ATE253898T1 - Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen - Google Patents

Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen

Info

Publication number
ATE253898T1
ATE253898T1 AT95929935T AT95929935T ATE253898T1 AT E253898 T1 ATE253898 T1 AT E253898T1 AT 95929935 T AT95929935 T AT 95929935T AT 95929935 T AT95929935 T AT 95929935T AT E253898 T1 ATE253898 T1 AT E253898T1
Authority
AT
Austria
Prior art keywords
during drying
biological substances
substances during
improved method
subsequent storage
Prior art date
Application number
AT95929935T
Other languages
English (en)
Inventor
Camilo Colaco
Bruce Joseph Roser
Shevanti Sen
Original Assignee
Elan Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Drug Delivery Ltd filed Critical Elan Drug Delivery Ltd
Application granted granted Critical
Publication of ATE253898T1 publication Critical patent/ATE253898T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Drying Of Solid Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
AT95929935T 1994-08-19 1995-08-18 Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen ATE253898T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/293,157 US5955448A (en) 1994-08-19 1994-08-19 Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
PCT/GB1995/001967 WO1996005809A1 (en) 1994-08-19 1995-08-18 Improved method for stabilization of biological substances during drying and subsequent storage and compositions thereof

Publications (1)

Publication Number Publication Date
ATE253898T1 true ATE253898T1 (de) 2003-11-15

Family

ID=23127893

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95929935T ATE253898T1 (de) 1994-08-19 1995-08-18 Verbessertes verfahren zur stabilisierung biologischer substanzen während der trocknung und anschliessender lagerung sowie die entsprechenden zusammensetzungen

Country Status (11)

Country Link
US (2) US5955448A (de)
EP (1) EP0804163B1 (de)
JP (1) JP3815793B2 (de)
CN (1) CN1160345A (de)
AT (1) ATE253898T1 (de)
AU (1) AU3349695A (de)
DE (1) DE69532137T2 (de)
DK (1) DK0804163T3 (de)
ES (1) ES2208693T3 (de)
PT (1) PT804163E (de)
WO (1) WO1996005809A1 (de)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2179831T3 (es) 1992-09-29 2003-02-01 Inhale Therapeutic Syst Liberacion en los pulmones de fragmentos activos de hormona paratiroidiana.
NZ281112A (en) 1994-03-07 1998-04-27 Inhale Therapeutic Syst Powdered insulin delivered as an aerosol
US5955448A (en) * 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
US6290991B1 (en) 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
AU3570495A (en) 1994-09-22 1996-04-09 Quadrant Holdings Cambridge Limited Compositions for use in rehydration and nutrition during athletic exercise and methods of making same
US7253262B2 (en) * 1995-01-19 2007-08-07 Quandrant Drug Delivery Limited Dried blood factor composition comprising trehalose
GB9501040D0 (en) * 1995-01-19 1995-03-08 Quadrant Holdings Cambridge Dried composition
US6964771B1 (en) * 1995-06-07 2005-11-15 Elan Drug Delivery Limited Method for stably incorporating substances within dry, foamed glass matrices
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
JP3896430B2 (ja) * 1996-07-15 2007-03-22 アークレイ株式会社 糖化アミノ化合物の製造方法
US6468782B1 (en) * 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
GB9705588D0 (en) 1997-03-18 1997-05-07 Anglia Research Foundation Stable particle in liquid formulations
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
EP0913177A1 (de) * 1997-11-03 1999-05-06 Roche Diagnostics GmbH Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung
US6919446B1 (en) 1998-01-20 2005-07-19 Grain Processing Corp. Reduced malto-oligosaccharides
WO1999036442A1 (en) * 1998-01-20 1999-07-22 Grain Processing Corporation Reduced malto-oligosaccharides
EP1071465A1 (de) * 1998-03-18 2001-01-31 Ronai, Peter Amorphe gläser zur stabilisierung von empfindlichen produkten
US6451572B1 (en) 1998-06-25 2002-09-17 Cornell Research Foundation, Inc. Overexpression of phytase genes in yeast systems
EP2921180B1 (de) 1999-02-22 2019-08-14 University of Connecticut Albuminfreie Faktor-VIII-Formulierungen
MXPA01009809A (es) * 1999-03-31 2002-07-30 Cornell Res Foundation Inc Fosfatasas con actividad de fitasa mejorada.
NL1012300C2 (nl) * 1999-06-11 2000-12-12 Rijksuniversiteit Stabilisator voor farmaca.
JP2003501479A (ja) * 1999-06-12 2003-01-14 ビトプ ゲゼルシャフト ミット ベシュレンクテル ハフツング 薬 剤
GB9916316D0 (en) 1999-07-12 1999-09-15 Quadrant Holdings Cambridge Dry powder compositions
US6380379B1 (en) 1999-08-20 2002-04-30 Grain Processing Corporation Derivatized reduced malto-oligosaccharides
US6593469B1 (en) 1999-10-20 2003-07-15 Grain Processing Corporation Compositions including reduced malto-oligosaccharide preserving agents
WO2001029164A1 (en) 1999-10-20 2001-04-26 Grain Processing Corporation Reduced malto-oligosaccharide cleansing compositions
US6841370B1 (en) 1999-11-18 2005-01-11 Cornell Research Foundation, Inc. Site-directed mutagenesis of Escherichia coli phytase
KR100771294B1 (ko) 1999-12-14 2007-10-29 써모 바이오스타, 인크. 폴리펩티드 및 항원 안정화 희석제
MXPA02006079A (es) * 1999-12-20 2004-08-23 Nicholas J Kerkhof Proceso para producir particulas de nanometro mediante secado por aspersion de lecho fluido.
US8771740B2 (en) * 1999-12-20 2014-07-08 Nicholas J. Kerkhof Process for producing nanoparticles by spray drying
JP4711520B2 (ja) * 2000-03-21 2011-06-29 日本ケミカルリサーチ株式会社 生理活性ペプチド含有粉末
ES2525087T5 (es) 2000-05-10 2018-06-28 Novartis Ag Polvos basados en fosfolípidos para administración de fármacos
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
US6653062B1 (en) 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
ES2180416B1 (es) 2001-03-12 2004-06-01 BIOTOOLS BIOTECHNOLOGICAL & MEDICAL LABORATORIES, S.A. Procedimiento para la preparacion de mezclas de reaccion estabilizadas, total o parcialmente desecadas, que comprenden, al menos, una enzima, mezclas de reaccion y kits que las contienen.
CA2449593A1 (en) * 2001-06-08 2002-12-19 Powderject Vaccines, Inc. Spray freeze-dried compositions
JP4169344B2 (ja) * 2001-07-02 2008-10-22 旭化成ファーマ株式会社 アルカリホスファターゼ安定化方法
US7101693B2 (en) 2001-09-07 2006-09-05 Brigham Young University Plasticized hydrophilic glasses for improved stabilization of biological agents
ES2597503T3 (es) * 2001-10-31 2017-01-19 Huvepharma Eood Alimento para animales que contiene fitasa y método
WO2003037303A1 (en) 2001-11-01 2003-05-08 Nektar Therapeutics Spray drying methods and compositions thereof
EP1455822A4 (de) * 2001-11-09 2004-12-29 Centocor Inc Lyophilisierte monoklonale antikörper-zusammensetzungen
JP2005514393A (ja) 2001-12-19 2005-05-19 ネクター セラピューティクス アミノグリコシドの肺への供給
PL209134B1 (pl) * 2002-04-03 2011-07-29 Solvay Pharm Bv Sposób wytwarzania kompozycji farmaceutycznej zawierającej naturalny związek kanabinoidowy i kompozycja farmaceutyczna otrzymywana tym sposobem
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
US20040002451A1 (en) * 2002-06-20 2004-01-01 Bruce Kerwin Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing
US7309505B2 (en) * 2002-09-13 2007-12-18 Cornell Research Foundation, Inc. Using mutations to improve Aspergillus phytases
US7270946B2 (en) * 2002-10-04 2007-09-18 Organ Recovery Systems, Inc. Method for treatment of cellular materials with sugars prior to preservation
US6927062B2 (en) * 2002-11-25 2005-08-09 Agdia, Inc. Controls and standards for assays and method for manufacture thereof
US20050095320A1 (en) * 2003-10-29 2005-05-05 Richard Botteri [An Isotonic Sports Drink for Female Athletes Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Nutrition During Execise and Competition]
US20050100636A1 (en) * 2003-11-10 2005-05-12 Megan Botteri [A Low-Calorie Sports Drink For Physically Active Women That is Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Replacing Electrolytes Lost During Periods of Physical Activity]
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
US7842382B2 (en) 2004-03-11 2010-11-30 Knauf Insulation Gmbh Binder compositions and associated methods
CA2560513A1 (en) 2004-04-08 2005-12-01 Biomatrica, Inc. Integration of sample storage and sample management for life science
US7319032B2 (en) * 2004-04-22 2008-01-15 Medtox Non-sugar sweeteners for use in test devices
DE102004022928A1 (de) * 2004-05-10 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulver enthaltend neuartige Oligosacharidgemische und Verfahren zu deren Herstellung
DE102004022926A1 (de) * 2004-05-10 2005-12-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Sprühgetrocknete Pulver enthaltend zumindest ein 1,4 O-verknüpftes Saccharose-Derivat und Verfahren zu deren Herstellung
EP1758937B1 (de) 2004-05-24 2009-09-02 Genvault Corporation Stabile lagerung von protein und stabile lagerung von nukleinsäure in wiedergewinnbarer form
EP1814927A1 (de) 2004-10-13 2007-08-08 Knauf Insulation GmbH Polyesterbindemittelzusammensetzungen
AU2006247039B2 (en) * 2005-05-19 2011-03-03 Amgen Inc. Compositions and methods for increasing the stability of antibodies
MX2007015476A (es) 2005-06-14 2008-02-25 Amgen Inc Formulaciones de proteina autoamortiguadoras.
US20070003564A1 (en) * 2005-06-30 2007-01-04 Hurley John K Diluent for immunohistochemistry
CN101287788B (zh) * 2005-07-26 2012-09-19 可耐福保温材料有限公司 粘结剂和由其制备的材料
AR059066A1 (es) 2006-01-27 2008-03-12 Amgen Inc Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf)
US7919297B2 (en) * 2006-02-21 2011-04-05 Cornell Research Foundation, Inc. Mutants of Aspergillus niger PhyA phytase and Aspergillus fumigatus phytase
CA2653454A1 (en) * 2006-05-23 2007-11-29 Molecular Detection, Inc. Ambient temperature stable kits for molecular diagnostics
WO2008017066A2 (en) * 2006-08-03 2008-02-07 Cornell Research Foundation, Inc. Phytases with improved thermal stability
EP2081553B1 (de) * 2006-10-06 2020-08-12 Amgen Inc. Stabile antikörper-formulierungen
US7705132B2 (en) * 2006-10-20 2010-04-27 Amgen Inc. Stable polypeptide formulations
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
CN101210353A (zh) * 2006-12-28 2008-07-02 山东海龙股份有限公司 阻燃抗熔融粘胶纤维及其生产方法
HUE068424T2 (hu) 2007-01-25 2024-12-28 Knauf Insulation Ásványi szálas lemez
BRPI0721232B1 (pt) 2007-01-25 2023-01-24 Knauf Insulation Limited Placa de madeira compósita
SI2826903T1 (sl) 2007-01-25 2023-10-30 Knauf Insulation Postopek za izdelavo izolacijskega izdelka iz mineralnih vlaken
PT2108006T (pt) 2007-01-25 2020-12-21 Knauf Insulation Gmbh Ligantes e materiais feitos com os mesmos
JP5966202B2 (ja) * 2007-02-20 2016-08-10 アラガン ファーマシューティカルズ インターナショナル リミテッド 安定な消化酵素組成物
US20090117180A1 (en) * 2007-02-20 2009-05-07 Giovanni Ortenzi Stable digestive enzyme compositions
WO2008127936A2 (en) 2007-04-13 2008-10-23 Knauf Insulation Gmbh Composite maillard-resole binders
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US8192734B2 (en) 2007-07-09 2012-06-05 Cornell University Compositions and methods for bone strengthening
GB0715100D0 (en) 2007-08-03 2007-09-12 Knauf Insulation Ltd Binders
CN101801405A (zh) 2007-08-07 2010-08-11 先进科技及再生医学有限责任公司 包含于酸性水溶液中的gdf-5的蛋白质配方
EP2236135A4 (de) * 2008-01-18 2012-05-02 Asahi Kasei Pharma Corp Stabile pharmazeutische zusammensetzung
US10087493B2 (en) 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations
BRPI0911048A2 (pt) * 2008-04-14 2015-12-29 Atrm Llc formulações líquidas tamponadas de gdf-5
EP2334792B1 (de) 2008-09-12 2020-09-09 GenTegra LLC Matrizes und medien zur lagerung und stabilisierung von biomolekülen
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations
CA2753291C (en) * 2009-02-23 2017-08-15 Cell & Tissue Systems, Inc. Method for ice-free cryopreservation of tissue
WO2010144682A1 (en) 2009-06-12 2010-12-16 Micronics, Inc. Rehydratable matrices for dry storage of taq polymerase in a microfluidic device
JP5953229B2 (ja) 2009-06-12 2016-07-20 マイクロニクス， インコーポレイテッド マイクロ流体デバイス内でオンボード試薬を脱水保存する組成物および方法
US8900495B2 (en) 2009-08-07 2014-12-02 Knauf Insulation Molasses binder
US20130157265A1 (en) 2009-10-22 2013-06-20 Jesus Mingorance Cruz Composition, method and kit for detecting bacteria by means of sequencing
WO2011069529A1 (en) * 2009-12-09 2011-06-16 Curevac Gmbh Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids
CN103025777B (zh) 2010-05-07 2016-01-20 克瑙夫绝缘私人有限公司 碳水化合物粘合剂及用其制备的材料
PH12012502183A1 (en) 2010-05-07 2017-06-23 Knauf Insulation Carbohydrate polyamine binders and materials made therewith
US20130082205A1 (en) 2010-06-07 2013-04-04 Knauf Insulation Sprl Fiber products having temperature control additives
CA2806670A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
US9845489B2 (en) 2010-07-26 2017-12-19 Biomatrica, Inc. Compositions for stabilizing DNA, RNA and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
ES2657673T3 (es) 2010-10-01 2018-03-06 Aptalis Pharma Limited Formulaciones recubiertas entéricas de pancrelipasa, de baja intensidad
US20140186635A1 (en) 2011-05-07 2014-07-03 Knauf Insulation Liquid high solids binder composition
CA2843556A1 (en) 2011-08-08 2013-02-14 Aptalis Pharma Ltd. Method for dissolution testing of solid compositions containing digestive enzymes
GB2498774A (en) 2012-01-27 2013-07-31 Bruce Roser Glass-stabilised biological materials and syringe
GB201206193D0 (en) 2012-04-05 2012-05-23 Knauf Insulation Ltd Binders and associated products
GB201214734D0 (en) 2012-08-17 2012-10-03 Knauf Insulation Ltd Wood board and process for its production
ES2921601T3 (es) 2012-12-05 2022-08-30 Knauf Insulation Sprl Aglutinante
US9725703B2 (en) 2012-12-20 2017-08-08 Biomatrica, Inc. Formulations and methods for stabilizing PCR reagents
US9700486B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US10184121B2 (en) 2013-06-28 2019-01-22 Allergan Pharmaceuticals International Limited Methods for removing viral contaminants from pancreatic extracts
CA2920844A1 (en) 2013-08-09 2015-02-12 Allergan Pharmaceuticals International Limited Digestive enzyme composition suitable for enteral administration
EP3038465B1 (de) 2013-08-30 2021-10-06 Merck Sharp & Dohme Corp. Oral anzuwendende arzneiformulierung mit omarigliptin
PL3102587T3 (pl) 2014-02-07 2019-01-31 Knauf Insulation, Inc. Nieutwardzone wyroby o ulepszonym okresie trwałości
GB201408909D0 (en) 2014-05-20 2014-07-02 Knauf Insulation Ltd Binders
CN106572650B (zh) 2014-06-10 2021-08-31 生物马特里卡公司 在环境温度下稳定凝血细胞
GB201412709D0 (en) 2014-07-17 2014-09-03 Knauf Insulation And Knauf Insulation Ltd Improved binder compositions and uses thereof
AU2015335743B2 (en) 2014-10-23 2020-12-24 Amgen Inc. Reducing viscosity of pharmaceutical formulations
LT4209499T (lt) 2015-08-13 2024-11-25 Amgen Inc. Antigeną surišančių baltymų įkrautas giluminis filtravimas
GB201517867D0 (en) 2015-10-09 2015-11-25 Knauf Insulation Ltd Wood particle boards
SG11201804776SA (en) 2015-12-08 2018-07-30 Biomatrica Inc Reduction of erythrocyte sedimentation rate
GB201610063D0 (en) 2016-06-09 2016-07-27 Knauf Insulation Ltd Binders
WO2018017843A1 (en) 2016-07-22 2018-01-25 Tissue Testing Technologies Llc Enhancement of cell cryopreservation with glycolipids
US11246308B2 (en) 2016-12-20 2022-02-15 Tissue Testing Technologies Llc Ice-free preservation of large volume tissue samples for viable, functional tissue banking
GB201701569D0 (en) 2017-01-31 2017-03-15 Knauf Insulation Ltd Improved binder compositions and uses thereof
JP7377596B2 (ja) 2017-02-22 2023-11-10 アムジエン・インコーポレーテツド 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法
US11517613B2 (en) 2017-06-07 2022-12-06 Amano Enzyme Inc. Lactase bulk powder and lactase preparation
ES3041301T3 (en) * 2017-11-29 2025-11-11 Medice Arzneimittel Puetter Gmbh & Co Kg Pharmaceutical composition comprising benzocaine with enhanced stability
GB201804907D0 (en) 2018-03-27 2018-05-09 Knauf Insulation Ltd Composite products
GB201804908D0 (en) 2018-03-27 2018-05-09 Knauf Insulation Ltd Binder compositions and uses thereof
US11968975B2 (en) * 2019-04-30 2024-04-30 Regents Of The University Of Minnesota Compositions and methods for storing liquid biospecimens
CN114727594B (zh) 2019-11-07 2024-07-12 组织测试技术有限公司 大型组织样品的无冰玻璃化和纳米升温
CN116887871A (zh) 2020-10-21 2023-10-13 组织测试技术有限公司 最小化脱细胞组织的免疫原性
US20220354108A1 (en) 2021-05-04 2022-11-10 Tissue Testing Technologies Llc Preservation methods using trehalose with other cryoprotectants being absent from the cryopreservation protocol
JP7844634B2 (ja) 2021-11-15 2026-04-13 ティシュー テスティング テクノロジーズ エルエルシー 天然組織および生体組織の保存用カセット
CN118541029A (zh) 2021-11-15 2024-08-23 组织测试技术有限公司 天然和生物工程改造组织的保存以及储存和运输方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3557717A (en) * 1968-05-17 1971-01-26 Gen Mills Inc Process for making candy floss
US3619294A (en) * 1968-07-15 1971-11-09 Penick & Ford Ltd Method of combining crystalline sugar with impregnating agents and products produced thereby
US3632357A (en) * 1969-07-29 1972-01-04 Standard Brands Inc Method of producing hard candy
US3655442A (en) * 1969-08-27 1972-04-11 California & Hawaiian Sugar Method of making sugar and sugar products
US4127502A (en) * 1977-06-10 1978-11-28 Eastman Kodak Company Stabilizers for reconstituted, lyophilized samples
US4158544A (en) * 1978-07-17 1979-06-19 Beckman Instruments, Inc. Process for preparing a biological composition for use as a reference control in diagnostic analysis
US4588744A (en) * 1978-09-19 1986-05-13 Mchugh John E Method of forming an aqueous solution of 3-3-Bis(p-hydroxyphenyl)-phthalide
US4327076A (en) * 1980-11-17 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
US4371557A (en) * 1981-01-21 1983-02-01 General Foods Corporation Maintenance of protein quality in foods containing reducing sugars
US4327077A (en) * 1981-05-29 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
JPS58164683A (ja) * 1982-03-25 1983-09-29 Takeda Chem Ind Ltd 安定化された固体組成物
US4883762A (en) * 1983-06-06 1989-11-28 Ciba Corning Diagnostics Corp. Stabilized isoenzyme control products
US4865871A (en) * 1983-08-23 1989-09-12 Board Of Regents The University Of Texas System Method for cryopreparing biological tissue
US4758583A (en) * 1984-03-19 1988-07-19 The Rockefeller University Method and agents for inhibiting protein aging
DE3445010A1 (de) * 1984-12-10 1986-06-19 Boehringer Mannheim Gmbh Kontroll- bzw. eichserum fuer die lipid-diagnostik
ATE68524T1 (de) * 1985-07-09 1991-11-15 Quadrant Bioresources Ltd Beschuetzung von proteinen und aehnlichem.
JPH0710344B2 (ja) * 1985-12-26 1995-02-08 株式会社林原生物化学研究所 無水グリコシルフルクト−スによる含水物の脱水方法
GB8715238D0 (en) * 1987-06-29 1987-08-05 Quadrant Bioresources Ltd Food process
CA1327161C (en) * 1987-09-01 1994-02-22 Mitsugu Kobayashi Lyophilized pharmaceutical composition of neocarzinostatin derivative
GB8801338D0 (en) * 1988-01-21 1988-02-17 Quadrant Bioresources Ltd Preservation of viruses
GB8903593D0 (en) * 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
GB8917470D0 (en) * 1989-07-31 1989-09-13 Quadrant Bioresources Ltd Composition and method
JP2854631B2 (ja) * 1989-11-21 1999-02-03 千寿製薬株式会社 糖尿病合併症および老化によって引き起こされる疾患の予防・治療剤
GB9010742D0 (en) * 1990-05-14 1990-07-04 Quadrant Bioresources Ltd Stabilization of biological macromolecular substances
JPH06500632A (ja) * 1990-08-10 1994-01-20 アナリティカル・コントロール・システムズ・インコーポレーテッド 改良された診断および治療組成物
US5200399A (en) * 1990-09-14 1993-04-06 Boyce Thompson Institute For Plant Research, Inc. Method of protecting biological materials from destructive reactions in the dry state
US5422384A (en) * 1992-11-25 1995-06-06 Battelle Memorial Institute Glass/polymer composites and methods of making
JP3168550B2 (ja) * 1992-12-02 2001-05-21 株式会社林原生物化学研究所 脱水剤およびそれを用いる含水物の脱水方法並びにその方法で得られる脱水物品
US5955448A (en) * 1994-08-19 1999-09-21 Quadrant Holdings Cambridge Limited Method for stabilization of biological substances during drying and subsequent storage and compositions thereof
CN1188171C (zh) * 1994-06-02 2005-02-09 廓德伦特控股剑桥有限公司 防止各种特质在再水化或熔化时聚集的方法以及由此获得的组合物

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DE69532137T2 (de) 2004-04-22
DK0804163T3 (da) 2004-03-29
WO1996005809A1 (en) 1996-02-29
US5955448A (en) 1999-09-21
CN1160345A (zh) 1997-09-24
EP0804163B1 (de) 2003-11-12
JP3815793B2 (ja) 2006-08-30
EP0804163A1 (de) 1997-11-05
AU3349695A (en) 1996-03-14
PT804163E (pt) 2004-04-30
JPH10505591A (ja) 1998-06-02
ES2208693T3 (es) 2004-06-16
DE69532137D1 (de) 2003-12-18

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