ATE241367T1 - Halbsynthetische sulfatierte sulfoaminoheparosane mit hoher antimetastatischer wirkung und reduziertem hämorrhagischem risiko - Google Patents

Halbsynthetische sulfatierte sulfoaminoheparosane mit hoher antimetastatischer wirkung und reduziertem hämorrhagischem risiko

Info

Publication number
ATE241367T1
ATE241367T1 AT97942887T AT97942887T ATE241367T1 AT E241367 T1 ATE241367 T1 AT E241367T1 AT 97942887 T AT97942887 T AT 97942887T AT 97942887 T AT97942887 T AT 97942887T AT E241367 T1 ATE241367 T1 AT E241367T1
Authority
AT
Austria
Prior art keywords
sulfoaminoheparosans
semi
antimetastatic effect
synthetic sulfated
hemorrhagic risk
Prior art date
Application number
AT97942887T
Other languages
English (en)
Inventor
Annamaria Naggi
Giangiacomo Torri
Original Assignee
Istituto Scient Di Chimica E B
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Scient Di Chimica E B filed Critical Istituto Scient Di Chimica E B
Application granted granted Critical
Publication of ATE241367T1 publication Critical patent/ATE241367T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
AT97942887T 1996-09-06 1997-08-28 Halbsynthetische sulfatierte sulfoaminoheparosane mit hoher antimetastatischer wirkung und reduziertem hämorrhagischem risiko ATE241367T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI001840A IT1284143B1 (it) 1996-09-06 1996-09-06 Eparansolfati semi-sintetici ad elevata attivita' antimetastica e ridotto rischio emorragico
PCT/EP1997/004682 WO1998009636A1 (en) 1996-09-06 1997-08-28 Semi-synthetic sulphaminoheparosansulphates having high anti-metastatic activity and reduced haemorrhagic risk

Publications (1)

Publication Number Publication Date
ATE241367T1 true ATE241367T1 (de) 2003-06-15

Family

ID=11374854

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97942887T ATE241367T1 (de) 1996-09-06 1997-08-28 Halbsynthetische sulfatierte sulfoaminoheparosane mit hoher antimetastatischer wirkung und reduziertem hämorrhagischem risiko

Country Status (12)

Country Link
EP (1) EP0956027B1 (de)
JP (1) JP2000517328A (de)
KR (1) KR20000068468A (de)
AT (1) ATE241367T1 (de)
AU (1) AU715868B2 (de)
CA (1) CA2264929C (de)
DE (1) DE69722450T2 (de)
IT (1) IT1284143B1 (de)
NZ (1) NZ334566A (de)
PL (1) PL331798A1 (de)
RU (1) RU2176915C2 (de)
WO (1) WO1998009636A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20010779A1 (it) * 2001-04-12 2002-10-12 Giorgio Zoppetti Uso di polisaccaridi batterici solfati atti all'inibizione dell'angiogenesi
RU2005100966A (ru) * 2002-06-18 2005-08-10 Гликорес 2000 С.Р.Л. (It) Низкомолекулярный сверхсульфатированный полисахарид
US8513407B2 (en) 2002-06-18 2013-08-20 Glycores 2000 S.R.L. Process for the preparation of N-acyl-(epi)K5-amine-O-sulfate-derivatives and products thus obtained
CN1675249A (zh) * 2002-06-18 2005-09-28 格利考斯2000有限公司 N－酰基－(表)k5－胺－o－硫酸盐衍生物及其产品的制备方法
FR2857971B1 (fr) * 2003-07-24 2005-08-26 Aventis Pharma Sa Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
WO2015085094A1 (en) 2013-12-04 2015-06-11 Heartware, Inc. Apparatus and methods for cutting an atrial wall

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988001280A1 (en) * 1986-08-21 1988-02-25 Board Of Regents, The University Of Texas System Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.
IT1270823B (it) * 1993-06-04 1997-05-13 Italfarmaco Spa Polisaccaridi ad elevata attivita' antitrombotica e anticoagulante

Also Published As

Publication number Publication date
WO1998009636A1 (en) 1998-03-12
IT1284143B1 (it) 1998-05-08
EP0956027B1 (de) 2003-05-28
AU4456197A (en) 1998-03-26
DE69722450T2 (de) 2004-05-06
DE69722450D1 (de) 2003-07-03
ITMI961840A1 (it) 1998-03-06
CA2264929A1 (en) 1998-03-12
NZ334566A (en) 2000-01-28
RU2176915C2 (ru) 2001-12-20
PL331798A1 (en) 1999-08-02
JP2000517328A (ja) 2000-12-26
EP0956027A1 (de) 1999-11-17
CA2264929C (en) 2006-10-24
AU715868B2 (en) 2000-02-10
KR20000068468A (ko) 2000-11-25

Similar Documents

Publication Publication Date Title
AU2285583A (en) Depolymerized and supersulfated heparin
ES2140082T3 (es) Composiciones peptidicas con actividad de tipo factor de crecimiento.
ES2054017T3 (es) Metodo para combatir pneumocystis carinii.
IT1271057B (it) Polisaccaridi aventi un elevato contenuto di acido iduronico
ATE1019T1 (de) Hyaluronidase und seine herstellung.
FI873176L (fi) Anordning foer spaend infaestning av en injektionsspruta i ett stycke, som kan kopplas till sprutan.
IE811074L (en) Sulphated polysaccharides
ATE369346T1 (de) Halogenpyrimidinylaryl(thio)ether als pestizide
ES2176456T3 (es) Procedimiento de preparacion de un compuesto inhibidor del vih proteasa.
ATE271560T1 (de) Verbindungen mit antiviraler aktivität
ATE241367T1 (de) Halbsynthetische sulfatierte sulfoaminoheparosane mit hoher antimetastatischer wirkung und reduziertem hämorrhagischem risiko
FR2607375B1 (fr) Fauteuil ou analogue, fixe ou mobile, comportant une structure de verticalisation
ATE63750T1 (de) Peptid, dessen herstellung und benutzung.
ES2094848T3 (es) Agente de crecimiento del hepatocito.
FI891677A0 (fi) Menetelmä 4-demetoksidaunomysinonin valmistamiseksi
DE58907121D1 (de) Zwei- oder mehrstufige Hochvakuumpumpe.
FI943642A0 (fi) Sulfatoidut polysakkaridit, menetelmä niiden valmistamiseksi, farmaseuttinen valmistus ja käyttö
IT1207580B (it) Peptide arrestante la crescita ottenuto da veleno di serpente.
RU99106795A (ru) Полусинтетические сульфаминогепаросансульфаты, имеющие высокую антиметастатическую активность и пониженный геморрагический риск
DK0571475T3 (da) Beta-1,4-galactanase og en DNA-sekvens
MX9207468A (es) Proceso para preparar acido 2,6-naftalenodicarboxilico purificado.
BR0013840A (pt) Análogos monoméricos de insulina humana
ATE43964T1 (de) Ester der (+)-6-methoxy-alpha-methyl-2naphthalenessigs|ure mit mucosekretolytischer, entzuendungshemmender, schmerzstillender, fieber erniedrigender wirkung, dessen herstellungsverfahren und dessen pharmazeutische zusammensetzungen.
ES2134971T3 (es) Derivado de acido octahidro-2-naftaleno-carboxilico, su produccion y uso.
JPS56803A (en) Preparation of vegetable polysaccharide sulfate ester

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties