B (en) * 1996-07-03 2002-08-11 Res Dev Foundation High dose liposomal aerosol formulations
EP0927025A4 (de) * 1996-09-18 2001-07-25 Dragoco Inc Trockene pulverzusammensetzung mit in liposomen verkapseltem wirkstoff
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
PL337722A1 (en) * 1997-06-27 2000-08-28 Astra Ab Novel combination antiasthmatic drugs
AU729100B2 (en) * 1997-06-27 2001-01-25 Astra Aktiebolag Proliposome powders for inhalation stabilised by tocopherol
US7052678B2 (en) * 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US6090407A (en) 1997-09-23 2000-07-18 Research Development Foundation Small particle liposome aerosols for delivery of anti-cancer drugs
US7348025B2 (en) 1997-09-23 2008-03-25 Research Development Foundation Small particle liposome aerosols for delivery of anticancer drugs
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US20020017295A1 (en) * 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
SE9704833D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New formulation
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
EP1839648A3 (de) * 1998-11-12 2007-11-21 Transave, Inc. Inhalationssystem
KR20010111564A (ko) * 1998-11-12 2001-12-19 프랭크 쥐. 필키윅즈 흡입 시스템
GB9912639D0 (en) * 1999-05-28 1999-07-28 Britannia Pharmaceuticals Ltd Improvements in and relating to treatment of respiratory conditions
GB2359749B (en) * 1998-11-26 2004-05-05 Britannia Pharmaceuticals Ltd Anti-asthmatic combinations comprising surface active phospholipids
ATE363892T1 (de) * 1999-03-05 2007-06-15 Chiesi Farma Spa Verbesserte pulverformulierungen zur inhalation
EP1043016B1 (de) * 1999-03-30 2014-08-20 Sodic Sa Pflanzenextrakt auf Glycerid-, Phospholipid- und Phytosphingolipidbasis, Verfahren für die Gewinnung dieses Extrakts und ihn enthaltende kosmetische Zusammensetzungen
DE60026982T2 (de) * 1999-04-05 2006-11-16 Mannkind Corp., Danbury Verfahren zur bildung von feinem pulver
US7364749B1 (en) 1999-05-27 2008-04-29 Euro-Celtique, S.A. Preparations for the application of anti-infective and/or anti-inflammatory agents
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
EP1210067A2 (de) * 1999-08-25 2002-06-05 Advanced Inhalation Research, Inc. Modulation der freigabe aus trockenpulverformulierungen
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
US6156294A (en) 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
GB9928311D0 (en) * 1999-11-30 2000-01-26 Novartis Ag Organic compounds
DE10012151A1 (de) * 2000-03-13 2001-09-27 Gsf Forschungszentrum Umwelt Mittel zur Behandlung von Erkrankungen des Tracheo-Brochialtraktes, insbesondere der COPD
GB0008660D0 (en) * 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
PT1280520E (pt) 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
SI1775305T1 (sl) 2000-08-05 2015-01-30 Glaxo Group Limited S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-((2-furanilkarboksil)oksi)- 11beta-hidroksi-16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
ES2474199T3 (es) 2000-11-30 2014-07-08 Vectura Limited Composiciones farmacéuticas para inhalaci�n
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
KR100831534B1 (ko) 2001-04-30 2008-05-22 글락소 그룹 리미티드 17.알파 위치에 시클릭 에스테르기를 지닌 항염증성의안드로스탄의 17.베타.-카르보티오에이트 에스테르 유도체
AU2002352836B2 (en) * 2001-11-20 2005-09-29 Alkermes, Inc. Improved particulate compositions for pulmonary delivery
PT1458360E (pt) 2001-12-19 2011-07-13 Novartis Ag Derivados de indole como agonistas do recetor s1p1
AU2003201569B2 (en) * 2002-01-21 2008-09-11 Vasogen Ireland Limited Pharmaceutically acceptable phosphate-glycerol carrying bodies
JP2005530704A (ja) * 2002-03-05 2005-10-13 トランセイブ， インク． 細胞内感染を予防及び治療するための吸入システム
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
PT1581236E (pt) * 2002-10-29 2013-12-24 Insmed Inc Libertação prolongada de anti-infecciosos
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
CN1208052C (zh) 2003-03-20 2005-06-29 上海家化联合股份有限公司 一种辅酶q10前体脂质体及其制备方法
JP2006522634A (ja) * 2003-04-14 2006-10-05 ベクトゥラ・リミテッド 投与効率を向上させるデバイス及び製薬組成
US20060147389A1 (en) * 2004-04-14 2006-07-06 Vectura Ltd. Devices and pharmaceutical compositions for enhancing dosing efficiency
US20040204439A1 (en) * 2003-04-14 2004-10-14 Staniforth John Nicholas Composition, device, and method for treating sexual dysfunction via inhalation
CN100427064C (zh) * 2003-04-16 2008-10-22 沈阳药科大学 一种制备脂质体的新方法
CA2575957C (en) * 2003-09-02 2010-11-30 Norton Healthcare Ltd. Process for preparing a medicament
US20050214224A1 (en) * 2003-11-04 2005-09-29 Nektar Therapeutics Lipid formulations for spontaneous drug encapsulation
PL1786784T3 (pl) 2004-08-20 2011-04-29 Mannkind Corp Kataliza syntezy diketopiperazyn
KR101644250B1 (ko) 2004-08-23 2016-07-29 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
CN104324362B (zh) 2005-09-14 2018-04-24 曼金德公司 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法
EP3067047B1 (de) 2005-12-08 2022-04-20 Insmed Incorporated Antiinfektive zusammensetzungen auf lipidbasis zur behandlung von lungeninfekten
IN2015DN00888A (de) 2006-02-22 2015-07-10 Mannkind Corp
CN1895223B (zh) * 2006-04-05 2012-06-27 沈阳药科大学 一种新的脂质体制备方法
US9814672B2 (en) * 2007-03-09 2017-11-14 Susan T. Laing Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
EP2146692A1 (de) * 2007-03-19 2010-01-27 Fresenius Kabi Oncology Limited Proliposomale und liposomale zusammensetzungen
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US20090047336A1 (en) * 2007-08-17 2009-02-19 Hong Kong Baptist University novel formulation of dehydrated lipid vesicles for controlled release of active pharmaceutical ingredient via inhalation
ES2929343T3 (es) 2008-06-13 2022-11-28 Mannkind Corp Inhalador de polvo seco accionado por aspiración para la administración de fármacos
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
KR101628410B1 (ko) 2008-06-20 2016-06-08 맨카인드 코포레이션 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DK2400950T3 (da) 2009-02-26 2019-07-29 Glaxo Group Ltd Farmaceutiske formuleringer omfattende 4-{(1 r)-2-[(6-{2-[(2,6-dichlorbenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
DK2405963T3 (da) 2009-03-11 2013-12-16 Mannkind Corp Apparat, system og fremgangsmåde til at måle modstand i en inhalator
CN104721825B (zh) 2009-06-12 2019-04-12 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
IL223742A (en) 2010-06-21 2016-06-30 Mannkind Corp A dry powder inhaler and preparation for it
AU2012236150B2 (en) 2011-04-01 2016-03-31 Mannkind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
PL2852391T3 (pl) 2012-05-21 2022-04-11 Insmed Incorporated Układy do leczenia infekcji płuc
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
EP2884962B1 (de) * 2012-08-17 2019-05-01 Smartek International LLC Präparat aus entwässerten liposomen zur verwendung in komprimierbaren abgabesystemen
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
US10124066B2 (en) 2012-11-29 2018-11-13 Insmed Incorporated Stabilized vancomycin formulations
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
US9603799B2 (en) * 2013-03-15 2017-03-28 Htd Biosystems Inc. Liposomal vaccine adjuvants and methods of making and using same
MX375448B (es) 2013-07-18 2025-03-06 Mannkind Corp Composiciones farmacéuticas en polvo seco estables al calor y métodos.
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
LT3466432T (lt) 2014-05-15 2020-12-28 Insmed Incorporated Būdai, skirti plaučių netuberkuliozinėms mikobakterinėms infekcijoms gydyti
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US11458106B2 (en) * 2016-05-09 2022-10-04 Astrazeneca Ab Lipid nanoparticles comprising lipophilic anti-inflammatory agents and methods of use thereof
JP7379348B2 (ja) * 2017-10-11 2023-11-14 バスト バイオテクノロジー 線維症の治療のための組成物および方法
EP3773505B1 (de) 2018-03-30 2026-04-29 Insmed Incorporated Verfahren zur kontinuierlichen herstellung von liposomalen arzneimittelprodukten
JP7449275B2 (ja) 2018-05-02 2024-03-13 インスメッド インコーポレイテッド リポソーム薬物製剤の製造方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US514674A (en) * 1894-02-13 Ejector for breakdown guns
DE2966795D1 (en) * 1978-10-12 1984-04-19 Bowater Scott Ltd Holder and dispenser for stacked rolls
GB2135647A (en) * 1983-02-15 1984-09-05 Squibb & Sons Inc Method of preparing liposomes and products produced thereby
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
JPH0753661B2 (ja) * 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
SE8601457D0 (sv) * 1986-04-01 1986-04-01 Draco Ab Compositions of liposomes and b?712-receptor active substances for inhalation
SE8603812D0 (sv) * 1986-09-12 1986-09-12 Draco Ab Administration of liposomes to mammals
US5096629A (en) * 1988-08-29 1992-03-17 501 Nippon Fine Chemical Co., Ltd. Method for preparing lipid powder for use in preparing liposomes and method for preparing liposomes
RU2014071C1 (ru) * 1991-03-26 1994-06-15 Научно-производственный центр медицинской биотехнологии Способ получения липосом, содержащих водорастворимые низкомолекулярные соединения
CA2087902C (en) * 1992-02-05 2006-10-17 Narendra Raghunathji Desai Liposome compositions of porphyrin photosensitizers
AU7384894A (en) * 1993-08-06 1995-02-28 Opperbas Holding B.V. A method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
US5635206A (en) * 1994-01-20 1997-06-03 Hoffmann-La Roche Inc. Process for liposomes or proliposomes
AR002009A1 (es) * 1994-12-22 1998-01-07 Astra Ab Composicion farmaceutica, procedimiento para la manufactura de un polvo de proliposoma como el utilizado en dicha composicion, procedimiento para lamanufactura de dicha composicion, uso de dicha composicion farmaceutica en la manufactura de un medicamento y dispositivo inhalador de polvo seco.

Also Published As

Publication number Publication date
TW508248B (en) 2002-11-01
DK0800383T3 (da) 2003-07-07
EP0800383A1 (de) 1997-10-15
CZ194897A3 (en) 1997-10-15
CN1087932C (zh) 2002-07-24
PL184393B1 (pl) 2002-10-31
CZ286469B6 (en) 2000-04-12
NZ298180A (en) 1999-01-28
JPH10510830A (ja) 1998-10-20
HUT77628A (hu) 1998-06-29
MY114114A (en) 2002-08-30
IS1978B (is) 2005-01-14
MX9704406A (es) 1997-10-31
DE69530792T2 (de) 2004-04-15
WO1996019199A1 (en) 1996-06-27
SK284918B6 (sk) 2006-02-02
FI972653A0 (fi) 1997-06-19
FI972653L (fi) 1997-08-20
EG23683A (en) 2007-05-09
PL320825A1 (en) 1997-11-10
BR9510512A (pt) 1998-07-07
NO972847L (no) 1997-06-19
SA95160463B1 (ar) 2005-10-04
EE9700134A (et) 1997-12-15
DE69530792D1 (de) 2003-06-18
CN1171047A (zh) 1998-01-21
KR100432461B1 (ko) 2004-07-16
NO972847D0 (no) 1997-06-19
IS4500A (is) 1997-06-06
PT800383E (pt) 2003-07-31
AU4360596A (en) 1996-07-10
RU2162689C2 (ru) 2001-02-10
UA43886C2 (uk) 2002-01-15
AU693632B2 (en) 1998-07-02
ES2194931T3 (es) 2003-12-01
FI972653A7 (fi) 1997-08-20
IL116454A0 (en) 1996-03-31
US6045828A (en) 2000-04-04
AR002009A1 (es) 1998-01-07
EP0800383B1 (de) 2003-05-14
IL116454A (en) 2002-03-10
EE03592B1 (et) 2002-02-15
TR199501633A1 (tr) 1997-03-21
SK81497A3 (en) 1997-11-05
NO320434B1 (no) 2005-12-05
CA2208517A1 (en) 1996-06-27

Similar Documents

Publication Publication Date Title
ATE240095T1 (de) Pharmazeutische zusammensetzung enthaltend proliposomen pulver zur inhalation
EP0768094A3 (de) Inhalator für Arzneimittel in Pulverform
ZA9810490B (en) 2-Aryl-8-oxodihydropurine derivative process for the preparation thereof pharmaceutical composition containing the same and intermediate therefor
HUP9802999A3 (en) Pharmaceutical composition containing n-propargyl-1-aminoindan
IL120246A0 (en) Powdered medication inhaler
HUP0104255A3 (en) An pharmaceutical composition suitable for inhalation
IL99521A0 (en) Nasal pharmaceutical composition
HUP9701554D0 (en) Pharmaceutical composition containing plazma proteins
NO953388D0 (no) Medikamentbærer for törr-pulver inhalator
IL118369A0 (en) Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
IL116211A0 (en) Peptide compounds pharmaceutical compositions containing the same and processes for the preparation thereof
SG52435A1 (en) Pharmaceutical composition containing lipophilic drugs
HUP9903407A3 (en) Oral pharmaceutical preparation containing ibandronat
IL122618A0 (en) Substituted imidazolylacetonitrile compounds their preparation and pharmaceutical compositions containing them
ZA962916B (en) New arylglycineamide derivatives processes for the manufacture thereof and pharmaceutical compositions containing these compounds
AP9701160A0 (en) Compounds and pharmaceutical compositions containing them
IL117620A0 (en) Heterocyclic compounds processes for the preparation thereof and pharmaceutical compositions containing the same
IL125820A0 (en) Therapeutic agent for diabetes and a pharmaceutical composition containing the same
EP0448091A3 (en) Pharmaceutical composition containing slightly water-soluble drug
IL116771A (en) 9-Substituted 2-(2-n-alkoxyphenyl) purin-6-one compounds their preparation and pharmaceutical compositions containing them
IL133928A0 (en) Pharmaceutical composition containing peptichemio
IL117397A (en) Substituted naphthyl compounds and pharmaceutical compositions comprising them
IL115272A0 (en) Asp-pallidipin pharmaceutical compositions containing the same and processes for the preparation thereof
IL118007A0 (en) Isoxazoline compounds pharmaceutical compositions containing them and their use
IL123424A0 (en) Heterocyclic compounds their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0800383

Country of ref document: EP

REN Ceased due to non-payment of the annual fee