ATE241962T1 - Verfahren zur herstellung feinteiliger pharmazeutischer formulierungen - Google Patents
Verfahren zur herstellung feinteiliger pharmazeutischer formulierungenInfo
- Publication number
- ATE241962T1 ATE241962T1 AT95909559T AT95909559T ATE241962T1 AT E241962 T1 ATE241962 T1 AT E241962T1 AT 95909559 T AT95909559 T AT 95909559T AT 95909559 T AT95909559 T AT 95909559T AT E241962 T1 ATE241962 T1 AT E241962T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical formulations
- fine particle
- producing fine
- particle pharmaceutical
- extrusion
- Prior art date
Links
- 239000010419 fine particle Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000001125 extrusion Methods 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000005563 spheronization Methods 0.000 abstract 1
- 239000001993 wax Substances 0.000 abstract 1
- 238000009736 wetting Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19702594A | 1994-02-16 | 1994-02-16 | |
| PCT/US1995/001943 WO1995022319A1 (en) | 1994-02-16 | 1995-02-14 | Process for preparing fine particle pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE241962T1 true ATE241962T1 (de) | 2003-06-15 |
Family
ID=22727703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95909559T ATE241962T1 (de) | 1994-02-16 | 1995-02-14 | Verfahren zur herstellung feinteiliger pharmazeutischer formulierungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6063313A (de) |
| EP (1) | EP0744941B1 (de) |
| JP (1) | JP4040084B2 (de) |
| AT (1) | ATE241962T1 (de) |
| CA (1) | CA2182282C (de) |
| DE (1) | DE69530973T2 (de) |
| DK (1) | DK0744941T3 (de) |
| ES (1) | ES2199981T3 (de) |
| MX (1) | MX9603480A (de) |
| PT (1) | PT744941E (de) |
| WO (1) | WO1995022319A1 (de) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19531277A1 (de) * | 1995-08-25 | 1997-02-27 | Basf Ag | Verwendung von Lipiden als Hilfsmittel bei der Herstellung von festen Arzneiformen nach dem Schmelzextrusionsverfahren |
| WO1997049384A1 (en) | 1996-06-26 | 1997-12-31 | Board Of Regents, The University Of Texas System | Hot-melt extrudable pharmaceutical formulation |
| US6139872A (en) * | 1996-08-14 | 2000-10-31 | Henkel Corporation | Method of producing a vitamin product |
| FR2753904B1 (fr) * | 1996-10-01 | 1998-10-30 | Gattefosse Ets Sa | Composition pharmaceutique a liberation modifiee de principe actif, comportant une matrice, et procede de fabrication |
| IT1298574B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione |
| ES2207211T3 (es) * | 1998-04-24 | 2004-05-16 | Basf Corporation | Procedimiento mejorado para la extrusion. |
| JP2000128774A (ja) * | 1998-10-26 | 2000-05-09 | Tanabe Seiyaku Co Ltd | 薬物を含有する球形微粒子の製法 |
| SI20150A (sl) * | 1999-02-19 | 2000-08-31 | Lek, Tovarna Farmacevtskih In | Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| US6365216B1 (en) | 1999-03-26 | 2002-04-02 | The Nutrasweet Company | Particles of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester |
| DE19916383A1 (de) * | 1999-03-31 | 2000-10-05 | Schering Ag | Pharmazeutische Zusammensetzung mit einem Extrusionsstoff |
| EP1175205B1 (de) | 1999-11-12 | 2006-06-14 | Abbott Laboratories | Feste dispersion mit ritonavir, fenofibrat oder griseofulvin |
| US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
| NZ521368A (en) * | 2000-03-28 | 2004-05-28 | Biochemie Ges M | Granulated particles of an active compound, with a film-forming coating resulting in the masked taste of said active compound |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| DE60108255T2 (de) * | 2000-09-22 | 2005-12-22 | Galephar M/F | Clarithromycin enthaltende zubereitung mit verlängerter freisetzung |
| FR2816507B1 (fr) | 2000-11-16 | 2003-02-28 | Ethypharm Lab Prod Ethiques | Microgranules a base de principe actif, procede de fabrication et compositons pharmaceutiques integrant lesdits microgranules |
| ITRN20000051A1 (it) | 2000-12-22 | 2002-06-22 | Ascor Chimici Srl | Metodo e apparecchiatura per formare sferule composite contenenti principi attivi del tipo farmaceutico e/o integratori alimentari o cosmeti |
| WO2002092069A1 (en) | 2001-05-11 | 2002-11-21 | Elan Corporation, Plc | Permeation enhancers |
| US20030203019A1 (en) * | 2002-04-30 | 2003-10-30 | Cornelius John Mark | Coated conditioners for use in foods and pharmaceuticals |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| WO2004073632A2 (en) * | 2003-02-19 | 2004-09-02 | Biovail Laboratories Inc. | Rapid absorption selective 5-ht agonist formulations |
| EP2535042A1 (de) | 2003-06-16 | 2012-12-19 | ANDRX Pharmaceuticals LLC. | Orale Makrolidusammensetzung mit erweiterter Freisetzung |
| US20060165790A1 (en) * | 2003-06-27 | 2006-07-27 | Malcolm Walden | Multiparticulates |
| TWI357815B (en) * | 2003-06-27 | 2012-02-11 | Euro Celtique Sa | Multiparticulates |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| WO2005023221A1 (en) * | 2003-09-05 | 2005-03-17 | Ranbaxy Laboratories Limited | Clarithromycin formulations having improved biovailability |
| GB2411355B (en) | 2004-02-27 | 2006-02-22 | Niche Generics Ltd | Pharmaceutical composition |
| US7491263B2 (en) * | 2004-04-05 | 2009-02-17 | Technology Innovation, Llc | Storage assembly |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| GB2418854B (en) | 2004-08-31 | 2009-12-23 | Euro Celtique Sa | Multiparticulates |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102006006532B4 (de) * | 2006-02-10 | 2007-11-08 | Biogenerics Pharma Gmbh | Pharmazeutische Zubereitung |
| CN105232482A (zh) | 2006-04-07 | 2016-01-13 | 默里昂研究Iii有限公司 | 包含增强剂的固体口服剂型 |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| US20080131504A1 (en) * | 2006-12-01 | 2008-06-05 | Mission Pharmacal Co. | Short Term Slow Release Drug Delivery System |
| WO2009092601A1 (en) | 2008-01-25 | 2009-07-30 | Grünenthal GmbH | Pharmaceutical dosage form |
| AU2009244799B2 (en) | 2008-05-07 | 2014-11-20 | Merrion Research Iii Limited | Compositions of GnRH related compounds and processes of preparation |
| CA2723438C (en) | 2008-05-09 | 2016-10-11 | Gruenenthal Gmbh | Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step |
| PE20120572A1 (es) | 2009-07-22 | 2012-06-06 | Gruenenthal Chemie | Forma de dosificacion de oxidacion estabilizada resistente a la manipulacion |
| WO2011009602A1 (en) | 2009-07-22 | 2011-01-27 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
| US9163133B2 (en) * | 2009-12-23 | 2015-10-20 | Essilor International (Compagnie Générale d'Optique) | Method of converting a polymerizable composition into thermoplastic polyurethane of improved yellowness index and article obtained by this method |
| US9089484B2 (en) | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
| PE20131102A1 (es) | 2010-09-02 | 2013-10-12 | Gruenenthal Chemie | Forma de dosificacion resistente a manipulacion que comprende una sal inorganica |
| TWI516286B (zh) | 2010-09-02 | 2016-01-11 | 歌林達股份有限公司 | 含陰離子聚合物之抗破碎劑型 |
| AU2012204213A1 (en) | 2011-01-07 | 2013-06-13 | Merrion Research Iii Limited | Pharmaceutical compositions of iron for oral administration |
| DK2736497T3 (da) | 2011-07-29 | 2017-11-13 | Gruenenthal Gmbh | Stød-resistent tablet, der tilvejebringer en øjeblikkelig frigivelse af et lægemiddel. |
| LT2736495T (lt) | 2011-07-29 | 2017-11-10 | Grünenthal GmbH | Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu |
| CA2864949A1 (en) | 2012-02-28 | 2013-09-06 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
| RS57913B1 (sr) | 2012-04-18 | 2019-01-31 | Gruenenthal Gmbh | Farmaceutske dozne forme otporne na neovlašćenu upotrebu i naglo oslobađanje celokupne doze |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| US10154966B2 (en) | 2013-05-29 | 2018-12-18 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
| AR096438A1 (es) | 2013-05-29 | 2015-12-30 | Gruenenthal Gmbh | Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso |
| MX368846B (es) | 2013-07-12 | 2019-10-18 | Gruenenthal Gmbh | Forma de dosificación resistente a la alteración que contiene polímero de acetato de etilen-vinilo. |
| EP3073994A1 (de) | 2013-11-26 | 2016-10-05 | Grünenthal GmbH | Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels kryogenen mahlens |
| JP2017518980A (ja) | 2014-05-12 | 2017-07-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールを含む、改変防止即時放出カプセル製剤 |
| US9872835B2 (en) | 2014-05-26 | 2018-01-23 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
| US10265384B2 (en) | 2015-01-29 | 2019-04-23 | Novo Nordisk A/S | Tablets comprising GLP-1 agonist and enteric coating |
| JP2018517676A (ja) | 2015-04-24 | 2018-07-05 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時放出および溶媒抽出に対する耐性を有する改変防止製剤 |
| US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB757165A (en) * | 1953-10-30 | 1956-09-12 | Abbott Lab | Compositions of erythromycin for combating bacterial infections |
| US4374082A (en) * | 1981-08-18 | 1983-02-15 | Richard Hochschild | Method for making a pharmaceutical and/or nutritional dosage form |
| FR2581541B1 (fr) * | 1985-05-09 | 1988-05-20 | Rhone Poulenc Sante | Nouvelles compositions pharmaceutiques permettant la liberation prolongee d'un principe actif et leur procede de preparation |
| DE3524572A1 (de) * | 1985-07-10 | 1987-01-15 | Thomae Gmbh Dr K | Feste arzneimittelformen zur peroralen anwendung enthaltend 9-deoxo-11-deoxy-9,11-(imino(2-(2-methoxyethoxy)ethyliden)-oxy)-(9s)-erythromycin und verfahren zu ihrer herstellung |
| US4686231A (en) * | 1985-12-12 | 1987-08-11 | Smithkline Beckman Corporation | Inhibition of 5-lipoxygenase products |
| US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
| IL84944A (en) * | 1987-01-19 | 1992-02-16 | Ici Plc | Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation |
| IT1226549B (it) * | 1988-07-12 | 1991-01-24 | Resa Farma | Composizioni farmaceutiche ad attivita' analgesica ed antiinfiammatoria per uso orale, dotate di ottima palatabilita' ed esenti da effetti irritanti sulle mucose. |
| US5126145A (en) * | 1989-04-13 | 1992-06-30 | Upsher Smith Laboratories Inc | Controlled release tablet containing water soluble medicament |
| US5002774A (en) * | 1989-06-08 | 1991-03-26 | Erbamont, Inc. | Sustained release pharmaceutical tablet |
| US5169645A (en) * | 1989-10-31 | 1992-12-08 | Duquesne University Of The Holy Ghost | Directly compressible granules having improved flow properties |
| FR2657257B1 (fr) * | 1990-01-19 | 1994-09-02 | Rhone Poulenc Sante | Procede de preparation de medicaments sous forme de perles. |
| FR2663818B1 (fr) * | 1990-06-29 | 1993-07-09 | Rhone Poulenc Nutrition Animale | Procede de preparation de granules de principes actifs par extrusion. |
| JP3265680B2 (ja) * | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
| US5292900A (en) * | 1992-12-18 | 1994-03-08 | Abbott Laboratories | O-substituted N-hydroxyurea derivatives |
-
1995
- 1995-02-14 CA CA002182282A patent/CA2182282C/en not_active Expired - Fee Related
- 1995-02-14 ES ES95909559T patent/ES2199981T3/es not_active Expired - Lifetime
- 1995-02-14 DK DK95909559T patent/DK0744941T3/da active
- 1995-02-14 AT AT95909559T patent/ATE241962T1/de not_active IP Right Cessation
- 1995-02-14 JP JP52190295A patent/JP4040084B2/ja not_active Expired - Fee Related
- 1995-02-14 PT PT95909559T patent/PT744941E/pt unknown
- 1995-02-14 WO PCT/US1995/001943 patent/WO1995022319A1/en not_active Ceased
- 1995-02-14 MX MX9603480A patent/MX9603480A/es not_active IP Right Cessation
- 1995-02-14 DE DE69530973T patent/DE69530973T2/de not_active Expired - Fee Related
- 1995-02-14 EP EP95909559A patent/EP0744941B1/de not_active Expired - Lifetime
-
1996
- 1996-05-30 US US08/655,491 patent/US6063313A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK0744941T3 (da) | 2003-09-29 |
| DE69530973D1 (de) | 2003-07-10 |
| ES2199981T3 (es) | 2004-03-01 |
| US6063313A (en) | 2000-05-16 |
| WO1995022319A1 (en) | 1995-08-24 |
| PT744941E (pt) | 2003-10-31 |
| JP4040084B2 (ja) | 2008-01-30 |
| CA2182282A1 (en) | 1995-08-24 |
| EP0744941B1 (de) | 2003-06-04 |
| CA2182282C (en) | 2006-04-18 |
| MX9603480A (es) | 1997-12-31 |
| DE69530973T2 (de) | 2004-05-19 |
| JPH09509176A (ja) | 1997-09-16 |
| EP0744941A1 (de) | 1996-12-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE241962T1 (de) | Verfahren zur herstellung feinteiliger pharmazeutischer formulierungen | |
| DE69519664D1 (de) | Verfahren zur herstellung fester pharmazeutischer dosierungsform | |
| DE69315578D1 (de) | Verfahren zur herstellung von arzneiformulierungen | |
| PL315181A1 (en) | Method of producing pharmaceutical doses of hydrophobous substances in solid form | |
| DE68907397D1 (de) | Fluessige photopolymerisierbare zusammensetzung, viskoelastisches produkt, erhalten aus dieser zusammensetzung und verfahren zur herstellung dieses viskoelastischen produktes. | |
| ATE253898T1 (de) | Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen | |
| ATE82495T1 (de) | Verfahren zur herstellung pharmazeutischer mischungen. | |
| DE59807213D1 (de) | 11beta-halogen-7alpha-substituierte-estratriene, verfahren zur herstellung pharmazeutischer präparate, die diese 11beta-halogen-7alpha-substituierte-estratriene enthalten, sowie deren verwendung zur herstellung von arzneimitteln | |
| AT400109B (de) | Verfahren und pressform zur herstellung eines skibauteiles, nach diesem verfahren hergestellter skibauteil, sowie nach dem verfahren hergestellter ski | |
| ATE154512T1 (de) | Kontinuierliches verfahren zur herstellung von einem nicht-newton'schen pastigen oder cremösen mittel | |
| ATE149826T1 (de) | Verfahren zur herstellung von festen pharmazeutischen retardformen | |
| DE69924846D1 (de) | Thyroidhormon-analoga und verfahren zu ihrer herstellung | |
| DE69612685D1 (de) | Bilderzeugungsmaterial, Verfahren zu dessen Herstellung und Bilderzeugungsverfahren unter Anwendung desselben | |
| DE69612684D1 (de) | Bilderzeugungsmaterial, Verfahren zu dessen Herstellung und Bilderzeugungsverfahren unter Anwendung desselben | |
| ATE116541T1 (de) | Verfahren zur herstellung mikronisierter bioabbaubarer partikel. | |
| NO303715B1 (no) | Stabilt, vandig apparat | |
| ATE269057T1 (de) | Arzneizubereitungen und deren herstellungsverfahren | |
| DE69302309D1 (de) | Verfahren für die Herstellung von Dialkyl-2,3-pyridinedicarboxylaten und deren Derivaten aus einem alpha-beta-ungesättigten Oxim und einem Aminobutenedioat | |
| PL371340A1 (en) | Method for producing steroid crystals, crystals obtained by said method and their use in pharmaceutical formulations | |
| DE69316787D1 (de) | Toner, Verfahren zur dessen Herstellung und Bilderzeugungsgerät unter Anwendung desselben | |
| DE69007294D1 (de) | Verfahren zur herstellung eines aktiven feinen zuschlagstoffes zur betonherstellung. | |
| DE69603530D1 (de) | Verfahren zur Herstellung von 1,1-Difluorethan | |
| AT399504B (de) | Neue aminopropoxyimino-cycloalkanderivate, deren herstellung, arzneimittel, die diese verbindungen als wirkstoff enthalten sowie verfahren zur herstellung derselben | |
| PT77825A (de) | Neue 2-azabicyclo<2.2.1>heptan-derivate verfahren zu ihrer herstellung diese enthaltende mittel und deren verwendung sowie 2-azabicyclo/2.2.1/heptan-derivate als zwischenprodukte und verfahren zu deren herstellung | |
| DE3761405D1 (de) | Verfahren zur herstellung eines roentgenbildverstaerkers und nach diesem verfahren hergestellter bildverstaerker. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0744941 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |