ES2194931T3 - Composicion farmaceutica que contiene polvos de proliposomas, destinada a la inhalacion. - Google Patents

Composicion farmaceutica que contiene polvos de proliposomas, destinada a la inhalacion.

Info

Publication number
ES2194931T3
ES2194931T3 ES95942357T ES95942357T ES2194931T3 ES 2194931 T3 ES2194931 T3 ES 2194931T3 ES 95942357 T ES95942357 T ES 95942357T ES 95942357 T ES95942357 T ES 95942357T ES 2194931 T3 ES2194931 T3 ES 2194931T3
Authority
ES
Spain
Prior art keywords
proliposoma
powder
inhalation
intended
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95942357T
Other languages
English (en)
Inventor
Katarina Bystrom
Per-Gunnar Nilsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9404466A external-priority patent/SE9404466D0/xx
Priority claimed from SE9502369A external-priority patent/SE9502369D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2194931T3 publication Critical patent/ES2194931T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN POLVO PROLIPOSOMA QUE CONSTA EN UNA FASE UNICA DE PARTICULAS DISCRETAS DE UN COMPUESTO BIOLOGICAMENTE ACTIVO JUNTO CON UN LIPIDO O UNA MEZCLA DE LIPIDOS CON UNA TEMPERATURA DE TRANSICION DE FASE INFERIOR A 37 (GRADOS) C.
ES95942357T 1994-12-22 1995-12-20 Composicion farmaceutica que contiene polvos de proliposomas, destinada a la inhalacion. Expired - Lifetime ES2194931T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9404466A SE9404466D0 (sv) 1994-12-22 1994-12-22 Process for the preparation of powders for inhalation
SE9502369A SE9502369D0 (sv) 1995-06-30 1995-06-30 Process for the preparation of compositions for inhalation

Publications (1)

Publication Number Publication Date
ES2194931T3 true ES2194931T3 (es) 2003-12-01

Family

ID=26662194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95942357T Expired - Lifetime ES2194931T3 (es) 1994-12-22 1995-12-20 Composicion farmaceutica que contiene polvos de proliposomas, destinada a la inhalacion.

Country Status (32)

Country Link
US (1) US6045828A (es)
EP (1) EP0800383B1 (es)
JP (1) JPH10510830A (es)
KR (1) KR100432461B1 (es)
CN (1) CN1087932C (es)
AR (1) AR002009A1 (es)
AT (1) ATE240095T1 (es)
AU (1) AU693632B2 (es)
BR (1) BR9510512A (es)
CA (1) CA2208517A1 (es)
CZ (1) CZ286469B6 (es)
DE (1) DE69530792T2 (es)
DK (1) DK0800383T3 (es)
EE (1) EE03592B1 (es)
EG (1) EG23683A (es)
ES (1) ES2194931T3 (es)
FI (1) FI972653L (es)
HU (1) HUT77628A (es)
IL (1) IL116454A (es)
IS (1) IS1978B (es)
MY (1) MY114114A (es)
NO (1) NO320434B1 (es)
NZ (1) NZ298180A (es)
PL (1) PL184393B1 (es)
PT (1) PT800383E (es)
RU (1) RU2162689C2 (es)
SA (1) SA95160463B1 (es)
SK (1) SK284918B6 (es)
TR (1) TR199501633A1 (es)
TW (1) TW508248B (es)
UA (1) UA43886C2 (es)
WO (1) WO1996019199A1 (es)

Families Citing this family (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA95160463B1 (ar) * 1994-12-22 2005-10-04 استرا أكتيبولاج مساحيق للاستنشاق
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
TW497974B (en) * 1996-07-03 2002-08-11 Res Dev Foundation High dose liposomal aerosol formulations
AU4424797A (en) * 1996-09-18 1998-04-14 Dragoco Inc. Liposome encapsulated active agent dry powder composition
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
SK184799A3 (en) * 1997-06-27 2000-06-12 Astra Ab New combination of antiasthma medicaments
PL337723A1 (en) * 1997-06-27 2000-08-28 Astra Ab Inhalable tocopherol-stabilised prolyposomic powders
US7052678B2 (en) * 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
US7348025B2 (en) 1997-09-23 2008-03-25 Research Development Foundation Small particle liposome aerosols for delivery of anticancer drugs
US6090407A (en) 1997-09-23 2000-07-18 Research Development Foundation Small particle liposome aerosols for delivery of anti-cancer drugs
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20020017295A1 (en) * 2000-07-07 2002-02-14 Weers Jeffry G. Phospholipid-based powders for inhalation
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
SE9704833D0 (sv) * 1997-12-22 1997-12-22 Astra Ab New formulation
US6956021B1 (en) * 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
KR20010111564A (ko) * 1998-11-12 2001-12-19 프랭크 쥐. 필키윅즈 흡입 시스템
EP1839648A3 (en) * 1998-11-12 2007-11-21 Transave, Inc. An inhalation system
EP1133301A1 (en) * 1998-11-26 2001-09-19 Britannia Pharmaceuticals Limited Anti-asthmatic combinations comprising surface active phospholipids
GB9912639D0 (en) 1999-05-28 1999-07-28 Britannia Pharmaceuticals Ltd Improvements in and relating to treatment of respiratory conditions
PT1158958E (pt) * 1999-03-05 2007-08-13 Chiesi Farma Spa ''composições farmacêuticas em pó, melhoradas, para inalação''
EP1043016B1 (en) * 1999-03-30 2014-08-20 Sodic Sa A plant extract based on glycerides,phospholipids and phytosphingolipids, a method for the preparation of this extract and a cosmetic composition containing the same
DK1165050T3 (da) 1999-04-05 2006-05-01 Mannkind Corp Fremgangsmåde til dannelse af fint pulver
ATE458471T1 (de) 1999-05-27 2010-03-15 Euro Celtique Sa Formulierungen mit povidon-iod zur behandlung von wunden
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US20010036481A1 (en) * 1999-08-25 2001-11-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US6749835B1 (en) 1999-08-25 2004-06-15 Advanced Inhalation Research, Inc. Formulation for spray-drying large porous particles
CA2382821A1 (en) * 1999-08-25 2001-03-01 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
US7678364B2 (en) 1999-08-25 2010-03-16 Alkermes, Inc. Particles for inhalation having sustained release properties
US6156294A (en) 1999-11-28 2000-12-05 Scientific Development And Research, Inc. Composition and method for treatment of otitis media
GB9928311D0 (en) * 1999-11-30 2000-01-26 Novartis Ag Organic compounds
DE10012151A1 (de) * 2000-03-13 2001-09-27 Gsf Forschungszentrum Umwelt Mittel zur Behandlung von Erkrankungen des Tracheo-Brochialtraktes, insbesondere der COPD
GB0008660D0 (en) * 2000-04-07 2000-05-31 Arakis Ltd The treatment of respiratory diseases
PT1280520E (pt) 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
CA2417826A1 (en) 2000-08-05 2002-02-14 Glaxo Group Limited 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
EP2283817B1 (en) 2000-11-30 2016-05-18 Vectura Limited Method of making particles for use in a pharmaceutical composition
US20020141946A1 (en) * 2000-12-29 2002-10-03 Advanced Inhalation Research, Inc. Particles for inhalation having rapid release properties
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
AR033290A1 (es) 2001-04-30 2003-12-10 Glaxo Group Ltd Derivados antiinflamatorios de androstano
CA2465675C (en) * 2001-11-20 2008-06-10 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
PL371626A1 (en) * 2002-01-21 2005-06-27 Vasogen Ireland Limited Pharmaceutically acceptable phosphate-glycerol carrying bodies
AU2003230600B2 (en) * 2002-03-05 2009-06-04 Transave, Inc. An inhalation system for prevention and treatment of intracellular infections
JP4681231B2 (ja) 2002-03-20 2011-05-11 マンカインド コーポレイション 吸入装置
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
AU2003304204B2 (en) * 2002-10-29 2009-12-24 Insmed Incorporated Sustained release of antiinfectives
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
CN1208052C (zh) 2003-03-20 2005-06-29 上海家化联合股份有限公司 一种辅酶q10前体脂质体及其制备方法
JP2006522634A (ja) * 2003-04-14 2006-10-05 ベクトゥラ・リミテッド 投与効率を向上させるデバイス及び製薬組成
US20040204439A1 (en) * 2003-04-14 2004-10-14 Staniforth John Nicholas Composition, device, and method for treating sexual dysfunction via inhalation
US20060147389A1 (en) * 2004-04-14 2006-07-06 Vectura Ltd. Devices and pharmaceutical compositions for enhancing dosing efficiency
CN100427064C (zh) * 2003-04-16 2008-10-22 沈阳药科大学 一种制备脂质体的新方法
PL1699434T3 (pl) 2003-09-02 2011-09-30 Norton Healthcare Ltd Sposób wytwarzania leku
WO2005044226A2 (en) * 2003-11-04 2005-05-19 Nectar Therapeutics Lipid formulations for spontaneous drug encapsulation
ATE486064T1 (de) 2004-08-20 2010-11-15 Mannkind Corp Katalyse der diketopiperazinsynthese
HUE025151T2 (en) 2004-08-23 2016-01-28 Mannkind Corp Diceto-piperazine salts for drug delivery
GB0425758D0 (en) 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
MX373000B (es) 2005-09-14 2020-05-21 Mannkind Corp Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
ES2798263T3 (es) 2005-12-08 2020-12-10 Insmed Inc Composiciones a base de lípidos de antiinfecciosos para tratar infecciones pulmonares
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
CN1895223B (zh) * 2006-04-05 2012-06-27 沈阳药科大学 一种新的脂质体制备方法
US9814672B2 (en) * 2007-03-09 2017-11-14 Susan T. Laing Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
AU2008227852B2 (en) * 2007-03-19 2011-02-24 Fresenius Kabi Oncology Ltd. Proliposomal and liposomal compositions
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US20090047336A1 (en) * 2007-08-17 2009-02-19 Hong Kong Baptist University novel formulation of dehydrated lipid vesicles for controlled release of active pharmaceutical ingredient via inhalation
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
MY155524A (en) 2008-06-13 2015-10-30 Mannkind Corp A dry powder inhaler and system for drug delivery
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
ES2739352T3 (es) 2009-02-26 2020-01-30 Glaxo Group Ltd Formulaciones farmacéuticas que comprenden 4-{(1R)-2-[(6-{2-[(2,6-diclorobencil)oxi]etoxi}hexil)amino]-1-hidroxietil}-2-(hidroximetil)fenol
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
AU2010259943C1 (en) 2009-06-12 2016-03-03 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
MX353285B (es) 2011-04-01 2018-01-05 Mannkind Corp Paquete de blister para cartuchos farmaceuticos.
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
PL2852391T3 (pl) 2012-05-21 2022-04-11 Insmed Incorporated Układy do leczenia infekcji płuc
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
EA035868B1 (ru) 2012-08-17 2020-08-24 Смартек Интернэшнл Эл-Эл-Си Приготовление высушенных липосом для применения в системах выпуска в прессованном виде
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
CA2891487A1 (en) 2012-11-29 2014-06-05 Insmed Incorporated Stabilized vancomycin formulations
BR112015023168B1 (pt) 2013-03-15 2021-08-10 Mannkind Corporation Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina
US9603799B2 (en) * 2013-03-15 2017-03-28 Htd Biosystems Inc. Liposomal vaccine adjuvants and methods of making and using same
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
MX384843B (es) 2014-05-15 2025-03-14 Insmed Inc Métodos para tratar infecciones pulmonares micobacterianas no tuberculosas.
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2017194454A1 (en) * 2016-05-09 2017-11-16 Astrazeneca Ab Lipid nanoparticles comprising lipophilic anti-inflammatory agents and methods of use thereof
CN111278441A (zh) * 2017-10-11 2020-06-12 巴斯特生物技术 用于治疗纤维化的组合物和方法
EP3773505B1 (en) 2018-03-30 2026-04-29 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
EP3787602A4 (en) 2018-05-02 2022-03-23 Insmed Incorporated PROCESS FOR THE MANUFACTURE OF LIPOSOMAL DRUG FORMULATIONS
AU2023288123A1 (en) * 2022-06-21 2025-01-16 Hovione Scientia Limited Crystalline pharmaceutical composition for inhalation comprising sugar and lipid composite particles and process for manufacture

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US514674A (en) * 1894-02-13 Ejector for breakdown guns
EP0026241B1 (en) * 1978-10-12 1984-03-14 Bowater-Scott Limited Holder and dispenser for stacked rolls
GB2135647A (en) * 1983-02-15 1984-09-05 Squibb & Sons Inc Method of preparing liposomes and products produced thereby
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
JPH0753661B2 (ja) * 1984-03-08 1995-06-07 フアレス フアーマスーチカル リサーチ エヌブイ プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
SE8601457D0 (sv) * 1986-04-01 1986-04-01 Draco Ab Compositions of liposomes and b?712-receptor active substances for inhalation
SE8603812D0 (sv) * 1986-09-12 1986-09-12 Draco Ab Administration of liposomes to mammals
US5096629A (en) * 1988-08-29 1992-03-17 501 Nippon Fine Chemical Co., Ltd. Method for preparing lipid powder for use in preparing liposomes and method for preparing liposomes
RU2014071C1 (ru) * 1991-03-26 1994-06-15 Научно-производственный центр медицинской биотехнологии Способ получения липосом, содержащих водорастворимые низкомолекулярные соединения
CA2087902C (en) * 1992-02-05 2006-10-17 Narendra Raghunathji Desai Liposome compositions of porphyrin photosensitizers
JPH09501168A (ja) * 1993-08-06 1997-02-04 オパーバス ホールディング ビー ヴィ 生物構造体、生体ポリマー及び/又はオリゴマーを充填した小胞の調製方法
US5635206A (en) * 1994-01-20 1997-06-03 Hoffmann-La Roche Inc. Process for liposomes or proliposomes
SA95160463B1 (ar) * 1994-12-22 2005-10-04 استرا أكتيبولاج مساحيق للاستنشاق

Also Published As

Publication number Publication date
SK284918B6 (sk) 2006-02-02
TR199501633A1 (tr) 1997-03-21
EE9700134A (et) 1997-12-15
FI972653A0 (fi) 1997-06-19
IS4500A (is) 1997-06-06
NO972847D0 (no) 1997-06-19
ATE240095T1 (de) 2003-05-15
AU693632B2 (en) 1998-07-02
EG23683A (en) 2007-05-09
CA2208517A1 (en) 1996-06-27
FI972653A7 (fi) 1997-08-20
DE69530792D1 (de) 2003-06-18
MX9704406A (es) 1997-10-31
JPH10510830A (ja) 1998-10-20
KR100432461B1 (ko) 2004-07-16
TW508248B (en) 2002-11-01
IL116454A0 (en) 1996-03-31
IL116454A (en) 2002-03-10
PL184393B1 (pl) 2002-10-31
BR9510512A (pt) 1998-07-07
US6045828A (en) 2000-04-04
DE69530792T2 (de) 2004-04-15
PL320825A1 (en) 1997-11-10
DK0800383T3 (da) 2003-07-07
WO1996019199A1 (en) 1996-06-27
AR002009A1 (es) 1998-01-07
EP0800383B1 (en) 2003-05-14
UA43886C2 (uk) 2002-01-15
FI972653L (fi) 1997-08-20
MY114114A (en) 2002-08-30
CZ194897A3 (en) 1997-10-15
AU4360596A (en) 1996-07-10
SA95160463B1 (ar) 2005-10-04
CZ286469B6 (en) 2000-04-12
PT800383E (pt) 2003-07-31
RU2162689C2 (ru) 2001-02-10
NO320434B1 (no) 2005-12-05
EE03592B1 (et) 2002-02-15
NZ298180A (en) 1999-01-28
EP0800383A1 (en) 1997-10-15
NO972847L (no) 1997-06-19
HUT77628A (hu) 1998-06-29
SK81497A3 (en) 1997-11-05
IS1978B (is) 2005-01-14
CN1087932C (zh) 2002-07-24
CN1171047A (zh) 1998-01-21

Similar Documents

Publication Publication Date Title
AU7729998A (en) Active principles and gas containing microparticles
BG105033A (bg) Фармацевтични състави за аерозоли с две, или повече активни вещества
AU3559895A (en) Polyethylene glycol modified ceramide lipids and liposome uses thereof
ZA953358B (en) New pharmaceutical composition based on taxoids
PL319833A1 (en) Compounds and composition for carrying active media
AU2845599A (en) Pharmaceutical compositions and their use
HU9303357D0 (en) Pharmaceutical composition containing well-defined lipide-systhem
EP0993831A3 (en) Compounds and compositions for delivering active agents
HUP9901710A3 (en) New, stable medicinal compositions for generating propellant-free aerosols
IL138767A0 (en) Anticancer compositions
WO2002002074A3 (en) Skin conditioning compositions containing compounds for mimicking the effect on skin of retinoic acid
EP2258342A3 (en) Improvements in and relating to carrier particles for use in dry powder inhalers
MX9301787A (es) Producto nutricional liquido para alimentacion enteral.
MY132999A (en) New formulation for inhalation
IL133397A (en) Pharmaceutical compositions for oral administration comprising an active substance and a cyclodextrin
BR9807383A (pt) Formulação farmacêutica que compreende amoxicilina e clavulanato
NZ336592A (en) Formulation for inhalation having a poured bulk density of from 0.28 to 0.38 g/ml comprising finely divided budesonide and a carrier
MXPA97007996A (es) Preparado para el transporte de sustancias activas a traves de barreras.
ATE158504T1 (de) Brausemischungen enthaltend ibuprofen und verfahren
TNSN01003A1 (fr) Appareil d'administration d'aerosols a comptage de dose dans des propulseurs hydrofluoroalcanes.
ES2174054T3 (es) Composiciones farmaceuticas acuosas liquidas que comprenden alginato sodico y bicarbonato potasico.
BR9810280A (pt) Pós de prolipossomo para inalação estabelizada por tocoferol.
TR199903192T2 (xx) Eritropoetin, de�i�tirilmi� hemoglobin i�eren farmasotik kombine m�stahzarlar.
BG105570A (en) Pharmaceutical compositions for modified release insulin sensitiser
WO2002053108A3 (en) Skin care product containing retinoids, retinoid booster and phytoestrogens in a dual compartment package