ATE241978T1 - Therapeutische anwendung von dioxabicyclo(3.3.0)oktan-verbindungen - Google Patents

Therapeutische anwendung von dioxabicyclo(3.3.0)oktan-verbindungen

Info

Publication number: ATE241978T1
Authority: AT; Austria
Prior art keywords: sup; dioxabicyclo; octane; methoxy; methylenedioxyphenyl
Prior art date: 1989-07-21

Application number

AT97112930T

Other languages

English (en)

Inventor

Yoshifumi Shinmen

Kengo Akimoto

Sumio Asami

Yoshihide Suwa

Yoshinori Kitagawa

Michihiro Sugano

Hideaki Yamada

Sakayu Shimizu

Original Assignee

Suntory Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-21

Filing date

1990-07-20

Publication date

2003-06-15

1989-07-21 Priority claimed from JP1187497A external-priority patent/JP3001589B2/ja

1990-07-20 Application filed by Suntory Ltd filed Critical Suntory Ltd

2003-06-15 Application granted granted Critical

2003-06-15 Publication of ATE241978T1 publication Critical patent/ATE241978T1/de

Links

XNWFXTOHNKPYMK-UHFFFAOYSA-N 3,3a,4,5,6,6a-hexahydrocyclopenta[c]dioxole Chemical class C1OOC2CCCC21 XNWFXTOHNKPYMK-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
PEYUIKBAABKQKQ-AFHBHXEDSA-N (+)-sesamin Chemical compound C1=C2OCOC2=CC([C@H]2OC[C@H]3[C@@H]2CO[C@@H]3C2=CC=C3OCOC3=C2)=C1 PEYUIKBAABKQKQ-AFHBHXEDSA-N 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
PEYUIKBAABKQKQ-UHFFFAOYSA-N epiasarinin Natural products C1=C2OCOC2=CC(C2OCC3C2COC3C2=CC=C3OCOC3=C2)=C1 PEYUIKBAABKQKQ-UHFFFAOYSA-N 0.000 abstract 2
-1 octane compound Chemical class 0.000 abstract 2
ZZMNWJVJUKMZJY-AFHBHXEDSA-N Sesamolin Chemical compound C1=C2OCOC2=CC([C@H]2OC[C@H]3[C@@H]2CO[C@@H]3OC2=CC=C3OCOC3=C2)=C1 ZZMNWJVJUKMZJY-AFHBHXEDSA-N 0.000 abstract 1
ZZMNWJVJUKMZJY-UHFFFAOYSA-N Sesamolin Natural products C1=C2OCOC2=CC(C2OCC3C2COC3OC2=CC=C3OCOC3=C2)=C1 ZZMNWJVJUKMZJY-UHFFFAOYSA-N 0.000 abstract 1
VBIRCRCPHNUJAS-UHFFFAOYSA-N Xanthoxylol Chemical compound C1=C(O)C(OC)=CC(C2C3C(C(OC3)C=3C=C4OCOC4=CC=3)CO2)=C1 VBIRCRCPHNUJAS-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000003908 liver function Effects 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
HGXBRUKMWQGOIE-UHFFFAOYSA-N pinoresinol Chemical compound C1=C(O)C(OC)=CC(C2C3C(C(OC3)C=3C=C(OC)C(O)=CC=3)CO2)=C1 HGXBRUKMWQGOIE-UHFFFAOYSA-N 0.000 abstract 1
VRMHCMWQHAXTOR-CMOCDZPBSA-N sesamin Natural products C1=C2OCOC2=CC([C@@H]2OC[C@@]3(C)[C@H](C=4C=C5OCOC5=CC=4)OC[C@]32C)=C1 VRMHCMWQHAXTOR-CMOCDZPBSA-N 0.000 abstract 1
KQRXQIPRDKVZPW-ISZNXKAUSA-N sesaminol Chemical compound C1=C2OCOC2=CC([C@H]2OC[C@H]3[C@@H]2CO[C@@H]3C2=CC=3OCOC=3C=C2O)=C1 KQRXQIPRDKVZPW-ISZNXKAUSA-N 0.000 abstract 1
KQRXQIPRDKVZPW-UHFFFAOYSA-N sesaminol Natural products C1=C2OCOC2=CC(C2OCC3C2COC3C2=CC=3OCOC=3C=C2O)=C1 KQRXQIPRDKVZPW-UHFFFAOYSA-N 0.000 abstract 1
OJVGWDJIYBTWDS-UHFFFAOYSA-N sesamolinol Chemical compound C1=C(O)C(OC)=CC(OC2C3C(C(OC3)C=3C=C4OCOC4=CC=3)CO2)=C1 OJVGWDJIYBTWDS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
- A23D7/0056—Spread compositions
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/60—Salad dressings; Mayonnaise; Ketchup
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Nutrition Science (AREA)
Epidemiology (AREA)
Mycology (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Cosmetics (AREA)
Medicines Containing Plant Substances (AREA)
Finger-Pressure Massage (AREA)
Fats And Perfumes (AREA)

AT97112930T 1989-07-21 1990-07-20 Therapeutische anwendung von dioxabicyclo(3.3.0)oktan-verbindungen ATE241978T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP1187497A JP3001589B2 (ja)	1989-07-21	1989-07-21	リグナン類含有飲食物
JP8750090		1990-04-03

Publications (1)

Publication Number	Publication Date
ATE241978T1 true ATE241978T1 (de)	2003-06-15

Family

ID=26428763

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT90307978T ATE208195T1 (de)	1989-07-21	1990-07-20	Mittel zur verbesserung der leberfunktion
AT97112931T ATE285765T1 (de)	1989-07-21	1990-07-20	Kapsel, enthaltend ein dioxabicyclo(3.3.0)oktan
AT97112930T ATE241978T1 (de)	1989-07-21	1990-07-20	Therapeutische anwendung von dioxabicyclo(3.3.0)oktan-verbindungen

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT90307978T ATE208195T1 (de)	1989-07-21	1990-07-20	Mittel zur verbesserung der leberfunktion
AT97112931T ATE285765T1 (de)	1989-07-21	1990-07-20	Kapsel, enthaltend ein dioxabicyclo(3.3.0)oktan

Country Status (8)

Country	Link
US (1)	US5180588A (de)
EP (3)	EP0818196B1 (de)
AT (3)	ATE208195T1 (de)
CA (2)	CA2021714C (de)
DE (3)	DE69034181T2 (de)
DK (3)	DK0409654T3 (de)
ES (3)	ES2195058T3 (de)
SG (1)	SG42967A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3183664B2 (ja) *	1990-10-22	2001-07-09	サントリー株式会社	コレステロール及び胆汁酸の代謝阻害剤
JP3283274B2 (ja) *	1991-06-15	2002-05-20	サントリー株式会社	新規組成物
US20020031563A1 (en) *	1992-09-30	2002-03-14	Hodge Thomas W.	Method of inhibiting tumor necrosis factor
US5397778A (en) *	1994-02-25	1995-03-14	New England Deaconess Hospital Corporation	Enteral formulations for treatment of inflammation and infection
JPH10500937A (ja) *	1994-02-25	1998-01-27	ニューイングランドディーコネスホスピタルコーポレイション	セサミン系リグナンの抗炎症及び感染防護効果
JP3818680B2 (ja) *	1994-05-12	2006-09-06	サントリー株式会社	アレルギー症状の予防又は改善剤
JPH08268887A (ja) *	1995-02-01	1996-10-15	Suntory Ltd	高血圧症又はそれに起因する医学的症状の予防又は改善剤
KR970705345A (ko) *	1995-07-04	1997-10-09	도리이 신이치로	오메가 6계ㆍ오메가 3계 불포화 지방산의 밸런스 조절제를 배합하여 이루어진 식품 조성물(Food composition containing balancing agent for ω- 6 and ω- 3 unsaturated fatty acids)
FR2738828B1 (fr) *	1995-09-20	1997-10-17	Commissariat Energie Atomique	Utilisation de cyclodextrines naturelles et de leurs derives pour la solubilisation d'agents anti-agregants plaquettaires de la famille des ginkgolides
US5993795A (en) *	1995-11-09	1999-11-30	Takemoto Yushi Kabushiki Kaisha	Protein composition derived from sesame seed and use thereof
US5811313A (en) *	1997-06-17	1998-09-22	King Pharmaceuticals, Inc.	Identification test for highly refined sesame oil
KR20040058192A (ko) *	2001-10-19	2004-07-03	맥심 파마수티컬즈 인크.	간 질환 치료용으로서의 히스타민 용도
JP4388248B2 (ja) *	2001-10-29	2009-12-24	株式会社日立製作所	最適ポートフォリオ決定方法および装置
FI114917B (fi) *	2002-08-29	2005-01-31	Hormos Nutraceutical Oy Ltd	Lignaanikomplekseja
CA2592532C (en) *	2004-12-28	2015-02-17	Suntory Limited	Sesamin/episesamin compositions with improved bioavailability
ES2375115T3 (es) *	2005-03-31	2012-02-24	Suntory Holdings Limited	Emulsión de aceite en agua que contiene un compuesto de lignano y composición que comprenden al mismo.
EP1930333B1 (de)	2005-09-30	2014-11-05	Suntory Holdings Limited	Verfahren und vorrichtung zur herstellung einer an episesamin reichen zusammensetzung
WO2007119378A1 (ja) *	2006-03-15	2007-10-25	Suntory Limited	リボフラビンとセサミン類とを含有する組成物
JP5069416B2 (ja) *	2006-03-15	2012-11-07	サントリーホールディングス株式会社	吸湿性の改善された飲食品用組成物
EP2002832A4 (de)	2006-03-31	2009-11-11	Suntory Holdings Ltd	Zusammensetzung mit einer lignan-verbindung
AU2008239318B2 (en) *	2007-03-15	2013-10-03	Suntory Holdings Limited	Anti-fatigue agent
WO2009038090A1 (ja) *	2007-09-19	2009-03-26	Suntory Holdings Limited	セサミン類とアラキドン酸類を含有する組成物
SG10201510301UA (en) *	2007-09-19	2016-01-28	Suntory Holdings Ltd	Compositions incorporating sesamin-class compounds and vitamin b1 class compounds
JP6156795B2 (ja) *	2013-07-05	2017-07-05	公立大学法人大阪市立大学	脂肪細胞分化の抑制用、脂肪細胞の脂肪蓄積量低減用および／または脂肪細胞のアディポネクチン分泌促進用組成物
CN104804012B (zh) *	2015-04-24	2017-06-30	沈阳药科大学	一种具有抗耐药菌活性的化合物止泻木脂素a及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4427694A (en) *	1982-06-11	1984-01-24	The Vinoxen Company, Inc.	Sesamin as a psychotropic agent
US4904694A (en) *	1986-06-13	1990-02-27	Tsumura & Co.	Biphenyl derivative useful in the treatment of liver diseases
JPH01135892A (ja) *	1987-11-20	1989-05-29	Kuki Sangyo Kk	抗酸化性物質の製造方法
US4868207A (en) *	1988-07-28	1989-09-19	Taisho Pharmaceutical Co., Ltd.	Bis (methylenedioxy) biphenyl compounds useful for the treatment of liver diseases
JP3070611B2 (ja) *	1989-03-07	2000-07-31	サントリー株式会社	△▲上５▼―不飽和化酵素阻害剤
JPH02255616A (ja) *	1989-03-27	1990-10-16	Rooman Kogyo:Kk	肝臓疾患用剤

1990
- 1990-07-20 DE DE69034181T patent/DE69034181T2/de not_active Expired - Lifetime
- 1990-07-20 CA CA002021714A patent/CA2021714C/en not_active Expired - Lifetime
- 1990-07-20 AT AT90307978T patent/ATE208195T1/de not_active IP Right Cessation
- 1990-07-20 US US07/555,586 patent/US5180588A/en not_active Expired - Lifetime
- 1990-07-20 DK DK90307978T patent/DK0409654T3/da active
- 1990-07-20 DE DE69034084T patent/DE69034084T2/de not_active Expired - Lifetime
- 1990-07-20 DK DK97112930T patent/DK0826369T3/da active
- 1990-07-20 EP EP97112931A patent/EP0818196B1/de not_active Expired - Lifetime
- 1990-07-20 SG SG1996001570A patent/SG42967A1/en unknown
- 1990-07-20 DK DK97112931T patent/DK0818196T3/da active
- 1990-07-20 ES ES97112930T patent/ES2195058T3/es not_active Expired - Lifetime
- 1990-07-20 CA CA002172855A patent/CA2172855C/en not_active Expired - Lifetime
- 1990-07-20 EP EP90307978A patent/EP0409654B1/de not_active Expired - Lifetime
- 1990-07-20 AT AT97112931T patent/ATE285765T1/de not_active IP Right Cessation
- 1990-07-20 AT AT97112930T patent/ATE241978T1/de not_active IP Right Cessation
- 1990-07-20 ES ES90307978T patent/ES2161680T3/es not_active Expired - Lifetime
- 1990-07-20 EP EP97112930A patent/EP0826369B1/de not_active Expired - Lifetime
- 1990-07-20 ES ES97112931T patent/ES2235205T3/es not_active Expired - Lifetime
- 1990-07-20 DE DE69033848T patent/DE69033848T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2195058T3 (es)	2003-12-01
DK0826369T3 (da)	2003-09-29
US5180588A (en)	1993-01-19
DE69034084D1 (de)	2003-07-10
CA2021714A1 (en)	1991-01-22
EP0409654A3 (en)	1992-05-27
ES2235205T3 (es)	2005-07-01
EP0818196B1 (de)	2004-12-29
DK0409654T3 (da)	2001-12-27
ES2161680T3 (es)	2001-12-16
ATE208195T1 (de)	2001-11-15
DE69033848D1 (de)	2001-12-13
EP0409654A2 (de)	1991-01-23
CA2172855C (en)	2000-02-15
DE69034084T2 (de)	2003-12-04
EP0409654B1 (de)	2001-11-07
EP0818196A1 (de)	1998-01-14
EP0826369B1 (de)	2003-06-04
DE69033848T2 (de)	2002-04-04
SG42967A1 (en)	1997-10-17
DE69034181D1 (de)	2005-02-03
ATE285765T1 (de)	2005-01-15
EP0826369A1 (de)	1998-03-04
DE69034181T2 (de)	2006-01-26
CA2172855A1 (en)	1991-01-22
CA2021714C (en)	1996-07-23
DK0818196T3 (da)	2005-05-02

Legal Events

Date

Code

Title

Description

2004-01-15

UEP

Publication of translation of european patent specification

Ref document number: 0826369

Country of ref document: EP

2010-10-15

EELA

Cancelled due to lapse of time

Publication	Publication Date	Title
DE69034084D1 (de)	2003-07-10	Therapeutische Anwendung von Dioxabicyclo(3.3.0)oktan-Verbindungen
DE69019565D1 (de)	1995-06-29	Arzneimittel zur Behandlung von Thromben, Entzündungen und hohem Blutdruck.
IL77452A (en)	1991-08-16	Derivatives of arylcyclobutylalkyl-amines,their preparation and pharmaceutical compositions containing them
EP0340754A3 (de)	1991-05-15	Monopersulfate von Amino-(poly)percarbonsäuren
DE69230958D1 (de)	2000-05-31	Arzneizusammensetzung auf Basis von Dioxabicyclo[3.3.0]octanderivaten
JPS5798545A (en)	1982-06-18	Acetal resin composition
EP0488513A3 (de)	1992-06-17	Verwendung von Dioxabicyclo [3.3.0]octane Derivaten zur Herstellung eines Arzneimittels zur Hemmung des Cholesterinmetabolismus.
WO1999030722A8 (en)	1999-09-10	Pharmaceutical compositions for mucolysis and treatment of inflammation
EP0681788A3 (de)	1998-01-14	Dioxabicyclo 3.3.0 octan-Derivate, z.B. Sesamin etc., zur Vorbeugung und Erleichterung von Allergiesymptomen
IL78273A0 (en)	1986-07-31	(4.2.0)bicyclooctane derivatives,their preparation and pharmaceutical compositions containing them
ATE21695T1 (de)	1986-09-15	Aminocyclopentanester, ihre herstellung und pharmazeutische formulierungen.
DE3579345D1 (de)	1990-10-04	Medizinische oelbaeder.
FI912269A0 (fi)	1991-05-10	3'-deamino - 4'deoxi - 4'-amino- 8 -fluorantracykliner och framstaellningsfoerfaranden foer dessa.
JPS5436255A (en)	1979-03-16	Novel sesquiterpene analogue, its preparation, and pharmatheutical containing the same
JPS5323997A (en)	1978-03-06	Imidazoquinazoline derivatives and their preparation
EP0304842A3 (de)	1991-01-16	Isoprenderivate und diese enthaltende Anti-Ulcus-Mittel
IE900218L (en)	1990-07-20	Benzopyran derivatives
JPS5328177A (en)	1978-03-16	Optical active piperidine derivatives and their preparation
JPS5325554A (en)	1978-03-09	2-omega,omega-bis(alkyulthio)-or omega,omega(alkylenedithio)-alkyl-5-methylfuran and their preparation
JPS5325514A (en)	1978-03-09	Omega,omega-bis(alkylthio)-or omega,omega-(alkylenedithio)-2,5-dioxoalkane and its preparation
JPS53124241A (en)	1978-10-30	Methylenomycin a derivatives and their preparation
HUT58742A (en)	1992-03-30	Process for producing alpha-adrenerg-receptor antagonistic thieno-benzazepines and pharmaceutical compositions containing them
JPS53137970A (en)	1978-12-01	Sterylglucoside acetal derivatives
SU1513867A1 (ru)	1999-09-10	2,2'-азобис{2-циано-5-[6-или(4-метил-3)(2,3-эпоксипропоксикарбамино)гексил - или (фенил)аминокарбокси]пентаны} в качестве промежуточных продуктов для получения эпоксидных олигомеров
JPS56122372A (en)	1981-09-25	Prostaglandin i2 derivative