ATE240335T1 - Azaheterocyclylmethyl-derivate von 2,3,8,9- tetrahydro-7h-1,4-dioxino(2,3-e)indol-8-on - Google Patents

Azaheterocyclylmethyl-derivate von 2,3,8,9- tetrahydro-7h-1,4-dioxino(2,3-e)indol-8-on

Info

Publication number: ATE240335T1
Authority: AT; Austria
Prior art keywords: optionally substituted; defined above; hydrogen; phenyl; benzoisothiazolyl
Prior art date: 1996-10-15

Application number

AT97910866T

Other languages

English (en)

Inventor

Gary Paul Stack

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-15

Filing date

1997-10-10

Publication date

2003-05-15

1997-10-10 Application filed by Wyeth Corp filed Critical Wyeth Corp

2003-05-15 Application granted granted Critical

2003-05-15 Publication of ATE240335T1 publication Critical patent/ATE240335T1/de

Links

SDSPXRGIPYHEJB-UHFFFAOYSA-N 2,3,7,9-tetrahydro-[1,4]dioxino[2,3-e]indol-8-one Chemical class O1CCOC2=C1C=CC1=C2CC(=O)N1 SDSPXRGIPYHEJB-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 abstract 3
-1 benzoisothiazolyl Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000001041 indolyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
125000001624 naphthyl group Chemical group 0.000 abstract 2
125000001544 thienyl group Chemical group 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
210000004556 brain Anatomy 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229960003638 dopamine Drugs 0.000 abstract 1
230000008482 dysregulation Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT97910866T 1996-10-15 1997-10-10 Azaheterocyclylmethyl-derivate von 2,3,8,9- tetrahydro-7h-1,4-dioxino(2,3-e)indol-8-on ATE240335T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73280796A	1996-10-15	1996-10-15
PCT/US1997/018275 WO1998016530A1 (en)	1996-10-15	1997-10-10	AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-e]INDOL-8-ONE

Publications (1)

Publication Number	Publication Date
ATE240335T1 true ATE240335T1 (de)	2003-05-15

Family

ID=24945030

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97910866T ATE240335T1 (de)	1996-10-15	1997-10-10	Azaheterocyclylmethyl-derivate von 2,3,8,9- tetrahydro-7h-1,4-dioxino(2,3-e)indol-8-on

Country Status (10)

Country	Link
EP (1)	EP0932609B1 (de)
JP (1)	JP2001502327A (de)
AT (1)	ATE240335T1 (de)
AU (1)	AU4813897A (de)
CA (1)	CA2268195C (de)
DE (1)	DE69722020T2 (de)
DK (1)	DK0932609T3 (de)
ES (1)	ES2196312T3 (de)
PT (1)	PT932609E (de)
WO (1)	WO1998016530A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9627005D0 (en) *	1996-12-27	1997-02-12	Knoll Ag	Therapeutic agents
US6800641B2 (en)	2001-04-26	2004-10-05	Wyeth	Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-2,3-diaza-cyclopenta[a]naphthalene
ES2247327T3 (es)	2001-04-26	2006-03-01	Wyeth	Derivados azaheterociclimetilicos antidepresivos (isrs) de 7,8-dihidro-3h-6,9-dioxa-1,3-diazaciclopenta(a) naftaleno.
US6861427B2 (en) *	2001-04-26	2005-03-01	Wyeth	Azabicyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoline as 5-HT1A antagonists
US6656947B2 (en)	2001-04-26	2003-12-02	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline
US6706736B2 (en)	2001-04-26	2004-03-16	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans
ES2229138T3 (es)	2001-04-26	2005-04-16	Wyeth	Derivados antidepresivos azaheterociclilmetilicos de (1,4)- benzodiaxanos condensados con oxaheterociclos.
US6927226B2 (en)	2001-04-26	2005-08-09	Wyeth	Antidepressant azaheterocyclymethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diazacyclopenta[a]naphthalene
BR0209407A (pt) *	2001-04-30	2004-07-06	Wyeth Corp	Antidepressivos de azaheterociclilmetila derivados de 7,8-dihidro-1,6,9-trioxa-3-aza-ciclopenta[a[]naftaleno , método de tratamento usando tais compostos e processo para prepará-los
US6617334B2 (en)	2001-04-30	2003-09-09	Wyeth	Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene
ES2323451T7 (es)	2001-07-20	2011-08-01	Psychogenics Inc.	Tratamiento para el trastorno de hiperactividad con deficit de atencion.
US6939877B2 (en) *	2002-09-12	2005-09-06	Wyeth	Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
US7153849B2 (en)	2002-09-12	2006-12-26	Wyeth	Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991013872A1 (en) *	1990-03-15	1991-09-19	The Upjohn Company	Therapeutically useful heterocyclic indole compounds
DE4135474A1 (de) *	1991-10-28	1993-04-29	Bayer Ag	2-aminomethyl-chromane
DE4140540A1 (de) *	1991-12-09	1993-06-17	Bayer Ag	Neue azaheterocyclylmethyl-chromane
AR004523A1 (es) *	1995-11-06	1998-12-16	American Home Prod	2-(AMINOMETIL)-3,4,7,9-TETRAHIDRO-2H-PIRANO-[2,3e] INDOL-8-ONAS Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN

1997
- 1997-10-10 DK DK97910866T patent/DK0932609T3/da active
- 1997-10-10 PT PT97910866T patent/PT932609E/pt unknown
- 1997-10-10 JP JP10518447A patent/JP2001502327A/ja not_active Ceased
- 1997-10-10 CA CA002268195A patent/CA2268195C/en not_active Expired - Fee Related
- 1997-10-10 DE DE69722020T patent/DE69722020T2/de not_active Expired - Fee Related
- 1997-10-10 AT AT97910866T patent/ATE240335T1/de not_active IP Right Cessation
- 1997-10-10 ES ES97910866T patent/ES2196312T3/es not_active Expired - Lifetime
- 1997-10-10 EP EP97910866A patent/EP0932609B1/de not_active Expired - Lifetime
- 1997-10-10 AU AU48138/97A patent/AU4813897A/en not_active Abandoned
- 1997-10-10 WO PCT/US1997/018275 patent/WO1998016530A1/en not_active Ceased

Also Published As

Publication number	Publication date
CA2268195C (en)	2006-08-29
DE69722020T2 (de)	2004-01-22
CA2268195A1 (en)	1998-04-23
DE69722020D1 (de)	2003-06-18
EP0932609B1 (de)	2003-05-14
AU4813897A (en)	1998-05-11
PT932609E (pt)	2003-09-30
JP2001502327A (ja)	2001-02-20
EP0932609A1 (de)	1999-08-04
WO1998016530A1 (en)	1998-04-23
DK0932609T3 (da)	2003-09-01
ES2196312T3 (es)	2003-12-16

Legal Events

Date

Code

Title

Description

2003-11-15

UEP

Publication of translation of european patent specification

Ref document number: 0932609

Country of ref document: EP

2007-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE240335T1 (de)	2003-05-15	Azaheterocyclylmethyl-derivate von 2,3,8,9- tetrahydro-7h-1,4-dioxino(2,3-e)indol-8-on
TW222584B (de)	1994-04-21
IL99571A0 (en)	1992-08-18	Process for the preparation of water soluble camptothecin analogs,compounds prepared by said process,and methods of use thereof
SI1312359T1 (sl)	2008-08-31	Uporaba 1,3-propandiolnih spojin
MX9803455A (es)	1998-09-30	Derivados de indolalquilo de benzodioxanmetilamina como ligandos del receptor 5-ht1a.
WO1994019343A3 (en)	1994-10-27	Novel use as anti-inflammatory agents for bis-heterocyclic compounds and pharmaceutical compositions thereof
CA2268399A1 (en)	1998-05-07	Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
NZ503710A (en)	2002-04-26	2-Substituted- 4'-hydroxy-5,9,9-trimethyl-6,7-benzomorphan derivatives useful in treating vascular diseases
AU4200089A (en)	1990-04-02	Substituted beta-diketones
GB2151624B (en)	1987-11-11	Imidazo1 2-cpyrimidine
PL337188A1 (en)	2000-08-14	Derivatives of 17beta - allyloxy (thio) alkyl - androstane for modulation of meiosis
TW334428B (en)	1998-06-21	Novel benzodiazepine derivatives
YU140491A (sh)	1994-01-20	6-supstituisani-tetrahidrobenz(c,d) indoli
PY0101637A (es)	2001-12-03	Aminomethyl-2 3 8 9-tetrahydro-7h-1 4-dioxino(2 3-e)-indol-8-ones and derivatives
CA2144974A1 (en)	1994-03-31	Camphidine derivative, production thereof, and use thereof