ATE253898T1 - Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen - Google Patents

Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen

Info

Publication number
ATE253898T1
ATE253898T1 AT95929935T AT95929935T ATE253898T1 AT E253898 T1 ATE253898 T1 AT E253898T1 AT 95929935 T AT95929935 T AT 95929935T AT 95929935 T AT95929935 T AT 95929935T AT E253898 T1 ATE253898 T1 AT E253898T1
Authority
AT
Austria
Prior art keywords
during drying
biological substances
substances during
improved method
subsequent storage
Prior art date
Application number
AT95929935T
Other languages
English (en)
Inventor
Camilo Colaco
Bruce Joseph Roser
Shevanti Sen
Original Assignee
Elan Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Drug Delivery Ltd filed Critical Elan Drug Delivery Ltd
Application granted granted Critical
Publication of ATE253898T1 publication Critical patent/ATE253898T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Drying Of Solid Materials (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
AT95929935T 1994-08-19 1995-08-18 Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen ATE253898T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/293,157 US5955448A (en) 1994-08-19 1994-08-19 Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
PCT/GB1995/001967 WO1996005809A1 (en) 1994-08-19 1995-08-18 Improved method for stabilization of biological substances during drying and subsequent storage and compositions thereof

Publications (1)

Publication Number Publication Date
ATE253898T1 true ATE253898T1 (de) 2003-11-15

Family

ID=23127893

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95929935T ATE253898T1 (de) 1994-08-19 1995-08-18 Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen

Country Status (11)

Country Link
US (2) US5955448A (de)
EP (1) EP0804163B1 (de)
JP (1) JP3815793B2 (de)
CN (1) CN1160345A (de)
AT (1) ATE253898T1 (de)
AU (1) AU3349695A (de)
DE (1) DE69532137T2 (de)
DK (1) DK0804163T3 (de)
ES (1) ES2208693T3 (de)
PT (1) PT804163E (de)
WO (1) WO1996005809A1 (de)

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EP0804163B1 (de) 2003-11-12
WO1996005809A1 (en) 1996-02-29
DK0804163T3 (da) 2004-03-29
ES2208693T3 (es) 2004-06-16
US6313102B1 (en) 2001-11-06
JPH10505591A (ja) 1998-06-02
AU3349695A (en) 1996-03-14
JP3815793B2 (ja) 2006-08-30
DE69532137T2 (de) 2004-04-22
US5955448A (en) 1999-09-21
PT804163E (pt) 2004-04-30
DE69532137D1 (de) 2003-12-18
EP0804163A1 (de) 1997-11-05
CN1160345A (zh) 1997-09-24

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